Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICU3_LEIIN

TriTrypDb:

LINF_360009700

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICU3

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0000963	mitochondrial RNA processing	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010467	gene expression	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044528	regulation of mitochondrial mRNA stability	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140053	mitochondrial gene expression	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.296
CLV_C14_Caspase3-7	372	376	PF00656	0.466
CLV_NRD_NRD_1	214	216	PF00675	0.493
CLV_NRD_NRD_1	3	5	PF00675	0.565
CLV_NRD_NRD_1	41	43	PF00675	0.431
CLV_PCSK_KEX2_1	2	4	PF00082	0.574
CLV_PCSK_KEX2_1	41	43	PF00082	0.530
CLV_PCSK_SKI1_1	17	21	PF00082	0.443
CLV_PCSK_SKI1_1	458	462	PF00082	0.330
CLV_Separin_Metazoa	44	48	PF03568	0.506
DEG_APCC_DBOX_1	181	189	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.568
DOC_CDC14_PxL_1	131	139	PF14671	0.468
DOC_CYCLIN_yCln2_LP_2	257	263	PF00134	0.361
DOC_MAPK_gen_1	47	57	PF00069	0.397
DOC_MAPK_MEF2A_6	199	207	PF00069	0.389
DOC_MAPK_MEF2A_6	439	446	PF00069	0.521
DOC_PP1_RVXF_1	195	201	PF00149	0.382
DOC_PP2B_LxvP_1	257	260	PF13499	0.375
DOC_PP4_FxxP_1	200	203	PF00568	0.391
DOC_USP7_MATH_1	420	424	PF00917	0.446
DOC_USP7_MATH_1	440	444	PF00917	0.316
DOC_USP7_MATH_1	68	72	PF00917	0.425
DOC_WW_Pin1_4	218	223	PF00397	0.515
DOC_WW_Pin1_4	438	443	PF00397	0.464
DOC_WW_Pin1_4	63	68	PF00397	0.379
LIG_14-3-3_CanoR_1	113	121	PF00244	0.400
LIG_14-3-3_CanoR_1	17	25	PF00244	0.398
LIG_Actin_WH2_2	107	124	PF00022	0.472
LIG_Actin_WH2_2	202	217	PF00022	0.474
LIG_Actin_WH2_2	221	238	PF00022	0.379
LIG_Actin_WH2_2	48	64	PF00022	0.397
LIG_APCC_ABBA_1	424	429	PF00400	0.483
LIG_eIF4E_1	395	401	PF01652	0.465
LIG_FHA_1	146	152	PF00498	0.410
LIG_FHA_1	285	291	PF00498	0.468
LIG_FHA_1	430	436	PF00498	0.502
LIG_FHA_1	439	445	PF00498	0.557
LIG_FHA_1	449	455	PF00498	0.274
LIG_FHA_1	463	469	PF00498	0.257
LIG_FHA_1	64	70	PF00498	0.367
LIG_FHA_1	89	95	PF00498	0.489
LIG_FHA_2	206	212	PF00498	0.433
LIG_FHA_2	225	231	PF00498	0.300
LIG_FHA_2	35	41	PF00498	0.550
LIG_LIR_Gen_1	128	137	PF02991	0.342
LIG_LIR_Gen_1	230	238	PF02991	0.351
LIG_LIR_Gen_1	344	354	PF02991	0.366
LIG_LIR_Gen_1	381	388	PF02991	0.343
LIG_LIR_Nem_3	128	134	PF02991	0.340
LIG_LIR_Nem_3	230	235	PF02991	0.346
LIG_LIR_Nem_3	240	246	PF02991	0.388
LIG_LIR_Nem_3	344	349	PF02991	0.328
LIG_LIR_Nem_3	352	357	PF02991	0.275
LIG_LIR_Nem_3	381	386	PF02991	0.335
LIG_LIR_Nem_3	398	404	PF02991	0.514
LIG_LYPXL_yS_3	404	407	PF13949	0.430
LIG_PTB_Apo_2	187	194	PF02174	0.459
LIG_PTB_Apo_2	301	308	PF02174	0.371
LIG_PTB_Phospho_1	187	193	PF10480	0.462
LIG_PTB_Phospho_1	301	307	PF10480	0.367
LIG_SH2_CRK	167	171	PF00017	0.366
LIG_SH2_CRK	90	94	PF00017	0.476
LIG_SH2_PTP2	370	373	PF00017	0.374
LIG_SH2_SRC	370	373	PF00017	0.484
LIG_SH2_STAP1	246	250	PF00017	0.441
LIG_SH2_STAP1	307	311	PF00017	0.400
LIG_SH2_STAP1	53	57	PF00017	0.386
LIG_SH2_STAP1	90	94	PF00017	0.347
LIG_SH2_STAT3	48	51	PF00017	0.496
LIG_SH2_STAT5	370	373	PF00017	0.374
LIG_SH2_STAT5	395	398	PF00017	0.327
LIG_SH2_STAT5	65	68	PF00017	0.484
LIG_SH2_STAT5	75	78	PF00017	0.461
LIG_SH2_STAT5	90	93	PF00017	0.384
LIG_SH3_3	158	164	PF00018	0.502
LIG_SH3_3	178	184	PF00018	0.362
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.361
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.336
LIG_SUMO_SIM_par_1	205	211	PF11976	0.471
LIG_SUMO_SIM_par_1	221	227	PF11976	0.395
LIG_SUMO_SIM_par_1	286	293	PF11976	0.342
LIG_TRAF2_1	385	388	PF00917	0.403
LIG_WRC_WIRS_1	130	135	PF05994	0.472
LIG_WRC_WIRS_1	380	385	PF05994	0.324
MOD_CK1_1	23	29	PF00069	0.406
MOD_CK1_1	264	270	PF00069	0.439
MOD_CK2_1	23	29	PF00069	0.438
MOD_CK2_1	241	247	PF00069	0.298
MOD_GlcNHglycan	122	125	PF01048	0.512
MOD_GlcNHglycan	158	161	PF01048	0.411
MOD_GlcNHglycan	243	246	PF01048	0.501
MOD_GlcNHglycan	343	346	PF01048	0.311
MOD_GlcNHglycan	478	481	PF01048	0.631
MOD_GSK3_1	20	27	PF00069	0.386
MOD_GSK3_1	218	225	PF00069	0.502
MOD_GSK3_1	472	479	PF00069	0.486
MOD_NEK2_1	205	210	PF00069	0.446
MOD_NEK2_1	261	266	PF00069	0.327
MOD_NEK2_1	356	361	PF00069	0.369
MOD_NEK2_1	446	451	PF00069	0.438
MOD_NEK2_1	94	99	PF00069	0.460
MOD_PIKK_1	395	401	PF00454	0.354
MOD_PIKK_1	462	468	PF00454	0.534
MOD_PIKK_1	75	81	PF00454	0.368
MOD_Plk_1	462	468	PF00069	0.491
MOD_Plk_1	94	100	PF00069	0.414
MOD_Plk_2-3	310	316	PF00069	0.411
MOD_Plk_4	173	179	PF00069	0.388
MOD_Plk_4	20	26	PF00069	0.363
MOD_Plk_4	224	230	PF00069	0.331
MOD_Plk_4	261	267	PF00069	0.288
MOD_Plk_4	335	341	PF00069	0.448
MOD_Plk_4	440	446	PF00069	0.480
MOD_ProDKin_1	218	224	PF00069	0.510
MOD_ProDKin_1	438	444	PF00069	0.457
MOD_ProDKin_1	63	69	PF00069	0.375
MOD_SUMO_rev_2	443	451	PF00179	0.557
MOD_SUMO_rev_2	54	64	PF00179	0.430
TRG_DiLeu_BaEn_3	462	468	PF01217	0.482
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.414
TRG_DiLeu_LyEn_5	352	357	PF01217	0.356
TRG_ENDOCYTIC_2	167	170	PF00928	0.341
TRG_ENDOCYTIC_2	370	373	PF00928	0.495
TRG_ENDOCYTIC_2	404	407	PF00928	0.566
TRG_ENDOCYTIC_2	90	93	PF00928	0.426
TRG_ER_diArg_1	1	4	PF00400	0.570
TRG_ER_diArg_1	41	43	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z9	Leptomonas seymouri	75%	100%
A0A0S4JM31	Bodo saltans	41%	100%
A0A1X0NEZ9	Trypanosomatidae	27%	93%
A0A1X0P8G7	Trypanosomatidae	55%	100%
A0A3Q8IIP3	Leishmania donovani	100%	100%
A0A422NFX5	Trypanosoma rangeli	24%	92%
A0A422P283	Trypanosoma rangeli	53%	100%
A4HNQ2	Leishmania braziliensis	90%	100%
C9ZPF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	93%
D0A2L1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ASG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q234	Leishmania major	99%	100%
V5BEF0	Trypanosoma cruzi	24%	93%
V5BQI6	Trypanosoma cruzi	53%	100%