Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Afadin- and alpha -actinin-Binding - putative

Species:

Leishmania infantum

UniProt:

A4ICW3_LEIIN

TriTrypDb:

LINF_360007600

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.407
CLV_NRD_NRD_1	138	140	PF00675	0.474
CLV_NRD_NRD_1	183	185	PF00675	0.491
CLV_NRD_NRD_1	187	189	PF00675	0.401
CLV_NRD_NRD_1	57	59	PF00675	0.547
CLV_NRD_NRD_1	70	72	PF00675	0.710
CLV_PCSK_KEX2_1	138	140	PF00082	0.436
CLV_PCSK_KEX2_1	156	158	PF00082	0.514
CLV_PCSK_KEX2_1	183	185	PF00082	0.458
CLV_PCSK_KEX2_1	57	59	PF00082	0.552
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.590
CLV_PCSK_SKI1_1	189	193	PF00082	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.609
DOC_CYCLIN_RxL_1	183	196	PF00134	0.414
DOC_USP7_MATH_1	113	117	PF00917	0.526
DOC_WW_Pin1_4	63	68	PF00397	0.613
DOC_WW_Pin1_4	94	99	PF00397	0.451
LIG_14-3-3_CanoR_1	124	128	PF00244	0.563
LIG_14-3-3_CanoR_1	17	22	PF00244	0.715
LIG_14-3-3_CanoR_1	174	178	PF00244	0.502
LIG_14-3-3_CanoR_1	57	67	PF00244	0.593
LIG_Actin_WH2_2	152	169	PF00022	0.463
LIG_BRCT_BRCA1_1	96	100	PF00533	0.409
LIG_eIF4E_1	104	110	PF01652	0.439
LIG_eIF4E_1	87	93	PF01652	0.456
LIG_FHA_1	46	52	PF00498	0.405
LIG_FHA_2	124	130	PF00498	0.602
LIG_FHA_2	194	200	PF00498	0.515
LIG_LIR_Nem_3	83	89	PF02991	0.460
LIG_MYND_1	94	98	PF01753	0.417
LIG_SH2_STAP1	104	108	PF00017	0.407
LIG_SH3_2	67	72	PF14604	0.621
LIG_SH3_3	61	67	PF00018	0.632
LIG_SH3_3	8	14	PF00018	0.609
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.383
LIG_SxIP_EBH_1	15	25	PF03271	0.476
LIG_UBA3_1	21	25	PF00899	0.629
MOD_CK1_1	173	179	PF00069	0.472
MOD_CK2_1	193	199	PF00069	0.494
MOD_CK2_1	41	47	PF00069	0.653
MOD_CK2_1	63	69	PF00069	0.666
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.631
MOD_GlcNHglycan	115	118	PF01048	0.530
MOD_GlcNHglycan	120	123	PF01048	0.596
MOD_GlcNHglycan	26	29	PF01048	0.445
MOD_GSK3_1	41	48	PF00069	0.504
MOD_GSK3_1	59	66	PF00069	0.638
MOD_N-GLC_1	211	216	PF02516	0.445
MOD_NEK2_1	100	105	PF00069	0.438
MOD_NEK2_1	145	150	PF00069	0.541
MOD_NEK2_1	193	198	PF00069	0.398
MOD_NEK2_1	24	29	PF00069	0.477
MOD_PKA_1	57	63	PF00069	0.562
MOD_PKA_2	123	129	PF00069	0.560
MOD_PKA_2	173	179	PF00069	0.477
MOD_PKA_2	41	47	PF00069	0.606
MOD_PKA_2	57	63	PF00069	0.476
MOD_Plk_1	211	217	PF00069	0.445
MOD_Plk_4	17	23	PF00069	0.612
MOD_Plk_4	88	94	PF00069	0.521
MOD_ProDKin_1	63	69	PF00069	0.611
MOD_ProDKin_1	94	100	PF00069	0.447
MOD_SUMO_for_1	155	158	PF00179	0.564
TRG_DiLeu_BaEn_1	88	93	PF01217	0.448
TRG_ER_diArg_1	51	54	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5U6	Leptomonas seymouri	63%	98%
A0A1X0P8P1	Trypanosomatidae	38%	97%
A0A3Q8IQF0	Leishmania donovani	100%	100%
A0A422P2B9	Trypanosoma rangeli	40%	98%
A4HNN2	Leishmania braziliensis	82%	100%
D0A2I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ASE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q254	Leishmania major	96%	100%