LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICX6_LEIIN
TriTrypDb:
LINF_360006100 *
Length:
904

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4ICX6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICX6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 215 219 PF00656 0.448
CLV_C14_Caspase3-7 241 245 PF00656 0.501
CLV_C14_Caspase3-7 714 718 PF00656 0.610
CLV_MEL_PAP_1 28 34 PF00089 0.472
CLV_NRD_NRD_1 161 163 PF00675 0.558
CLV_NRD_NRD_1 189 191 PF00675 0.481
CLV_NRD_NRD_1 237 239 PF00675 0.512
CLV_NRD_NRD_1 274 276 PF00675 0.490
CLV_NRD_NRD_1 3 5 PF00675 0.514
CLV_NRD_NRD_1 395 397 PF00675 0.545
CLV_NRD_NRD_1 402 404 PF00675 0.577
CLV_NRD_NRD_1 427 429 PF00675 0.491
CLV_NRD_NRD_1 645 647 PF00675 0.558
CLV_NRD_NRD_1 671 673 PF00675 0.480
CLV_NRD_NRD_1 675 677 PF00675 0.451
CLV_NRD_NRD_1 99 101 PF00675 0.502
CLV_PCSK_FUR_1 235 239 PF00082 0.443
CLV_PCSK_FUR_1 271 275 PF00082 0.689
CLV_PCSK_FUR_1 97 101 PF00082 0.525
CLV_PCSK_KEX2_1 12 14 PF00082 0.512
CLV_PCSK_KEX2_1 161 163 PF00082 0.558
CLV_PCSK_KEX2_1 189 191 PF00082 0.481
CLV_PCSK_KEX2_1 237 239 PF00082 0.512
CLV_PCSK_KEX2_1 273 275 PF00082 0.687
CLV_PCSK_KEX2_1 3 5 PF00082 0.514
CLV_PCSK_KEX2_1 311 313 PF00082 0.505
CLV_PCSK_KEX2_1 395 397 PF00082 0.502
CLV_PCSK_KEX2_1 401 403 PF00082 0.505
CLV_PCSK_KEX2_1 421 423 PF00082 0.375
CLV_PCSK_KEX2_1 427 429 PF00082 0.471
CLV_PCSK_KEX2_1 645 647 PF00082 0.563
CLV_PCSK_KEX2_1 671 673 PF00082 0.457
CLV_PCSK_KEX2_1 99 101 PF00082 0.510
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.522
CLV_PCSK_PC1ET2_1 311 313 PF00082 0.505
CLV_PCSK_PC1ET2_1 421 423 PF00082 0.514
CLV_PCSK_SKI1_1 15 19 PF00082 0.511
CLV_PCSK_SKI1_1 162 166 PF00082 0.559
CLV_PCSK_SKI1_1 21 25 PF00082 0.486
CLV_PCSK_SKI1_1 220 224 PF00082 0.466
CLV_PCSK_SKI1_1 360 364 PF00082 0.615
CLV_PCSK_SKI1_1 375 379 PF00082 0.445
CLV_PCSK_SKI1_1 568 572 PF00082 0.601
CLV_PCSK_SKI1_1 631 635 PF00082 0.603
CLV_PCSK_SKI1_1 645 649 PF00082 0.430
CLV_PCSK_SKI1_1 70 74 PF00082 0.585
DEG_APCC_DBOX_1 20 28 PF00400 0.482
DEG_APCC_DBOX_1 219 227 PF00400 0.564
DEG_APCC_DBOX_1 402 410 PF00400 0.514
DEG_APCC_DBOX_1 617 625 PF00400 0.580
DEG_APCC_DBOX_1 69 77 PF00400 0.583
DEG_APCC_DBOX_1 694 702 PF00400 0.557
DEG_MDM2_SWIB_1 366 373 PF02201 0.562
DEG_SPOP_SBC_1 76 80 PF00917 0.552
DOC_CYCLIN_RxL_1 197 208 PF00134 0.510
DOC_MAPK_gen_1 235 242 PF00069 0.512
DOC_MAPK_gen_1 311 317 PF00069 0.505
DOC_MAPK_gen_1 526 534 PF00069 0.512
DOC_MAPK_gen_1 546 554 PF00069 0.424
DOC_MAPK_gen_1 671 682 PF00069 0.498
DOC_MAPK_HePTP_8 28 40 PF00069 0.473
DOC_MAPK_MEF2A_6 21 28 PF00069 0.479
DOC_MAPK_MEF2A_6 289 297 PF00069 0.468
DOC_MAPK_MEF2A_6 31 40 PF00069 0.468
DOC_MAPK_MEF2A_6 526 534 PF00069 0.580
DOC_MAPK_MEF2A_6 546 554 PF00069 0.402
DOC_MAPK_MEF2A_6 885 894 PF00069 0.497
DOC_MAPK_NFAT4_5 21 29 PF00069 0.472
DOC_MAPK_RevD_3 390 403 PF00069 0.505
DOC_PP1_RVXF_1 272 279 PF00149 0.566
DOC_PP1_RVXF_1 834 841 PF00149 0.537
DOC_PP1_RVXF_1 90 97 PF00149 0.644
DOC_PP2B_LxvP_1 890 893 PF13499 0.428
DOC_PP4_FxxP_1 61 64 PF00568 0.521
DOC_PP4_FxxP_1 840 843 PF00568 0.464
DOC_USP7_MATH_1 113 117 PF00917 0.452
DOC_USP7_MATH_1 207 211 PF00917 0.499
DOC_USP7_MATH_1 55 59 PF00917 0.574
DOC_USP7_MATH_1 62 66 PF00917 0.535
DOC_USP7_MATH_1 635 639 PF00917 0.575
DOC_USP7_MATH_1 694 698 PF00917 0.660
DOC_USP7_MATH_1 780 784 PF00917 0.678
DOC_USP7_MATH_1 884 888 PF00917 0.545
DOC_USP7_MATH_1 893 897 PF00917 0.408
DOC_USP7_UBL2_3 375 379 PF12436 0.501
DOC_USP7_UBL2_3 673 677 PF12436 0.505
DOC_WW_Pin1_4 689 694 PF00397 0.706
LIG_14-3-3_CanoR_1 15 25 PF00244 0.503
LIG_14-3-3_CanoR_1 189 193 PF00244 0.496
LIG_14-3-3_CanoR_1 284 288 PF00244 0.535
LIG_14-3-3_CanoR_1 289 294 PF00244 0.490
LIG_14-3-3_CanoR_1 31 35 PF00244 0.452
LIG_14-3-3_CanoR_1 322 330 PF00244 0.538
LIG_14-3-3_CanoR_1 346 352 PF00244 0.514
LIG_14-3-3_CanoR_1 427 431 PF00244 0.458
LIG_14-3-3_CanoR_1 468 472 PF00244 0.591
LIG_14-3-3_CanoR_1 568 576 PF00244 0.489
LIG_14-3-3_CanoR_1 591 597 PF00244 0.607
LIG_14-3-3_CanoR_1 631 640 PF00244 0.551
LIG_14-3-3_CanoR_1 646 656 PF00244 0.459
LIG_14-3-3_CanoR_1 700 708 PF00244 0.618
LIG_14-3-3_CanoR_1 734 743 PF00244 0.500
LIG_14-3-3_CanoR_1 836 841 PF00244 0.513
LIG_Actin_WH2_2 334 350 PF00022 0.503
LIG_BRCT_BRCA1_1 57 61 PF00533 0.540
LIG_BRCT_BRCA1_1 684 688 PF00533 0.513
LIG_Clathr_ClatBox_1 551 555 PF01394 0.548
LIG_Clathr_ClatBox_1 621 625 PF01394 0.583
LIG_deltaCOP1_diTrp_1 665 669 PF00928 0.494
LIG_deltaCOP1_diTrp_1 706 715 PF00928 0.541
LIG_eIF4E_1 753 759 PF01652 0.511
LIG_FHA_1 132 138 PF00498 0.482
LIG_FHA_1 17 23 PF00498 0.509
LIG_FHA_1 323 329 PF00498 0.492
LIG_FHA_1 415 421 PF00498 0.498
LIG_FHA_1 570 576 PF00498 0.522
LIG_FHA_1 632 638 PF00498 0.527
LIG_FHA_1 846 852 PF00498 0.627
LIG_FHA_1 875 881 PF00498 0.540
LIG_FHA_2 213 219 PF00498 0.444
LIG_FHA_2 348 354 PF00498 0.535
LIG_FHA_2 593 599 PF00498 0.489
LIG_LIR_Apic_2 58 64 PF02991 0.552
LIG_LIR_Apic_2 837 843 PF02991 0.468
LIG_LIR_Gen_1 20 28 PF02991 0.484
LIG_LIR_Gen_1 527 535 PF02991 0.580
LIG_LIR_Gen_1 738 748 PF02991 0.529
LIG_LIR_Gen_1 766 771 PF02991 0.608
LIG_LIR_Nem_3 165 171 PF02991 0.530
LIG_LIR_Nem_3 198 203 PF02991 0.510
LIG_LIR_Nem_3 20 26 PF02991 0.486
LIG_LIR_Nem_3 33 38 PF02991 0.452
LIG_LIR_Nem_3 357 362 PF02991 0.455
LIG_LIR_Nem_3 384 390 PF02991 0.550
LIG_LIR_Nem_3 527 532 PF02991 0.531
LIG_LIR_Nem_3 705 711 PF02991 0.706
LIG_LIR_Nem_3 738 743 PF02991 0.589
LIG_LIR_Nem_3 766 770 PF02991 0.573
LIG_MYND_1 83 87 PF01753 0.609
LIG_NRBOX 294 300 PF00104 0.504
LIG_NRBOX 405 411 PF00104 0.510
LIG_OCRL_FandH_1 175 187 PF00620 0.480
LIG_PCNA_PIPBox_1 253 262 PF02747 0.518
LIG_Pex14_1 370 374 PF04695 0.497
LIG_Pex14_2 366 370 PF04695 0.561
LIG_Pex14_2 818 822 PF04695 0.456
LIG_PTB_Apo_2 135 142 PF02174 0.554
LIG_PTB_Phospho_1 135 141 PF10480 0.551
LIG_Rb_LxCxE_1 103 120 PF01857 0.489
LIG_Rb_LxCxE_1 188 208 PF01857 0.536
LIG_Rb_LxCxE_1 334 355 PF01857 0.479
LIG_Rb_LxCxE_1 501 519 PF01857 0.533
LIG_REV1ctd_RIR_1 531 540 PF16727 0.426
LIG_RPA_C_Fungi 391 403 PF08784 0.565
LIG_SH2_CRK 374 378 PF00017 0.520
LIG_SH2_CRK 740 744 PF00017 0.535
LIG_SH2_PTP2 529 532 PF00017 0.577
LIG_SH2_SRC 529 532 PF00017 0.488
LIG_SH2_STAP1 291 295 PF00017 0.486
LIG_SH2_STAT5 39 42 PF00017 0.476
LIG_SH2_STAT5 434 437 PF00017 0.564
LIG_SH2_STAT5 498 501 PF00017 0.578
LIG_SH2_STAT5 529 532 PF00017 0.509
LIG_SH2_STAT5 753 756 PF00017 0.501
LIG_SH3_2 87 92 PF14604 0.577
LIG_SH3_3 169 175 PF00018 0.578
LIG_SH3_3 690 696 PF00018 0.607
LIG_SH3_3 83 89 PF00018 0.595
LIG_SUMO_SIM_anti_2 313 319 PF11976 0.448
LIG_SUMO_SIM_par_1 238 244 PF11976 0.556
LIG_SUMO_SIM_par_1 295 301 PF11976 0.484
LIG_SUMO_SIM_par_1 313 319 PF11976 0.528
LIG_SUMO_SIM_par_1 470 476 PF11976 0.544
LIG_SUMO_SIM_par_1 550 557 PF11976 0.547
LIG_TRAF2_1 225 228 PF00917 0.569
LIG_TRAF2_1 350 353 PF00917 0.523
LIG_TRAF2_1 442 445 PF00917 0.566
LIG_TRAF2_1 473 476 PF00917 0.588
LIG_TRAF2_1 515 518 PF00917 0.583
LIG_TRAF2_1 595 598 PF00917 0.510
LIG_TRFH_1 32 36 PF08558 0.469
LIG_UBA3_1 532 536 PF00899 0.433
LIG_WRC_WIRS_1 114 119 PF05994 0.433
LIG_WRC_WIRS_1 39 44 PF05994 0.481
MOD_CDC14_SPxK_1 692 695 PF00782 0.555
MOD_CDK_SPxK_1 689 695 PF00069 0.545
MOD_CK1_1 318 324 PF00069 0.533
MOD_CK1_1 381 387 PF00069 0.529
MOD_CK1_1 41 47 PF00069 0.501
MOD_CK1_1 574 580 PF00069 0.559
MOD_CK1_1 699 705 PF00069 0.574
MOD_CK1_1 775 781 PF00069 0.608
MOD_CK1_1 814 820 PF00069 0.559
MOD_CK2_1 112 118 PF00069 0.453
MOD_CK2_1 227 233 PF00069 0.533
MOD_CK2_1 347 353 PF00069 0.532
MOD_CK2_1 439 445 PF00069 0.569
MOD_CK2_1 581 587 PF00069 0.561
MOD_CK2_1 592 598 PF00069 0.438
MOD_CK2_1 635 641 PF00069 0.573
MOD_CK2_1 647 653 PF00069 0.542
MOD_CK2_1 776 782 PF00069 0.633
MOD_Cter_Amidation 1 4 PF01082 0.506
MOD_GlcNHglycan 207 210 PF01048 0.466
MOD_GlcNHglycan 43 46 PF01048 0.532
MOD_GlcNHglycan 555 559 PF01048 0.585
MOD_GlcNHglycan 637 640 PF01048 0.575
MOD_GlcNHglycan 650 653 PF01048 0.436
MOD_GlcNHglycan 778 781 PF01048 0.693
MOD_GlcNHglycan 782 786 PF01048 0.601
MOD_GlcNHglycan 886 889 PF01048 0.573
MOD_GSK3_1 127 134 PF00069 0.548
MOD_GSK3_1 318 325 PF00069 0.484
MOD_GSK3_1 378 385 PF00069 0.538
MOD_GSK3_1 631 638 PF00069 0.707
MOD_GSK3_1 682 689 PF00069 0.618
MOD_GSK3_1 717 724 PF00069 0.629
MOD_GSK3_1 735 742 PF00069 0.521
MOD_GSK3_1 77 84 PF00069 0.707
MOD_GSK3_1 771 778 PF00069 0.606
MOD_GSK3_1 814 821 PF00069 0.506
MOD_N-GLC_1 814 819 PF02516 0.522
MOD_NEK2_1 127 132 PF00069 0.463
MOD_NEK2_1 205 210 PF00069 0.466
MOD_NEK2_1 38 43 PF00069 0.496
MOD_NEK2_1 571 576 PF00069 0.559
MOD_NEK2_1 647 652 PF00069 0.534
MOD_NEK2_1 686 691 PF00069 0.605
MOD_NEK2_1 77 82 PF00069 0.568
MOD_NEK2_1 771 776 PF00069 0.501
MOD_NEK2_1 818 823 PF00069 0.501
MOD_NEK2_2 30 35 PF00069 0.481
MOD_NEK2_2 735 740 PF00069 0.617
MOD_PIKK_1 322 328 PF00454 0.536
MOD_PIKK_1 360 366 PF00454 0.566
MOD_PIKK_1 77 83 PF00454 0.575
MOD_PIKK_1 822 828 PF00454 0.428
MOD_PK_1 671 677 PF00069 0.486
MOD_PK_1 805 811 PF00069 0.388
MOD_PKA_1 671 677 PF00069 0.486
MOD_PKA_2 188 194 PF00069 0.503
MOD_PKA_2 205 211 PF00069 0.418
MOD_PKA_2 283 289 PF00069 0.531
MOD_PKA_2 30 36 PF00069 0.484
MOD_PKA_2 321 327 PF00069 0.538
MOD_PKA_2 347 353 PF00069 0.518
MOD_PKA_2 426 432 PF00069 0.456
MOD_PKA_2 467 473 PF00069 0.587
MOD_PKA_2 592 598 PF00069 0.650
MOD_PKA_2 62 68 PF00069 0.605
MOD_PKA_2 671 677 PF00069 0.509
MOD_PKA_2 682 688 PF00069 0.483
MOD_PKA_2 694 700 PF00069 0.589
MOD_PKA_2 733 739 PF00069 0.508
MOD_PKA_2 853 859 PF00069 0.579
MOD_Plk_1 195 201 PF00069 0.497
MOD_Plk_1 381 387 PF00069 0.529
MOD_Plk_1 781 787 PF00069 0.647
MOD_Plk_1 814 820 PF00069 0.510
MOD_Plk_1 834 840 PF00069 0.429
MOD_Plk_2-3 283 289 PF00069 0.474
MOD_Plk_4 382 388 PF00069 0.522
MOD_Plk_4 405 411 PF00069 0.555
MOD_Plk_4 467 473 PF00069 0.587
MOD_Plk_4 560 566 PF00069 0.540
MOD_Plk_4 571 577 PF00069 0.503
MOD_Plk_4 81 87 PF00069 0.599
MOD_Plk_4 868 874 PF00069 0.421
MOD_ProDKin_1 689 695 PF00069 0.709
MOD_SUMO_rev_2 103 108 PF00179 0.540
TRG_DiLeu_BaEn_1 120 125 PF01217 0.535
TRG_DiLeu_BaEn_1 149 154 PF01217 0.506
TRG_DiLeu_BaEn_1 405 410 PF01217 0.557
TRG_DiLeu_BaEn_1 601 606 PF01217 0.514
TRG_DiLeu_BaEn_1 653 658 PF01217 0.520
TRG_DiLeu_BaEn_4 103 109 PF01217 0.544
TRG_DiLeu_BaEn_4 517 523 PF01217 0.577
TRG_DiLeu_BaLyEn_6 235 240 PF01217 0.580
TRG_DiLeu_BaLyEn_6 643 648 PF01217 0.457
TRG_ENDOCYTIC_2 374 377 PF00928 0.532
TRG_ENDOCYTIC_2 39 42 PF00928 0.476
TRG_ENDOCYTIC_2 529 532 PF00928 0.577
TRG_ENDOCYTIC_2 740 743 PF00928 0.531
TRG_ER_diArg_1 13 16 PF00400 0.512
TRG_ER_diArg_1 234 237 PF00400 0.498
TRG_ER_diArg_1 271 274 PF00400 0.633
TRG_ER_diArg_1 346 349 PF00400 0.552
TRG_ER_diArg_1 394 396 PF00400 0.501
TRG_ER_diArg_1 401 403 PF00400 0.505
TRG_ER_diArg_1 511 514 PF00400 0.623
TRG_ER_diArg_1 590 593 PF00400 0.580
TRG_ER_diArg_1 645 647 PF00400 0.586
TRG_ER_diArg_1 96 99 PF00400 0.540
TRG_NES_CRM1_1 288 301 PF08389 0.478
TRG_NLS_MonoExtC_3 11 16 PF00514 0.520
TRG_NLS_MonoExtN_4 9 16 PF00514 0.510
TRG_Pf-PMV_PEXEL_1 190 195 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 237 241 PF00026 0.580
TRG_Pf-PMV_PEXEL_1 274 279 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 396 400 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 428 432 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 497 501 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 520 524 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 549 553 PF00026 0.579
TRG_Pf-PMV_PEXEL_1 99 103 PF00026 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVC9 Leptomonas seymouri 43% 100%
A0A3S7XA57 Leishmania donovani 99% 100%
A4HNL8 Leishmania braziliensis 72% 100%
E9ASC9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q267 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS