Stress-inducible protein STI1 homolog

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stress-inducible protein STI1 homolog

Species:

Leishmania infantum

UniProt:

A4ICY0_LEIIN

TriTrypDb:

LINF_360005700

Length:

255

Annotations

Annotations by Jardim et al.

Metal Binding, Stress-inducible STI1 homolog

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICY0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.302
CLV_PCSK_KEX2_1	15	17	PF00082	0.367
CLV_PCSK_KEX2_1	211	213	PF00082	0.289
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.367
CLV_PCSK_SKI1_1	223	227	PF00082	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_CYCLIN_RxL_1	93	102	PF00134	0.304
DOC_MAPK_MEF2A_6	73	82	PF00069	0.261
DOC_PP1_SILK_1	244	249	PF00149	0.329
DOC_USP7_MATH_1	240	244	PF00917	0.343
DOC_USP7_MATH_1	58	62	PF00917	0.438
DOC_USP7_MATH_1	81	85	PF00917	0.255
DOC_USP7_UBL2_3	93	97	PF12436	0.304
DOC_WW_Pin1_4	130	135	PF00397	0.438
DOC_WW_Pin1_4	233	238	PF00397	0.387
DOC_WW_Pin1_4	99	104	PF00397	0.416
LIG_deltaCOP1_diTrp_1	70	76	PF00928	0.333
LIG_FHA_1	156	162	PF00498	0.405
LIG_FHA_1	163	169	PF00498	0.526
LIG_FHA_1	23	29	PF00498	0.254
LIG_FHA_2	131	137	PF00498	0.392
LIG_LIR_Gen_1	185	192	PF02991	0.340
LIG_LIR_Gen_1	47	54	PF02991	0.498
LIG_LIR_Nem_3	47	51	PF02991	0.490
LIG_Pex14_1	71	75	PF04695	0.333
LIG_PTB_Apo_2	139	146	PF02174	0.255
LIG_REV1ctd_RIR_1	142	150	PF16727	0.261
LIG_SH2_GRB2like	175	178	PF00017	0.319
LIG_SH2_GRB2like	41	44	PF00017	0.312
LIG_SH2_NCK_1	150	154	PF00017	0.251
LIG_SH2_NCK_1	229	233	PF00017	0.305
LIG_SH2_NCK_1	88	92	PF00017	0.311
LIG_SH2_SRC	17	20	PF00017	0.275
LIG_SH2_SRC	88	91	PF00017	0.233
LIG_SH2_STAP1	150	154	PF00017	0.250
LIG_SH2_STAP1	157	161	PF00017	0.227
LIG_SH2_STAP1	175	179	PF00017	0.178
LIG_SH2_STAP1	188	192	PF00017	0.328
LIG_SH2_STAP1	24	28	PF00017	0.262
LIG_SH2_STAP1	41	45	PF00017	0.308
LIG_SH2_STAT5	157	160	PF00017	0.385
LIG_SH2_STAT5	175	178	PF00017	0.183
LIG_SH2_STAT5	209	212	PF00017	0.440
LIG_SH2_STAT5	229	232	PF00017	0.186
LIG_SH2_STAT5	24	27	PF00017	0.243
LIG_SH2_STAT5	75	78	PF00017	0.385
LIG_TRAF2_1	133	136	PF00917	0.466
MOD_CK2_1	130	136	PF00069	0.410
MOD_GlcNHglycan	35	39	PF01048	0.397
MOD_GSK3_1	182	189	PF00069	0.489
MOD_GSK3_1	227	234	PF00069	0.380
MOD_NEK2_1	140	145	PF00069	0.350
MOD_PIKK_1	125	131	PF00454	0.428
MOD_PIKK_1	240	246	PF00454	0.343
MOD_PK_1	231	237	PF00069	0.356
MOD_Plk_4	140	146	PF00069	0.240
MOD_Plk_4	186	192	PF00069	0.470
MOD_ProDKin_1	130	136	PF00069	0.436
MOD_ProDKin_1	233	239	PF00069	0.383
MOD_ProDKin_1	99	105	PF00069	0.416
MOD_SUMO_rev_2	135	140	PF00179	0.381
MOD_SUMO_rev_2	2	6	PF00179	0.278
TRG_DiLeu_BaEn_4	135	141	PF01217	0.462
TRG_ENDOCYTIC_2	188	191	PF00928	0.319
TRG_ENDOCYTIC_2	216	219	PF00928	0.277
TRG_ENDOCYTIC_2	75	78	PF00928	0.261
TRG_ER_diArg_1	210	212	PF00400	0.298
TRG_ER_diArg_1	65	68	PF00400	0.400
TRG_NES_CRM1_1	70	83	PF08389	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	83%	100%
A0A0N1IBD2	Leptomonas seymouri	26%	76%
A0A0S4JPS0	Bodo saltans	60%	99%
A0A0S4JRK3	Bodo saltans	26%	73%
A0A1X0P8F0	Trypanosomatidae	55%	99%
A0A3Q8IJP8	Leishmania donovani	100%	100%
A0A3S7WZC1	Leishmania donovani	24%	76%
A0A422NB01	Trypanosoma rangeli	56%	99%
A4HEB3	Leishmania braziliensis	24%	71%
A4HNL2	Leishmania braziliensis	85%	100%
A4I1Q9	Leishmania infantum	24%	100%
A4K2V0	Pongo abelii	24%	83%
D0A2G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AXU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
O16259	Caenorhabditis elegans	28%	80%
Q15785	Homo sapiens	24%	83%
Q3KRD5	Rattus norvegicus	24%	83%
Q4Q271	Leishmania major	98%	100%
Q4Q9M8	Leishmania major	24%	72%
Q9CYG7	Mus musculus	27%	83%
V5BA34	Trypanosoma cruzi	54%	99%