TatD related DNase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase - putative

Species:

Leishmania infantum

UniProt:

A4ICZ0_LEIIN

TriTrypDb:

LINF_360049600

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.356
CLV_NRD_NRD_1	256	258	PF00675	0.603
CLV_NRD_NRD_1	327	329	PF00675	0.458
CLV_NRD_NRD_1	36	38	PF00675	0.363
CLV_PCSK_KEX2_1	203	205	PF00082	0.356
CLV_PCSK_KEX2_1	255	257	PF00082	0.513
CLV_PCSK_KEX2_1	285	287	PF00082	0.759
CLV_PCSK_KEX2_1	327	329	PF00082	0.413
CLV_PCSK_KEX2_1	36	38	PF00082	0.330
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.513
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.759
CLV_PCSK_SKI1_1	246	250	PF00082	0.315
CLV_PCSK_SKI1_1	327	331	PF00082	0.414
CLV_PCSK_SKI1_1	92	96	PF00082	0.340
DOC_ANK_TNKS_1	256	263	PF00023	0.540
DOC_ANK_TNKS_1	35	42	PF00023	0.451
DOC_CYCLIN_RxL_1	243	253	PF00134	0.576
DOC_CYCLIN_RxL_1	325	335	PF00134	0.491
DOC_MAPK_DCC_7	37	47	PF00069	0.451
DOC_MAPK_gen_1	295	302	PF00069	0.490
DOC_MAPK_MEF2A_6	212	220	PF00069	0.550
DOC_PP1_RVXF_1	295	302	PF00149	0.384
DOC_USP7_MATH_1	115	119	PF00917	0.544
DOC_USP7_MATH_1	149	153	PF00917	0.564
DOC_USP7_MATH_1	260	264	PF00917	0.703
DOC_USP7_MATH_1	344	348	PF00917	0.535
DOC_USP7_MATH_1	357	361	PF00917	0.653
DOC_USP7_MATH_1	401	405	PF00917	0.587
DOC_USP7_MATH_1	423	427	PF00917	0.538
DOC_USP7_MATH_1	43	47	PF00917	0.533
DOC_USP7_MATH_1	50	54	PF00917	0.502
DOC_USP7_MATH_1	86	90	PF00917	0.537
DOC_WW_Pin1_4	226	231	PF00397	0.484
DOC_WW_Pin1_4	262	267	PF00397	0.669
DOC_WW_Pin1_4	46	51	PF00397	0.477
LIG_14-3-3_CanoR_1	197	206	PF00244	0.511
LIG_14-3-3_CanoR_1	286	296	PF00244	0.662
LIG_14-3-3_CanoR_1	386	392	PF00244	0.426
LIG_14-3-3_CanoR_1	425	433	PF00244	0.607
LIG_14-3-3_CanoR_1	92	97	PF00244	0.540
LIG_Actin_WH2_2	21	38	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BRCT_BRCA1_1	116	120	PF00533	0.487
LIG_BRCT_BRCA1_1	306	310	PF00533	0.510
LIG_FHA_1	237	243	PF00498	0.490
LIG_FHA_1	291	297	PF00498	0.550
LIG_FHA_1	315	321	PF00498	0.457
LIG_FHA_2	287	293	PF00498	0.699
LIG_LIR_Apic_2	200	205	PF02991	0.462
LIG_LIR_Gen_1	79	88	PF02991	0.494
LIG_LIR_Nem_3	298	304	PF02991	0.429
LIG_LIR_Nem_3	334	340	PF02991	0.636
LIG_LIR_Nem_3	79	85	PF02991	0.479
LIG_PTB_Apo_2	391	398	PF02174	0.569
LIG_SH2_CRK	202	206	PF00017	0.505
LIG_SH2_NCK_1	420	424	PF00017	0.514
LIG_SH2_STAP1	420	424	PF00017	0.514
LIG_SH3_1	37	43	PF00018	0.451
LIG_SH3_3	37	43	PF00018	0.558
LIG_SH3_3	44	50	PF00018	0.574
LIG_SUMO_SIM_par_1	247	253	PF11976	0.565
LIG_UBA3_1	248	255	PF00899	0.528
MOD_CK1_1	125	131	PF00069	0.507
MOD_CK1_1	133	139	PF00069	0.552
MOD_CK1_1	2	8	PF00069	0.688
MOD_CK1_1	247	253	PF00069	0.564
MOD_CK1_1	316	322	PF00069	0.502
MOD_CK1_1	404	410	PF00069	0.459
MOD_CK1_1	428	434	PF00069	0.652
MOD_CK1_1	46	52	PF00069	0.506
MOD_CK2_1	121	127	PF00069	0.569
MOD_CK2_1	132	138	PF00069	0.508
MOD_CK2_1	335	341	PF00069	0.652
MOD_CK2_1	423	429	PF00069	0.593
MOD_GlcNHglycan	124	127	PF01048	0.314
MOD_GlcNHglycan	135	138	PF01048	0.289
MOD_GlcNHglycan	168	171	PF01048	0.336
MOD_GlcNHglycan	199	202	PF01048	0.179
MOD_GlcNHglycan	261	265	PF01048	0.652
MOD_GlcNHglycan	275	278	PF01048	0.754
MOD_GlcNHglycan	337	340	PF01048	0.673
MOD_GlcNHglycan	346	349	PF01048	0.686
MOD_GlcNHglycan	380	383	PF01048	0.478
MOD_GlcNHglycan	409	412	PF01048	0.536
MOD_GSK3_1	121	128	PF00069	0.504
MOD_GSK3_1	286	293	PF00069	0.707
MOD_GSK3_1	46	53	PF00069	0.448
MOD_N-GLC_1	122	127	PF02516	0.323
MOD_N-GLC_1	313	318	PF02516	0.528
MOD_NEK2_1	15	20	PF00069	0.621
MOD_NEK2_1	28	33	PF00069	0.252
MOD_NEK2_1	412	417	PF00069	0.494
MOD_NEK2_1	73	78	PF00069	0.476
MOD_NEK2_2	115	120	PF00069	0.487
MOD_NEK2_2	357	362	PF00069	0.703
MOD_PIKK_1	314	320	PF00454	0.465
MOD_PK_1	204	210	PF00069	0.474
MOD_PKA_2	133	139	PF00069	0.587
MOD_PKA_2	16	22	PF00069	0.682
MOD_PKA_2	281	287	PF00069	0.786
MOD_Plk_1	401	407	PF00069	0.516
MOD_Plk_4	115	121	PF00069	0.487
MOD_Plk_4	244	250	PF00069	0.503
MOD_Plk_4	387	393	PF00069	0.553
MOD_Plk_4	412	418	PF00069	0.512
MOD_Plk_4	92	98	PF00069	0.576
MOD_ProDKin_1	226	232	PF00069	0.484
MOD_ProDKin_1	262	268	PF00069	0.669
MOD_ProDKin_1	46	52	PF00069	0.477
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.576
TRG_ENDOCYTIC_2	337	340	PF00928	0.669
TRG_ER_diArg_1	202	204	PF00400	0.556
TRG_ER_diArg_1	256	258	PF00400	0.635
TRG_ER_diArg_1	327	329	PF00400	0.455
TRG_ER_diArg_1	35	37	PF00400	0.551
TRG_NLS_MonoCore_2	253	258	PF00514	0.551
TRG_NLS_MonoExtC_3	253	258	PF00514	0.613
TRG_NLS_MonoExtN_4	252	259	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL6	Leptomonas seymouri	50%	100%
A0A0S4JGI4	Bodo saltans	35%	100%
A0A1X0P3J3	Trypanosomatidae	42%	100%
A0A3S5IS07	Trypanosoma rangeli	40%	100%
A0A3S7XBG3	Leishmania donovani	99%	100%
D0A8N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ATI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q110	Leishmania major	88%	100%