Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4ICZ6_LEIIN

TriTrypDb:

LINF_360049000

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0031499	TRAMP complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0110165	cellular anatomical entity	1	5
GO:0140513	nuclear protein-containing complex	2	5

Expansion

Sequence features

A4ICZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0031123	RNA 3'-end processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043631	RNA polyadenylation	6	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071076	RNA 3' uridylation	8	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016779	nucleotidyltransferase activity	4	5
GO:0050265	RNA uridylyltransferase activity	4	5
GO:0070566	adenylyltransferase activity	5	5
GO:0070569	uridylyltransferase activity	5	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	535	539	PF00656	0.747
CLV_C14_Caspase3-7	657	661	PF00656	0.742
CLV_NRD_NRD_1	142	144	PF00675	0.696
CLV_NRD_NRD_1	487	489	PF00675	0.751
CLV_NRD_NRD_1	719	721	PF00675	0.590
CLV_PCSK_KEX2_1	142	144	PF00082	0.696
CLV_PCSK_KEX2_1	278	280	PF00082	0.516
CLV_PCSK_KEX2_1	719	721	PF00082	0.590
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.516
CLV_PCSK_SKI1_1	268	272	PF00082	0.622
CLV_PCSK_SKI1_1	279	283	PF00082	0.404
CLV_PCSK_SKI1_1	622	626	PF00082	0.433
DEG_ODPH_VHL_1	271	284	PF01847	0.535
DOC_CKS1_1	145	150	PF01111	0.721
DOC_CYCLIN_RxL_1	663	673	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.754
DOC_MAPK_DCC_7	503	512	PF00069	0.751
DOC_MAPK_gen_1	277	284	PF00069	0.504
DOC_PP2B_LxvP_1	235	238	PF13499	0.535
DOC_PP2B_LxvP_1	270	273	PF13499	0.592
DOC_PP2B_LxvP_1	409	412	PF13499	0.708
DOC_PP2B_LxvP_1	440	443	PF13499	0.762
DOC_PP2B_LxvP_1	586	589	PF13499	0.771
DOC_PP4_FxxP_1	692	695	PF00568	0.473
DOC_PP4_FxxP_1	730	733	PF00568	0.494
DOC_USP7_MATH_1	128	132	PF00917	0.691
DOC_USP7_MATH_1	20	24	PF00917	0.782
DOC_USP7_MATH_1	273	277	PF00917	0.526
DOC_USP7_MATH_1	446	450	PF00917	0.720
DOC_USP7_MATH_1	475	479	PF00917	0.646
DOC_USP7_MATH_1	569	573	PF00917	0.808
DOC_USP7_MATH_1	580	584	PF00917	0.625
DOC_USP7_MATH_1	658	662	PF00917	0.657
DOC_USP7_MATH_1	680	684	PF00917	0.513
DOC_USP7_UBL2_3	364	368	PF12436	0.513
DOC_WW_Pin1_4	11	16	PF00397	0.731
DOC_WW_Pin1_4	144	149	PF00397	0.738
DOC_WW_Pin1_4	350	355	PF00397	0.448
DOC_WW_Pin1_4	407	412	PF00397	0.613
DOC_WW_Pin1_4	430	435	PF00397	0.659
DOC_WW_Pin1_4	451	456	PF00397	0.698
DOC_WW_Pin1_4	554	559	PF00397	0.715
DOC_WW_Pin1_4	563	568	PF00397	0.717
DOC_WW_Pin1_4	616	621	PF00397	0.442
DOC_WW_Pin1_4	88	93	PF00397	0.798
LIG_14-3-3_CanoR_1	160	169	PF00244	0.583
LIG_14-3-3_CanoR_1	295	301	PF00244	0.510
LIG_14-3-3_CanoR_1	469	477	PF00244	0.756
LIG_14-3-3_CanoR_1	561	567	PF00244	0.806
LIG_14-3-3_CanoR_1	702	712	PF00244	0.544
LIG_14-3-3_CanoR_1	719	723	PF00244	0.602
LIG_Actin_WH2_2	280	297	PF00022	0.478
LIG_Actin_WH2_2	477	495	PF00022	0.495
LIG_APCC_ABBAyCdc20_2	279	285	PF00400	0.581
LIG_BIR_III_4	644	648	PF00653	0.427
LIG_BRCT_BRCA1_1	296	300	PF00533	0.592
LIG_BRCT_BRCA1_1	726	730	PF00533	0.480
LIG_CtBP_PxDLS_1	509	513	PF00389	0.516
LIG_EVH1_1	144	148	PF00568	0.660
LIG_FHA_1	173	179	PF00498	0.443
LIG_FHA_1	220	226	PF00498	0.535
LIG_FHA_1	256	262	PF00498	0.561
LIG_FHA_1	29	35	PF00498	0.716
LIG_FHA_1	554	560	PF00498	0.724
LIG_FHA_1	726	732	PF00498	0.582
LIG_FHA_2	186	192	PF00498	0.479
LIG_FHA_2	297	303	PF00498	0.586
LIG_FHA_2	524	530	PF00498	0.715
LIG_FHA_2	704	710	PF00498	0.536
LIG_FHA_2	99	105	PF00498	0.814
LIG_LIR_Apic_2	691	695	PF02991	0.467
LIG_LIR_Apic_2	727	733	PF02991	0.492
LIG_LIR_Gen_1	383	394	PF02991	0.417
LIG_LIR_Gen_1	448	458	PF02991	0.683
LIG_LIR_Nem_3	131	136	PF02991	0.762
LIG_LIR_Nem_3	147	153	PF02991	0.663
LIG_LIR_Nem_3	180	185	PF02991	0.400
LIG_LIR_Nem_3	297	303	PF02991	0.586
LIG_LIR_Nem_3	374	380	PF02991	0.501
LIG_LIR_Nem_3	383	389	PF02991	0.368
LIG_LIR_Nem_3	448	453	PF02991	0.689
LIG_PCNA_PIPBox_1	203	212	PF02747	0.565
LIG_PCNA_yPIPBox_3	197	210	PF02747	0.546
LIG_PCNA_yPIPBox_3	364	376	PF02747	0.447
LIG_RPA_C_Fungi	336	348	PF08784	0.542
LIG_SH2_CRK	386	390	PF00017	0.414
LIG_SH2_NCK_1	414	418	PF00017	0.622
LIG_SH2_NCK_1	540	544	PF00017	0.688
LIG_SH2_SRC	414	417	PF00017	0.627
LIG_SH2_SRC	479	482	PF00017	0.581
LIG_SH2_STAP1	414	418	PF00017	0.709
LIG_SH2_STAT3	183	186	PF00017	0.477
LIG_SH2_STAT5	184	187	PF00017	0.461
LIG_SH2_STAT5	201	204	PF00017	0.229
LIG_SH2_STAT5	386	389	PF00017	0.415
LIG_SH2_STAT5	479	482	PF00017	0.680
LIG_SH2_STAT5	540	543	PF00017	0.689
LIG_SH3_1	142	148	PF00018	0.745
LIG_SH3_3	134	140	PF00018	0.655
LIG_SH3_3	142	148	PF00018	0.703
LIG_SH3_3	150	156	PF00018	0.593
LIG_SH3_3	209	215	PF00018	0.557
LIG_SH3_3	730	736	PF00018	0.494
LIG_SUMO_SIM_par_1	257	263	PF11976	0.474
LIG_SUMO_SIM_par_1	508	513	PF11976	0.672
LIG_SUMO_SIM_par_1	588	594	PF11976	0.656
LIG_TRAF2_1	189	192	PF00917	0.567
LIG_TRAF2_1	249	252	PF00917	0.399
LIG_TRAF2_1	260	263	PF00917	0.408
LIG_UBA3_1	623	629	PF00899	0.435
LIG_WRC_WIRS_1	133	138	PF05994	0.760
LIG_WW_1	411	414	PF00397	0.644
LIG_WW_3	410	414	PF00397	0.614
MOD_CDC14_SPxK_1	410	413	PF00782	0.612
MOD_CDC14_SPxK_1	619	622	PF00782	0.431
MOD_CDK_SPxK_1	11	17	PF00069	0.681
MOD_CDK_SPxK_1	407	413	PF00069	0.595
MOD_CDK_SPxK_1	616	622	PF00069	0.445
MOD_CDK_SPxxK_3	554	561	PF00069	0.716
MOD_CK1_1	236	242	PF00069	0.380
MOD_CK1_1	333	339	PF00069	0.467
MOD_CK1_1	433	439	PF00069	0.666
MOD_CK1_1	518	524	PF00069	0.725
MOD_CK1_1	549	555	PF00069	0.661
MOD_CK1_1	591	597	PF00069	0.623
MOD_CK1_1	688	694	PF00069	0.503
MOD_CK1_1	704	710	PF00069	0.450
MOD_CK1_1	87	93	PF00069	0.795
MOD_CK2_1	185	191	PF00069	0.475
MOD_CK2_1	214	220	PF00069	0.727
MOD_CK2_1	296	302	PF00069	0.600
MOD_CK2_1	523	529	PF00069	0.710
MOD_CK2_1	703	709	PF00069	0.535
MOD_CK2_1	98	104	PF00069	0.817
MOD_GlcNHglycan	130	133	PF01048	0.705
MOD_GlcNHglycan	160	163	PF01048	0.591
MOD_GlcNHglycan	262	267	PF01048	0.662
MOD_GlcNHglycan	296	299	PF01048	0.607
MOD_GlcNHglycan	335	338	PF01048	0.553
MOD_GlcNHglycan	470	473	PF01048	0.708
MOD_GlcNHglycan	504	507	PF01048	0.769
MOD_GlcNHglycan	548	551	PF01048	0.719
MOD_GlcNHglycan	583	586	PF01048	0.714
MOD_GlcNHglycan	593	596	PF01048	0.696
MOD_GlcNHglycan	603	606	PF01048	0.438
MOD_GlcNHglycan	63	66	PF01048	0.727
MOD_GlcNHglycan	631	634	PF01048	0.449
MOD_GlcNHglycan	660	663	PF01048	0.657
MOD_GlcNHglycan	683	686	PF01048	0.635
MOD_GlcNHglycan	687	690	PF01048	0.466
MOD_GlcNHglycan	86	89	PF01048	0.786
MOD_GSK3_1	128	135	PF00069	0.731
MOD_GSK3_1	158	165	PF00069	0.659
MOD_GSK3_1	20	27	PF00069	0.600
MOD_GSK3_1	233	240	PF00069	0.370
MOD_GSK3_1	329	336	PF00069	0.445
MOD_GSK3_1	421	428	PF00069	0.624
MOD_GSK3_1	429	436	PF00069	0.704
MOD_GSK3_1	475	482	PF00069	0.721
MOD_GSK3_1	515	522	PF00069	0.676
MOD_GSK3_1	545	552	PF00069	0.636
MOD_GSK3_1	553	560	PF00069	0.715
MOD_GSK3_1	576	583	PF00069	0.773
MOD_GSK3_1	681	688	PF00069	0.516
MOD_GSK3_1	703	710	PF00069	0.361
MOD_GSK3_1	721	728	PF00069	0.633
MOD_GSK3_1	84	91	PF00069	0.789
MOD_GSK3_1	9	16	PF00069	0.760
MOD_LATS_1	317	323	PF00433	0.559
MOD_N-GLC_1	330	335	PF02516	0.430
MOD_N-GLC_1	407	412	PF02516	0.613
MOD_N-GLC_1	446	451	PF02516	0.685
MOD_N-GLC_1	492	497	PF02516	0.550
MOD_N-GLC_2	125	127	PF02516	0.758
MOD_NEK2_1	185	190	PF00069	0.490
MOD_NEK2_1	227	232	PF00069	0.353
MOD_NEK2_1	233	238	PF00069	0.322
MOD_NEK2_1	244	249	PF00069	0.339
MOD_NEK2_1	294	299	PF00069	0.502
MOD_NEK2_1	429	434	PF00069	0.649
MOD_NEK2_1	492	497	PF00069	0.705
MOD_NEK2_1	545	550	PF00069	0.618
MOD_NEK2_1	59	64	PF00069	0.562
MOD_NEK2_1	701	706	PF00069	0.450
MOD_NEK2_1	725	730	PF00069	0.583
MOD_OFUCOSY	323	328	PF10250	0.485
MOD_PIKK_1	421	427	PF00454	0.621
MOD_PIKK_1	538	544	PF00454	0.611
MOD_PIKK_1	606	612	PF00454	0.388
MOD_PKA_2	114	120	PF00069	0.757
MOD_PKA_2	294	300	PF00069	0.494
MOD_PKA_2	360	366	PF00069	0.506
MOD_PKA_2	468	474	PF00069	0.766
MOD_PKA_2	546	552	PF00069	0.644
MOD_PKA_2	701	707	PF00069	0.537
MOD_PKA_2	718	724	PF00069	0.599
MOD_Plk_1	330	336	PF00069	0.429
MOD_Plk_1	4	10	PF00069	0.762
MOD_Plk_1	446	452	PF00069	0.685
MOD_Plk_1	518	524	PF00069	0.689
MOD_Plk_4	132	138	PF00069	0.758
MOD_Plk_4	475	481	PF00069	0.616
MOD_Plk_4	707	713	PF00069	0.504
MOD_Plk_4	721	727	PF00069	0.529
MOD_ProDKin_1	11	17	PF00069	0.732
MOD_ProDKin_1	144	150	PF00069	0.731
MOD_ProDKin_1	350	356	PF00069	0.443
MOD_ProDKin_1	407	413	PF00069	0.619
MOD_ProDKin_1	430	436	PF00069	0.662
MOD_ProDKin_1	451	457	PF00069	0.694
MOD_ProDKin_1	554	560	PF00069	0.715
MOD_ProDKin_1	563	569	PF00069	0.717
MOD_ProDKin_1	616	622	PF00069	0.445
MOD_ProDKin_1	88	94	PF00069	0.800
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.541
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.424
TRG_ENDOCYTIC_2	133	136	PF00928	0.679
TRG_ENDOCYTIC_2	184	187	PF00928	0.402
TRG_ENDOCYTIC_2	386	389	PF00928	0.415
TRG_ER_diArg_1	141	143	PF00400	0.698
TRG_ER_diArg_1	345	348	PF00400	0.445
TRG_ER_diArg_1	53	56	PF00400	0.762
TRG_ER_diArg_1	613	616	PF00400	0.577
TRG_ER_diArg_1	718	720	PF00400	0.593
TRG_NES_CRM1_1	177	191	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P668	Leptomonas seymouri	52%	96%
A0A3Q8IPC3	Leishmania donovani	98%	100%
E9ATI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%