Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICU6_LEIIN

TriTrypDb:

LINF_360009400

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.481
CLV_NRD_NRD_1	6	8	PF00675	0.557
CLV_NRD_NRD_1	99	101	PF00675	0.487
CLV_PCSK_KEX2_1	164	166	PF00082	0.527
CLV_PCSK_KEX2_1	99	101	PF00082	0.458
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.533
CLV_PCSK_SKI1_1	35	39	PF00082	0.522
CLV_PCSK_SKI1_1	62	66	PF00082	0.463
DEG_Nend_Nbox_1	1	3	PF02207	0.612
DOC_CDC14_PxL_1	78	86	PF14671	0.459
DOC_MAPK_gen_1	60	70	PF00069	0.514
DOC_MAPK_MEF2A_6	60	68	PF00069	0.533
DOC_MAPK_NFAT4_5	63	71	PF00069	0.359
DOC_PP1_RVXF_1	127	133	PF00149	0.479
DOC_PP2B_LxvP_1	166	169	PF13499	0.497
DOC_USP7_UBL2_3	36	40	PF12436	0.539
DOC_WW_Pin1_4	154	159	PF00397	0.487
LIG_14-3-3_CanoR_1	177	187	PF00244	0.499
LIG_14-3-3_CanoR_1	7	11	PF00244	0.549
LIG_14-3-3_CanoR_1	99	109	PF00244	0.493
LIG_DLG_GKlike_1	179	187	PF00625	0.508
LIG_FHA_2	18	24	PF00498	0.465
LIG_FHA_2	56	62	PF00498	0.456
LIG_FHA_2	7	13	PF00498	0.507
LIG_Integrin_isoDGR_2	92	94	PF01839	0.551
LIG_IRF3_LxIS_1	130	136	PF10401	0.370
LIG_LIR_Gen_1	111	121	PF02991	0.480
LIG_LIR_Gen_1	131	140	PF02991	0.182
LIG_LIR_Gen_1	157	166	PF02991	0.408
LIG_LIR_Nem_3	111	117	PF02991	0.486
LIG_LIR_Nem_3	131	135	PF02991	0.180
LIG_LIR_Nem_3	157	162	PF02991	0.384
LIG_LIR_Nem_3	46	52	PF02991	0.471
LIG_NRBOX	64	70	PF00104	0.568
LIG_PCNA_PIPBox_1	42	51	PF02747	0.537
LIG_PCNA_yPIPBox_3	35	49	PF02747	0.485
LIG_REV1ctd_RIR_1	49	58	PF16727	0.544
LIG_SH2_CRK	180	184	PF00017	0.484
LIG_SH2_STAP1	180	184	PF00017	0.467
LIG_SH2_STAT5	102	105	PF00017	0.427
LIG_SH2_STAT5	180	183	PF00017	0.515
LIG_SH3_3	67	73	PF00018	0.535
LIG_SH3_3	79	85	PF00018	0.318
LIG_SUMO_SIM_par_1	114	120	PF11976	0.428
LIG_UBA3_1	183	191	PF00899	0.529
MOD_CK1_1	167	173	PF00069	0.589
MOD_CK1_1	182	188	PF00069	0.502
MOD_CK2_1	17	23	PF00069	0.460
MOD_CK2_1	55	61	PF00069	0.470
MOD_CK2_1	6	12	PF00069	0.507
MOD_GlcNHglycan	110	114	PF01048	0.443
MOD_GlcNHglycan	134	138	PF01048	0.406
MOD_GlcNHglycan	169	172	PF01048	0.616
MOD_GlcNHglycan	184	187	PF01048	0.521
MOD_GSK3_1	178	185	PF00069	0.494
MOD_NEK2_1	109	114	PF00069	0.481
MOD_NEK2_1	117	122	PF00069	0.446
MOD_NEK2_1	133	138	PF00069	0.278
MOD_NEK2_1	68	73	PF00069	0.503
MOD_PIKK_1	38	44	PF00454	0.560
MOD_PK_1	164	170	PF00069	0.582
MOD_PKA_1	164	170	PF00069	0.519
MOD_PKA_1	35	41	PF00069	0.565
MOD_PKA_2	164	170	PF00069	0.606
MOD_PKA_2	178	184	PF00069	0.440
MOD_PKA_2	6	12	PF00069	0.521
MOD_PKA_2	93	99	PF00069	0.531
MOD_PKB_1	177	185	PF00069	0.532
MOD_Plk_1	109	115	PF00069	0.437
MOD_Plk_2-3	55	61	PF00069	0.552
MOD_Plk_2-3	6	12	PF00069	0.551
MOD_Plk_4	179	185	PF00069	0.467
MOD_ProDKin_1	154	160	PF00069	0.484
MOD_SUMO_rev_2	3	10	PF00179	0.599
MOD_SUMO_rev_2	55	65	PF00179	0.549
TRG_DiLeu_BaEn_1	61	66	PF01217	0.509
TRG_DiLeu_BaEn_4	26	32	PF01217	0.503
TRG_ENDOCYTIC_2	180	183	PF00928	0.476
TRG_ER_diArg_1	176	179	PF00400	0.544
TRG_ER_diArg_1	99	101	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I786	Leptomonas seymouri	84%	100%
A0A0S4JIF8	Bodo saltans	28%	96%
A0A1X0P8L2	Trypanosomatidae	45%	100%
A0A3S7XA94	Leishmania donovani	100%	100%
A0A422P2B0	Trypanosoma rangeli	40%	99%
A4HNP9	Leishmania braziliensis	85%	100%
D0A2K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
E9ASF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q237	Leishmania major	96%	100%
V5BA10	Trypanosoma cruzi	49%	100%