Dihydrouridine synthase domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase domain protein-like protein

Species:

Leishmania infantum

UniProt:

A4ICU0_LEIIN

TriTrypDb:

LINF_360010000

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4ICU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICU0

Function

Biological processes
Term	Name	Level	Count
GO:0002943	tRNA dihydrouridine synthesis	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0017150	tRNA dihydrouridine synthase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106413	dihydrouridine synthase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.537
CLV_NRD_NRD_1	298	300	PF00675	0.273
CLV_NRD_NRD_1	408	410	PF00675	0.588
CLV_PCSK_KEX2_1	154	156	PF00082	0.356
CLV_PCSK_KEX2_1	182	184	PF00082	0.265
CLV_PCSK_KEX2_1	410	412	PF00082	0.632
CLV_PCSK_KEX2_1	78	80	PF00082	0.364
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.356
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.301
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.632
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.378
CLV_PCSK_SKI1_1	105	109	PF00082	0.328
CLV_PCSK_SKI1_1	11	15	PF00082	0.313
CLV_PCSK_SKI1_1	204	208	PF00082	0.337
CLV_PCSK_SKI1_1	275	279	PF00082	0.367
CLV_PCSK_SKI1_1	288	292	PF00082	0.291
CLV_PCSK_SKI1_1	330	334	PF00082	0.371
CLV_PCSK_SKI1_1	340	344	PF00082	0.378
CLV_PCSK_SKI1_1	358	362	PF00082	0.506
CLV_PCSK_SKI1_1	46	50	PF00082	0.469
CLV_Separin_Metazoa	244	248	PF03568	0.556
DEG_Nend_UBRbox_1	1	4	PF02207	0.453
DEG_SCF_FBW7_2	60	66	PF00400	0.521
DOC_CKS1_1	211	216	PF01111	0.529
DOC_CKS1_1	60	65	PF01111	0.526
DOC_CKS1_1	83	88	PF01111	0.394
DOC_CYCLIN_RxL_1	327	336	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.443
DOC_MAPK_gen_1	179	188	PF00069	0.453
DOC_MAPK_gen_1	299	306	PF00069	0.403
DOC_MAPK_MEF2A_6	100	108	PF00069	0.512
DOC_MAPK_MEF2A_6	11	20	PF00069	0.324
DOC_MAPK_NFAT4_5	105	113	PF00069	0.537
DOC_PP1_RVXF_1	328	335	PF00149	0.473
DOC_USP7_MATH_1	169	173	PF00917	0.540
DOC_USP7_MATH_1	310	314	PF00917	0.605
DOC_USP7_MATH_1	416	420	PF00917	0.643
DOC_USP7_UBL2_3	74	78	PF12436	0.412
DOC_WW_Pin1_4	19	24	PF00397	0.491
DOC_WW_Pin1_4	210	215	PF00397	0.509
DOC_WW_Pin1_4	225	230	PF00397	0.400
DOC_WW_Pin1_4	59	64	PF00397	0.536
DOC_WW_Pin1_4	82	87	PF00397	0.391
LIG_14-3-3_CanoR_1	183	189	PF00244	0.462
LIG_14-3-3_CanoR_1	338	343	PF00244	0.461
LIG_14-3-3_CanoR_1	382	386	PF00244	0.418
LIG_AP2alpha_2	71	73	PF02296	0.484
LIG_APCC_ABBA_1	360	365	PF00400	0.498
LIG_BRCT_BRCA1_1	21	25	PF00533	0.471
LIG_EH1_1	395	403	PF00400	0.397
LIG_FHA_1	213	219	PF00498	0.459
LIG_FHA_1	37	43	PF00498	0.406
LIG_FHA_1	395	401	PF00498	0.604
LIG_FHA_1	78	84	PF00498	0.437
LIG_FHA_2	382	388	PF00498	0.493
LIG_GBD_Chelix_1	184	192	PF00786	0.337
LIG_LIR_Gen_1	341	350	PF02991	0.416
LIG_LIR_Gen_1	376	385	PF02991	0.452
LIG_LIR_Nem_3	22	28	PF02991	0.442
LIG_LIR_Nem_3	252	258	PF02991	0.533
LIG_LIR_Nem_3	331	337	PF02991	0.367
LIG_LIR_Nem_3	341	346	PF02991	0.383
LIG_LIR_Nem_3	351	357	PF02991	0.177
LIG_LIR_Nem_3	376	381	PF02991	0.405
LIG_LIR_Nem_3	66	70	PF02991	0.341
LIG_LYPXL_yS_3	57	60	PF13949	0.506
LIG_PCNA_PIPBox_1	326	335	PF02747	0.453
LIG_PTB_Apo_2	342	349	PF02174	0.471
LIG_PTB_Phospho_1	342	348	PF10480	0.475
LIG_REV1ctd_RIR_1	378	386	PF16727	0.420
LIG_SH2_CRK	339	343	PF00017	0.385
LIG_SH2_NCK_1	239	243	PF00017	0.462
LIG_SH2_STAP1	239	243	PF00017	0.462
LIG_SH2_STAP1	324	328	PF00017	0.475
LIG_SH2_STAP1	335	339	PF00017	0.465
LIG_SH2_STAP1	374	378	PF00017	0.367
LIG_SH2_STAT5	67	70	PF00017	0.432
LIG_SH3_3	109	115	PF00018	0.477
LIG_SH3_3	17	23	PF00018	0.463
LIG_SH3_3	211	217	PF00018	0.521
LIG_SH3_3	52	58	PF00018	0.513
LIG_SH3_3	83	89	PF00018	0.485
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.500
LIG_SUMO_SIM_par_1	79	85	PF11976	0.428
LIG_TRAF2_1	384	387	PF00917	0.394
LIG_TRAF2_1	418	421	PF00917	0.636
LIG_TYR_ITIM	337	342	PF00017	0.470
LIG_TYR_ITIM	55	60	PF00017	0.510
MOD_CDK_SPxxK_3	19	26	PF00069	0.478
MOD_CDK_SPxxK_3	225	232	PF00069	0.537
MOD_CK1_1	187	193	PF00069	0.480
MOD_CK1_1	265	271	PF00069	0.462
MOD_CK1_1	405	411	PF00069	0.417
MOD_CK2_1	171	177	PF00069	0.473
MOD_CK2_1	381	387	PF00069	0.420
MOD_Cter_Amidation	180	183	PF01082	0.294
MOD_DYRK1A_RPxSP_1	19	23	PF00069	0.485
MOD_GlcNHglycan	307	310	PF01048	0.340
MOD_GlcNHglycan	403	407	PF01048	0.485
MOD_GSK3_1	192	199	PF00069	0.454
MOD_GSK3_1	310	317	PF00069	0.584
MOD_GSK3_1	390	397	PF00069	0.525
MOD_GSK3_1	412	419	PF00069	0.632
MOD_GSK3_1	431	438	PF00069	0.669
MOD_GSK3_1	73	80	PF00069	0.445
MOD_N-GLC_1	262	267	PF02516	0.251
MOD_NEK2_1	262	267	PF00069	0.465
MOD_NEK2_1	304	309	PF00069	0.492
MOD_NEK2_1	333	338	PF00069	0.447
MOD_NEK2_1	390	395	PF00069	0.473
MOD_NEK2_1	73	78	PF00069	0.510
MOD_PK_1	140	146	PF00069	0.451
MOD_PKA_1	140	146	PF00069	0.451
MOD_PKA_1	299	305	PF00069	0.473
MOD_PKA_2	304	310	PF00069	0.465
MOD_PKA_2	381	387	PF00069	0.468
MOD_Plk_1	196	202	PF00069	0.537
MOD_Plk_1	3	9	PF00069	0.487
MOD_Plk_2-3	370	376	PF00069	0.490
MOD_Plk_2-3	66	72	PF00069	0.423
MOD_Plk_4	262	268	PF00069	0.504
MOD_Plk_4	3	9	PF00069	0.433
MOD_ProDKin_1	19	25	PF00069	0.489
MOD_ProDKin_1	210	216	PF00069	0.509
MOD_ProDKin_1	225	231	PF00069	0.400
MOD_ProDKin_1	59	65	PF00069	0.529
MOD_ProDKin_1	82	88	PF00069	0.395
MOD_SUMO_for_1	1	4	PF00179	0.473
MOD_SUMO_rev_2	268	277	PF00179	0.512
MOD_SUMO_rev_2	420	430	PF00179	0.639
TRG_DiLeu_BaEn_1	256	261	PF01217	0.431
TRG_ENDOCYTIC_2	339	342	PF00928	0.393
TRG_ENDOCYTIC_2	378	381	PF00928	0.381
TRG_ENDOCYTIC_2	57	60	PF00928	0.506
TRG_ENDOCYTIC_2	70	73	PF00928	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z1	Leptomonas seymouri	66%	100%
A0A0S4JLG1	Bodo saltans	38%	87%
A0A0S4JUA9	Bodo saltans	24%	96%
A0A1X0P8K8	Trypanosomatidae	44%	100%
A0A3Q8IJ00	Leishmania donovani	100%	100%
A0A3Q8IN46	Leishmania donovani	23%	89%
A0A3R7KZP3	Trypanosoma rangeli	27%	100%
A0A422P287	Trypanosoma rangeli	48%	100%
A4HAN2	Leishmania braziliensis	22%	100%
A4HNQ5	Leishmania braziliensis	79%	100%
A4I9S4	Leishmania infantum	23%	100%
D0A2L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ASG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B4T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O74553	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O74731	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	92%
P37567	Bacillus subtilis (strain 168)	25%	100%
P53720	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4Q231	Leishmania major	92%	100%
Q4Q391	Leishmania major	25%	89%
Q8CU07	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	100%
Q8PP72	Xanthomonas axonopodis pv. citri (strain 306)	27%	100%
Q8XYX1	Ralstonia solanacearum (strain GMI1000)	28%	100%
Q9D7B1	Mus musculus	28%	89%
Q9NX74	Homo sapiens	28%	89%
V5DJT2	Trypanosoma cruzi	27%	100%
V5DRQ6	Trypanosoma cruzi	49%	100%