TFIIS central domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICV9_LEIIN

TriTrypDb:

LINF_360008000

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICV9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006351	DNA-templated transcription	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0032774	RNA biosynthetic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034654	nucleobase-containing compound biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0097659	nucleic acid-templated transcription	6	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.566
CLV_NRD_NRD_1	136	138	PF00675	0.524
CLV_NRD_NRD_1	81	83	PF00675	0.647
CLV_PCSK_KEX2_1	105	107	PF00082	0.531
CLV_PCSK_KEX2_1	114	116	PF00082	0.485
CLV_PCSK_KEX2_1	136	138	PF00082	0.524
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.621
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.490
DEG_SPOP_SBC_1	5	9	PF00917	0.688
DOC_CYCLIN_yClb5_NLxxxL_5	69	75	PF00134	0.489
DOC_MAPK_gen_1	136	142	PF00069	0.481
DOC_MAPK_MEF2A_6	14	23	PF00069	0.567
DOC_USP7_MATH_1	146	150	PF00917	0.550
DOC_USP7_MATH_1	193	197	PF00917	0.692
DOC_USP7_MATH_1	5	9	PF00917	0.688
DOC_USP7_MATH_1	98	102	PF00917	0.595
LIG_14-3-3_CanoR_1	37	47	PF00244	0.582
LIG_14-3-3_CterR_2	198	201	PF00244	0.539
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_FHA_2	118	124	PF00498	0.627
LIG_FHA_2	192	198	PF00498	0.735
LIG_FHA_2	51	57	PF00498	0.503
LIG_GBD_Chelix_1	15	23	PF00786	0.552
LIG_Pex14_2	156	160	PF04695	0.539
LIG_SH2_STAP1	39	43	PF00017	0.453
LIG_SH2_STAT3	39	42	PF00017	0.570
LIG_TRAF2_1	53	56	PF00917	0.578
LIG_UBA3_1	18	25	PF00899	0.516
LIG_UBA3_1	61	69	PF00899	0.491
MOD_CK1_1	149	155	PF00069	0.685
MOD_CK1_1	167	173	PF00069	0.475
MOD_CK1_1	188	194	PF00069	0.683
MOD_CK1_1	3	9	PF00069	0.682
MOD_CK2_1	167	173	PF00069	0.680
MOD_CK2_1	174	180	PF00069	0.720
MOD_CK2_1	50	56	PF00069	0.500
MOD_CK2_1	84	90	PF00069	0.568
MOD_GlcNHglycan	150	154	PF01048	0.696
MOD_GlcNHglycan	176	179	PF01048	0.755
MOD_GlcNHglycan	3	6	PF01048	0.722
MOD_GlcNHglycan	32	35	PF01048	0.612
MOD_GlcNHglycan	86	89	PF01048	0.597
MOD_GSK3_1	1	8	PF00069	0.700
MOD_GSK3_1	104	111	PF00069	0.624
MOD_GSK3_1	123	130	PF00069	0.536
MOD_GSK3_1	160	167	PF00069	0.537
MOD_GSK3_1	193	200	PF00069	0.676
MOD_N-GLC_1	50	55	PF02516	0.572
MOD_N-GLC_2	162	164	PF02516	0.470
MOD_NEK2_1	1	6	PF00069	0.710
MOD_NEK2_1	108	113	PF00069	0.591
MOD_NEK2_1	127	132	PF00069	0.303
MOD_NEK2_1	160	165	PF00069	0.645
MOD_PIKK_1	38	44	PF00454	0.492
MOD_PKA_2	173	179	PF00069	0.738
MOD_PKB_1	115	123	PF00069	0.627
MOD_Plk_1	122	128	PF00069	0.488
MOD_Plk_1	182	188	PF00069	0.735
MOD_Plk_2-3	90	96	PF00069	0.591
MOD_SUMO_rev_2	7	16	PF00179	0.592
TRG_ER_diArg_1	112	115	PF00400	0.547
TRG_ER_diArg_1	135	137	PF00400	0.484
TRG_ER_diArg_1	99	102	PF00400	0.556
TRG_NLS_MonoExtC_3	112	117	PF00514	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E0	Leptomonas seymouri	62%	100%
A0A0S4JM83	Bodo saltans	35%	100%
A0A1X0P8N4	Trypanosomatidae	47%	100%
A0A3Q8IVQ2	Leishmania donovani	99%	70%
A0A422P2F0	Trypanosoma rangeli	45%	100%
A4HNN6	Leishmania braziliensis	79%	100%
D0A2I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ASE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q250	Leishmania major	95%	100%
V5DRU1	Trypanosoma cruzi	46%	100%