LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

ER membrane protein complex subunit 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ER membrane protein complex subunit 3
Gene product:
Integral membrane protein DUF106 - putative
Species:
Leishmania infantum
UniProt:
A4ICV1_LEIIN
TriTrypDb:
LINF_360008800
Length:
259

Annotations

LeishMANIAdb annotations

A very conserved component of the ER translocon. Localization: ER (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0032991 protein-containing complex 1 1
GO:0072546 EMC complex 3 1
GO:0098796 membrane protein complex 2 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Expansion

Sequence features

A4ICV1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICV1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 249 251 PF00082 0.626
CLV_PCSK_KEX2_1 257 259 PF00082 0.709
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.626
CLV_PCSK_PC1ET2_1 257 259 PF00082 0.709
CLV_PCSK_SKI1_1 214 218 PF00082 0.509
CLV_PCSK_SKI1_1 249 253 PF00082 0.597
CLV_PCSK_SKI1_1 60 64 PF00082 0.457
DOC_CYCLIN_RxL_1 57 64 PF00134 0.272
DOC_MAPK_DCC_7 14 24 PF00069 0.357
DOC_MAPK_FxFP_2 138 141 PF00069 0.552
DOC_MAPK_MEF2A_6 14 23 PF00069 0.382
DOC_MAPK_MEF2A_6 32 39 PF00069 0.241
DOC_PP2B_PxIxI_1 19 25 PF00149 0.335
DOC_PP4_FxxP_1 138 141 PF00568 0.552
DOC_USP7_MATH_1 203 207 PF00917 0.512
DOC_WW_Pin1_4 38 43 PF00397 0.246
DOC_WW_Pin1_4 67 72 PF00397 0.272
LIG_BRCT_BRCA1_1 126 130 PF00533 0.300
LIG_BRCT_BRCA1_1 142 146 PF00533 0.447
LIG_BRCT_BRCA1_1 167 171 PF00533 0.300
LIG_EH1_1 32 40 PF00400 0.408
LIG_LIR_Gen_1 15 24 PF02991 0.300
LIG_LIR_Gen_1 211 219 PF02991 0.347
LIG_LIR_Nem_3 127 133 PF02991 0.290
LIG_LIR_Nem_3 15 19 PF02991 0.300
LIG_LIR_Nem_3 168 173 PF02991 0.300
LIG_LIR_Nem_3 211 215 PF02991 0.314
LIG_MLH1_MIPbox_1 126 130 PF16413 0.300
LIG_MLH1_MIPbox_1 167 171 PF16413 0.300
LIG_NRBOX 179 185 PF00104 0.303
LIG_NRP_CendR_1 257 259 PF00754 0.733
LIG_PCNA_PIPBox_1 122 131 PF02747 0.300
LIG_Pex14_2 129 133 PF04695 0.300
LIG_Pex14_2 212 216 PF04695 0.371
LIG_PTB_Apo_2 157 164 PF02174 0.533
LIG_PTB_Phospho_1 157 163 PF10480 0.533
LIG_SH2_CRK 58 62 PF00017 0.259
LIG_SH2_GRB2like 234 237 PF00017 0.346
LIG_SH2_NCK_1 234 238 PF00017 0.358
LIG_SH2_PTP2 34 37 PF00017 0.408
LIG_SH2_SRC 234 237 PF00017 0.370
LIG_SH2_STAT5 128 131 PF00017 0.300
LIG_SH2_STAT5 163 166 PF00017 0.291
LIG_SH2_STAT5 170 173 PF00017 0.280
LIG_SH2_STAT5 34 37 PF00017 0.408
LIG_SH3_3 14 20 PF00018 0.300
LIG_SH3_3 39 45 PF00018 0.325
LIG_SH3_3 89 95 PF00018 0.336
LIG_SUMO_SIM_anti_2 155 160 PF11976 0.533
LIG_UBA3_1 105 110 PF00899 0.274
LIG_UBA3_1 81 88 PF00899 0.352
MOD_CDC14_SPxK_1 41 44 PF00782 0.325
MOD_CDK_SPxK_1 38 44 PF00069 0.325
MOD_CK1_1 70 76 PF00069 0.283
MOD_GlcNHglycan 130 133 PF01048 0.295
MOD_GlcNHglycan 174 177 PF01048 0.420
MOD_GlcNHglycan 194 197 PF01048 0.666
MOD_GlcNHglycan 205 208 PF01048 0.630
MOD_GlcNHglycan 63 66 PF01048 0.518
MOD_GSK3_1 124 131 PF00069 0.309
MOD_GSK3_1 188 195 PF00069 0.460
MOD_N-GLC_1 192 197 PF02516 0.637
MOD_NEK2_1 124 129 PF00069 0.332
MOD_NEK2_1 172 177 PF00069 0.307
MOD_PIKK_1 244 250 PF00454 0.449
MOD_Plk_1 192 198 PF00069 0.439
MOD_Plk_4 124 130 PF00069 0.320
MOD_Plk_4 165 171 PF00069 0.290
MOD_Plk_4 33 39 PF00069 0.336
MOD_ProDKin_1 38 44 PF00069 0.246
MOD_ProDKin_1 67 73 PF00069 0.272
MOD_SUMO_for_1 86 89 PF00179 0.348
TRG_DiLeu_BaEn_1 4 9 PF01217 0.533
TRG_DiLeu_BaLyEn_6 17 22 PF01217 0.300
TRG_ENDOCYTIC_2 170 173 PF00928 0.300
TRG_ENDOCYTIC_2 34 37 PF00928 0.300
TRG_ENDOCYTIC_2 58 61 PF00928 0.259
TRG_NLS_MonoExtN_4 246 253 PF00514 0.438
TRG_Pf-PMV_PEXEL_1 152 157 PF00026 0.325

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P702 Leptomonas seymouri 78% 100%
A0A0S4JI82 Bodo saltans 52% 100%
A0A1X0P9P9 Trypanosomatidae 62% 100%
A0A3S7XAB1 Leishmania donovani 100% 100%
A0A422P2C0 Trypanosoma rangeli 60% 100%
A4HNP4 Leishmania braziliensis 89% 100%
A7A082 Saccharomyces cerevisiae (strain YJM789) 30% 100%
B3LQQ2 Saccharomyces cerevisiae (strain RM11-1a) 28% 100%
B5VLV9 Saccharomyces cerevisiae (strain AWRI1631) 28% 100%
D0A2K0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ASF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
P36039 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q3ZCB8 Bos taurus 34% 99%
Q4Q242 Leishmania major 99% 100%
Q54YN3 Dictyostelium discoideum 29% 82%
Q5R7C1 Pongo abelii 34% 99%
Q5U2V8 Rattus norvegicus 34% 99%
Q7SXW4 Danio rerio 35% 99%
Q99KI3 Mus musculus 34% 99%
Q9P0I2 Homo sapiens 34% 99%
Q9P787 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
V5DRR4 Trypanosoma cruzi 60% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS