LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICZ1_LEIIN
TriTrypDb:
LINF_360049500
Length:
430

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ICZ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICZ1

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 1
GO:0006335 DNA replication-dependent chromatin assembly 5 1
GO:0006338 chromatin remodeling 5 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0031055 chromatin remodeling at centromere 6 1
GO:0034080 CENP-A containing chromatin assembly 7 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042393 histone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 401 403 PF00675 0.625
CLV_PCSK_KEX2_1 406 408 PF00082 0.643
CLV_PCSK_KEX2_1 421 423 PF00082 0.646
CLV_PCSK_PC1ET2_1 406 408 PF00082 0.707
CLV_PCSK_PC1ET2_1 421 423 PF00082 0.646
CLV_PCSK_PC7_1 402 408 PF00082 0.709
CLV_PCSK_SKI1_1 127 131 PF00082 0.470
CLV_PCSK_SKI1_1 24 28 PF00082 0.674
DEG_APCC_DBOX_1 266 274 PF00400 0.461
DEG_SPOP_SBC_1 50 54 PF00917 0.683
DOC_CKS1_1 322 327 PF01111 0.652
DOC_CYCLIN_yCln2_LP_2 357 363 PF00134 0.632
DOC_PP1_RVXF_1 167 173 PF00149 0.329
DOC_PP2B_LxvP_1 357 360 PF13499 0.542
DOC_PP2B_LxvP_1 381 384 PF13499 0.615
DOC_USP7_MATH_1 10 14 PF00917 0.751
DOC_USP7_MATH_1 352 356 PF00917 0.660
DOC_USP7_MATH_1 384 388 PF00917 0.707
DOC_USP7_MATH_1 64 68 PF00917 0.672
DOC_USP7_MATH_2 325 331 PF00917 0.618
DOC_WW_Pin1_4 321 326 PF00397 0.653
DOC_WW_Pin1_4 388 393 PF00397 0.714
LIG_14-3-3_CanoR_1 265 271 PF00244 0.481
LIG_Actin_WH2_2 239 257 PF00022 0.377
LIG_BIR_II_1 1 5 PF00653 0.783
LIG_BIR_III_2 226 230 PF00653 0.498
LIG_FHA_1 158 164 PF00498 0.426
LIG_FHA_1 391 397 PF00498 0.751
LIG_FHA_2 1 7 PF00498 0.635
LIG_FHA_2 142 148 PF00498 0.640
LIG_FHA_2 267 273 PF00498 0.482
LIG_FHA_2 322 328 PF00498 0.548
LIG_FHA_2 406 412 PF00498 0.715
LIG_FHA_2 51 57 PF00498 0.813
LIG_FHA_2 78 84 PF00498 0.514
LIG_GBD_Chelix_1 281 289 PF00786 0.532
LIG_LIR_Gen_1 160 170 PF02991 0.348
LIG_LIR_Gen_1 353 363 PF02991 0.601
LIG_LIR_Nem_3 105 111 PF02991 0.379
LIG_LIR_Nem_3 160 165 PF02991 0.357
LIG_LIR_Nem_3 327 331 PF02991 0.645
LIG_NRBOX 288 294 PF00104 0.465
LIG_PCNA_PIPBox_1 107 116 PF02747 0.375
LIG_PCNA_yPIPBox_3 138 150 PF02747 0.602
LIG_SH2_CRK 108 112 PF00017 0.381
LIG_SH2_CRK 221 225 PF00017 0.443
LIG_SH2_GRB2like 162 165 PF00017 0.493
LIG_SH2_PTP2 162 165 PF00017 0.493
LIG_SH2_SRC 100 103 PF00017 0.439
LIG_SH2_STAP1 100 104 PF00017 0.415
LIG_SH2_STAP1 207 211 PF00017 0.386
LIG_SH2_STAP1 214 218 PF00017 0.316
LIG_SH2_STAT5 128 131 PF00017 0.361
LIG_SH2_STAT5 162 165 PF00017 0.493
LIG_SH2_STAT5 356 359 PF00017 0.656
LIG_SH3_3 146 152 PF00018 0.647
LIG_SH3_3 389 395 PF00018 0.760
LIG_SUMO_SIM_anti_2 230 238 PF11976 0.608
LIG_TRAF2_1 228 231 PF00917 0.640
