LeishMANIAdb
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Peroxisomal biogenesis factor 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxisomal biogenesis factor 3
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICZ4_LEIIN
TriTrypDb:
LINF_360049200
Length:
526

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ICZ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICZ4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.705
CLV_NRD_NRD_1 146 148 PF00675 0.574
CLV_NRD_NRD_1 171 173 PF00675 0.770
CLV_NRD_NRD_1 310 312 PF00675 0.623
CLV_NRD_NRD_1 319 321 PF00675 0.602
CLV_NRD_NRD_1 396 398 PF00675 0.761
CLV_NRD_NRD_1 413 415 PF00675 0.710
CLV_NRD_NRD_1 428 430 PF00675 0.557
CLV_PCSK_KEX2_1 146 148 PF00082 0.572
CLV_PCSK_KEX2_1 171 173 PF00082 0.764
CLV_PCSK_KEX2_1 310 312 PF00082 0.638
CLV_PCSK_KEX2_1 319 321 PF00082 0.630
CLV_PCSK_KEX2_1 395 397 PF00082 0.710
CLV_PCSK_KEX2_1 413 415 PF00082 0.706
CLV_PCSK_KEX2_1 428 430 PF00082 0.559
CLV_PCSK_KEX2_1 434 436 PF00082 0.578
CLV_PCSK_KEX2_1 473 475 PF00082 0.630
CLV_PCSK_PC1ET2_1 434 436 PF00082 0.621
CLV_PCSK_PC1ET2_1 473 475 PF00082 0.615
CLV_PCSK_PC7_1 392 398 PF00082 0.759
CLV_PCSK_SKI1_1 225 229 PF00082 0.730
CLV_PCSK_SKI1_1 256 260 PF00082 0.601
CLV_PCSK_SKI1_1 473 477 PF00082 0.621
CLV_PCSK_SKI1_1 77 81 PF00082 0.368
CLV_PCSK_SKI1_1 99 103 PF00082 0.398
DEG_APCC_DBOX_1 110 118 PF00400 0.561
DEG_APCC_DBOX_1 171 179 PF00400 0.565
DEG_APCC_DBOX_1 76 84 PF00400 0.646
DEG_Nend_UBRbox_2 1 3 PF02207 0.713
DOC_CYCLIN_RxL_1 134 145 PF00134 0.396
DOC_MAPK_gen_1 108 117 PF00069 0.569
DOC_MAPK_HePTP_8 131 143 PF00069 0.480
DOC_MAPK_MEF2A_6 134 143 PF00069 0.319
DOC_MAPK_MEF2A_6 256 263 PF00069 0.395
DOC_MAPK_RevD_3 131 147 PF00069 0.537
DOC_PP1_RVXF_1 136 143 PF00149 0.394
DOC_PP2B_LxvP_1 215 218 PF13499 0.596
DOC_USP7_MATH_1 273 277 PF00917 0.401
DOC_USP7_MATH_1 312 316 PF00917 0.437
DOC_USP7_MATH_1 321 325 PF00917 0.499
DOC_USP7_MATH_1 339 343 PF00917 0.557
DOC_USP7_MATH_1 366 370 PF00917 0.532
DOC_USP7_MATH_1 380 384 PF00917 0.444
DOC_USP7_MATH_1 493 497 PF00917 0.387
DOC_WW_Pin1_4 193 198 PF00397 0.423
DOC_WW_Pin1_4 335 340 PF00397 0.569
DOC_WW_Pin1_4 43 48 PF00397 0.624
LIG_14-3-3_CanoR_1 111 115 PF00244 0.561
LIG_14-3-3_CanoR_1 311 321 PF00244 0.427
LIG_14-3-3_CanoR_1 332 340 PF00244 0.563
LIG_14-3-3_CanoR_1 474 479 PF00244 0.431
LIG_APCC_ABBA_1 512 517 PF00400 0.352
LIG_BRCT_BRCA1_1 446 450 PF00533 0.370
LIG_EH1_1 285 293 PF00400 0.387
LIG_EVH1_1 215 219 PF00568 0.564
LIG_FHA_1 121 127 PF00498 0.385
LIG_FHA_1 207 213 PF00498 0.597
LIG_FHA_1 335 341 PF00498 0.561
LIG_FHA_1 382 388 PF00498 0.454
LIG_FHA_1 66 72 PF00498 0.628
LIG_FHA_1 74 80 PF00498 0.559
LIG_FHA_2 369 375 PF00498 0.576
LIG_FHA_2 44 50 PF00498 0.645
LIG_FHA_2 67 73 PF00498 0.633
LIG_FHA_2 95 101 PF00498 0.621
LIG_LIR_Gen_1 510 515 PF02991 0.404
LIG_LIR_Nem_3 447 453 PF02991 0.373
LIG_LIR_Nem_3 510 514 PF02991 0.402
LIG_MYND_1 323 327 PF01753 0.552
LIG_NRBOX 139 145 PF00104 0.376
LIG_NRBOX 296 302 PF00104 0.373
LIG_Pex14_1 106 110 PF04695 0.604
LIG_Rb_LxCxE_1 510 526 PF01857 0.409
LIG_SH2_CRK 511 515 PF00017 0.399
LIG_SH2_NCK_1 478 482 PF00017 0.409
LIG_SH2_STAP1 122 126 PF00017 0.485
LIG_SH2_STAP1 457 461 PF00017 0.357
LIG_SH2_STAT5 122 125 PF00017 0.418
LIG_SH2_STAT5 37 40 PF00017 0.631
LIG_SH3_1 213 219 PF00018 0.599
LIG_SH3_3 213 219 PF00018 0.570
