Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICX3_LEIIN

TriTrypDb:

LINF_360006400

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICX3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	1
GO:0004672	protein kinase activity	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.489
CLV_C14_Caspase3-7	483	487	PF00656	0.388
CLV_MEL_PAP_1	109	115	PF00089	0.475
CLV_PCSK_FUR_1	57	61	PF00082	0.441
CLV_PCSK_KEX2_1	251	253	PF00082	0.488
CLV_PCSK_KEX2_1	413	415	PF00082	0.508
CLV_PCSK_KEX2_1	59	61	PF00082	0.501
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.488
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.492
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.501
CLV_PCSK_SKI1_1	220	224	PF00082	0.664
CLV_PCSK_SKI1_1	251	255	PF00082	0.495
CLV_PCSK_SKI1_1	3	7	PF00082	0.548
CLV_PCSK_SKI1_1	305	309	PF00082	0.479
CLV_PCSK_SKI1_1	323	327	PF00082	0.285
CLV_PCSK_SKI1_1	361	365	PF00082	0.380
CLV_PCSK_SKI1_1	456	460	PF00082	0.492
CLV_PCSK_SKI1_1	476	480	PF00082	0.211
CLV_PCSK_SKI1_1	497	501	PF00082	0.556
CLV_PCSK_SKI1_1	549	553	PF00082	0.496
CLV_PCSK_SKI1_1	59	63	PF00082	0.422
CLV_PCSK_SKI1_1	75	79	PF00082	0.360
DEG_APCC_DBOX_1	360	368	PF00400	0.379
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DEG_ODPH_VHL_1	117	129	PF01847	0.464
DOC_CDC14_PxL_1	394	402	PF14671	0.481
DOC_CKS1_1	299	304	PF01111	0.535
DOC_CYCLIN_RxL_1	494	505	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	556	562	PF00134	0.481
DOC_MAPK_DCC_7	361	369	PF00069	0.433
DOC_MAPK_DCC_7	427	436	PF00069	0.417
DOC_MAPK_DCC_7	552	562	PF00069	0.557
DOC_MAPK_gen_1	381	390	PF00069	0.430
DOC_MAPK_gen_1	75	83	PF00069	0.504
DOC_MAPK_HePTP_8	424	436	PF00069	0.425
DOC_MAPK_MEF2A_6	147	155	PF00069	0.362
DOC_MAPK_MEF2A_6	361	369	PF00069	0.348
DOC_MAPK_MEF2A_6	427	436	PF00069	0.387
DOC_MAPK_RevD_3	90	104	PF00069	0.408
DOC_PP1_RVXF_1	102	109	PF00149	0.409
DOC_PP1_RVXF_1	495	502	PF00149	0.471
DOC_PP2B_LxvP_1	182	185	PF13499	0.525
DOC_PP2B_LxvP_1	283	286	PF13499	0.497
DOC_PP2B_LxvP_1	430	433	PF13499	0.431
DOC_PP2B_LxvP_1	467	470	PF13499	0.491
DOC_PP4_FxxP_1	175	178	PF00568	0.448
DOC_PP4_FxxP_1	299	302	PF00568	0.549
DOC_PP4_FxxP_1	362	365	PF00568	0.415
DOC_USP7_MATH_1	12	16	PF00917	0.557
DOC_USP7_MATH_1	156	160	PF00917	0.420
DOC_USP7_MATH_1	191	195	PF00917	0.487
DOC_USP7_MATH_1	519	523	PF00917	0.516
DOC_USP7_MATH_1	550	554	PF00917	0.481
DOC_USP7_MATH_1	572	576	PF00917	0.501
DOC_USP7_MATH_1	605	609	PF00917	0.721
DOC_WW_Pin1_4	298	303	PF00397	0.543
DOC_WW_Pin1_4	459	464	PF00397	0.490
DOC_WW_Pin1_4	542	547	PF00397	0.527
LIG_14-3-3_CanoR_1	112	116	PF00244	0.419
LIG_14-3-3_CanoR_1	179	185	PF00244	0.501
LIG_14-3-3_CanoR_1	265	271	PF00244	0.495
LIG_14-3-3_CanoR_1	287	295	PF00244	0.489
LIG_14-3-3_CanoR_1	427	431	PF00244	0.348
LIG_14-3-3_CanoR_1	64	74	PF00244	0.448
LIG_Actin_WH2_2	466	481	PF00022	0.342
LIG_BRCT_BRCA1_1	274	278	PF00533	0.474
LIG_BRCT_BRCA1_1	33	37	PF00533	0.464
LIG_BRCT_BRCA1_1	521	525	PF00533	0.499
LIG_BRCT_BRCA1_2	33	39	PF00533	0.454
LIG_deltaCOP1_diTrp_1	164	175	PF00928	0.454
LIG_EH1_1	570	578	PF00400	0.480
LIG_EVH1_1	285	289	PF00568	0.494
LIG_EVH1_2	186	190	PF00568	0.591
LIG_FAT_LD_1	530	538	PF03623	0.455
LIG_FHA_1	203	209	PF00498	0.451
LIG_FHA_1	242	248	PF00498	0.401
LIG_FHA_1	290	296	PF00498	0.513
LIG_FHA_1	390	396	PF00498	0.445
LIG_FHA_1	427	433	PF00498	0.358
LIG_FHA_1	460	466	PF00498	0.515
LIG_FHA_1	513	519	PF00498	0.565
LIG_FHA_1	53	59	PF00498	0.406
LIG_FHA_2	331	337	PF00498	0.536
LIG_FHA_2	380	386	PF00498	0.501
LIG_FHA_2	498	504	PF00498	0.505
LIG_FHA_2	632	638	PF00498	0.475
LIG_FHA_2	64	70	PF00498	0.408
LIG_LIR_Apic_2	172	178	PF02991	0.457
LIG_LIR_Apic_2	296	302	PF02991	0.558
LIG_LIR_Apic_2	617	621	PF02991	0.650
LIG_LIR_Gen_1	205	215	PF02991	0.510
LIG_LIR_Gen_1	237	248	PF02991	0.376
LIG_LIR_Gen_1	385	395	PF02991	0.385
LIG_LIR_Gen_1	522	533	PF02991	0.531
LIG_LIR_Gen_1	636	643	PF02991	0.539
LIG_LIR_Nem_3	205	210	PF02991	0.457
LIG_LIR_Nem_3	235	241	PF02991	0.340
LIG_LIR_Nem_3	312	316	PF02991	0.439
LIG_LIR_Nem_3	319	325	PF02991	0.406
LIG_LIR_Nem_3	385	390	PF02991	0.387
LIG_LIR_Nem_3	453	458	PF02991	0.455
LIG_LIR_Nem_3	522	528	PF02991	0.556
LIG_LIR_Nem_3	636	642	PF02991	0.549
LIG_MLH1_MIPbox_1	274	278	PF16413	0.546
LIG_MYND_1	398	402	PF01753	0.495
LIG_MYND_1	555	559	PF01753	0.485
LIG_MYND_1	621	625	PF01753	0.663
LIG_PCNA_PIPBox_1	304	313	PF02747	0.450
LIG_Pex14_2	488	492	PF04695	0.445
LIG_Pex14_2	639	643	PF04695	0.512
LIG_Rb_pABgroove_1	323	331	PF01858	0.458
LIG_SH2_CRK	238	242	PF00017	0.422
LIG_SH2_CRK	329	333	PF00017	0.400
LIG_SH2_NCK_1	21	25	PF00017	0.375
LIG_SH2_STAP1	406	410	PF00017	0.451
LIG_SH2_STAP1	579	583	PF00017	0.597
LIG_SH2_STAT3	406	409	PF00017	0.455
LIG_SH2_STAT5	161	164	PF00017	0.410
LIG_SH2_STAT5	202	205	PF00017	0.364
LIG_SH2_STAT5	207	210	PF00017	0.406
LIG_SH2_STAT5	277	280	PF00017	0.497
LIG_SH2_STAT5	386	389	PF00017	0.375
LIG_SH3_3	113	119	PF00018	0.520
LIG_SH3_3	182	188	PF00018	0.533
LIG_SH3_3	192	198	PF00018	0.446
LIG_SH3_3	283	289	PF00018	0.489
LIG_SH3_3	618	624	PF00018	0.615
LIG_SH3_5	198	202	PF00018	0.382
LIG_SUMO_SIM_anti_2	149	154	PF11976	0.296
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.406
LIG_SUMO_SIM_anti_2	68	75	PF11976	0.510
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.388
LIG_SUMO_SIM_par_1	241	246	PF11976	0.419
LIG_SUMO_SIM_par_1	291	296	PF11976	0.516
LIG_SUMO_SIM_par_1	347	354	PF11976	0.432
LIG_SUMO_SIM_par_1	91	97	PF11976	0.465
LIG_UBA3_1	1	6	PF00899	0.560
LIG_UBA3_1	430	437	PF00899	0.426
LIG_UBA3_1	53	59	PF00899	0.451
LIG_UBA3_1	536	543	PF00899	0.559
LIG_WRC_WIRS_1	310	315	PF05994	0.457
LIG_WRC_WIRS_1	498	503	PF05994	0.473
MOD_CDK_SPxxK_3	298	305	PF00069	0.540
MOD_CDK_SPxxK_3	459	466	PF00069	0.487
MOD_CDK_SPxxK_3	542	549	PF00069	0.515
MOD_CK1_1	11	17	PF00069	0.503
MOD_CK1_1	26	32	PF00069	0.399
MOD_CK1_1	375	381	PF00069	0.525
MOD_CK1_1	389	395	PF00069	0.372
MOD_CK1_1	52	58	PF00069	0.362
MOD_CK1_1	524	530	PF00069	0.477
MOD_CK1_1	597	603	PF00069	0.681
MOD_CK2_1	265	271	PF00069	0.508
MOD_CK2_1	379	385	PF00069	0.501
MOD_CK2_1	497	503	PF00069	0.577
MOD_CK2_1	63	69	PF00069	0.430
MOD_Cter_Amidation	249	252	PF01082	0.466
MOD_Cter_Amidation	47	50	PF01082	0.490
MOD_GlcNHglycan	10	13	PF01048	0.558
MOD_GlcNHglycan	182	185	PF01048	0.427
MOD_GlcNHglycan	25	28	PF01048	0.474
MOD_GlcNHglycan	374	377	PF01048	0.420
MOD_GlcNHglycan	584	587	PF01048	0.692
MOD_GlcNHglycan	596	599	PF01048	0.765
MOD_GlcNHglycan	603	606	PF01048	0.695
MOD_GlcNHglycan	607	610	PF01048	0.651
MOD_GlcNHglycan	625	628	PF01048	0.686
MOD_GSK3_1	156	163	PF00069	0.401
MOD_GSK3_1	22	29	PF00069	0.414
MOD_GSK3_1	289	296	PF00069	0.480
MOD_GSK3_1	305	312	PF00069	0.463
MOD_GSK3_1	375	382	PF00069	0.481
MOD_GSK3_1	457	464	PF00069	0.458
MOD_GSK3_1	480	487	PF00069	0.472
MOD_GSK3_1	497	504	PF00069	0.411
MOD_GSK3_1	514	521	PF00069	0.399
MOD_GSK3_1	584	591	PF00069	0.674
MOD_GSK3_1	593	600	PF00069	0.592
MOD_GSK3_1	601	608	PF00069	0.635
MOD_GSK3_1	619	626	PF00069	0.552
MOD_GSK3_1	8	15	PF00069	0.541
MOD_N-GLC_1	512	517	PF02516	0.518
MOD_N-GLC_1	519	524	PF02516	0.522
MOD_N-GLC_1	564	569	PF02516	0.418
MOD_NEK2_1	155	160	PF00069	0.375
MOD_NEK2_1	23	28	PF00069	0.508
MOD_NEK2_1	379	384	PF00069	0.464
MOD_NEK2_1	5	10	PF00069	0.549
MOD_NEK2_1	514	519	PF00069	0.449
MOD_NEK2_1	582	587	PF00069	0.674
MOD_NEK2_1	601	606	PF00069	0.631
MOD_NEK2_1	614	619	PF00069	0.689
MOD_NEK2_2	156	161	PF00069	0.420
MOD_NEK2_2	564	569	PF00069	0.448
MOD_PIKK_1	457	463	PF00454	0.477
MOD_PIKK_1	616	622	PF00454	0.765
MOD_PK_1	49	55	PF00069	0.364
MOD_PKA_1	49	55	PF00069	0.441
MOD_PKA_2	111	117	PF00069	0.391
MOD_PKA_2	426	432	PF00069	0.286
MOD_PKA_2	63	69	PF00069	0.530
MOD_Plk_1	379	385	PF00069	0.323
MOD_Plk_1	519	525	PF00069	0.481
MOD_Plk_4	111	117	PF00069	0.361
MOD_Plk_4	156	162	PF00069	0.420
MOD_Plk_4	289	295	PF00069	0.440
MOD_Plk_4	386	392	PF00069	0.384
MOD_Plk_4	426	432	PF00069	0.388
MOD_Plk_4	49	55	PF00069	0.387
MOD_Plk_4	5	11	PF00069	0.472
MOD_Plk_4	572	578	PF00069	0.442
MOD_Plk_4	638	644	PF00069	0.525
MOD_ProDKin_1	298	304	PF00069	0.536
MOD_ProDKin_1	459	465	PF00069	0.500
MOD_ProDKin_1	542	548	PF00069	0.520
MOD_SUMO_rev_2	503	508	PF00179	0.411
MOD_SUMO_rev_2	96	106	PF00179	0.560
TRG_DiLeu_BaEn_1	146	151	PF01217	0.461
TRG_DiLeu_BaEn_1	69	74	PF01217	0.446
TRG_DiLeu_BaEn_1	79	84	PF01217	0.324
TRG_DiLeu_BaEn_2	138	144	PF01217	0.510
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.446
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.458
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.434
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.464
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.427
TRG_ENDOCYTIC_2	207	210	PF00928	0.475
TRG_ENDOCYTIC_2	238	241	PF00928	0.422
TRG_ENDOCYTIC_2	329	332	PF00928	0.433
TRG_ENDOCYTIC_2	579	582	PF00928	0.515
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P470	Leptomonas seymouri	71%	100%
A0A1X0P8C9	Trypanosomatidae	33%	100%
A0A3Q8IIL7	Leishmania donovani	100%	100%
A4HNM1	Leishmania braziliensis	76%	100%
E9ASD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F4I313	Arabidopsis thaliana	22%	71%
Q4Q264	Leishmania major	92%	100%
Q9C9H8	Arabidopsis thaliana	21%	71%