LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICU7_LEIIN
TriTrypDb:
LINF_360009300
Length:
446

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICU7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 43 45 PF00675 0.602
CLV_NRD_NRD_1 7 9 PF00675 0.494
CLV_NRD_NRD_1 88 90 PF00675 0.606
CLV_PCSK_KEX2_1 7 9 PF00082 0.625
CLV_PCSK_KEX2_1 88 90 PF00082 0.627
CLV_PCSK_SKI1_1 339 343 PF00082 0.591
CLV_PCSK_SKI1_1 439 443 PF00082 0.495
DEG_SPOP_SBC_1 325 329 PF00917 0.630
DEG_SPOP_SBC_1 63 67 PF00917 0.792
DOC_CKS1_1 408 413 PF01111 0.547
DOC_MIT_MIM_1 261 270 PF04212 0.603
DOC_PP2B_LxvP_1 335 338 PF13499 0.584
DOC_SPAK_OSR1_1 8 12 PF12202 0.619
DOC_USP7_MATH_1 118 122 PF00917 0.478
DOC_USP7_MATH_1 187 191 PF00917 0.519
DOC_USP7_MATH_1 255 259 PF00917 0.602
DOC_USP7_MATH_1 330 334 PF00917 0.795
DOC_USP7_MATH_1 63 67 PF00917 0.721
DOC_USP7_MATH_2 292 298 PF00917 0.569
DOC_WW_Pin1_4 280 285 PF00397 0.702
DOC_WW_Pin1_4 321 326 PF00397 0.753
DOC_WW_Pin1_4 347 352 PF00397 0.795
DOC_WW_Pin1_4 407 412 PF00397 0.503
LIG_14-3-3_CanoR_1 108 116 PF00244 0.575
LIG_14-3-3_CanoR_1 120 126 PF00244 0.526
LIG_14-3-3_CanoR_1 316 325 PF00244 0.741
LIG_14-3-3_CanoR_1 339 347 PF00244 0.711
LIG_14-3-3_CanoR_1 366 372 PF00244 0.504
LIG_14-3-3_CanoR_1 439 446 PF00244 0.521
LIG_14-3-3_CanoR_1 88 94 PF00244 0.632
LIG_Actin_WH2_2 233 250 PF00022 0.569
LIG_AP2alpha_2 432 434 PF02296 0.597
LIG_EVH1_1 354 358 PF00568 0.604
LIG_FHA_1 111 117 PF00498 0.590
LIG_FHA_1 124 130 PF00498 0.535
LIG_FHA_1 213 219 PF00498 0.532
LIG_FHA_1 326 332 PF00498 0.754
LIG_FHA_1 56 62 PF00498 0.574
LIG_FHA_2 122 128 PF00498 0.523
LIG_FHA_2 168 174 PF00498 0.539
LIG_FHA_2 254 260 PF00498 0.623
LIG_FHA_2 360 366 PF00498 0.622
LIG_FHA_2 427 433 PF00498 0.575
LIG_Integrin_isoDGR_2 435 437 PF01839 0.625
LIG_LIR_Gen_1 211 221 PF02991 0.489
LIG_LIR_Gen_1 232 242 PF02991 0.609
LIG_LIR_Nem_3 211 217 PF02991 0.454
LIG_LIR_Nem_3 232 237 PF02991 0.645
LIG_LIR_Nem_3 429 434 PF02991 0.583
LIG_PTB_Apo_2 3 10 PF02174 0.550
LIG_Rb_LxCxE_1 245 264 PF01857 0.595
LIG_RPA_C_Fungi 388 400 PF08784 0.553
LIG_SH2_STAP1 125 129 PF00017 0.469
LIG_SH2_STAP1 214 218 PF00017 0.556
LIG_SH2_STAT5 125 128 PF00017 0.534
LIG_SH2_STAT5 21 24 PF00017 0.444
LIG_SH2_STAT5 214 217 PF00017 0.518
LIG_SH3_3 297 303 PF00018 0.693
LIG_SH3_3 349 355 PF00018 0.691
LIG_SH3_3 405 411 PF00018 0.559
LIG_SH3_3 94 100 PF00018 0.597
LIG_SH3_CIN85_PxpxPR_1 351 356 PF14604 0.565
LIG_SUMO_SIM_anti_2 172 180 PF11976 0.507
LIG_SUMO_SIM_anti_2 24 30 PF11976 0.467
LIG_SUMO_SIM_par_1 20 27 PF11976 0.470
LIG_TRAF2_1 170 173 PF00917 0.501
LIG_TRAF2_1 262 265 PF00917 0.641
LIG_TRAF2_1 307 310 PF00917 0.580
LIG_TRAF2_1 413 416 PF00917 0.551
LIG_TYR_ITIM 92 97 PF00017 0.652
MOD_CDK_SPK_2 321 326 PF00069 0.804
MOD_CK1_1 110 116 PF00069 0.570
MOD_CK1_1 121 127 PF00069 0.560
MOD_CK1_1 200 206 PF00069 0.610
MOD_CK1_1 212 218 PF00069 0.277
MOD_CK1_1 314 320 PF00069 0.752
MOD_CK1_1 345 351 PF00069 0.744
MOD_CK1_1 359 365 PF00069 0.370
MOD_CK1_1 70 76 PF00069 0.603
MOD_CK2_1 121 127 PF00069 0.557
MOD_CK2_1 167 173 PF00069 0.539
MOD_CK2_1 255 261 PF00069 0.682
MOD_CK2_1 304 310 PF00069 0.667
MOD_CK2_1 359 365 PF00069 0.705
MOD_DYRK1A_RPxSP_1 321 325 PF00069 0.731
MOD_GlcNHglycan 139 142 PF01048 0.551
MOD_GlcNHglycan 14 17 PF01048 0.496
MOD_GlcNHglycan 278 281 PF01048 0.539
MOD_GlcNHglycan 316 319 PF01048 0.742
MOD_GlcNHglycan 339 342 PF01048 0.804
MOD_GSK3_1 208 215 PF00069 0.557
MOD_GSK3_1 255 262 PF00069 0.593
MOD_GSK3_1 269 276 PF00069 0.553
MOD_GSK3_1 321 328 PF00069 0.782
MOD_GSK3_1 342 349 PF00069 0.816
MOD_GSK3_1 403 410 PF00069 0.622
MOD_GSK3_1 53 60 PF00069 0.760
MOD_GSK3_1 63 70 PF00069 0.688
MOD_N-GLC_1 314 319 PF02516 0.800
MOD_N-GLC_1 33 38 PF02516 0.477
MOD_NEK2_1 12 17 PF00069 0.487
MOD_NEK2_1 181 186 PF00069 0.543
MOD_NEK2_1 210 215 PF00069 0.553
MOD_NEK2_1 304 309 PF00069 0.682
MOD_NEK2_2 57 62 PF00069 0.651
MOD_OFUCOSY 13 18 PF10250 0.546
MOD_PIKK_1 148 154 PF00454 0.574
MOD_PIKK_1 200 206 PF00454 0.486
MOD_PIKK_1 304 310 PF00454 0.793
MOD_PIKK_1 319 325 PF00454 0.748
MOD_PIKK_1 356 362 PF00454 0.563
MOD_PIKK_1 87 93 PF00454 0.658
MOD_PKA_2 107 113 PF00069 0.555
MOD_PKA_2 345 351 PF00069 0.825
MOD_PKA_2 87 93 PF00069 0.638
MOD_PKB_1 437 445 PF00069 0.565
MOD_Plk_1 118 124 PF00069 0.485
MOD_Plk_2-3 259 265 PF00069 0.572
MOD_Plk_4 110 116 PF00069 0.570
MOD_Plk_4 162 168 PF00069 0.488
MOD_Plk_4 17 23 PF00069 0.466
MOD_Plk_4 24 30 PF00069 0.468
MOD_Plk_4 269 275 PF00069 0.593
MOD_ProDKin_1 280 286 PF00069 0.703
MOD_ProDKin_1 321 327 PF00069 0.752
MOD_ProDKin_1 347 353 PF00069 0.797
MOD_ProDKin_1 407 413 PF00069 0.500
MOD_SUMO_for_1 39 42 PF00179 0.521
MOD_SUMO_rev_2 127 132 PF00179 0.605
TRG_ENDOCYTIC_2 214 217 PF00928 0.613
TRG_ENDOCYTIC_2 234 237 PF00928 0.299
TRG_ENDOCYTIC_2 431 434 PF00928 0.597
TRG_ENDOCYTIC_2 94 97 PF00928 0.658
TRG_ER_diArg_1 437 440 PF00400 0.562
TRG_ER_diArg_1 7 9 PF00400 0.625
TRG_Pf-PMV_PEXEL_1 194 198 PF00026 0.552
TRG_Pf-PMV_PEXEL_1 361 365 PF00026 0.658
TRG_Pf-PMV_PEXEL_1 439 444 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0I6 Leptomonas seymouri 56% 94%
A0A1X0P8C3 Trypanosomatidae 30% 100%
A0A3S5H814 Leishmania donovani 100% 100%
A4HNP8 Leishmania braziliensis 76% 100%
E9ASF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q238 Leishmania major 91% 100%
V5DRR0 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS