Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICU2_LEIIN

TriTrypDb:

LINF_360009800

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.819
CLV_C14_Caspase3-7	309	313	PF00656	0.765
CLV_C14_Caspase3-7	508	512	PF00656	0.668
CLV_NRD_NRD_1	278	280	PF00675	0.691
CLV_NRD_NRD_1	379	381	PF00675	0.739
CLV_NRD_NRD_1	492	494	PF00675	0.596
CLV_PCSK_KEX2_1	278	280	PF00082	0.691
CLV_PCSK_KEX2_1	379	381	PF00082	0.739
CLV_PCSK_KEX2_1	492	494	PF00082	0.655
CLV_PCSK_SKI1_1	123	127	PF00082	0.727
CLV_PCSK_SKI1_1	449	453	PF00082	0.754
CLV_PCSK_SKI1_1	81	85	PF00082	0.511
DEG_APCC_DBOX_1	80	88	PF00400	0.540
DEG_SPOP_SBC_1	235	239	PF00917	0.691
DEG_SPOP_SBC_1	27	31	PF00917	0.689
DEG_SPOP_SBC_1	294	298	PF00917	0.826
DEG_SPOP_SBC_1	432	436	PF00917	0.708
DOC_MAPK_gen_1	461	471	PF00069	0.609
DOC_MAPK_gen_1	78	86	PF00069	0.601
DOC_MAPK_MEF2A_6	78	86	PF00069	0.601
DOC_USP7_MATH_1	130	134	PF00917	0.648
DOC_USP7_MATH_1	142	146	PF00917	0.712
DOC_USP7_MATH_1	198	202	PF00917	0.700
DOC_USP7_MATH_1	204	208	PF00917	0.704
DOC_USP7_MATH_1	234	238	PF00917	0.703
DOC_USP7_MATH_1	28	32	PF00917	0.696
DOC_USP7_MATH_1	320	324	PF00917	0.813
DOC_USP7_MATH_1	361	365	PF00917	0.653
DOC_USP7_MATH_1	431	435	PF00917	0.775
DOC_USP7_MATH_1	465	469	PF00917	0.784
DOC_USP7_MATH_1	470	474	PF00917	0.676
DOC_USP7_MATH_1	501	505	PF00917	0.740
DOC_WW_Pin1_4	165	170	PF00397	0.713
DOC_WW_Pin1_4	213	218	PF00397	0.717
DOC_WW_Pin1_4	350	355	PF00397	0.713
DOC_WW_Pin1_4	405	410	PF00397	0.705
DOC_WW_Pin1_4	66	71	PF00397	0.798
LIG_14-3-3_CanoR_1	111	116	PF00244	0.547
LIG_14-3-3_CanoR_1	197	203	PF00244	0.686
LIG_14-3-3_CanoR_1	268	276	PF00244	0.679
LIG_14-3-3_CanoR_1	449	457	PF00244	0.740
LIG_14-3-3_CanoR_1	464	470	PF00244	0.659
LIG_14-3-3_CanoR_1	62	70	PF00244	0.601
LIG_BIR_III_4	445	449	PF00653	0.750
LIG_DLG_GKlike_1	111	118	PF00625	0.654
LIG_FHA_1	120	126	PF00498	0.663
LIG_FHA_1	129	135	PF00498	0.785
LIG_FHA_1	144	150	PF00498	0.507
LIG_FHA_1	27	33	PF00498	0.697
LIG_FHA_1	271	277	PF00498	0.661
LIG_FHA_1	406	412	PF00498	0.635
LIG_FHA_1	452	458	PF00498	0.806
LIG_FHA_1	464	470	PF00498	0.583
LIG_FHA_2	327	333	PF00498	0.824
LIG_FHA_2	367	373	PF00498	0.701
LIG_FHA_2	453	459	PF00498	0.723
LIG_FHA_2	75	81	PF00498	0.645
LIG_FHA_2	98	104	PF00498	0.535
LIG_Integrin_RGD_1	474	476	PF01839	0.594
LIG_LIR_Nem_3	150	155	PF02991	0.704
LIG_LIR_Nem_3	364	368	PF02991	0.569
LIG_LIR_Nem_3	510	516	PF02991	0.627
LIG_NRBOX	82	88	PF00104	0.539
LIG_SH2_CRK	152	156	PF00017	0.699
LIG_SH2_CRK	378	382	PF00017	0.620
LIG_SH2_NCK_1	368	372	PF00017	0.727
LIG_SH2_STAP1	516	520	PF00017	0.559
LIG_SH2_STAT3	189	192	PF00017	0.809
LIG_SH2_STAT3	88	91	PF00017	0.534
LIG_SH2_STAT5	362	365	PF00017	0.575
LIG_SH2_STAT5	368	371	PF00017	0.661
LIG_SH2_STAT5	39	42	PF00017	0.759
LIG_SH3_1	379	385	PF00018	0.726
LIG_SH3_3	246	252	PF00018	0.673
LIG_SH3_3	348	354	PF00018	0.775
LIG_SH3_3	360	366	PF00018	0.679
LIG_SH3_3	371	377	PF00018	0.671
LIG_SH3_3	379	385	PF00018	0.626
LIG_SH3_3	9	15	PF00018	0.770
LIG_SUMO_SIM_anti_2	468	473	PF11976	0.607
MOD_CK1_1	119	125	PF00069	0.608
MOD_CK1_1	132	138	PF00069	0.746
MOD_CK1_1	143	149	PF00069	0.609
MOD_CK1_1	219	225	PF00069	0.726
MOD_CK1_1	241	247	PF00069	0.688
MOD_CK1_1	256	262	PF00069	0.725
MOD_CK1_1	26	32	PF00069	0.677
MOD_CK1_1	267	273	PF00069	0.669
MOD_CK1_1	285	291	PF00069	0.553
MOD_CK1_1	314	320	PF00069	0.712
MOD_CK1_1	323	329	PF00069	0.690
MOD_CK1_1	330	336	PF00069	0.618
MOD_CK1_1	353	359	PF00069	0.696
MOD_CK1_1	37	43	PF00069	0.583
MOD_CK1_1	370	376	PF00069	0.716
MOD_CK1_1	401	407	PF00069	0.723
MOD_CK1_1	436	442	PF00069	0.724
MOD_CK1_1	515	521	PF00069	0.559
MOD_CK1_1	65	71	PF00069	0.727
MOD_CK2_1	144	150	PF00069	0.795
MOD_CK2_1	204	210	PF00069	0.701
MOD_CK2_1	420	426	PF00069	0.804
MOD_CK2_1	452	458	PF00069	0.728
MOD_CK2_1	5	11	PF00069	0.776
MOD_CK2_1	66	72	PF00069	0.798
MOD_CK2_1	97	103	PF00069	0.507
MOD_Cter_Amidation	276	279	PF01082	0.699
MOD_DYRK1A_RPxSP_1	213	217	PF00069	0.692
MOD_GlcNHglycan	136	139	PF01048	0.665
MOD_GlcNHglycan	146	149	PF01048	0.598
MOD_GlcNHglycan	16	19	PF01048	0.762
MOD_GlcNHglycan	171	174	PF01048	0.731
MOD_GlcNHglycan	182	185	PF01048	0.689
MOD_GlcNHglycan	200	203	PF01048	0.744
MOD_GlcNHglycan	232	235	PF01048	0.716
MOD_GlcNHglycan	243	246	PF01048	0.720
MOD_GlcNHglycan	258	261	PF01048	0.727
MOD_GlcNHglycan	273	276	PF01048	0.580
MOD_GlcNHglycan	316	319	PF01048	0.730
MOD_GlcNHglycan	325	328	PF01048	0.751
MOD_GlcNHglycan	369	372	PF01048	0.734
MOD_GlcNHglycan	400	403	PF01048	0.647
MOD_GlcNHglycan	412	415	PF01048	0.665
MOD_GlcNHglycan	422	425	PF01048	0.610
MOD_GlcNHglycan	45	48	PF01048	0.643
MOD_GlcNHglycan	501	504	PF01048	0.718
MOD_GlcNHglycan	64	67	PF01048	0.525
MOD_GlcNHglycan	7	10	PF01048	0.726
MOD_GSK3_1	119	126	PF00069	0.617
MOD_GSK3_1	128	135	PF00069	0.786
MOD_GSK3_1	140	147	PF00069	0.688
MOD_GSK3_1	165	172	PF00069	0.706
MOD_GSK3_1	180	187	PF00069	0.777
MOD_GSK3_1	204	211	PF00069	0.685
MOD_GSK3_1	219	226	PF00069	0.794
MOD_GSK3_1	23	30	PF00069	0.729
MOD_GSK3_1	230	237	PF00069	0.635
MOD_GSK3_1	252	259	PF00069	0.706
MOD_GSK3_1	264	271	PF00069	0.723
MOD_GSK3_1	282	289	PF00069	0.568
MOD_GSK3_1	316	323	PF00069	0.707
MOD_GSK3_1	326	333	PF00069	0.660
MOD_GSK3_1	366	373	PF00069	0.697
MOD_GSK3_1	37	44	PF00069	0.555
MOD_GSK3_1	396	403	PF00069	0.718
MOD_GSK3_1	412	419	PF00069	0.743
MOD_GSK3_1	432	439	PF00069	0.602
MOD_GSK3_1	495	502	PF00069	0.724
MOD_GSK3_1	62	69	PF00069	0.805
MOD_LATS_1	121	127	PF00433	0.674
MOD_LATS_1	195	201	PF00433	0.684
MOD_LATS_1	266	272	PF00433	0.726
MOD_N-GLC_1	253	258	PF02516	0.706
MOD_N-GLC_1	441	446	PF02516	0.689
MOD_NEK2_1	134	139	PF00069	0.763
MOD_NEK2_1	164	169	PF00069	0.797
MOD_NEK2_1	209	214	PF00069	0.691
MOD_NEK2_1	283	288	PF00069	0.693
MOD_NEK2_1	311	316	PF00069	0.683
MOD_NEK2_1	35	40	PF00069	0.647
MOD_NEK2_1	420	425	PF00069	0.736
MOD_NEK2_1	437	442	PF00069	0.614
MOD_PIKK_1	330	336	PF00454	0.831
MOD_PKA_2	116	122	PF00069	0.572
MOD_PKA_2	196	202	PF00069	0.682
MOD_PKA_2	267	273	PF00069	0.689
MOD_PKA_2	41	47	PF00069	0.689
MOD_PKA_2	463	469	PF00069	0.802
MOD_PKB_1	447	455	PF00069	0.834
MOD_Plk_1	253	259	PF00069	0.812
MOD_Plk_1	311	317	PF00069	0.717
MOD_Plk_1	416	422	PF00069	0.735
MOD_Plk_1	452	458	PF00069	0.709
MOD_Plk_1	505	511	PF00069	0.668
MOD_Plk_4	184	190	PF00069	0.749
MOD_Plk_4	204	210	PF00069	0.655
MOD_Plk_4	370	376	PF00069	0.622
MOD_Plk_4	433	439	PF00069	0.613
MOD_ProDKin_1	165	171	PF00069	0.716
MOD_ProDKin_1	213	219	PF00069	0.718
MOD_ProDKin_1	350	356	PF00069	0.712
MOD_ProDKin_1	405	411	PF00069	0.704
MOD_ProDKin_1	66	72	PF00069	0.798
MOD_SUMO_rev_2	298	308	PF00179	0.825
TRG_DiLeu_BaEn_1	79	84	PF01217	0.545
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.693
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.541
TRG_ENDOCYTIC_2	152	155	PF00928	0.659
TRG_ENDOCYTIC_2	362	365	PF00928	0.575
TRG_ENDOCYTIC_2	378	381	PF00928	0.706
TRG_ER_diArg_1	378	380	PF00400	0.742
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL9	Leptomonas seymouri	49%	100%
A0A3Q8INA6	Leishmania donovani	100%	100%
A4HNQ3	Leishmania braziliensis	78%	100%
E9ASG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%