LeishMANIAdb
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Putative DNA damage repair protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative DNA damage repair protein
Gene product:
DNA damage repair protein - putative
Species:
Leishmania infantum
UniProt:
A4ICX7_LEIIN
TriTrypDb:
LINF_360006000
Length:
619

Annotations

Annotations by Jardim et al.

DNA repair, DNA damage repair

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICX7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICX7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006281 DNA repair 5 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0033554 cellular response to stress 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000731 DNA synthesis involved in DNA repair 6 1
GO:0006301 postreplication repair 6 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0019985 translesion synthesis 7 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0042276 error-prone translesion synthesis 8 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0070987 error-free translesion synthesis 8 1
GO:0071897 DNA biosynthetic process 5 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003684 damaged DNA binding 5 12
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003824 catalytic activity 1 2
GO:0003887 DNA-directed DNA polymerase activity 5 2
GO:0016740 transferase activity 2 2
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 2
GO:0016779 nucleotidyltransferase activity 4 2
GO:0017125 deoxycytidyl transferase activity 5 1
GO:0034061 DNA polymerase activity 4 2
GO:0140097 catalytic activity, acting on DNA 3 2
GO:0140640 catalytic activity, acting on a nucleic acid 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 263 267 PF00656 0.567
CLV_C14_Caspase3-7 535 539 PF00656 0.592
CLV_NRD_NRD_1 186 188 PF00675 0.303
CLV_NRD_NRD_1 359 361 PF00675 0.466
CLV_NRD_NRD_1 417 419 PF00675 0.417
CLV_NRD_NRD_1 552 554 PF00675 0.465
CLV_NRD_NRD_1 562 564 PF00675 0.401
CLV_PCSK_KEX2_1 186 188 PF00082 0.305
CLV_PCSK_KEX2_1 279 281 PF00082 0.467
CLV_PCSK_KEX2_1 289 291 PF00082 0.618
CLV_PCSK_KEX2_1 321 323 PF00082 0.516
CLV_PCSK_KEX2_1 359 361 PF00082 0.465
CLV_PCSK_KEX2_1 505 507 PF00082 0.611
CLV_PCSK_KEX2_1 552 554 PF00082 0.472
CLV_PCSK_KEX2_1 562 564 PF00082 0.451
CLV_PCSK_PC1ET2_1 279 281 PF00082 0.443
CLV_PCSK_PC1ET2_1 289 291 PF00082 0.620
CLV_PCSK_PC1ET2_1 321 323 PF00082 0.540
CLV_PCSK_PC1ET2_1 505 507 PF00082 0.599
CLV_PCSK_PC7_1 285 291 PF00082 0.463
CLV_PCSK_PC7_1 317 323 PF00082 0.606
CLV_PCSK_SKI1_1 137 141 PF00082 0.274
CLV_PCSK_SKI1_1 187 191 PF00082 0.339
CLV_PCSK_SKI1_1 209 213 PF00082 0.249
CLV_PCSK_SKI1_1 280 284 PF00082 0.437
CLV_PCSK_SKI1_1 305 309 PF00082 0.408
CLV_PCSK_SKI1_1 348 352 PF00082 0.365
CLV_PCSK_SKI1_1 468 472 PF00082 0.397
CLV_PCSK_SKI1_1 582 586 PF00082 0.421
DEG_APCC_DBOX_1 279 287 PF00400 0.444
DEG_APCC_DBOX_1 347 355 PF00400 0.354
DEG_APCC_DBOX_1 581 589 PF00400 0.492
DOC_CYCLIN_RxL_1 184 193 PF00134 0.504
DOC_CYCLIN_RxL_1 345 353 PF00134 0.358
DOC_CYCLIN_yCln2_LP_2 612 618 PF00134 0.399
DOC_MAPK_DCC_7 418 426 PF00069 0.440
DOC_MAPK_gen_1 119 128 PF00069 0.539
DOC_MAPK_gen_1 137 147 PF00069 0.542
DOC_MAPK_gen_1 214 222 PF00069 0.488
DOC_MAPK_gen_1 389 397 PF00069 0.480
DOC_MAPK_gen_1 418 426 PF00069 0.559
DOC_MAPK_gen_1 505 515 PF00069 0.693
DOC_MAPK_MEF2A_6 389 397 PF00069 0.480
DOC_MAPK_MEF2A_6 57 64 PF00069 0.402
DOC_PP1_RVXF_1 21 27 PF00149 0.357
DOC_PP2B_LxvP_1 612 615 PF13499 0.420
DOC_USP7_MATH_1 243 247 PF00917 0.495
DOC_USP7_MATH_1 455 459 PF00917 0.395
DOC_USP7_MATH_1 532 536 PF00917 0.614
DOC_USP7_UBL2_3 381 385 PF12436 0.423
DOC_WW_Pin1_4 516 521 PF00397 0.686
LIG_14-3-3_CanoR_1 137 143 PF00244 0.539
LIG_14-3-3_CanoR_1 209 217 PF00244 0.472
LIG_14-3-3_CanoR_1 369 373 PF00244 0.418
LIG_14-3-3_CanoR_1 468 473 PF00244 0.454
LIG_14-3-3_CanoR_1 506 515 PF00244 0.657
LIG_Actin_WH2_2 343 361 PF00022 0.462
LIG_Actin_WH2_2 444 462 PF00022 0.491
LIG_APCC_ABBAyCdc20_2 57 63 PF00400 0.449
LIG_BIR_III_4 266 270 PF00653 0.431
LIG_CaM_IQ_9 15 31 PF13499 0.357
LIG_deltaCOP1_diTrp_1 40 48 PF00928 0.418
LIG_FHA_1 359 365 PF00498 0.382
LIG_FHA_1 451 457 PF00498 0.384
LIG_FHA_1 539 545 PF00498 0.575
LIG_FHA_1 81 87 PF00498 0.491
LIG_FHA_2 30 36 PF00498 0.472
LIG_FHA_2 369 375 PF00498 0.366
LIG_FHA_2 512 518 PF00498 0.786
LIG_FHA_2 525 531 PF00498 0.820
LIG_GBD_Chelix_1 364 372 PF00786 0.475
LIG_LIR_Apic_2 589 594 PF02991 0.460
LIG_LIR_Gen_1 141 151 PF02991 0.457
LIG_LIR_Gen_1 172 181 PF02991 0.488
LIG_LIR_Gen_1 293 303 PF02991 0.432
LIG_LIR_Gen_1 58 67 PF02991 0.311
LIG_LIR_Gen_1 599 608 PF02991 0.516
LIG_LIR_Gen_1 77 86 PF02991 0.362
LIG_LIR_Nem_3 141 146 PF02991 0.504
LIG_LIR_Nem_3 172 178 PF02991 0.504
LIG_LIR_Nem_3 293 299 PF02991 0.368
LIG_LIR_Nem_3 541 546 PF02991 0.521
LIG_LIR_Nem_3 573 577 PF02991 0.464
LIG_LIR_Nem_3 58 62 PF02991 0.336
LIG_LIR_Nem_3 599 604 PF02991 0.424
LIG_LIR_Nem_3 65 71 PF02991 0.414
LIG_LIR_Nem_3 77 81 PF02991 0.362
LIG_LYPXL_yS_3 574 577 PF13949 0.491
LIG_MAD2 305 313 PF02301 0.516
LIG_Pex14_2 26 30 PF04695 0.347
LIG_Pex14_2 38 42 PF04695 0.354
LIG_REV1ctd_RIR_1 499 506 PF16727 0.682
LIG_SH2_CRK 143 147 PF00017 0.437
LIG_SH2_CRK 175 179 PF00017 0.539
LIG_SH2_CRK 296 300 PF00017 0.428
LIG_SH2_GRB2like 114 117 PF00017 0.448
LIG_SH2_SRC 114 117 PF00017 0.448
LIG_SH2_SRC 143 146 PF00017 0.457
LIG_SH2_STAP1 130 134 PF00017 0.527
LIG_SH2_STAT5 102 105 PF00017 0.437
LIG_SH2_STAT5 114 117 PF00017 0.437
LIG_SH2_STAT5 25 28 PF00017 0.542
LIG_SH2_STAT5 543 546 PF00017 0.415
LIG_SH2_STAT5 580 583 PF00017 0.390
LIG_SH3_3 374 380 PF00018 0.367
LIG_SH3_3 392 398 PF00018 0.342
LIG_SH3_3 417 423 PF00018 0.467
LIG_SH3_3 512 518 PF00018 0.628
LIG_SUMO_SIM_anti_2 511 517 PF11976 0.675
LIG_SUMO_SIM_par_1 422 428 PF11976 0.488
LIG_SUMO_SIM_par_1 452 458 PF11976 0.365
LIG_TRFH_1 147 151 PF08558 0.445
LIG_TYR_ITIM 572 577 PF00017 0.450
LIG_TYR_ITSM 139 146 PF00017 0.539
LIG_TYR_ITSM 292 299 PF00017 0.425
LIG_WRC_WIRS_1 178 183 PF05994 0.523
LIG_WRC_WIRS_1 604 609 PF05994 0.455
MOD_CK1_1 95 101 PF00069 0.437
MOD_CK2_1 114 120 PF00069 0.526
MOD_CK2_1 159 165 PF00069 0.448
MOD_CK2_1 177 183 PF00069 0.448
MOD_CK2_1 243 249 PF00069 0.570
MOD_CK2_1 29 35 PF00069 0.472
MOD_CK2_1 368 374 PF00069 0.345
MOD_CK2_1 429 435 PF00069 0.436
MOD_CK2_1 440 446 PF00069 0.490
MOD_CK2_1 511 517 PF00069 0.728
MOD_CK2_1 524 530 PF00069 0.756
MOD_Cter_Amidation 287 290 PF01082 0.450
MOD_Cter_Amidation 319 322 PF01082 0.484
MOD_GlcNHglycan 116 119 PF01048 0.291
MOD_GlcNHglycan 190 193 PF01048 0.300
MOD_GlcNHglycan 273 276 PF01048 0.497
MOD_GlcNHglycan 490 493 PF01048 0.708
MOD_GlcNHglycan 566 569 PF01048 0.515
MOD_GSK3_1 177 184 PF00069 0.511
MOD_GSK3_1 425 432 PF00069 0.485
MOD_GSK3_1 468 475 PF00069 0.398
MOD_GSK3_1 603 610 PF00069 0.411
MOD_GSK3_1 92 99 PF00069 0.457
MOD_NEK2_1 177 182 PF00069 0.485
MOD_NEK2_1 190 195 PF00069 0.430
MOD_NEK2_1 368 373 PF00069 0.347
MOD_NEK2_1 4 9 PF00069 0.599
MOD_NEK2_1 425 430 PF00069 0.464
MOD_NEK2_1 440 445 PF00069 0.549
MOD_NEK2_1 607 612 PF00069 0.488
MOD_NEK2_1 67 72 PF00069 0.448
MOD_NEK2_2 455 460 PF00069 0.449
MOD_NEK2_2 524 529 PF00069 0.616
MOD_PIKK_1 380 386 PF00454 0.460
MOD_PIKK_1 506 512 PF00454 0.571
MOD_PKA_2 358 364 PF00069 0.404
MOD_PKA_2 368 374 PF00069 0.298
MOD_PKA_2 488 494 PF00069 0.650
MOD_Plk_1 244 250 PF00069 0.443
MOD_Plk_1 533 539 PF00069 0.511
MOD_Plk_2-3 159 165 PF00069 0.450
MOD_Plk_2-3 511 517 PF00069 0.675
MOD_Plk_4 138 144 PF00069 0.504
MOD_Plk_4 291 297 PF00069 0.520
MOD_Plk_4 368 374 PF00069 0.327
MOD_Plk_4 511 517 PF00069 0.718
MOD_Plk_4 538 544 PF00069 0.459
MOD_ProDKin_1 516 522 PF00069 0.688
MOD_SUMO_for_1 278 281 PF00179 0.499
MOD_SUMO_for_1 74 77 PF00179 0.462
TRG_DiLeu_BaLyEn_6 420 425 PF01217 0.434
TRG_ENDOCYTIC_2 143 146 PF00928 0.437
TRG_ENDOCYTIC_2 175 178 PF00928 0.504
TRG_ENDOCYTIC_2 296 299 PF00928 0.427
TRG_ENDOCYTIC_2 574 577 PF00928 0.416
TRG_ENDOCYTIC_2 78 81 PF00928 0.591
TRG_ER_diArg_1 185 187 PF00400 0.488
TRG_ER_diArg_1 358 360 PF00400 0.479
TRG_ER_diArg_1 487 490 PF00400 0.744
TRG_ER_diArg_1 551 553 PF00400 0.470
TRG_ER_diArg_1 561 563 PF00400 0.398
TRG_NES_CRM1_1 63 77 PF08389 0.437
TRG_NLS_MonoCore_2 504 509 PF00514 0.655
TRG_Pf-PMV_PEXEL_1 253 257 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.369
TRG_Pf-PMV_PEXEL_1 429 433 PF00026 0.438

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA19 Leptomonas seymouri 70% 100%
A0A0S4JRX6 Bodo saltans 42% 87%
A0A1X0P8Q5 Trypanosomatidae 50% 98%
A0A3S7XA64 Leishmania donovani 100% 100%
A0A422NAZ8 Trypanosoma rangeli 48% 100%
A4HNL7 Leishmania braziliensis 82% 100%
D0A2H2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ASC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q268 Leishmania major 94% 100%
V5BV86 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS