Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAP domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICY1_LEIIN

TriTrypDb:

LINF_360005600

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 254, 258

Expansion

Sequence features

A4ICY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.387
CLV_NRD_NRD_1	263	265	PF00675	0.632
CLV_NRD_NRD_1	318	320	PF00675	0.547
CLV_NRD_NRD_1	6	8	PF00675	0.477
CLV_PCSK_KEX2_1	208	210	PF00082	0.383
CLV_PCSK_KEX2_1	317	319	PF00082	0.570
CLV_PCSK_KEX2_1	5	7	PF00082	0.476
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.348
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.476
CLV_PCSK_SKI1_1	105	109	PF00082	0.536
CLV_PCSK_SKI1_1	112	116	PF00082	0.446
CLV_PCSK_SKI1_1	189	193	PF00082	0.292
CLV_PCSK_SKI1_1	74	78	PF00082	0.590
CLV_Separin_Metazoa	190	194	PF03568	0.294
DEG_Nend_UBRbox_2	1	3	PF02207	0.625
DEG_SPOP_SBC_1	136	140	PF00917	0.661
DEG_SPOP_SBC_1	42	46	PF00917	0.595
DOC_CKS1_1	92	97	PF01111	0.582
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.668
DOC_MAPK_gen_1	29	38	PF00069	0.566
DOC_MAPK_gen_1	5	11	PF00069	0.470
DOC_MAPK_MEF2A_6	32	40	PF00069	0.610
DOC_PP2B_LxvP_1	253	256	PF13499	0.519
DOC_PP2B_LxvP_1	36	39	PF13499	0.618
DOC_PP2B_LxvP_1	40	43	PF13499	0.601
DOC_PP4_FxxP_1	92	95	PF00568	0.585
DOC_USP7_MATH_1	136	140	PF00917	0.668
DOC_USP7_MATH_1	215	219	PF00917	0.672
DOC_USP7_MATH_1	259	263	PF00917	0.718
DOC_USP7_MATH_1	295	299	PF00917	0.605
DOC_USP7_MATH_1	43	47	PF00917	0.641
DOC_USP7_UBL2_3	208	212	PF12436	0.348
DOC_WW_Pin1_4	154	159	PF00397	0.741
DOC_WW_Pin1_4	22	27	PF00397	0.536
DOC_WW_Pin1_4	251	256	PF00397	0.689
DOC_WW_Pin1_4	263	268	PF00397	0.664
DOC_WW_Pin1_4	38	43	PF00397	0.570
DOC_WW_Pin1_4	46	51	PF00397	0.608
DOC_WW_Pin1_4	91	96	PF00397	0.595
LIG_14-3-3_CanoR_1	171	180	PF00244	0.615
LIG_14-3-3_CanoR_1	296	300	PF00244	0.565
LIG_14-3-3_CanoR_1	32	40	PF00244	0.581
LIG_14-3-3_CanoR_1	91	95	PF00244	0.719
LIG_14-3-3_CterR_2	317	322	PF00244	0.539
LIG_BRCT_BRCA1_1	287	291	PF00533	0.464
LIG_BRCT_BRCA1_1	297	301	PF00533	0.559
LIG_BRCT_BRCA1_1	88	92	PF00533	0.590
LIG_FHA_1	222	228	PF00498	0.749
LIG_FHA_1	32	38	PF00498	0.641
LIG_FHA_2	138	144	PF00498	0.645
LIG_FHA_2	150	156	PF00498	0.679
LIG_FHA_2	182	188	PF00498	0.257
LIG_FHA_2	269	275	PF00498	0.655
LIG_FHA_2	92	98	PF00498	0.630
LIG_LIR_Apic_2	89	95	PF02991	0.575
LIG_LIR_Nem_3	278	283	PF02991	0.460
LIG_LIR_Nem_3	79	83	PF02991	0.563
LIG_MYND_1	255	259	PF01753	0.606
LIG_NRBOX	187	193	PF00104	0.294
LIG_PDZ_Class_2	317	322	PF00595	0.580
LIG_Pex14_2	114	118	PF04695	0.513
LIG_SH2_STAT5	10	13	PF00017	0.450
LIG_SH3_3	156	162	PF00018	0.596
LIG_SH3_3	249	255	PF00018	0.679
LIG_SH3_3	36	42	PF00018	0.668
LIG_SH3_3	50	56	PF00018	0.701
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.527
LIG_WW_3	55	59	PF00397	0.668
MOD_CDK_SPK_2	91	96	PF00069	0.566
MOD_CDK_SPxxK_3	154	161	PF00069	0.744
MOD_CDK_SPxxK_3	22	29	PF00069	0.534
MOD_CDK_SPxxK_3	51	58	PF00069	0.691
MOD_CK1_1	126	132	PF00069	0.578
MOD_CK1_1	134	140	PF00069	0.549
MOD_CK1_1	154	160	PF00069	0.682
MOD_CK1_1	20	26	PF00069	0.535
MOD_CK1_1	248	254	PF00069	0.616
MOD_CK1_1	31	37	PF00069	0.564
MOD_CK1_1	41	47	PF00069	0.574
MOD_CK1_1	49	55	PF00069	0.610
MOD_CK2_1	137	143	PF00069	0.622
MOD_CK2_1	144	150	PF00069	0.704
MOD_CK2_1	181	187	PF00069	0.270
MOD_CK2_1	268	274	PF00069	0.558
MOD_GlcNHglycan	133	136	PF01048	0.637
MOD_GlcNHglycan	21	25	PF01048	0.626
MOD_GlcNHglycan	247	250	PF01048	0.636
MOD_GlcNHglycan	87	91	PF01048	0.565
MOD_GSK3_1	126	133	PF00069	0.606
MOD_GSK3_1	150	157	PF00069	0.675
MOD_GSK3_1	232	239	PF00069	0.587
MOD_GSK3_1	241	248	PF00069	0.584
MOD_GSK3_1	251	258	PF00069	0.516
MOD_GSK3_1	259	266	PF00069	0.525
MOD_GSK3_1	38	45	PF00069	0.659
MOD_GSK3_1	86	93	PF00069	0.711
MOD_N-GLC_1	275	280	PF02516	0.567
MOD_NEK2_1	149	154	PF00069	0.790
MOD_NEK2_1	236	241	PF00069	0.665
MOD_NEK2_2	107	112	PF00069	0.496
MOD_PIKK_1	178	184	PF00454	0.462
MOD_PIKK_1	259	265	PF00454	0.625
MOD_PIKK_1	31	37	PF00454	0.697
MOD_PIKK_1	43	49	PF00454	0.662
MOD_PK_1	195	201	PF00069	0.304
MOD_PK_1	275	281	PF00069	0.511
MOD_PKA_2	162	168	PF00069	0.583
MOD_PKA_2	28	34	PF00069	0.553
MOD_PKA_2	295	301	PF00069	0.568
MOD_PKA_2	90	96	PF00069	0.570
MOD_PKB_1	193	201	PF00069	0.304
MOD_Plk_1	275	281	PF00069	0.561
MOD_Plk_2-3	144	150	PF00069	0.677
MOD_Plk_2-3	151	157	PF00069	0.643
MOD_Plk_4	137	143	PF00069	0.655
MOD_Plk_4	248	254	PF00069	0.545
MOD_Plk_4	275	281	PF00069	0.502
MOD_ProDKin_1	154	160	PF00069	0.742
MOD_ProDKin_1	22	28	PF00069	0.533
MOD_ProDKin_1	251	257	PF00069	0.693
MOD_ProDKin_1	263	269	PF00069	0.662
MOD_ProDKin_1	38	44	PF00069	0.570
MOD_ProDKin_1	46	52	PF00069	0.611
MOD_ProDKin_1	91	97	PF00069	0.589
MOD_SUMO_rev_2	239	246	PF00179	0.579
TRG_DiLeu_BaEn_1	14	19	PF01217	0.469
TRG_DiLeu_BaEn_1	187	192	PF01217	0.257
TRG_DiLeu_BaEn_4	144	150	PF01217	0.676
TRG_ENDOCYTIC_2	80	83	PF00928	0.634
TRG_ER_diArg_1	169	172	PF00400	0.657
TRG_ER_diArg_1	192	195	PF00400	0.446
TRG_ER_diArg_1	317	319	PF00400	0.575
TRG_ER_diArg_1	6	8	PF00400	0.477
TRG_NLS_MonoExtN_4	3	9	PF00514	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II75	Leptomonas seymouri	53%	100%
A0A1X0P8R1	Trypanosomatidae	32%	100%
A0A3S7XA97	Leishmania donovani	99%	100%
A0A422NB21	Trypanosoma rangeli	32%	100%
A4HNL1	Leishmania braziliensis	68%	100%
E9ASC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q272	Leishmania major	90%	100%