LIG_TRAF2_1 324 327 PF00917 0.517
LIG_TRAF2_1 45 48 PF00917 0.711
LIG_TRAF2_1 80 83 PF00917 0.510
LIG_TYR_ITIM 106 111 PF00017 0.373
LIG_TYR_ITIM 219 224 PF00017 0.403
MOD_CK1_1 355 361 PF00069 0.586
MOD_CK1_1 42 48 PF00069 0.751
MOD_CK1_1 51 57 PF00069 0.661
MOD_CK2_1 254 260 PF00069 0.567
MOD_CK2_1 266 272 PF00069 0.452
MOD_CK2_1 321 327 PF00069 0.525
MOD_CK2_1 42 48 PF00069 0.694
MOD_CK2_1 51 57 PF00069 0.619
MOD_CK2_1 77 83 PF00069 0.550
MOD_DYRK1A_RPxSP_1 388 392 PF00069 0.760
MOD_GlcNHglycan 121 124 PF01048 0.537
MOD_GlcNHglycan 340 343 PF01048 0.566
MOD_GlcNHglycan 361 364 PF01048 0.614
MOD_GlcNHglycan 388 391 PF01048 0.692
MOD_GlcNHglycan 426 429 PF01048 0.652
MOD_GSK3_1 1 8 PF00069 0.729
MOD_GSK3_1 277 284 PF00069 0.494
MOD_GSK3_1 355 362 PF00069 0.539
MOD_GSK3_1 367 374 PF00069 0.519
MOD_GSK3_1 384 391 PF00069 0.798
MOD_GSK3_1 39 46 PF00069 0.747
MOD_GSK3_1 405 412 PF00069 0.758
MOD_GSK3_1 48 55 PF00069 0.631
MOD_NEK2_1 377 382 PF00069 0.611
MOD_NEK2_2 157 162 PF00069 0.409
MOD_PIKK_1 132 138 PF00454 0.342
MOD_PIKK_1 43 49 PF00454 0.693
MOD_PKA_2 266 272 PF00069 0.485
MOD_PKB_1 422 430 PF00069 0.748
MOD_Plk_1 29 35 PF00069 0.528
MOD_Plk_1 352 358 PF00069 0.593
MOD_Plk_1 409 415 PF00069 0.771
MOD_Plk_1 64 70 PF00069 0.727
MOD_Plk_1 72 78 PF00069 0.709
MOD_Plk_2-3 327 333 PF00069 0.608
MOD_Plk_4 232 238 PF00069 0.483
MOD_Plk_4 281 287 PF00069 0.529
MOD_Plk_4 352 358 PF00069 0.702
MOD_Plk_4 377 383 PF00069 0.611
MOD_ProDKin_1 321 327 PF00069 0.653
MOD_ProDKin_1 388 394 PF00069 0.713
MOD_SUMO_for_1 35 38 PF00179 0.685
MOD_SUMO_rev_2 226 235 PF00179 0.504
MOD_SUMO_rev_2 271 275 PF00179 0.517
MOD_SUMO_rev_2 330 338 PF00179 0.659
MOD_SUMO_rev_2 414 423 PF00179 0.647
TRG_DiLeu_BaEn_1 21 26 PF01217 0.725
TRG_DiLeu_BaEn_1 288 293 PF01217 0.462
TRG_DiLeu_BaLyEn_6 135 140 PF01217 0.452
TRG_ENDOCYTIC_2 108 111 PF00928 0.376
TRG_ENDOCYTIC_2 162 165 PF00928 0.493
TRG_ENDOCYTIC_2 221 224 PF00928 0.376
TRG_ENDOCYTIC_2 356 359 PF00928 0.579
TRG_NLS_Bipartite_1 403 425 PF00514 0.708
TRG_NLS_MonoExtC_3 401 406 PF00514 0.634
TRG_NLS_MonoExtC_3 420 426 PF00514 0.606
TRG_NLS_MonoExtN_4 402 407 PF00514 0.616
TRG_NLS_MonoExtN_4 418 425 PF00514 0.662
TRG_Pf-PMV_PEXEL_1 138 143 PF00026 0.554
TRG_Pf-PMV_PEXEL_1 222 226 PF00026 0.397

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HXN4 Leptomonas seymouri 83% 100%
A0A0S4IPT5 Bodo saltans 46% 100%
A0A1X0P488 Trypanosomatidae 49% 89%
A0A3R7NPK3 Trypanosoma rangeli 49% 95%
A0A3S7XBE8 Leishmania donovani 100% 100%
A4HPS2 Leishmania braziliensis 87% 100%
D0A8N7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9ATI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q111 Leishmania major 97% 100%
V5BS19 Trypanosoma cruzi 53% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS