Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICV2_LEIIN

TriTrypDb:

LINF_360008700

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.604
CLV_NRD_NRD_1	248	250	PF00675	0.541
CLV_NRD_NRD_1	251	253	PF00675	0.507
CLV_NRD_NRD_1	290	292	PF00675	0.473
CLV_NRD_NRD_1	304	306	PF00675	0.340
CLV_NRD_NRD_1	308	310	PF00675	0.314
CLV_NRD_NRD_1	360	362	PF00675	0.552
CLV_NRD_NRD_1	411	413	PF00675	0.470
CLV_NRD_NRD_1	429	431	PF00675	0.407
CLV_NRD_NRD_1	47	49	PF00675	0.623
CLV_NRD_NRD_1	486	488	PF00675	0.463
CLV_PCSK_FUR_1	249	253	PF00082	0.502
CLV_PCSK_FUR_1	427	431	PF00082	0.553
CLV_PCSK_FUR_1	45	49	PF00082	0.623
CLV_PCSK_KEX2_1	248	250	PF00082	0.662
CLV_PCSK_KEX2_1	251	253	PF00082	0.649
CLV_PCSK_KEX2_1	290	292	PF00082	0.469
CLV_PCSK_KEX2_1	308	310	PF00082	0.319
CLV_PCSK_KEX2_1	360	362	PF00082	0.552
CLV_PCSK_KEX2_1	411	413	PF00082	0.470
CLV_PCSK_KEX2_1	429	431	PF00082	0.407
CLV_PCSK_KEX2_1	47	49	PF00082	0.623
CLV_PCSK_SKI1_1	170	174	PF00082	0.591
CLV_PCSK_SKI1_1	192	196	PF00082	0.532
CLV_PCSK_SKI1_1	214	218	PF00082	0.600
CLV_PCSK_SKI1_1	239	243	PF00082	0.539
CLV_PCSK_SKI1_1	342	346	PF00082	0.515
CLV_PCSK_SKI1_1	59	63	PF00082	0.661
DEG_Nend_UBRbox_3	1	3	PF02207	0.688
DEG_SCF_FBW7_1	442	447	PF00400	0.501
DEG_SCF_FBW7_2	199	205	PF00400	0.465
DOC_CKS1_1	199	204	PF01111	0.495
DOC_CYCLIN_RxL_1	167	178	PF00134	0.609
DOC_MAPK_gen_1	293	302	PF00069	0.423
DOC_PP1_RVXF_1	212	218	PF00149	0.492
DOC_PP1_RVXF_1	242	248	PF00149	0.499
DOC_PP2B_LxvP_1	216	219	PF13499	0.487
DOC_PP2B_LxvP_1	264	267	PF13499	0.537
DOC_PP2B_LxvP_1	51	54	PF13499	0.653
DOC_PP4_FxxP_1	62	65	PF00568	0.659
DOC_USP7_MATH_1	110	114	PF00917	0.637
DOC_USP7_MATH_1	368	372	PF00917	0.605
DOC_USP7_MATH_1	376	380	PF00917	0.508
DOC_USP7_MATH_1	82	86	PF00917	0.555
DOC_WW_Pin1_4	154	159	PF00397	0.785
DOC_WW_Pin1_4	195	200	PF00397	0.589
DOC_WW_Pin1_4	332	337	PF00397	0.538
DOC_WW_Pin1_4	440	445	PF00397	0.497
LIG_14-3-3_CanoR_1	104	109	PF00244	0.548
LIG_14-3-3_CanoR_1	255	263	PF00244	0.534
LIG_14-3-3_CanoR_1	411	419	PF00244	0.483
LIG_14-3-3_CanoR_1	47	52	PF00244	0.628
LIG_14-3-3_CanoR_1	5	13	PF00244	0.655
LIG_14-3-3_CanoR_1	88	93	PF00244	0.578
LIG_Actin_WH2_2	256	274	PF00022	0.489
LIG_Actin_WH2_2	395	413	PF00022	0.387
LIG_BRCT_BRCA1_1	403	407	PF00533	0.442
LIG_CaM_IQ_9	282	297	PF13499	0.484
LIG_Clathr_ClatBox_1	397	401	PF01394	0.440
LIG_eIF4E_1	210	216	PF01652	0.500
LIG_FHA_1	176	182	PF00498	0.518
LIG_FHA_1	232	238	PF00498	0.505
LIG_FHA_1	360	366	PF00498	0.601
LIG_FHA_1	401	407	PF00498	0.435
LIG_FHA_1	445	451	PF00498	0.532
LIG_FHA_1	474	480	PF00498	0.373
LIG_FHA_2	129	135	PF00498	0.627
LIG_FHA_2	319	325	PF00498	0.410
LIG_FHA_2	93	99	PF00498	0.526
LIG_LIR_Gen_1	257	267	PF02991	0.503
LIG_LIR_Gen_1	313	320	PF02991	0.462
LIG_LIR_Gen_1	386	394	PF02991	0.404
LIG_LIR_Gen_1	404	415	PF02991	0.408
LIG_LIR_Gen_1	466	473	PF02991	0.437
LIG_LIR_Nem_3	257	263	PF02991	0.508
LIG_LIR_Nem_3	301	307	PF02991	0.445
LIG_LIR_Nem_3	313	319	PF02991	0.351
LIG_LIR_Nem_3	386	390	PF02991	0.420
LIG_LIR_Nem_3	404	410	PF02991	0.387
LIG_LIR_Nem_3	466	472	PF02991	0.442
LIG_MAD2	115	123	PF02301	0.584
LIG_Pex14_2	217	221	PF04695	0.559
LIG_PTB_Apo_2	472	479	PF02174	0.418
LIG_PTB_Phospho_1	472	478	PF10480	0.413
LIG_SH2_CRK	210	214	PF00017	0.499
LIG_SH2_CRK	304	308	PF00017	0.438
LIG_SH2_CRK	469	473	PF00017	0.372
LIG_SH2_NCK_1	373	377	PF00017	0.478
LIG_SH2_STAP1	373	377	PF00017	0.583
LIG_SH2_STAP1	385	389	PF00017	0.406
LIG_SH2_STAP1	469	473	PF00017	0.372
LIG_SH2_STAT5	478	481	PF00017	0.406
LIG_SH2_STAT5	60	63	PF00017	0.615
LIG_SH3_1	162	168	PF00018	0.620
LIG_SH3_2	165	170	PF14604	0.632
LIG_SH3_3	15	21	PF00018	0.643
LIG_SH3_3	155	161	PF00018	0.660
LIG_SH3_3	162	168	PF00018	0.656
LIG_SH3_3	196	202	PF00018	0.550
LIG_SH3_3	330	336	PF00018	0.511
LIG_SH3_3	65	71	PF00018	0.669
LIG_TYR_ITIM	302	307	PF00017	0.442
LIG_UBA3_1	216	222	PF00899	0.487
LIG_UBA3_1	263	270	PF00899	0.415
LIG_WRC_WIRS_1	384	389	PF05994	0.377
MOD_CDK_SPK_2	154	159	PF00069	0.643
MOD_CDK_SPK_2	198	203	PF00069	0.558
MOD_CDK_SPxxK_3	332	339	PF00069	0.536
MOD_CK1_1	149	155	PF00069	0.732
MOD_CK1_1	188	194	PF00069	0.624
MOD_CK1_1	198	204	PF00069	0.478
MOD_CK1_1	96	102	PF00069	0.616
MOD_CK2_1	318	324	PF00069	0.408
MOD_CK2_1	363	369	PF00069	0.505
MOD_CK2_1	432	438	PF00069	0.508
MOD_DYRK1A_RPxSP_1	332	336	PF00069	0.541
MOD_GlcNHglycan	108	111	PF01048	0.629
MOD_GlcNHglycan	112	115	PF01048	0.596
MOD_GlcNHglycan	187	190	PF01048	0.611
MOD_GlcNHglycan	192	195	PF01048	0.581
MOD_GlcNHglycan	23	26	PF01048	0.535
MOD_GlcNHglycan	366	369	PF01048	0.580
MOD_GlcNHglycan	403	406	PF01048	0.431
MOD_GlcNHglycan	412	415	PF01048	0.406
MOD_GlcNHglycan	7	10	PF01048	0.636
MOD_GSK3_1	106	113	PF00069	0.524
MOD_GSK3_1	147	154	PF00069	0.622
MOD_GSK3_1	188	195	PF00069	0.637
MOD_GSK3_1	250	257	PF00069	0.496
MOD_GSK3_1	3	10	PF00069	0.636
MOD_GSK3_1	359	366	PF00069	0.593
MOD_GSK3_1	440	447	PF00069	0.495
MOD_GSK3_1	473	480	PF00069	0.421
MOD_GSK3_1	60	67	PF00069	0.656
MOD_GSK3_1	80	87	PF00069	0.436
MOD_GSK3_1	88	95	PF00069	0.561
MOD_LATS_1	86	92	PF00433	0.545
MOD_N-GLC_1	473	478	PF02516	0.414
MOD_N-GLC_2	475	477	PF02516	0.411
MOD_NEK2_1	148	153	PF00069	0.751
MOD_NEK2_1	185	190	PF00069	0.645
MOD_NEK2_1	400	405	PF00069	0.438
MOD_NEK2_1	410	415	PF00069	0.395
MOD_NEK2_1	423	428	PF00069	0.430
MOD_NEK2_1	449	454	PF00069	0.552
MOD_NEK2_1	473	478	PF00069	0.414
MOD_PIKK_1	135	141	PF00454	0.578
MOD_PIKK_1	318	324	PF00454	0.435
MOD_PK_1	354	360	PF00069	0.526
MOD_PKA_1	47	53	PF00069	0.615
MOD_PKA_2	231	237	PF00069	0.405
MOD_PKA_2	250	256	PF00069	0.476
MOD_PKA_2	359	365	PF00069	0.577
MOD_PKA_2	410	416	PF00069	0.473
MOD_PKA_2	47	53	PF00069	0.615
MOD_PKB_1	104	112	PF00069	0.547
MOD_PKB_1	352	360	PF00069	0.518
MOD_PKB_1	45	53	PF00069	0.660
MOD_Plk_1	135	141	PF00069	0.622
MOD_Plk_1	368	374	PF00069	0.557
MOD_Plk_1	473	479	PF00069	0.420
MOD_Plk_1	96	102	PF00069	0.526
MOD_Plk_2-3	369	375	PF00069	0.512
MOD_Plk_4	256	262	PF00069	0.546
MOD_Plk_4	393	399	PF00069	0.445
MOD_Plk_4	432	438	PF00069	0.463
MOD_Plk_4	464	470	PF00069	0.434
MOD_Plk_4	478	484	PF00069	0.335
MOD_Plk_4	96	102	PF00069	0.667
MOD_ProDKin_1	154	160	PF00069	0.783
MOD_ProDKin_1	195	201	PF00069	0.587
MOD_ProDKin_1	332	338	PF00069	0.536
MOD_ProDKin_1	440	446	PF00069	0.499
MOD_SUMO_rev_2	182	188	PF00179	0.510
MOD_SUMO_rev_2	481	489	PF00179	0.450
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.497
TRG_ENDOCYTIC_2	210	213	PF00928	0.501
TRG_ENDOCYTIC_2	304	307	PF00928	0.441
TRG_ENDOCYTIC_2	469	472	PF00928	0.418
TRG_ER_diArg_1	247	249	PF00400	0.559
TRG_ER_diArg_1	289	291	PF00400	0.490
TRG_ER_diArg_1	293	296	PF00400	0.439
TRG_ER_diArg_1	307	309	PF00400	0.280
TRG_ER_diArg_1	352	355	PF00400	0.525
TRG_ER_diArg_1	410	412	PF00400	0.467
TRG_ER_diArg_1	427	430	PF00400	0.415
TRG_ER_diArg_1	45	48	PF00400	0.639
TRG_ER_diArg_1	450	453	PF00400	0.557
TRG_ER_diArg_1	493	496	PF00400	0.492
TRG_NLS_Bipartite_1	290	309	PF00514	0.438
TRG_NLS_MonoExtC_3	304	309	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJS5	Leishmania donovani	99%	100%
A4HNP3	Leishmania braziliensis	63%	100%
E9ASF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q243	Leishmania major	90%	100%