LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICV8_LEIIN
TriTrypDb:
LINF_360008100
Length:
316

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Isochorismatase family, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4ICV8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICV8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.632
CLV_NRD_NRD_1 138 140 PF00675 0.641
CLV_NRD_NRD_1 205 207 PF00675 0.708
CLV_NRD_NRD_1 3 5 PF00675 0.461
CLV_NRD_NRD_1 94 96 PF00675 0.716
CLV_PCSK_KEX2_1 102 104 PF00082 0.632
CLV_PCSK_KEX2_1 138 140 PF00082 0.641
CLV_PCSK_KEX2_1 2 4 PF00082 0.473
CLV_PCSK_KEX2_1 204 206 PF00082 0.706
CLV_PCSK_KEX2_1 94 96 PF00082 0.716
CLV_PCSK_PC7_1 98 104 PF00082 0.710
CLV_PCSK_SKI1_1 236 240 PF00082 0.699
DEG_MDM2_SWIB_1 300 308 PF02201 0.391
DEG_Nend_UBRbox_1 1 4 PF02207 0.708
DOC_CYCLIN_yCln2_LP_2 251 254 PF00134 0.567
DOC_MAPK_gen_1 102 111 PF00069 0.492
DOC_MAPK_MEF2A_6 166 173 PF00069 0.412
DOC_PP2B_LxvP_1 251 254 PF13499 0.567
DOC_PP4_FxxP_1 35 38 PF00568 0.571
DOC_USP7_MATH_1 142 146 PF00917 0.537
DOC_USP7_MATH_1 194 198 PF00917 0.507
DOC_USP7_MATH_1 306 310 PF00917 0.550
DOC_WW_Pin1_4 214 219 PF00397 0.536
DOC_WW_Pin1_4 34 39 PF00397 0.484
LIG_14-3-3_CanoR_1 102 108 PF00244 0.445
LIG_14-3-3_CanoR_1 206 216 PF00244 0.495
LIG_AP2alpha_2 242 244 PF02296 0.442
LIG_APCC_ABBA_1 216 221 PF00400 0.576
LIG_EH1_1 11 19 PF00400 0.440
LIG_eIF4E_1 13 19 PF01652 0.514
LIG_FHA_1 208 214 PF00498 0.502
LIG_FHA_1 254 260 PF00498 0.503
LIG_FHA_1 294 300 PF00498 0.432
LIG_FHA_2 158 164 PF00498 0.497
LIG_GBD_Chelix_1 18 26 PF00786 0.382
LIG_LIR_Apic_2 135 140 PF02991 0.518
LIG_LIR_Gen_1 273 280 PF02991 0.513
LIG_LIR_Nem_3 241 247 PF02991 0.530
LIG_LIR_Nem_3 273 277 PF02991 0.466
LIG_LIR_Nem_3 309 313 PF02991 0.714
LIG_LIR_Nem_3 31 35 PF02991 0.466
LIG_MYND_1 249 253 PF01753 0.567
LIG_NRBOX 17 23 PF00104 0.498
LIG_Pex14_1 240 244 PF04695 0.449
LIG_Pex14_1 311 315 PF04695 0.641
LIG_Pex14_2 300 304 PF04695 0.412
LIG_PTB_Apo_2 258 265 PF02174 0.437
LIG_PTB_Phospho_1 258 264 PF10480 0.438
LIG_RPA_C_Fungi 193 205 PF08784 0.525
LIG_SH2_CRK 274 278 PF00017 0.671
LIG_SH2_NCK_1 127 131 PF00017 0.614
LIG_SH2_SRC 113 116 PF00017 0.637
LIG_SH2_STAP1 155 159 PF00017 0.495
LIG_SH2_STAT5 174 177 PF00017 0.448
LIG_SH2_STAT5 264 267 PF00017 0.566
LIG_SH2_STAT5 274 277 PF00017 0.576
LIG_SH3_3 240 246 PF00018 0.537
LIG_SH3_3 256 262 PF00018 0.457
LIG_TRAF2_1 145 148 PF00917 0.656
LIG_TYR_ITIM 272 277 PF00017 0.676
LIG_TYR_ITIM 308 313 PF00017 0.559
LIG_WW_3 252 256 PF00397 0.604
MOD_CDK_SPxK_1 214 220 PF00069 0.670
MOD_CK1_1 157 163 PF00069 0.499
MOD_CK1_1 62 68 PF00069 0.582
MOD_CK2_1 142 148 PF00069 0.693
MOD_CK2_1 157 163 PF00069 0.449
MOD_CK2_1 194 200 PF00069 0.527
MOD_CK2_1 34 40 PF00069 0.594
MOD_GlcNHglycan 7 10 PF01048 0.613
MOD_GSK3_1 155 162 PF00069 0.546
MOD_GSK3_1 219 226 PF00069 0.734
MOD_GSK3_1 24 31 PF00069 0.381
MOD_N-GLC_1 142 147 PF02516 0.500
MOD_NEK2_1 24 29 PF00069 0.400
MOD_NEK2_1 272 277 PF00069 0.553
MOD_NEK2_1 280 285 PF00069 0.579
MOD_NEK2_1 300 305 PF00069 0.263
MOD_NEK2_1 59 64 PF00069 0.539
MOD_NEK2_2 231 236 PF00069 0.622
MOD_PIKK_1 207 213 PF00454 0.597
MOD_PKA_2 219 225 PF00069 0.628
MOD_PKB_1 190 198 PF00069 0.560
MOD_Plk_2-3 87 93 PF00069 0.683
MOD_Plk_4 272 278 PF00069 0.670
MOD_Plk_4 282 288 PF00069 0.386
MOD_Plk_4 306 312 PF00069 0.629
MOD_Plk_4 59 65 PF00069 0.530
MOD_ProDKin_1 214 220 PF00069 0.670
MOD_ProDKin_1 34 40 PF00069 0.595
TRG_DiLeu_BaEn_3 91 97 PF01217 0.664
TRG_ENDOCYTIC_2 274 277 PF00928 0.576
TRG_ENDOCYTIC_2 310 313 PF00928 0.646
TRG_ER_diArg_1 1 4 PF00400 0.642
TRG_ER_diArg_1 102 104 PF00400 0.531
TRG_ER_diArg_1 137 139 PF00400 0.496
TRG_ER_diArg_1 181 184 PF00400 0.534
TRG_ER_diArg_1 203 206 PF00400 0.660
TRG_ER_diArg_1 94 96 PF00400 0.650
TRG_Pf-PMV_PEXEL_1 184 189 PF00026 0.587
TRG_Pf-PMV_PEXEL_1 245 250 PF00026 0.472

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Z7 Leptomonas seymouri 46% 99%
A0A3S7XAG8 Leishmania donovani 99% 100%
A4HNN7 Leishmania braziliensis 76% 100%
E9ASE6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q249 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS