Rieske domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICZ5_LEIIN

TriTrypDb:

LINF_360049100

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICZ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	30	34	PF00082	0.340
DEG_Kelch_Keap1_1	84	89	PF01344	0.361
DOC_CYCLIN_yCln2_LP_2	25	31	PF00134	0.377
DOC_PP4_FxxP_1	119	122	PF00568	0.517
DOC_USP7_MATH_1	120	124	PF00917	0.405
DOC_USP7_MATH_1	164	168	PF00917	0.419
DOC_WW_Pin1_4	48	53	PF00397	0.319
LIG_14-3-3_CanoR_1	30	35	PF00244	0.307
LIG_Clathr_ClatBox_1	82	86	PF01394	0.305
LIG_Clathr_ClatBox_1	92	96	PF01394	0.404
LIG_eIF4E_1	31	37	PF01652	0.434
LIG_FHA_1	144	150	PF00498	0.433
LIG_FHA_1	31	37	PF00498	0.323
LIG_IRF3_LxIS_1	32	38	PF10401	0.377
LIG_LIR_Nem_3	10	14	PF02991	0.366
LIG_LIR_Nem_3	26	32	PF02991	0.281
LIG_LYPXL_SIV_4	28	36	PF13949	0.382
LIG_PDZ_Class_3	189	194	PF00595	0.559
LIG_SH2_CRK	29	33	PF00017	0.348
LIG_SH2_PTP2	31	34	PF00017	0.376
LIG_SH2_STAT5	31	34	PF00017	0.381
LIG_SH2_STAT5	81	84	PF00017	0.382
LIG_SH3_3	110	116	PF00018	0.558
LIG_SH3_3	37	43	PF00018	0.506
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.519
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.448
LIG_SUMO_SIM_par_1	144	153	PF11976	0.370
LIG_SUMO_SIM_par_1	32	38	PF11976	0.445
LIG_SUMO_SIM_par_1	64	70	PF11976	0.441
LIG_UBA3_1	183	187	PF00899	0.492
MOD_GlcNHglycan	121	125	PF01048	0.475
MOD_GSK3_1	144	151	PF00069	0.408
MOD_NEK2_1	143	148	PF00069	0.377
MOD_NEK2_1	35	40	PF00069	0.477
MOD_Plk_2-3	7	13	PF00069	0.383
MOD_Plk_4	125	131	PF00069	0.505
MOD_Plk_4	30	36	PF00069	0.329
MOD_ProDKin_1	48	54	PF00069	0.320
MOD_SUMO_rev_2	44	49	PF00179	0.439
TRG_DiLeu_BaEn_1	67	72	PF01217	0.417
TRG_DiLeu_BaEn_3	144	150	PF01217	0.491
TRG_ENDOCYTIC_2	11	14	PF00928	0.369
TRG_ENDOCYTIC_2	29	32	PF00928	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H7	Leptomonas seymouri	75%	100%
A0A0S4IXL7	Bodo saltans	44%	97%
A0A1X0P3Z4	Trypanosomatidae	48%	90%
A0A3Q8IJQ0	Leishmania donovani	98%	100%
A0A422NVN8	Trypanosoma rangeli	52%	100%
A4HPR8	Leishmania braziliensis	89%	100%
D0A8N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	93%
E9ATI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q115	Leishmania major	96%	100%