LIG_SH3_3 258 264 PF00018 0.425
LIG_SH3_3 315 321 PF00018 0.415
LIG_SUMO_SIM_anti_2 127 132 PF11976 0.408
LIG_SUMO_SIM_par_1 125 132 PF11976 0.487
LIG_TRAF2_1 416 419 PF00917 0.443
LIG_TRAF2_1 421 424 PF00917 0.448
LIG_TRAF2_1 501 504 PF00917 0.399
LIG_UBA3_1 130 134 PF00899 0.454
LIG_UBA3_1 179 186 PF00899 0.619
MOD_CK1_1 129 135 PF00069 0.491
MOD_CK1_1 333 339 PF00069 0.678
MOD_CK1_1 369 375 PF00069 0.655
MOD_CK1_1 65 71 PF00069 0.546
MOD_CK2_1 142 148 PF00069 0.536
MOD_CK2_1 244 250 PF00069 0.624
MOD_CK2_1 368 374 PF00069 0.713
MOD_CK2_1 446 452 PF00069 0.453
MOD_CK2_1 66 72 PF00069 0.544
MOD_CK2_1 94 100 PF00069 0.539
MOD_Cter_Amidation 169 172 PF01082 0.721
MOD_GlcNHglycan 148 151 PF01048 0.616
MOD_GlcNHglycan 156 159 PF01048 0.649
MOD_GlcNHglycan 275 278 PF01048 0.490
MOD_GlcNHglycan 288 291 PF01048 0.447
MOD_GlcNHglycan 293 296 PF01048 0.364
MOD_GlcNHglycan 332 335 PF01048 0.689
MOD_GlcNHglycan 367 371 PF01048 0.733
MOD_GlcNHglycan 39 42 PF01048 0.554
MOD_GlcNHglycan 446 449 PF01048 0.505
MOD_GSK3_1 113 120 PF00069 0.379
MOD_GSK3_1 122 129 PF00069 0.328
MOD_GSK3_1 142 149 PF00069 0.250
MOD_GSK3_1 150 157 PF00069 0.549
MOD_GSK3_1 189 196 PF00069 0.710
MOD_GSK3_1 326 333 PF00069 0.696
MOD_GSK3_1 335 342 PF00069 0.678
MOD_GSK3_1 366 373 PF00069 0.685
MOD_GSK3_1 442 449 PF00069 0.545
MOD_GSK3_1 516 523 PF00069 0.411
MOD_GSK3_1 62 69 PF00069 0.532
MOD_NEK2_1 110 115 PF00069 0.344
MOD_NEK2_1 126 131 PF00069 0.344
MOD_NEK2_1 142 147 PF00069 0.435
MOD_NEK2_1 152 157 PF00069 0.673
MOD_NEK2_1 179 184 PF00069 0.660
MOD_NEK2_1 286 291 PF00069 0.421
MOD_NEK2_1 347 352 PF00069 0.740
MOD_NEK2_1 444 449 PF00069 0.456
MOD_NEK2_1 453 458 PF00069 0.408
MOD_NEK2_2 159 164 PF00069 0.610
MOD_NEK2_2 493 498 PF00069 0.493
MOD_NEK2_2 516 521 PF00069 0.399
MOD_PIKK_1 189 195 PF00454 0.699
MOD_PIKK_1 244 250 PF00454 0.641
MOD_PKA_1 146 152 PF00069 0.614
MOD_PKA_2 110 116 PF00069 0.425
MOD_PKA_2 146 152 PF00069 0.614
MOD_PKA_2 520 526 PF00069 0.445
MOD_PKA_2 63 69 PF00069 0.556
MOD_PKA_2 73 79 PF00069 0.467
MOD_Plk_1 13 19 PF00069 0.691
MOD_Plk_1 516 522 PF00069 0.422
MOD_Plk_1 62 68 PF00069 0.534
MOD_Plk_2-3 206 212 PF00069 0.680
MOD_Plk_4 110 116 PF00069 0.362
MOD_Plk_4 179 185 PF00069 0.584
MOD_Plk_4 296 302 PF00069 0.467
MOD_Plk_4 321 327 PF00069 0.746
MOD_Plk_4 382 388 PF00069 0.713
MOD_Plk_4 507 513 PF00069 0.499
MOD_ProDKin_1 193 199 PF00069 0.533
MOD_ProDKin_1 335 341 PF00069 0.733
MOD_ProDKin_1 43 49 PF00069 0.523
MOD_SUMO_rev_2 400 407 PF00179 0.636
MOD_SUMO_rev_2 468 475 PF00179 0.501
MOD_SUMO_rev_2 503 510 PF00179 0.519
MOD_SUMO_rev_2 95 103 PF00179 0.503
TRG_DiLeu_BaEn_1 358 363 PF01217 0.771
TRG_DiLeu_BaEn_4 210 216 PF01217 0.747
TRG_ENDOCYTIC_2 36 39 PF00928 0.608
TRG_ENDOCYTIC_2 511 514 PF00928 0.414
TRG_ER_diArg_1 318 320 PF00400 0.494
TRG_ER_diArg_1 394 397 PF00400 0.688
TRG_ER_diArg_1 413 415 PF00400 0.656
TRG_ER_diArg_1 427 429 PF00400 0.479
TRG_Pf-PMV_PEXEL_1 413 418 PF00026 0.699
TRG_Pf-PMV_PEXEL_1 77 81 PF00026 0.517

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL78 Leptomonas seymouri 69% 100%
A0A1X0P397 Trypanosomatidae 35% 100%
A0A3Q8IW98 Leishmania donovani 99% 100%
A0A3R7KTQ7 Trypanosoma rangeli 32% 100%
A4HPR9 Leishmania braziliensis 83% 99%
E9ATI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q114 Leishmania major 95% 100%
V5B6V7 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS