Translation, Eukaryotic translation initiation factor 3 subunit I
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 1 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | yes | yes: 2 |
| Forrest at al. (procyclic) | yes | yes: 2 |
| Silverman et al. | no | yes: 2 |
| Pissara et al. | yes | yes: 10 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005852 | eukaryotic translation initiation factor 3 complex | 2 | 12 |
| GO:0016282 | eukaryotic 43S preinitiation complex | 4 | 12 |
| GO:0032991 | protein-containing complex | 1 | 12 |
| GO:0033290 | eukaryotic 48S preinitiation complex | 4 | 12 |
| GO:0070993 | translation preinitiation complex | 3 | 12 |
| GO:1990904 | ribonucleoprotein complex | 2 | 12 |
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m | 3 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 1 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4ID08
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0001732 | formation of cytoplasmic translation initiation complex | 7 | 12 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0016043 | cellular component organization | 3 | 12 |
| GO:0022607 | cellular component assembly | 4 | 12 |
| GO:0022618 | ribonucleoprotein complex assembly | 6 | 12 |
| GO:0043933 | protein-containing complex organization | 4 | 12 |
| GO:0065003 | protein-containing complex assembly | 5 | 12 |
| GO:0071826 | ribonucleoprotein complex subunit organization | 5 | 12 |
| GO:0071840 | cellular component organization or biogenesis | 2 | 12 |
| GO:0002183 | cytoplasmic translational initiation | 4 | 1 |
| GO:0006413 | translational initiation | 3 | 1 |
| GO:0006417 | regulation of translation | 6 | 1 |
| GO:0006446 | regulation of translational initiation | 7 | 1 |
| GO:0008152 | metabolic process | 1 | 1 |
| GO:0009889 | regulation of biosynthetic process | 4 | 1 |
| GO:0010468 | regulation of gene expression | 5 | 1 |
| GO:0010556 | regulation of macromolecule biosynthetic process | 5 | 1 |
| GO:0010608 | post-transcriptional regulation of gene expression | 6 | 1 |
| GO:0019222 | regulation of metabolic process | 3 | 1 |
| GO:0031323 | regulation of cellular metabolic process | 4 | 1 |
| GO:0031326 | regulation of cellular biosynthetic process | 5 | 1 |
| GO:0034248 | regulation of amide metabolic process | 5 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0050789 | regulation of biological process | 2 | 1 |
| GO:0050794 | regulation of cellular process | 3 | 1 |
| GO:0051171 | regulation of nitrogen compound metabolic process | 4 | 1 |
| GO:0051246 | regulation of protein metabolic process | 5 | 1 |
| GO:0060255 | regulation of macromolecule metabolic process | 4 | 1 |
| GO:0065007 | biological regulation | 1 | 1 |
| GO:0080090 | regulation of primary metabolic process | 4 | 1 |
| GO:2000112 | obsolete regulation of cellular macromolecule biosynthetic process | 6 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 12 |
| GO:0003743 | translation initiation factor activity | 4 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0008135 | translation factor activity, RNA binding | 3 | 12 |
| GO:0045182 | translation regulator activity | 1 | 12 |
| GO:0090079 | translation regulator activity, nucleic acid binding | 2 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| GO:0003723 | RNA binding | 4 | 1 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_MEL_PAP_1 | 217 | 223 | PF00089 | 0.488 |
| CLV_PCSK_SKI1_1 | 17 | 21 | PF00082 | 0.246 |
| DEG_SCF_FBW7_1 | 157 | 164 | PF00400 | 0.584 |
| DOC_CKS1_1 | 158 | 163 | PF01111 | 0.586 |
| DOC_CKS1_1 | 168 | 173 | PF01111 | 0.383 |
| DOC_MAPK_gen_1 | 23 | 32 | PF00069 | 0.460 |
| DOC_PP4_FxxP_1 | 146 | 149 | PF00568 | 0.413 |
| DOC_PP4_FxxP_1 | 168 | 171 | PF00568 | 0.500 |
| DOC_USP7_MATH_1 | 231 | 235 | PF00917 | 0.428 |
| DOC_USP7_MATH_1 | 327 | 331 | PF00917 | 0.535 |
| DOC_USP7_MATH_1 | 84 | 88 | PF00917 | 0.479 |
| DOC_USP7_UBL2_3 | 294 | 298 | PF12436 | 0.346 |
| DOC_WW_Pin1_4 | 157 | 162 | PF00397 | 0.583 |
| DOC_WW_Pin1_4 | 167 | 172 | PF00397 | 0.379 |
| DOC_WW_Pin1_4 | 262 | 267 | PF00397 | 0.369 |
| DOC_WW_Pin1_4 | 344 | 349 | PF00397 | 0.433 |
| LIG_14-3-3_CanoR_1 | 108 | 116 | PF00244 | 0.527 |
| LIG_14-3-3_CanoR_1 | 132 | 139 | PF00244 | 0.546 |
| LIG_14-3-3_CanoR_1 | 220 | 224 | PF00244 | 0.401 |
| LIG_14-3-3_CanoR_1 | 324 | 334 | PF00244 | 0.526 |
| LIG_BRCT_BRCA1_1 | 114 | 118 | PF00533 | 0.442 |
| LIG_FHA_1 | 236 | 242 | PF00498 | 0.353 |
| LIG_FHA_1 | 247 | 253 | PF00498 | 0.361 |
| LIG_FHA_1 | 47 | 53 | PF00498 | 0.504 |
| LIG_LIR_Apic_2 | 166 | 171 | PF02991 | 0.537 |
| LIG_LIR_Gen_1 | 160 | 168 | PF02991 | 0.506 |
| LIG_LIR_Gen_1 | 190 | 201 | PF02991 | 0.487 |
| LIG_LIR_Gen_1 | 224 | 233 | PF02991 | 0.426 |
| LIG_LIR_Gen_1 | 55 | 62 | PF02991 | 0.519 |
| LIG_LIR_Nem_3 | 160 | 165 | PF02991 | 0.497 |
| LIG_LIR_Nem_3 | 190 | 196 | PF02991 | 0.479 |
| LIG_LIR_Nem_3 | 224 | 230 | PF02991 | 0.365 |
| LIG_LIR_Nem_3 | 243 | 247 | PF02991 | 0.495 |
| LIG_LIR_Nem_3 | 328 | 334 | PF02991 | 0.451 |
| LIG_LIR_Nem_3 | 55 | 59 | PF02991 | 0.500 |
| LIG_Pex14_1 | 223 | 227 | PF04695 | 0.502 |
| LIG_Pex14_2 | 291 | 295 | PF04695 | 0.369 |
| LIG_PTB_Apo_2 | 140 | 147 | PF02174 | 0.407 |
| LIG_REV1ctd_RIR_1 | 293 | 302 | PF16727 | 0.508 |
| LIG_SH2_CRK | 142 | 146 | PF00017 | 0.393 |
| LIG_SH2_CRK | 193 | 197 | PF00017 | 0.493 |
| LIG_SH2_CRK | 331 | 335 | PF00017 | 0.535 |
| LIG_SH2_CRK | 56 | 60 | PF00017 | 0.511 |
| LIG_SH2_GRB2like | 193 | 196 | PF00017 | 0.496 |
| LIG_SH2_NCK_1 | 142 | 146 | PF00017 | 0.404 |
| LIG_SH2_NCK_1 | 56 | 60 | PF00017 | 0.511 |
| LIG_SH2_STAP1 | 67 | 71 | PF00017 | 0.477 |
| LIG_SH2_STAT5 | 227 | 230 | PF00017 | 0.371 |
| LIG_SH2_STAT5 | 56 | 59 | PF00017 | 0.443 |
| LIG_SH3_3 | 155 | 161 | PF00018 | 0.549 |
| LIG_SUMO_SIM_par_1 | 195 | 200 | PF11976 | 0.376 |
| LIG_SUMO_SIM_par_1 | 70 | 75 | PF11976 | 0.424 |
| LIG_TRAF2_1 | 88 | 91 | PF00917 | 0.496 |
| LIG_WRC_WIRS_1 | 162 | 167 | PF05994 | 0.532 |
| MOD_CK1_1 | 109 | 115 | PF00069 | 0.545 |
| MOD_CK1_1 | 134 | 140 | PF00069 | 0.554 |
| MOD_CK1_1 | 281 | 287 | PF00069 | 0.564 |
| MOD_CK1_1 | 343 | 349 | PF00069 | 0.478 |
| MOD_CK1_1 | 55 | 61 | PF00069 | 0.535 |
| MOD_CK1_1 | 96 | 102 | PF00069 | 0.532 |
| MOD_CK2_1 | 163 | 169 | PF00069 | 0.528 |
| MOD_CK2_1 | 286 | 292 | PF00069 | 0.442 |
| MOD_CK2_1 | 84 | 90 | PF00069 | 0.415 |
| MOD_CMANNOS | 176 | 179 | PF00535 | 0.481 |
| MOD_GlcNHglycan | 111 | 114 | PF01048 | 0.389 |
| MOD_GlcNHglycan | 136 | 139 | PF01048 | 0.405 |
| MOD_GlcNHglycan | 327 | 330 | PF01048 | 0.252 |
| MOD_GlcNHglycan | 33 | 36 | PF01048 | 0.354 |
| MOD_GlcNHglycan | 40 | 43 | PF01048 | 0.494 |
| MOD_GlcNHglycan | 86 | 89 | PF01048 | 0.488 |
| MOD_GlcNHglycan | 98 | 101 | PF01048 | 0.357 |
| MOD_GSK3_1 | 102 | 109 | PF00069 | 0.477 |
| MOD_GSK3_1 | 112 | 119 | PF00069 | 0.405 |
| MOD_GSK3_1 | 126 | 133 | PF00069 | 0.460 |
| MOD_GSK3_1 | 157 | 164 | PF00069 | 0.511 |
| MOD_GSK3_1 | 182 | 189 | PF00069 | 0.396 |
| MOD_GSK3_1 | 231 | 238 | PF00069 | 0.361 |
| MOD_GSK3_1 | 31 | 38 | PF00069 | 0.470 |
| MOD_GSK3_1 | 340 | 347 | PF00069 | 0.515 |
| MOD_GSK3_1 | 78 | 85 | PF00069 | 0.365 |
| MOD_LATS_1 | 15 | 21 | PF00433 | 0.449 |
| MOD_N-GLC_1 | 182 | 187 | PF02516 | 0.402 |
| MOD_N-GLC_1 | 38 | 43 | PF02516 | 0.308 |
| MOD_NEK2_1 | 102 | 107 | PF00069 | 0.193 |
| MOD_NEK2_1 | 126 | 131 | PF00069 | 0.395 |
| MOD_NEK2_1 | 30 | 35 | PF00069 | 0.447 |
| MOD_NEK2_1 | 52 | 57 | PF00069 | 0.481 |
| MOD_NEK2_1 | 82 | 87 | PF00069 | 0.346 |
| MOD_NEK2_2 | 286 | 291 | PF00069 | 0.575 |
| MOD_PIKK_1 | 281 | 287 | PF00454 | 0.510 |
| MOD_PKA_2 | 131 | 137 | PF00069 | 0.571 |
| MOD_PKA_2 | 219 | 225 | PF00069 | 0.424 |
| MOD_PKA_2 | 77 | 83 | PF00069 | 0.487 |
| MOD_Plk_1 | 120 | 126 | PF00069 | 0.448 |
| MOD_Plk_1 | 182 | 188 | PF00069 | 0.442 |
| MOD_Plk_1 | 260 | 266 | PF00069 | 0.378 |
| MOD_Plk_1 | 78 | 84 | PF00069 | 0.386 |
| MOD_Plk_2-3 | 63 | 69 | PF00069 | 0.572 |
| MOD_Plk_4 | 120 | 126 | PF00069 | 0.497 |
| MOD_Plk_4 | 17 | 23 | PF00069 | 0.452 |
| MOD_Plk_4 | 182 | 188 | PF00069 | 0.388 |
| MOD_Plk_4 | 286 | 292 | PF00069 | 0.529 |
| MOD_Plk_4 | 78 | 84 | PF00069 | 0.368 |
| MOD_ProDKin_1 | 157 | 163 | PF00069 | 0.585 |
| MOD_ProDKin_1 | 167 | 173 | PF00069 | 0.382 |
| MOD_ProDKin_1 | 262 | 268 | PF00069 | 0.369 |
| MOD_ProDKin_1 | 344 | 350 | PF00069 | 0.431 |
| MOD_SUMO_rev_2 | 289 | 296 | PF00179 | 0.414 |
| TRG_DiLeu_BaEn_1 | 98 | 103 | PF01217 | 0.494 |
| TRG_ENDOCYTIC_2 | 193 | 196 | PF00928 | 0.405 |
| TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.353 |
| TRG_ENDOCYTIC_2 | 331 | 334 | PF00928 | 0.535 |
| TRG_ENDOCYTIC_2 | 56 | 59 | PF00928 | 0.493 |
| TRG_ER_diArg_1 | 205 | 208 | PF00400 | 0.546 |
| TRG_Pf-PMV_PEXEL_1 | 208 | 212 | PF00026 | 0.544 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P675 | Leptomonas seymouri | 83% | 100% |
| A0A0S4JEJ1 | Bodo saltans | 48% | 100% |
| A0A1X0P3N7 | Trypanosomatidae | 55% | 100% |
| A0A3S7XBB2 | Leishmania donovani | 100% | 100% |
| A0A422NKQ7 | Trypanosoma rangeli | 54% | 100% |
| A1CJY4 | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) | 33% | 100% |
| A1D7I5 | Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) | 33% | 100% |
| A2QEV8 | Aspergillus niger (strain CBS 513.88 / FGSC A1513) | 31% | 100% |
| A3LX18 | Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) | 32% | 100% |
| A4HPQ5 | Leishmania braziliensis | 98% | 100% |
| A4RDD7 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 32% | 100% |
| A5DGL8 | Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) | 32% | 100% |
| A5DVY3 | Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) | 32% | 100% |
| A6RUL1 | Botryotinia fuckeliana (strain B05.10) | 31% | 100% |
| A6ZMK5 | Saccharomyces cerevisiae (strain YJM789) | 29% | 100% |
| A7EF03 | Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) | 31% | 100% |
| A7RM20 | Nematostella vectensis | 32% | 100% |
| A7TH19 | Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) | 26% | 100% |
| A8QBF3 | Brugia malayi | 29% | 100% |
| A8WVX8 | Caenorhabditis briggsae | 31% | 100% |
| B0BNA7 | Rattus norvegicus | 30% | 100% |
| B0XFT7 | Culex quinquefasciatus | 32% | 100% |
| B0XYC8 | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) | 33% | 100% |
| B3MVL6 | Drosophila ananassae | 32% | 100% |
| B3N4C7 | Drosophila erecta | 32% | 100% |
| B4GSH1 | Drosophila persimilis | 32% | 100% |
| B4I195 | Drosophila sechellia | 32% | 100% |
| B4JB43 | Drosophila grimshawi | 31% | 100% |
| B4KGX9 | Drosophila mojavensis | 32% | 100% |
| B4LUA5 | Drosophila virilis | 32% | 100% |
| B4N0L0 | Drosophila willistoni | 34% | 100% |
| B4NW98 | Drosophila yakuba | 32% | 100% |
| B4Q354 | Drosophila simulans | 32% | 100% |
| B5FZ19 | Taeniopygia guttata | 30% | 100% |
| D0A8F9 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 55% | 100% |
| D3ZW91 | Rattus norvegicus | 25% | 75% |
| E3LB80 | Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL) | 26% | 100% |
| E9ATH0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 98% | 100% |
| O02195 | Drosophila melanogaster | 32% | 100% |
| P0CS32 | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) | 31% | 100% |
| P0CS33 | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) | 31% | 100% |
| P40217 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 100% |
| P79083 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 32% | 100% |
| Q0CXH9 | Aspergillus terreus (strain NIH 2624 / FGSC A1156) | 33% | 100% |
| Q0V320 | Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) | 30% | 100% |
| Q13347 | Homo sapiens | 30% | 100% |
| Q16K15 | Aedes aegypti | 31% | 100% |
| Q1DPU4 | Coccidioides immitis (strain RS) | 31% | 100% |
| Q1HPW4 | Bombyx mori | 31% | 100% |
| Q29L19 | Drosophila pseudoobscura pseudoobscura | 32% | 100% |
| Q2GTM8 | Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) | 32% | 100% |
| Q2UQ34 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 33% | 100% |
| Q38884 | Arabidopsis thaliana | 34% | 100% |
| Q4P6E2 | Ustilago maydis (strain 521 / FGSC 9021) | 33% | 100% |
| Q4Q127 | Leishmania major | 100% | 100% |
| Q4WX90 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 33% | 100% |
| Q54LT8 | Dictyostelium discoideum | 24% | 100% |
| Q54MT0 | Dictyostelium discoideum | 34% | 100% |
| Q5AI86 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 33% | 100% |
| Q5B8Y3 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 32% | 100% |
| Q5E966 | Bos taurus | 30% | 100% |
| Q5EBE8 | Xenopus tropicalis | 31% | 100% |
| Q5IH81 | Oryctolagus cuniculus | 29% | 100% |
| Q5R7R2 | Pongo abelii | 30% | 100% |
| Q66J51 | Xenopus laevis | 31% | 100% |
| Q6BSL7 | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) | 32% | 100% |
| Q6CI08 | Yarrowia lipolytica (strain CLIB 122 / E 150) | 31% | 100% |
| Q6CKX3 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 29% | 100% |
| Q6FL15 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 28% | 100% |
| Q759L2 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 28% | 100% |
| Q7PP77 | Anopheles gambiae | 31% | 100% |
| Q7RXH4 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 31% | 100% |
| Q7ZV55 | Danio rerio | 31% | 100% |
| Q7ZVF0 | Danio rerio | 23% | 86% |
| Q965S8 | Caenorhabditis elegans | 31% | 100% |
| Q9QZD9 | Mus musculus | 30% | 100% |
| V5BE86 | Trypanosoma cruzi | 55% | 100% |