Transcription initiation factor IIE subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor IIa - putative

Species:

Leishmania infantum

UniProt:

A4ICU4_LEIIN

TriTrypDb:

LINF_360009600

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	1
GO:0005672	transcription factor TFIIA complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4ICU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICU4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006367	transcription initiation at RNA polymerase II promoter	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.693
CLV_NRD_NRD_1	279	281	PF00675	0.642
CLV_PCSK_FUR_1	277	281	PF00082	0.715
CLV_PCSK_KEX2_1	279	281	PF00082	0.634
DEG_APCC_DBOX_1	254	262	PF00400	0.573
DEG_SCF_FBW7_1	155	161	PF00400	0.623
DEG_SCF_FBW7_2	122	129	PF00400	0.582
DEG_SPOP_SBC_1	170	174	PF00917	0.649
DOC_CKS1_1	155	160	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.722
DOC_MAPK_gen_1	62	72	PF00069	0.663
DOC_PP2B_LxvP_1	178	181	PF13499	0.652
DOC_PP4_FxxP_1	56	59	PF00568	0.656
DOC_USP7_MATH_1	10	14	PF00917	0.705
DOC_USP7_MATH_1	148	152	PF00917	0.557
DOC_USP7_MATH_1	170	174	PF00917	0.649
DOC_WW_Pin1_4	122	127	PF00397	0.590
DOC_WW_Pin1_4	154	159	PF00397	0.530
DOC_WW_Pin1_4	206	211	PF00397	0.729
DOC_WW_Pin1_4	57	62	PF00397	0.625
DOC_WW_Pin1_4	89	94	PF00397	0.667
LIG_14-3-3_CanoR_1	69	73	PF00244	0.630
LIG_deltaCOP1_diTrp_1	129	136	PF00928	0.487
LIG_eIF4E_1	48	54	PF01652	0.624
LIG_FHA_1	227	233	PF00498	0.461
LIG_FHA_1	234	240	PF00498	0.467
LIG_FHA_1	39	45	PF00498	0.686
LIG_FHA_1	48	54	PF00498	0.551
LIG_FHA_2	172	178	PF00498	0.721
LIG_FHA_2	201	207	PF00498	0.714
LIG_LIR_Gen_1	225	235	PF02991	0.473
LIG_LIR_Gen_1	252	261	PF02991	0.492
LIG_LIR_Nem_3	130	136	PF02991	0.484
LIG_LIR_Nem_3	225	231	PF02991	0.476
LIG_LIR_Nem_3	252	256	PF02991	0.478
LIG_LIR_Nem_3	97	102	PF02991	0.572
LIG_MYND_1	122	126	PF01753	0.587
LIG_Pex14_2	33	37	PF04695	0.615
LIG_SH2_CRK	168	172	PF00017	0.720
LIG_SH2_NCK_1	168	172	PF00017	0.720
LIG_SH2_SRC	179	182	PF00017	0.723
LIG_SH2_STAT5	179	182	PF00017	0.723
LIG_SH2_STAT5	253	256	PF00017	0.469
LIG_SH2_STAT5	48	51	PF00017	0.630
LIG_SH2_STAT5	96	99	PF00017	0.661
LIG_SH3_2	90	95	PF14604	0.670
LIG_SH3_3	152	158	PF00018	0.521
LIG_SH3_3	194	200	PF00018	0.748
LIG_SH3_3	41	47	PF00018	0.684
LIG_SH3_3	87	93	PF00018	0.674
LIG_SUMO_SIM_par_1	225	234	PF11976	0.490
LIG_TRAF2_1	126	129	PF00917	0.581
LIG_TYR_ITIM	251	256	PF00017	0.473
MOD_CDC14_SPxK_1	92	95	PF00782	0.668
MOD_CDK_SPK_2	122	127	PF00069	0.590
MOD_CDK_SPK_2	57	62	PF00069	0.669
MOD_CDK_SPxK_1	89	95	PF00069	0.669
MOD_CK1_1	151	157	PF00069	0.592
MOD_CK1_1	173	179	PF00069	0.681
MOD_CK1_1	60	66	PF00069	0.631
MOD_CK1_1	91	97	PF00069	0.668
MOD_CK2_1	171	177	PF00069	0.719
MOD_CK2_1	206	212	PF00069	0.723
MOD_GlcNHglycan	182	185	PF01048	0.677
MOD_GlcNHglycan	74	77	PF01048	0.693
MOD_GSK3_1	10	17	PF00069	0.701
MOD_GSK3_1	154	161	PF00069	0.537
MOD_GSK3_1	169	176	PF00069	0.507
MOD_GSK3_1	68	75	PF00069	0.656
MOD_NEK2_1	211	216	PF00069	0.654
MOD_NEK2_1	49	54	PF00069	0.679
MOD_NEK2_1	68	73	PF00069	0.371
MOD_NEK2_1	77	82	PF00069	0.578
MOD_PIKK_1	265	271	PF00454	0.645
MOD_PKA_2	104	110	PF00069	0.444
MOD_PKA_2	68	74	PF00069	0.652
MOD_Plk_1	211	217	PF00069	0.648
MOD_Plk_1	226	232	PF00069	0.539
MOD_Plk_4	233	239	PF00069	0.538
MOD_Plk_4	49	55	PF00069	0.679
MOD_Plk_4	68	74	PF00069	0.374
MOD_Plk_4	77	83	PF00069	0.577
MOD_ProDKin_1	122	128	PF00069	0.587
MOD_ProDKin_1	154	160	PF00069	0.538
MOD_ProDKin_1	206	212	PF00069	0.723
MOD_ProDKin_1	57	63	PF00069	0.624
MOD_ProDKin_1	89	95	PF00069	0.669
TRG_DiLeu_BaEn_1	227	232	PF01217	0.530
TRG_ENDOCYTIC_2	168	171	PF00928	0.723
TRG_ENDOCYTIC_2	221	224	PF00928	0.564
TRG_ENDOCYTIC_2	253	256	PF00928	0.469
TRG_ER_diArg_1	254	257	PF00400	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9A1	Trypanosomatidae	34%	100%
A0A3S7XAA2	Leishmania donovani	100%	100%
Q4Q235	Leishmania major	89%	100%