LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICZ1_LEIIN
TriTrypDb:
LINF_360049500
Length:
430

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005654 nucleoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4ICZ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICZ1

Function

Biological processes
TermNameLevelCount
GO:0006325 chromatin organization 4 1
GO:0006335 DNA replication-dependent chromatin assembly 5 1
GO:0006338 chromatin remodeling 5 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0031055 chromatin remodeling at centromere 6 1
GO:0034080 CENP-A containing chromatin assembly 7 1
GO:0071840 cellular component organization or biogenesis 2 1
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Molecular functions
TermNameLevelCount
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042393 histone binding 3 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 401 403 PF00675 0.625
CLV_PCSK_KEX2_1 406 408 PF00082 0.643
CLV_PCSK_KEX2_1 421 423 PF00082 0.646
CLV_PCSK_PC1ET2_1 406 408 PF00082 0.707
CLV_PCSK_PC1ET2_1 421 423 PF00082 0.646
CLV_PCSK_PC7_1 402 408 PF00082 0.709
CLV_PCSK_SKI1_1 127 131 PF00082 0.470
CLV_PCSK_SKI1_1 24 28 PF00082 0.674
DEG_APCC_DBOX_1 266 274 PF00400 0.461
DEG_SPOP_SBC_1 50 54 PF00917 0.683
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HXN4 Leptomonas seymouri 83% 100%
A0A0S4IPT5 Bodo saltans 46% 100%
A0A1X0P488 Trypanosomatidae 49% 89%
A0A3R7NPK3 Trypanosoma rangeli 49% 95%
A0A3S7XBE8 Leishmania donovani 100% 100%
A4HPS2 Leishmania braziliensis 87% 100%
D0A8N7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9ATI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q111 Leishmania major 97% 100%
V5BS19 Trypanosoma cruzi 53% 94%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS