LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
PUB domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4ICX4_LEIIN
TriTrypDb:
LINF_360006300
Length:
368

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ICX4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICX4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 234 238 PF00656 0.693
CLV_C14_Caspase3-7 31 35 PF00656 0.701
CLV_NRD_NRD_1 120 122 PF00675 0.625
CLV_NRD_NRD_1 131 133 PF00675 0.330
CLV_NRD_NRD_1 141 143 PF00675 0.341
CLV_NRD_NRD_1 155 157 PF00675 0.447
CLV_NRD_NRD_1 164 166 PF00675 0.437
CLV_NRD_NRD_1 188 190 PF00675 0.476
CLV_NRD_NRD_1 274 276 PF00675 0.426
CLV_NRD_NRD_1 355 357 PF00675 0.494
CLV_PCSK_FUR_1 118 122 PF00082 0.492
CLV_PCSK_KEX2_1 100 102 PF00082 0.523
CLV_PCSK_KEX2_1 120 122 PF00082 0.375
CLV_PCSK_KEX2_1 155 157 PF00082 0.447
CLV_PCSK_KEX2_1 164 166 PF00082 0.437
CLV_PCSK_KEX2_1 188 190 PF00082 0.483
CLV_PCSK_KEX2_1 276 278 PF00082 0.505
CLV_PCSK_KEX2_1 306 308 PF00082 0.274
CLV_PCSK_KEX2_1 355 357 PF00082 0.424
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.523
CLV_PCSK_PC1ET2_1 276 278 PF00082 0.505
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.274
CLV_PCSK_SKI1_1 100 104 PF00082 0.476
CLV_PCSK_SKI1_1 108 112 PF00082 0.430
CLV_PCSK_SKI1_1 142 146 PF00082 0.505
CLV_PCSK_SKI1_1 291 295 PF00082 0.300
DEG_APCC_DBOX_1 290 298 PF00400 0.368
DEG_SPOP_SBC_1 229 233 PF00917 0.560
DEG_SPOP_SBC_1 25 29 PF00917 0.676
DOC_MAPK_gen_1 120 130 PF00069 0.562
DOC_MAPK_gen_1 132 140 PF00069 0.418
DOC_MAPK_gen_1 174 181 PF00069 0.403
DOC_MAPK_gen_1 305 311 PF00069 0.417
DOC_MAPK_gen_1 314 323 PF00069 0.417
DOC_MAPK_gen_1 355 363 PF00069 0.484
DOC_MAPK_MEF2A_6 174 181 PF00069 0.402
DOC_PP1_RVXF_1 326 333 PF00149 0.352
DOC_USP7_UBL2_3 123 127 PF12436 0.451
DOC_WW_Pin1_4 7 12 PF00397 0.583
LIG_14-3-3_CanoR_1 146 154 PF00244 0.610
LIG_14-3-3_CanoR_1 310 316 PF00244 0.300
LIG_14-3-3_CanoR_1 51 58 PF00244 0.592
LIG_AP2alpha_2 300 302 PF02296 0.417
LIG_BIR_II_1 1 5 PF00653 0.601
LIG_BRCT_BRCA1_1 298 302 PF00533 0.460
LIG_FHA_1 237 243 PF00498 0.614
LIG_FHA_1 287 293 PF00498 0.417
LIG_FHA_1 306 312 PF00498 0.185
LIG_FHA_1 344 350 PF00498 0.322
LIG_FHA_1 35 41 PF00498 0.504
LIG_FHA_1 71 77 PF00498 0.393
LIG_FHA_2 102 108 PF00498 0.447
LIG_FHA_2 190 196 PF00498 0.527
LIG_FHA_2 31 37 PF00498 0.614
LIG_FHA_2 41 47 PF00498 0.470
LIG_FHA_2 85 91 PF00498 0.612
LIG_GBD_Chelix_1 353 361 PF00786 0.370
LIG_LIR_Gen_1 43 53 PF02991 0.426
LIG_LIR_Gen_1 73 83 PF02991 0.462
LIG_LIR_Nem_3 43 48 PF02991 0.440
LIG_PCNA_PIPBox_1 252 261 PF02747 0.486
LIG_RPA_C_Fungi 207 219 PF08784 0.489
LIG_SH2_NCK_1 204 208 PF00017 0.573
LIG_SH2_SRC 204 207 PF00017 0.437
LIG_SH2_STAP1 204 208 PF00017 0.442
LIG_SH2_STAT5 38 41 PF00017 0.476
LIG_SH3_3 17 23 PF00018 0.739
LIG_SH3_3 242 248 PF00018 0.496
LIG_SH3_3 295 301 PF00018 0.388
LIG_TRAF2_1 192 195 PF00917 0.383
LIG_UBA3_1 144 148 PF00899 0.545
MOD_CK1_1 236 242 PF00069 0.610
MOD_CK1_1 24 30 PF00069 0.614
MOD_CK1_1 243 249 PF00069 0.572
MOD_CK1_1 343 349 PF00069 0.333
MOD_CK2_1 101 107 PF00069 0.456
MOD_CK2_1 146 152 PF00069 0.438
MOD_CK2_1 189 195 PF00069 0.473
MOD_CK2_1 25 31 PF00069 0.619
MOD_CK2_1 266 272 PF00069 0.389
MOD_CK2_1 84 90 PF00069 0.650
MOD_Cter_Amidation 140 143 PF01082 0.474
MOD_GlcNHglycan 242 245 PF01048 0.615
MOD_GlcNHglycan 249 252 PF01048 0.586
MOD_GlcNHglycan 278 281 PF01048 0.607
MOD_GSK3_1 21 28 PF00069 0.665
MOD_GSK3_1 228 235 PF00069 0.627
MOD_GSK3_1 236 243 PF00069 0.581
MOD_GSK3_1 247 254 PF00069 0.515
MOD_GSK3_1 262 269 PF00069 0.497
MOD_GSK3_1 276 283 PF00069 0.323
MOD_GSK3_1 30 37 PF00069 0.587
MOD_GSK3_1 305 312 PF00069 0.306
MOD_GSK3_1 336 343 PF00069 0.301
MOD_N-GLC_1 240 245 PF02516 0.652
MOD_N-GLC_1 25 30 PF02516 0.712
MOD_N-GLC_1 343 348 PF02516 0.313
MOD_NEK2_1 309 314 PF00069 0.302
MOD_NEK2_1 347 352 PF00069 0.364
MOD_NEK2_2 286 291 PF00069 0.368
MOD_OFUCOSY 66 72 PF10250 0.392
MOD_PIKK_1 38 44 PF00454 0.405
MOD_PIKK_1 70 76 PF00454 0.404
MOD_PK_1 21 27 PF00069 0.517
MOD_PKA_1 276 282 PF00069 0.373
MOD_PKA_1 305 311 PF00069 0.334
MOD_PKA_2 276 282 PF00069 0.373
MOD_PKA_2 309 315 PF00069 0.417
MOD_Plk_1 240 246 PF00069 0.619
MOD_Plk_1 343 349 PF00069 0.343
MOD_Plk_4 251 257 PF00069 0.554
MOD_Plk_4 266 272 PF00069 0.465
MOD_Plk_4 348 354 PF00069 0.285
MOD_Plk_4 40 46 PF00069 0.395
MOD_Plk_4 58 64 PF00069 0.370
MOD_ProDKin_1 7 13 PF00069 0.582
MOD_SUMO_for_1 147 150 PF00179 0.503
MOD_SUMO_for_1 217 220 PF00179 0.457
MOD_SUMO_rev_2 105 112 PF00179 0.437
MOD_SUMO_rev_2 124 128 PF00179 0.541
MOD_SUMO_rev_2 2 8 PF00179 0.595
TRG_DiLeu_BaEn_1 325 330 PF01217 0.350
TRG_DiLeu_BaEn_4 125 131 PF01217 0.481
TRG_DiLeu_BaEn_4 194 200 PF01217 0.342
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.476
TRG_DiLeu_LyEn_5 325 330 PF01217 0.302
TRG_ER_diArg_1 118 121 PF00400 0.494
TRG_ER_diArg_1 154 156 PF00400 0.453
TRG_ER_diArg_1 174 177 PF00400 0.419
TRG_ER_diArg_1 274 277 PF00400 0.439
TRG_ER_diArg_1 354 356 PF00400 0.445
TRG_Pf-PMV_PEXEL_1 101 105 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 355 359 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I208 Leptomonas seymouri 63% 100%
A0A0S4JLL2 Bodo saltans 42% 94%
A0A1X0P8K7 Trypanosomatidae 48% 100%
A0A3S5IQV7 Trypanosoma rangeli 48% 100%
A0A3S7XA96 Leishmania donovani 99% 100%
A4HNM0 Leishmania braziliensis 77% 100%
D0A2H5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 89%
E9ASD1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q265 Leishmania major 90% 100%
V5BQK6 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS