Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania infantum

UniProt:

A4ICV0_LEIIN

TriTrypDb:

LINF_360008900

Length:

455

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, Phosphatidylinositol-4-phosphate 5-kinase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICV0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016307	phosphatidylinositol phosphate kinase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.397
CLV_NRD_NRD_1	292	294	PF00675	0.384
CLV_PCSK_KEX2_1	294	296	PF00082	0.403
CLV_PCSK_KEX2_1	333	335	PF00082	0.386
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.406
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.386
CLV_PCSK_PC7_1	290	296	PF00082	0.374
CLV_PCSK_PC7_1	329	335	PF00082	0.238
CLV_PCSK_SKI1_1	12	16	PF00082	0.473
CLV_PCSK_SKI1_1	135	139	PF00082	0.412
CLV_PCSK_SKI1_1	150	154	PF00082	0.432
CLV_PCSK_SKI1_1	280	284	PF00082	0.300
CLV_PCSK_SKI1_1	358	362	PF00082	0.355
CLV_PCSK_SKI1_1	416	420	PF00082	0.309
CLV_PCSK_SKI1_1	56	60	PF00082	0.561
CLV_PCSK_SKI1_1	79	83	PF00082	0.535
CLV_PCSK_SKI1_1	97	101	PF00082	0.326
CLV_Separin_Metazoa	299	303	PF03568	0.335
DEG_APCC_DBOX_1	149	157	PF00400	0.315
DEG_SPOP_SBC_1	342	346	PF00917	0.358
DEG_SPOP_SBC_1	350	354	PF00917	0.288
DOC_MAPK_gen_1	154	163	PF00069	0.277
DOC_MAPK_gen_1	77	85	PF00069	0.576
DOC_MAPK_HePTP_8	170	182	PF00069	0.339
DOC_MAPK_MEF2A_6	173	182	PF00069	0.305
DOC_MAPK_MEF2A_6	77	85	PF00069	0.587
DOC_MAPK_NFAT4_5	173	181	PF00069	0.309
DOC_PP1_RVXF_1	282	288	PF00149	0.283
DOC_PP1_RVXF_1	414	421	PF00149	0.374
DOC_PP2B_LxvP_1	69	72	PF13499	0.537
DOC_PP4_FxxP_1	286	289	PF00568	0.425
DOC_USP7_MATH_1	165	169	PF00917	0.413
DOC_USP7_MATH_1	343	347	PF00917	0.321
DOC_USP7_MATH_1	43	47	PF00917	0.509
DOC_USP7_MATH_1	52	56	PF00917	0.509
DOC_USP7_UBL2_3	205	209	PF12436	0.320
LIG_14-3-3_CanoR_1	12	19	PF00244	0.585
LIG_14-3-3_CanoR_1	157	162	PF00244	0.375
LIG_14-3-3_CanoR_1	24	31	PF00244	0.490
LIG_14-3-3_CanoR_1	358	363	PF00244	0.442
LIG_14-3-3_CanoR_1	372	381	PF00244	0.316
LIG_14-3-3_CanoR_1	436	441	PF00244	0.424
LIG_14-3-3_CanoR_1	84	92	PF00244	0.506
LIG_Actin_WH2_1	293	310	PF00022	0.374
LIG_Actin_WH2_2	10	26	PF00022	0.528
LIG_Actin_WH2_2	294	310	PF00022	0.374
LIG_AP2alpha_1	192	196	PF02296	0.293
LIG_BRCT_BRCA1_1	126	130	PF00533	0.428
LIG_DLG_GKlike_1	436	443	PF00625	0.425
LIG_FHA_1	141	147	PF00498	0.430
LIG_FHA_1	158	164	PF00498	0.225
LIG_FHA_1	402	408	PF00498	0.442
LIG_FHA_1	439	445	PF00498	0.320
LIG_FHA_2	274	280	PF00498	0.305
LIG_FHA_2	351	357	PF00498	0.374
LIG_FHA_2	375	381	PF00498	0.425
LIG_LIR_Apic_2	109	114	PF02991	0.404
LIG_LIR_Apic_2	283	289	PF02991	0.425
LIG_LIR_Gen_1	303	312	PF02991	0.324
LIG_LIR_Gen_1	314	323	PF02991	0.277
LIG_LIR_Gen_1	438	448	PF02991	0.429
LIG_LIR_Gen_1	91	99	PF02991	0.455
LIG_LIR_Nem_3	303	307	PF02991	0.323
LIG_LIR_Nem_3	314	318	PF02991	0.292
LIG_LIR_Nem_3	376	381	PF02991	0.336
LIG_LIR_Nem_3	392	398	PF02991	0.285
LIG_LIR_Nem_3	438	443	PF02991	0.362
LIG_LIR_Nem_3	91	96	PF02991	0.308
LIG_LYPXL_yS_3	221	224	PF13949	0.335
LIG_Pex14_2	107	111	PF04695	0.375
LIG_Pex14_2	192	196	PF04695	0.307
LIG_REV1ctd_RIR_1	128	137	PF16727	0.315
LIG_REV1ctd_RIR_1	412	420	PF16727	0.362
LIG_SH2_CRK	175	179	PF00017	0.425
LIG_SH2_CRK	304	308	PF00017	0.343
LIG_SH2_CRK	315	319	PF00017	0.253
LIG_SH2_PTP2	395	398	PF00017	0.305
LIG_SH2_STAP1	159	163	PF00017	0.281
LIG_SH2_STAP1	315	319	PF00017	0.313
LIG_SH2_STAP1	433	437	PF00017	0.363
LIG_SH2_STAT5	159	162	PF00017	0.335
LIG_SH2_STAT5	188	191	PF00017	0.332
LIG_SH2_STAT5	395	398	PF00017	0.305
LIG_SH2_STAT5	405	408	PF00017	0.305
LIG_SH3_3	99	105	PF00018	0.420
LIG_SUMO_SIM_par_1	142	148	PF11976	0.413
LIG_SUMO_SIM_par_1	397	404	PF11976	0.425
LIG_TRAF2_1	145	148	PF00917	0.390
LIG_TYR_ITIM	219	224	PF00017	0.335
LIG_TYR_ITIM	393	398	PF00017	0.290
LIG_UBA3_1	137	142	PF00899	0.406
LIG_WRC_WIRS_1	385	390	PF05994	0.374
LIG_WRC_WIRS_1	437	442	PF05994	0.425
LIG_WRC_WIRS_1	92	97	PF05994	0.458
MOD_CK2_1	109	115	PF00069	0.473
MOD_CK2_1	142	148	PF00069	0.346
MOD_CK2_1	224	230	PF00069	0.418
MOD_CK2_1	350	356	PF00069	0.440
MOD_CK2_1	374	380	PF00069	0.446
MOD_CK2_1	436	442	PF00069	0.399
MOD_CK2_1	47	53	PF00069	0.608
MOD_GlcNHglycan	226	229	PF01048	0.374
MOD_GlcNHglycan	260	263	PF01048	0.402
MOD_GlcNHglycan	345	348	PF01048	0.406
MOD_GlcNHglycan	353	356	PF01048	0.423
MOD_GlcNHglycan	61	66	PF01048	0.459
MOD_GlcNHglycan	9	12	PF01048	0.490
MOD_GSK3_1	157	164	PF00069	0.328
MOD_GSK3_1	337	344	PF00069	0.364
MOD_GSK3_1	370	377	PF00069	0.435
MOD_GSK3_1	43	50	PF00069	0.615
MOD_GSK3_1	67	74	PF00069	0.561
MOD_LATS_1	278	284	PF00433	0.425
MOD_NEK2_1	131	136	PF00069	0.305
MOD_NEK2_1	140	145	PF00069	0.305
MOD_NEK2_1	161	166	PF00069	0.414
MOD_NEK2_1	178	183	PF00069	0.359
MOD_NEK2_1	224	229	PF00069	0.374
MOD_NEK2_1	23	28	PF00069	0.447
MOD_NEK2_1	313	318	PF00069	0.316
MOD_NEK2_1	414	419	PF00069	0.346
MOD_NEK2_1	44	49	PF00069	0.626
MOD_NMyristoyl	1	7	PF02799	0.612
MOD_PIKK_1	124	130	PF00454	0.425
MOD_PIKK_1	250	256	PF00454	0.389
MOD_PIKK_1	38	44	PF00454	0.674
MOD_PK_1	142	148	PF00069	0.413
MOD_PKA_2	23	29	PF00069	0.512
MOD_PKA_2	258	264	PF00069	0.452
MOD_PKA_2	265	271	PF00069	0.260
MOD_PKA_2	371	377	PF00069	0.362
MOD_PKA_2	435	441	PF00069	0.338
MOD_PKA_2	83	89	PF00069	0.364
MOD_Plk_1	109	115	PF00069	0.457
MOD_Plk_1	280	286	PF00069	0.303
MOD_Plk_1	313	319	PF00069	0.305
MOD_Plk_1	61	67	PF00069	0.480
MOD_Plk_2-3	109	115	PF00069	0.467
MOD_Plk_4	133	139	PF00069	0.405
MOD_Plk_4	166	172	PF00069	0.305
MOD_Plk_4	197	203	PF00069	0.420
MOD_Plk_4	313	319	PF00069	0.305
MOD_Plk_4	414	420	PF00069	0.320
MOD_SUMO_for_1	118	121	PF00179	0.372
MOD_SUMO_for_1	448	451	PF00179	0.518
MOD_SUMO_for_1	58	61	PF00179	0.499
TRG_DiLeu_BaEn_1	148	153	PF01217	0.305
TRG_DiLeu_BaEn_2	90	96	PF01217	0.405
TRG_DiLeu_BaEn_4	185	191	PF01217	0.335
TRG_ENDOCYTIC_2	175	178	PF00928	0.390
TRG_ENDOCYTIC_2	221	224	PF00928	0.295
TRG_ENDOCYTIC_2	304	307	PF00928	0.329
TRG_ENDOCYTIC_2	315	318	PF00928	0.275
TRG_ENDOCYTIC_2	395	398	PF00928	0.305
TRG_ER_diArg_1	293	296	PF00400	0.409
TRG_NLS_MonoExtC_3	292	298	PF00514	0.452
TRG_NLS_MonoExtN_4	290	297	PF00514	0.374
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	23%	83%
A0A0N1PE70	Leptomonas seymouri	56%	100%
A0A0S4IZA7	Bodo saltans	25%	99%
A0A0S4JRR3	Bodo saltans	39%	98%
A0A1X0P9B0	Trypanosomatidae	48%	100%
A0A1X0PB79	Trypanosomatidae	22%	95%
A0A3R7KQW9	Trypanosoma rangeli	45%	100%
A0A3S7XA92	Leishmania donovani	100%	100%
A0A422N247	Trypanosoma rangeli	22%	95%
A4HNP5	Leishmania braziliensis	68%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
D0A2K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D3ZSI8	Rattus norvegicus	25%	83%
E9ASF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O13010	Sus scrofa	24%	100%
O60331	Homo sapiens	24%	68%
O70161	Mus musculus	26%	69%
O70172	Mus musculus	24%	100%
O88377	Rattus norvegicus	24%	100%
P48426	Homo sapiens	24%	100%
P70182	Mus musculus	24%	83%
P78356	Homo sapiens	24%	100%
Q0P5F7	Bos taurus	25%	100%
Q4Q241	Leishmania major	91%	100%
Q5F356	Gallus gallus	24%	100%
Q5I6B8	Rattus norvegicus	25%	66%
Q5PQ01	Xenopus laevis	26%	100%
Q5R488	Pongo abelii	26%	100%
Q6GL14	Xenopus tropicalis	26%	100%
Q6IQE1	Danio rerio	25%	100%
Q80XI4	Mus musculus	24%	100%
Q8TBX8	Homo sapiens	26%	100%
Q91XU3	Mus musculus	26%	100%
Q99755	Homo sapiens	25%	81%
Q9R0I8	Rattus norvegicus	24%	100%
V5BA13	Trypanosoma cruzi	46%	100%
V5BV28	Trypanosoma cruzi	22%	96%