LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICX1_LEIIN
TriTrypDb:
LINF_360006600
Length:
285

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 1
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4ICX1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICX1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 203 207 PF00656 0.481
CLV_NRD_NRD_1 137 139 PF00675 0.687
CLV_NRD_NRD_1 234 236 PF00675 0.472
CLV_PCSK_KEX2_1 137 139 PF00082 0.678
CLV_PCSK_KEX2_1 281 283 PF00082 0.460
CLV_PCSK_PC1ET2_1 281 283 PF00082 0.481
CLV_PCSK_SKI1_1 230 234 PF00082 0.455
DEG_Nend_UBRbox_3 1 3 PF02207 0.660
DEG_SPOP_SBC_1 96 100 PF00917 0.422
DOC_CKS1_1 154 159 PF01111 0.455
DOC_CYCLIN_yCln2_LP_2 154 160 PF00134 0.487
DOC_MAPK_RevD_3 220 236 PF00069 0.596
DOC_USP7_MATH_1 200 204 PF00917 0.584
DOC_USP7_MATH_1 273 277 PF00917 0.629
DOC_USP7_MATH_1 96 100 PF00917 0.467
DOC_WW_Pin1_4 119 124 PF00397 0.415
DOC_WW_Pin1_4 153 158 PF00397 0.439
DOC_WW_Pin1_4 250 255 PF00397 0.747
LIG_14-3-3_CanoR_1 94 103 PF00244 0.547
LIG_Actin_WH2_2 88 104 PF00022 0.565
LIG_FHA_1 174 180 PF00498 0.472
LIG_FHA_1 253 259 PF00498 0.643
LIG_FHA_1 29 35 PF00498 0.487
LIG_FHA_1 98 104 PF00498 0.478
LIG_FHA_2 56 62 PF00498 0.541
LIG_Integrin_isoDGR_2 150 152 PF01839 0.585
LIG_Integrin_isoDGR_2 64 66 PF01839 0.586
LIG_LIR_Apic_2 118 123 PF02991 0.429
LIG_NRBOX 11 17 PF00104 0.536
LIG_PCNA_yPIPBox_3 60 71 PF02747 0.386
LIG_PDZ_Class_1 280 285 PF00595 0.757
LIG_Rb_pABgroove_1 65 73 PF01858 0.482
LIG_SH2_CRK 82 86 PF00017 0.480
LIG_SH2_STAP1 48 52 PF00017 0.503
LIG_SH2_STAT5 164 167 PF00017 0.413
LIG_SH2_STAT5 231 234 PF00017 0.582
LIG_SH3_1 138 144 PF00018 0.483
LIG_SH3_3 138 144 PF00018 0.442
LIG_TYR_ITIM 80 85 PF00017 0.591
LIG_UBA3_1 267 272 PF00899 0.487
LIG_WRC_WIRS_1 126 131 PF05994 0.606
LIG_WW_1 45 48 PF00397 0.656
MOD_CDK_SPxK_1 153 159 PF00069 0.625
MOD_CDK_SPxxK_3 250 257 PF00069 0.690
MOD_CK1_1 207 213 PF00069 0.641
MOD_CK1_1 97 103 PF00069 0.549
MOD_CK2_1 55 61 PF00069 0.700
MOD_GlcNHglycan 146 149 PF01048 0.633
MOD_GlcNHglycan 202 205 PF01048 0.726
MOD_GlcNHglycan 209 212 PF01048 0.623
MOD_GlcNHglycan 23 26 PF01048 0.641
MOD_GlcNHglycan 274 278 PF01048 0.559
MOD_GlcNHglycan 6 9 PF01048 0.639
MOD_GSK3_1 115 122 PF00069 0.618
MOD_GSK3_1 169 176 PF00069 0.388
MOD_GSK3_1 17 24 PF00069 0.564
MOD_GSK3_1 200 207 PF00069 0.616
MOD_GSK3_1 248 255 PF00069 0.584
MOD_GSK3_1 28 35 PF00069 0.499
MOD_NEK2_1 16 21 PF00069 0.495
MOD_NEK2_1 239 244 PF00069 0.632
MOD_NEK2_1 4 9 PF00069 0.635
MOD_NEK2_2 17 22 PF00069 0.640
MOD_NEK2_2 55 60 PF00069 0.667
MOD_PIKK_1 183 189 PF00454 0.687
MOD_PIKK_1 252 258 PF00454 0.605
MOD_PKA_2 21 27 PF00069 0.662
MOD_Plk_1 239 245 PF00069 0.609
MOD_Plk_1 32 38 PF00069 0.509
MOD_Plk_1 48 54 PF00069 0.599
MOD_Plk_4 115 121 PF00069 0.618
MOD_Plk_4 169 175 PF00069 0.551
MOD_Plk_4 209 215 PF00069 0.436
MOD_Plk_4 33 39 PF00069 0.594
MOD_ProDKin_1 119 125 PF00069 0.510
MOD_ProDKin_1 153 159 PF00069 0.544
MOD_ProDKin_1 250 256 PF00069 0.693
MOD_SUMO_for_1 271 274 PF00179 0.504
TRG_DiLeu_BaEn_1 130 135 PF01217 0.571
TRG_DiLeu_BaEn_1 170 175 PF01217 0.462
TRG_DiLeu_BaLyEn_6 223 228 PF01217 0.501
TRG_ENDOCYTIC_2 82 85 PF00928 0.591
TRG_ER_diArg_1 136 138 PF00400 0.613
TRG_ER_diArg_1 158 161 PF00400 0.516
TRG_ER_diArg_1 196 199 PF00400 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3B3 Leptomonas seymouri 44% 99%
A0A1X0P8Q0 Trypanosomatidae 25% 100%
A0A3Q8IN72 Leishmania donovani 100% 100%
A4HNM3 Leishmania braziliensis 79% 100%
E9ASD4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q262 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS