LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICW0_LEIIN
TriTrypDb:
LINF_360007900
Length:
817

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICW0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICW0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 223 225 PF00675 0.558
CLV_NRD_NRD_1 238 240 PF00675 0.598
CLV_NRD_NRD_1 254 256 PF00675 0.630
CLV_NRD_NRD_1 265 267 PF00675 0.479
CLV_NRD_NRD_1 32 34 PF00675 0.638
CLV_NRD_NRD_1 498 500 PF00675 0.512
CLV_NRD_NRD_1 5 7 PF00675 0.710
CLV_NRD_NRD_1 644 646 PF00675 0.751
CLV_NRD_NRD_1 673 675 PF00675 0.786
CLV_NRD_NRD_1 741 743 PF00675 0.497
CLV_NRD_NRD_1 763 765 PF00675 0.407
CLV_NRD_NRD_1 802 804 PF00675 0.553
CLV_NRD_NRD_1 811 813 PF00675 0.642
CLV_NRD_NRD_1 92 94 PF00675 0.606
CLV_PCSK_KEX2_1 223 225 PF00082 0.627
CLV_PCSK_KEX2_1 238 240 PF00082 0.464
CLV_PCSK_KEX2_1 253 255 PF00082 0.762
CLV_PCSK_KEX2_1 265 267 PF00082 0.468
CLV_PCSK_KEX2_1 32 34 PF00082 0.618
CLV_PCSK_KEX2_1 498 500 PF00082 0.512
CLV_PCSK_KEX2_1 5 7 PF00082 0.512
CLV_PCSK_KEX2_1 644 646 PF00082 0.756
CLV_PCSK_KEX2_1 673 675 PF00082 0.752
CLV_PCSK_KEX2_1 740 742 PF00082 0.519
CLV_PCSK_KEX2_1 763 765 PF00082 0.427
CLV_PCSK_KEX2_1 802 804 PF00082 0.588
CLV_PCSK_KEX2_1 811 813 PF00082 0.576
CLV_PCSK_KEX2_1 92 94 PF00082 0.606
CLV_PCSK_PC7_1 737 743 PF00082 0.476
CLV_PCSK_SKI1_1 158 162 PF00082 0.743
CLV_PCSK_SKI1_1 223 227 PF00082 0.557
CLV_PCSK_SKI1_1 640 644 PF00082 0.793
CLV_PCSK_SKI1_1 69 73 PF00082 0.731
CLV_PCSK_SKI1_1 755 759 PF00082 0.552
DEG_APCC_DBOX_1 24 32 PF00400 0.607
DEG_APCC_DBOX_1 268 276 PF00400 0.437
DEG_APCC_DBOX_1 762 770 PF00400 0.481
DEG_COP1_1 476 483 PF00400 0.543
DEG_MDM2_SWIB_1 431 438 PF02201 0.531
DEG_SPOP_SBC_1 129 133 PF00917 0.626
DEG_SPOP_SBC_1 509 513 PF00917 0.528
DEG_SPOP_SBC_1 665 669 PF00917 0.748
DOC_ANK_TNKS_1 575 582 PF00023 0.524
DOC_MAPK_gen_1 326 336 PF00069 0.467
DOC_MAPK_gen_1 545 551 PF00069 0.595
DOC_MAPK_gen_1 562 571 PF00069 0.455
DOC_MAPK_gen_1 763 771 PF00069 0.480
DOC_MAPK_MEF2A_6 565 573 PF00069 0.404
DOC_PP1_RVXF_1 246 253 PF00149 0.540
DOC_PP1_RVXF_1 762 769 PF00149 0.428
DOC_PP1_RVXF_1 82 88 PF00149 0.686
DOC_PP1_SILK_1 669 674 PF00149 0.695
DOC_PP2B_LxvP_1 389 392 PF13499 0.583
DOC_PP2B_LxvP_1 478 481 PF13499 0.315
DOC_PP4_FxxP_1 519 522 PF00568 0.565
DOC_PP4_FxxP_1 777 780 PF00568 0.414
DOC_USP7_MATH_1 127 131 PF00917 0.705
DOC_USP7_MATH_1 153 157 PF00917 0.709
DOC_USP7_MATH_1 194 198 PF00917 0.780
DOC_USP7_MATH_1 244 248 PF00917 0.634
DOC_USP7_MATH_1 344 348 PF00917 0.509
DOC_USP7_MATH_1 4 8 PF00917 0.675
DOC_USP7_MATH_1 439 443 PF00917 0.580
DOC_USP7_MATH_1 497 501 PF00917 0.504
DOC_USP7_MATH_1 509 513 PF00917 0.615
DOC_USP7_MATH_1 535 539 PF00917 0.515
DOC_USP7_MATH_1 652 656 PF00917 0.777
DOC_USP7_MATH_1 663 667 PF00917 0.596
DOC_USP7_MATH_1 705 709 PF00917 0.479
DOC_USP7_UBL2_3 754 758 PF12436 0.530
DOC_WW_Pin1_4 110 115 PF00397 0.805
DOC_WW_Pin1_4 162 167 PF00397 0.781
DOC_WW_Pin1_4 223 228 PF00397 0.552
DOC_WW_Pin1_4 31 36 PF00397 0.588
DOC_WW_Pin1_4 345 350 PF00397 0.610
DOC_WW_Pin1_4 361 366 PF00397 0.310
DOC_WW_Pin1_4 370 375 PF00397 0.613
DOC_WW_Pin1_4 579 584 PF00397 0.605
DOC_WW_Pin1_4 601 606 PF00397 0.690
DOC_WW_Pin1_4 631 636 PF00397 0.758
DOC_WW_Pin1_4 647 652 PF00397 0.525
DOC_WW_Pin1_4 654 659 PF00397 0.593
LIG_14-3-3_CanoR_1 121 125 PF00244 0.741
LIG_14-3-3_CanoR_1 326 332 PF00244 0.546
LIG_14-3-3_CanoR_1 358 364 PF00244 0.614
LIG_14-3-3_CanoR_1 40 49 PF00244 0.546
LIG_14-3-3_CanoR_1 5 13 PF00244 0.697
LIG_14-3-3_CanoR_1 589 593 PF00244 0.596
LIG_14-3-3_CanoR_1 644 648 PF00244 0.743
LIG_14-3-3_CanoR_1 701 709 PF00244 0.512
LIG_14-3-3_CanoR_1 740 746 PF00244 0.602
LIG_Actin_WH2_2 17 34 PF00022 0.605
LIG_Actin_WH2_2 333 348 PF00022 0.503
LIG_BRCT_BRCA1_1 707 711 PF00533 0.435
LIG_BRCT_BRCA1_1 87 91 PF00533 0.739
LIG_FHA_1 131 137 PF00498 0.762
LIG_FHA_1 138 144 PF00498 0.758
LIG_FHA_1 373 379 PF00498 0.504
LIG_FHA_1 531 537 PF00498 0.526
LIG_FHA_1 542 548 PF00498 0.488
LIG_FHA_1 80 86 PF00498 0.713
LIG_FHA_2 183 189 PF00498 0.681
LIG_FHA_2 279 285 PF00498 0.524
LIG_FHA_2 308 314 PF00498 0.619
LIG_FHA_2 328 334 PF00498 0.519
LIG_FHA_2 349 355 PF00498 0.597
LIG_FHA_2 362 368 PF00498 0.583
LIG_FHA_2 7 13 PF00498 0.635
LIG_FHA_2 701 707 PF00498 0.465
LIG_FHA_2 81 87 PF00498 0.692
LIG_FHA_2 97 103 PF00498 0.775
LIG_GBD_Chelix_1 16 24 PF00786 0.641
LIG_GBD_Chelix_1 228 236 PF00786 0.594
LIG_Integrin_RGD_1 562 564 PF01839 0.520
LIG_LIR_Apic_2 205 211 PF02991 0.643
LIG_LIR_Apic_2 442 447 PF02991 0.586
LIG_LIR_Apic_2 715 721 PF02991 0.507
LIG_LIR_Gen_1 379 389 PF02991 0.555
LIG_LIR_Gen_1 767 776 PF02991 0.573
LIG_LIR_Nem_3 379 384 PF02991 0.540
LIG_LIR_Nem_3 410 416 PF02991 0.621
LIG_LIR_Nem_3 482 487 PF02991 0.458
LIG_LIR_Nem_3 767 771 PF02991 0.559
LIG_NRBOX 568 574 PF00104 0.536
LIG_Pex14_1 208 212 PF04695 0.640
LIG_Pex14_2 431 435 PF04695 0.540
LIG_Pex14_2 87 91 PF04695 0.805
LIG_SH2_CRK 413 417 PF00017 0.582
LIG_SH2_CRK 444 448 PF00017 0.552
LIG_SH2_NCK_1 14 18 PF00017 0.653
LIG_SH2_NCK_1 413 417 PF00017 0.660
LIG_SH2_NCK_1 702 706 PF00017 0.502
LIG_SH2_SRC 388 391 PF00017 0.523
LIG_SH2_SRC 413 416 PF00017 0.607
LIG_SH2_SRC 733 736 PF00017 0.439
LIG_SH2_STAP1 338 342 PF00017 0.487
LIG_SH2_STAT5 233 236 PF00017 0.513
LIG_SH2_STAT5 271 274 PF00017 0.433
LIG_SH2_STAT5 369 372 PF00017 0.630
LIG_SH2_STAT5 388 391 PF00017 0.277
LIG_SH2_STAT5 603 606 PF00017 0.656
LIG_SH2_STAT5 702 705 PF00017 0.424
LIG_SH2_STAT5 733 736 PF00017 0.536
LIG_SH2_STAT5 805 808 PF00017 0.570
LIG_SH3_1 645 651 PF00018 0.669
LIG_SH3_3 157 163 PF00018 0.652
LIG_SH3_3 285 291 PF00018 0.656
LIG_SH3_3 412 418 PF00018 0.663
LIG_SH3_3 580 586 PF00018 0.679
LIG_SH3_3 645 651 PF00018 0.754
LIG_SUMO_SIM_par_1 276 282 PF11976 0.613
LIG_TRAF2_1 351 354 PF00917 0.590
LIG_TRAF2_1 364 367 PF00917 0.512
LIG_TRAF2_1 391 394 PF00917 0.570
LIG_WRC_WIRS_1 536 541 PF05994 0.503
MOD_CDK_SPK_2 654 659 PF00069 0.752
MOD_CDK_SPxK_1 601 607 PF00069 0.783
MOD_CDK_SPxxK_3 110 117 PF00069 0.737
MOD_CDK_SPxxK_3 223 230 PF00069 0.619
MOD_CDK_SPxxK_3 647 654 PF00069 0.665
MOD_CK1_1 120 126 PF00069 0.770
MOD_CK1_1 130 136 PF00069 0.636
MOD_CK1_1 137 143 PF00069 0.571
MOD_CK1_1 203 209 PF00069 0.635
MOD_CK1_1 213 219 PF00069 0.649
MOD_CK1_1 347 353 PF00069 0.550
MOD_CK1_1 476 482 PF00069 0.499
MOD_CK1_1 538 544 PF00069 0.534
MOD_CK1_1 550 556 PF00069 0.463
MOD_CK1_1 621 627 PF00069 0.664
MOD_CK1_1 666 672 PF00069 0.712
MOD_CK2_1 276 282 PF00069 0.528
MOD_CK2_1 307 313 PF00069 0.596
MOD_CK2_1 327 333 PF00069 0.540
MOD_CK2_1 348 354 PF00069 0.587
MOD_CK2_1 361 367 PF00069 0.414
MOD_CK2_1 497 503 PF00069 0.502
MOD_CK2_1 62 68 PF00069 0.679
MOD_CK2_1 80 86 PF00069 0.733
MOD_DYRK1A_RPxSP_1 654 658 PF00069 0.659
MOD_GlcNHglycan 202 205 PF01048 0.673
MOD_GlcNHglycan 212 215 PF01048 0.589
MOD_GlcNHglycan 313 316 PF01048 0.647
MOD_GlcNHglycan 465 468 PF01048 0.498
MOD_GlcNHglycan 499 502 PF01048 0.510
MOD_GlcNHglycan 512 515 PF01048 0.633
MOD_GlcNHglycan 533 536 PF01048 0.462
MOD_GlcNHglycan 645 648 PF01048 0.803
MOD_GlcNHglycan 668 671 PF01048 0.742
MOD_GSK3_1 105 112 PF00069 0.780
MOD_GSK3_1 113 120 PF00069 0.782
MOD_GSK3_1 127 134 PF00069 0.683
MOD_GSK3_1 182 189 PF00069 0.738
MOD_GSK3_1 190 197 PF00069 0.744
MOD_GSK3_1 198 205 PF00069 0.632
MOD_GSK3_1 307 314 PF00069 0.397
MOD_GSK3_1 344 351 PF00069 0.559
MOD_GSK3_1 372 379 PF00069 0.516
MOD_GSK3_1 469 476 PF00069 0.489
MOD_GSK3_1 531 538 PF00069 0.525
MOD_GSK3_1 587 594 PF00069 0.675
MOD_GSK3_1 618 625 PF00069 0.657
MOD_GSK3_1 627 634 PF00069 0.636
MOD_GSK3_1 643 650 PF00069 0.700
MOD_GSK3_1 75 82 PF00069 0.639
MOD_N-GLC_1 137 142 PF02516 0.744
MOD_N-GLC_1 299 304 PF02516 0.480
MOD_N-GLC_1 530 535 PF02516 0.468
MOD_NEK2_1 299 304 PF00069 0.449
MOD_NEK2_1 307 312 PF00069 0.467
MOD_NEK2_1 384 389 PF00069 0.522
MOD_NEK2_1 41 46 PF00069 0.557
MOD_NEK2_1 622 627 PF00069 0.651
MOD_NEK2_1 643 648 PF00069 0.680
MOD_NEK2_2 153 158 PF00069 0.714
MOD_NEK2_2 376 381 PF00069 0.532
MOD_NEK2_2 439 444 PF00069 0.564
MOD_PIKK_1 151 157 PF00454 0.783
MOD_PKA_1 253 259 PF00069 0.748
MOD_PKA_1 741 747 PF00069 0.597
MOD_PKA_2 120 126 PF00069 0.752
MOD_PKA_2 253 259 PF00069 0.681
MOD_PKA_2 311 317 PF00069 0.461
MOD_PKA_2 4 10 PF00069 0.597
MOD_PKA_2 497 503 PF00069 0.493
MOD_PKA_2 588 594 PF00069 0.539
MOD_PKA_2 643 649 PF00069 0.743
MOD_PKA_2 700 706 PF00069 0.506
MOD_PKA_2 741 747 PF00069 0.597
MOD_PKA_2 810 816 PF00069 0.727
MOD_PKA_2 91 97 PF00069 0.651
MOD_Plk_1 137 143 PF00069 0.567
MOD_Plk_1 283 289 PF00069 0.709
MOD_Plk_1 553 559 PF00069 0.510
MOD_Plk_1 705 711 PF00069 0.440
MOD_Plk_4 131 137 PF00069 0.728
MOD_Plk_4 376 382 PF00069 0.469
MOD_Plk_4 384 390 PF00069 0.476
MOD_Plk_4 439 445 PF00069 0.547
MOD_Plk_4 479 485 PF00069 0.410
MOD_Plk_4 547 553 PF00069 0.502
MOD_Plk_4 588 594 PF00069 0.618
MOD_Plk_4 705 711 PF00069 0.540
MOD_Plk_4 741 747 PF00069 0.597
MOD_Plk_4 793 799 PF00069 0.455
MOD_ProDKin_1 110 116 PF00069 0.805
MOD_ProDKin_1 162 168 PF00069 0.782
MOD_ProDKin_1 223 229 PF00069 0.542
MOD_ProDKin_1 31 37 PF00069 0.583
MOD_ProDKin_1 345 351 PF00069 0.617
MOD_ProDKin_1 361 367 PF00069 0.313
MOD_ProDKin_1 370 376 PF00069 0.605
MOD_ProDKin_1 579 585 PF00069 0.615
MOD_ProDKin_1 601 607 PF00069 0.694
MOD_ProDKin_1 631 637 PF00069 0.755
MOD_ProDKin_1 647 653 PF00069 0.527
MOD_ProDKin_1 654 660 PF00069 0.592
TRG_DiLeu_BaLyEn_6 777 782 PF01217 0.379
TRG_ENDOCYTIC_2 233 236 PF00928 0.591
TRG_ENDOCYTIC_2 413 416 PF00928 0.583
TRG_ER_diArg_1 222 224 PF00400 0.580
TRG_ER_diArg_1 252 255 PF00400 0.720
TRG_ER_diArg_1 264 266 PF00400 0.463
TRG_ER_diArg_1 31 33 PF00400 0.660
TRG_ER_diArg_1 643 645 PF00400 0.706
TRG_ER_diArg_1 672 674 PF00400 0.747
TRG_ER_diArg_1 740 742 PF00400 0.514
TRG_ER_diArg_1 762 764 PF00400 0.473
TRG_ER_diArg_1 801 803 PF00400 0.568
TRG_ER_diArg_1 810 812 PF00400 0.577
TRG_ER_diArg_1 91 93 PF00400 0.710
TRG_Pf-PMV_PEXEL_1 217 221 PF00026 0.691
TRG_Pf-PMV_PEXEL_1 230 235 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 329 333 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0J3 Leptomonas seymouri 43% 100%
A0A3Q8IIY8 Leishmania donovani 99% 100%
A0A422P2B7 Trypanosoma rangeli 32% 100%
A4HNN5 Leishmania braziliensis 72% 100%
D0A2I8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9ASE4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q251 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS