LeishMANIAdb
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Putative SET domain protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative SET domain protein
Gene product:
SET domain protein - putative
Species:
Leishmania infantum
UniProt:
A4ICW6_LEIIN
TriTrypDb:
LINF_360007300
Length:
473

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, Histone-lysine N-methyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICW6

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016740 transferase activity 2 11
GO:0000166 nucleotide binding 3 2
GO:0005488 binding 1 2
GO:0005524 ATP binding 5 2
GO:0008168 methyltransferase activity 4 2
GO:0008716 D-alanine-D-alanine ligase activity 5 2
GO:0016741 transferase activity, transferring one-carbon groups 3 2
GO:0016874 ligase activity 2 2
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 2
GO:0016881 acid-amino acid ligase activity 4 2
GO:0017076 purine nucleotide binding 4 2
GO:0030554 adenyl nucleotide binding 5 2
GO:0032553 ribonucleotide binding 3 2
GO:0032555 purine ribonucleotide binding 4 2
GO:0032559 adenyl ribonucleotide binding 5 2
GO:0035639 purine ribonucleoside triphosphate binding 4 2
GO:0036094 small molecule binding 2 2
GO:0043167 ion binding 2 2
GO:0043168 anion binding 3 2
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2
GO:0097159 organic cyclic compound binding 2 2
GO:0097367 carbohydrate derivative binding 2 2
GO:1901265 nucleoside phosphate binding 3 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.497
CLV_C14_Caspase3-7 18 22 PF00656 0.526
CLV_NRD_NRD_1 130 132 PF00675 0.487
CLV_NRD_NRD_1 297 299 PF00675 0.506
CLV_NRD_NRD_1 314 316 PF00675 0.534
CLV_NRD_NRD_1 326 328 PF00675 0.275
CLV_NRD_NRD_1 461 463 PF00675 0.406
CLV_PCSK_KEX2_1 130 132 PF00082 0.358
CLV_PCSK_SKI1_1 233 237 PF00082 0.371
CLV_PCSK_SKI1_1 358 362 PF00082 0.271
CLV_PCSK_SKI1_1 469 473 PF00082 0.559
CLV_PCSK_SKI1_1 95 99 PF00082 0.387
DEG_APCC_KENBOX_2 249 253 PF00400 0.386
DOC_CYCLIN_yCln2_LP_2 136 142 PF00134 0.312
DOC_CYCLIN_yCln2_LP_2 99 105 PF00134 0.357
DOC_MAPK_gen_1 135 142 PF00069 0.499
DOC_MAPK_gen_1 185 193 PF00069 0.416
DOC_MAPK_gen_1 324 333 PF00069 0.455
DOC_MAPK_MEF2A_6 185 193 PF00069 0.399
DOC_PP1_RVXF_1 173 180 PF00149 0.355
DOC_PP2B_LxvP_1 136 139 PF13499 0.413
DOC_PP4_FxxP_1 397 400 PF00568 0.540
DOC_USP7_MATH_1 194 198 PF00917 0.481
DOC_USP7_MATH_1 206 210 PF00917 0.534
DOC_USP7_MATH_1 366 370 PF00917 0.484
DOC_USP7_MATH_1 52 56 PF00917 0.498
DOC_USP7_UBL2_3 324 328 PF12436 0.540
DOC_WW_Pin1_4 13 18 PF00397 0.595
DOC_WW_Pin1_4 50 55 PF00397 0.396
DOC_WW_Pin1_4 73 78 PF00397 0.381
LIG_14-3-3_CanoR_1 143 151 PF00244 0.533
LIG_14-3-3_CanoR_1 442 452 PF00244 0.507
LIG_14-3-3_CanoR_1 95 100 PF00244 0.416
LIG_APCC_ABBA_1 149 154 PF00400 0.473
LIG_APCC_ABBA_1 308 313 PF00400 0.539
LIG_BRCT_BRCA1_1 29 33 PF00533 0.481
LIG_EH1_1 102 110 PF00400 0.458
LIG_FHA_1 143 149 PF00498 0.467
LIG_FHA_1 210 216 PF00498 0.454
LIG_FHA_1 303 309 PF00498 0.530
LIG_FHA_1 321 327 PF00498 0.372
LIG_FHA_1 74 80 PF00498 0.486
LIG_FHA_2 13 19 PF00498 0.544
LIG_FHA_2 155 161 PF00498 0.407
LIG_FHA_2 246 252 PF00498 0.512
LIG_FHA_2 283 289 PF00498 0.372
LIG_FHA_2 357 363 PF00498 0.464
LIG_FHA_2 421 427 PF00498 0.316
LIG_LIR_Apic_2 349 355 PF02991 0.501
LIG_LIR_Apic_2 361 366 PF02991 0.394
LIG_LIR_Gen_1 339 348 PF02991 0.451
LIG_LIR_Gen_1 418 429 PF02991 0.472
LIG_LIR_Gen_1 55 63 PF02991 0.385
LIG_LIR_Nem_3 232 237 PF02991 0.399
LIG_LIR_Nem_3 339 343 PF02991 0.451
LIG_LIR_Nem_3 359 363 PF02991 0.338
LIG_LIR_Nem_3 418 424 PF02991 0.432
LIG_LIR_Nem_3 55 60 PF02991 0.452
LIG_SH2_NCK_1 112 116 PF00017 0.368
LIG_SH2_SRC 112 115 PF00017 0.405
LIG_SH2_STAP1 401 405 PF00017 0.385
LIG_SH2_STAP1 57 61 PF00017 0.246
LIG_SH2_STAT5 234 237 PF00017 0.378
LIG_SH2_STAT5 91 94 PF00017 0.412
LIG_SH3_3 112 118 PF00018 0.426
LIG_SH3_3 259 265 PF00018 0.433
LIG_SH3_3 340 346 PF00018 0.453
LIG_SH3_3 467 473 PF00018 0.451
LIG_SUMO_SIM_anti_2 104 109 PF11976 0.458
LIG_TYR_ITIM 110 115 PF00017 0.476
LIG_UBA3_1 166 175 PF00899 0.292
LIG_WRC_WIRS_1 421 426 PF05994 0.307
MOD_CK1_1 209 215 PF00069 0.348
MOD_CK1_1 229 235 PF00069 0.445
MOD_CK1_1 282 288 PF00069 0.582
MOD_CK2_1 12 18 PF00069 0.493
MOD_CK2_1 245 251 PF00069 0.499
MOD_CK2_1 282 288 PF00069 0.527
MOD_CK2_1 356 362 PF00069 0.477
MOD_CK2_1 52 58 PF00069 0.423
MOD_GlcNHglycan 228 231 PF01048 0.334
MOD_GlcNHglycan 281 284 PF01048 0.517
MOD_GlcNHglycan 445 448 PF01048 0.429
MOD_GlcNHglycan 465 468 PF01048 0.444
MOD_GlcNHglycan 66 70 PF01048 0.619
MOD_GSK3_1 85 92 PF00069 0.463
MOD_N-GLC_1 181 186 PF02516 0.463
MOD_N-GLC_1 387 392 PF02516 0.229
MOD_N-GLC_2 144 146 PF02516 0.387
MOD_N-GLC_2 62 64 PF02516 0.305
MOD_NEK2_1 279 284 PF00069 0.429
MOD_NEK2_1 289 294 PF00069 0.429
MOD_NEK2_1 320 325 PF00069 0.546
MOD_NEK2_1 356 361 PF00069 0.538
MOD_NEK2_1 89 94 PF00069 0.318
MOD_NEK2_2 194 199 PF00069 0.492
MOD_NEK2_2 425 430 PF00069 0.346
MOD_NEK2_2 78 83 PF00069 0.458
MOD_PIKK_1 1 7 PF00454 0.446
MOD_PKA_2 142 148 PF00069 0.461
MOD_Plk_1 162 168 PF00069 0.472
MOD_Plk_1 415 421 PF00069 0.455
MOD_Plk_1 456 462 PF00069 0.402
MOD_Plk_2-3 154 160 PF00069 0.277
MOD_Plk_2-3 415 421 PF00069 0.424
MOD_Plk_4 162 168 PF00069 0.400
MOD_Plk_4 289 295 PF00069 0.477
MOD_Plk_4 456 462 PF00069 0.482
MOD_Plk_4 52 58 PF00069 0.337
MOD_Plk_4 78 84 PF00069 0.347
MOD_ProDKin_1 13 19 PF00069 0.591
MOD_ProDKin_1 50 56 PF00069 0.395
MOD_ProDKin_1 73 79 PF00069 0.376
TRG_DiLeu_BaLyEn_6 467 472 PF01217 0.546
TRG_ENDOCYTIC_2 112 115 PF00928 0.358
TRG_ENDOCYTIC_2 421 424 PF00928 0.307
TRG_ENDOCYTIC_2 57 60 PF00928 0.441
TRG_Pf-PMV_PEXEL_1 168 172 PF00026 0.402

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILG6 Leptomonas seymouri 66% 100%
A0A0S4JLQ2 Bodo saltans 27% 100%
A0A0S4KKY2 Bodo saltans 42% 100%
A0A1X0P8J8 Trypanosomatidae 42% 100%
A0A3Q8IJR2 Leishmania donovani 100% 100%
A0A3R7MWC4 Trypanosoma rangeli 26% 92%
A0A3R7P2U3 Trypanosoma rangeli 39% 100%
A4HNM9 Leishmania braziliensis 83% 100%
D0A2I3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9ASD8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q257 Leishmania major 92% 100%
V5BQK1 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS