LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICT5_LEIIN
TriTrypDb:
LINF_360010500
Length:
444

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICT5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICT5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 431 435 PF00656 0.448
CLV_NRD_NRD_1 162 164 PF00675 0.517
CLV_NRD_NRD_1 199 201 PF00675 0.490
CLV_NRD_NRD_1 229 231 PF00675 0.566
CLV_NRD_NRD_1 321 323 PF00675 0.470
CLV_NRD_NRD_1 402 404 PF00675 0.469
CLV_NRD_NRD_1 75 77 PF00675 0.600
CLV_NRD_NRD_1 93 95 PF00675 0.737
CLV_PCSK_KEX2_1 150 152 PF00082 0.453
CLV_PCSK_KEX2_1 229 231 PF00082 0.453
CLV_PCSK_KEX2_1 35 37 PF00082 0.432
CLV_PCSK_KEX2_1 402 404 PF00082 0.469
CLV_PCSK_KEX2_1 423 425 PF00082 0.511
CLV_PCSK_KEX2_1 75 77 PF00082 0.600
CLV_PCSK_PC1ET2_1 150 152 PF00082 0.453
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.392
CLV_PCSK_PC1ET2_1 423 425 PF00082 0.545
CLV_PCSK_SKI1_1 164 168 PF00082 0.533
CLV_PCSK_SKI1_1 372 376 PF00082 0.612
CLV_PCSK_SKI1_1 85 89 PF00082 0.681
DEG_APCC_DBOX_1 410 418 PF00400 0.468
DEG_Nend_UBRbox_2 1 3 PF02207 0.505
DEG_ODPH_VHL_1 277 288 PF01847 0.553
DOC_MAPK_gen_1 200 207 PF00069 0.405
DOC_MAPK_gen_1 229 235 PF00069 0.522
DOC_MAPK_gen_1 75 83 PF00069 0.511
DOC_MAPK_MEF2A_6 108 117 PF00069 0.518
DOC_PP1_RVXF_1 161 168 PF00149 0.453
DOC_PP2B_LxvP_1 81 84 PF13499 0.731
DOC_PP2B_PxIxI_1 328 334 PF00149 0.585
DOC_PP4_FxxP_1 167 170 PF00568 0.483
DOC_PP4_FxxP_1 268 271 PF00568 0.413
DOC_USP7_MATH_1 159 163 PF00917 0.553
DOC_USP7_MATH_1 21 25 PF00917 0.517
DOC_USP7_MATH_1 428 432 PF00917 0.448
DOC_WW_Pin1_4 55 60 PF00397 0.671
DOC_WW_Pin1_4 85 90 PF00397 0.596
LIG_14-3-3_CanoR_1 200 208 PF00244 0.349
LIG_14-3-3_CanoR_1 315 324 PF00244 0.471
LIG_Actin_WH2_2 125 143 PF00022 0.389
LIG_Actin_WH2_2 376 394 PF00022 0.477
LIG_APCC_ABBA_1 234 239 PF00400 0.415
LIG_APCC_ABBA_1 331 336 PF00400 0.487
LIG_Clathr_ClatBox_1 380 384 PF01394 0.485
LIG_EH1_1 206 214 PF00400 0.399
LIG_FHA_1 134 140 PF00498 0.406
LIG_FHA_1 222 228 PF00498 0.403
LIG_FHA_1 271 277 PF00498 0.464
LIG_FHA_1 32 38 PF00498 0.426
LIG_FHA_2 265 271 PF00498 0.443
LIG_FHA_2 385 391 PF00498 0.550
LIG_FHA_2 399 405 PF00498 0.372
LIG_GBD_Chelix_1 10 18 PF00786 0.436
LIG_LIR_Apic_2 266 271 PF02991 0.483
LIG_LIR_Gen_1 128 134 PF02991 0.356
LIG_LIR_Gen_1 244 255 PF02991 0.390
LIG_LIR_Nem_3 128 133 PF02991 0.382
LIG_LIR_Nem_3 231 237 PF02991 0.455
LIG_LIR_Nem_3 240 246 PF02991 0.308
LIG_LIR_Nem_3 281 286 PF02991 0.615
LIG_MYND_1 55 59 PF01753 0.750
LIG_NRBOX 128 134 PF00104 0.406
LIG_Pex14_2 247 251 PF04695 0.452
LIG_Pex14_2 264 268 PF04695 0.352
LIG_PTB_Apo_2 306 313 PF02174 0.509
LIG_PTB_Phospho_1 306 312 PF10480 0.516
LIG_Rb_LxCxE_1 249 267 PF01857 0.430
LIG_SH2_CRK 283 287 PF00017 0.578
LIG_SH2_SRC 269 272 PF00017 0.452
LIG_SH2_STAP1 243 247 PF00017 0.344
LIG_SH2_STAP1 312 316 PF00017 0.556
LIG_SH2_STAP1 415 419 PF00017 0.451
LIG_SH2_STAT5 243 246 PF00017 0.370
LIG_SH2_STAT5 283 286 PF00017 0.482
LIG_SH2_STAT5 362 365 PF00017 0.437
LIG_SH3_3 215 221 PF00018 0.538
LIG_SH3_3 230 236 PF00018 0.584
LIG_SH3_3 276 282 PF00018 0.470
LIG_SH3_3 283 289 PF00018 0.502
LIG_SH3_3 342 348 PF00018 0.704
LIG_SH3_3 53 59 PF00018 0.548
LIG_SUMO_SIM_anti_2 376 382 PF11976 0.477
LIG_SUMO_SIM_par_1 379 384 PF11976 0.484
LIG_UBA3_1 356 360 PF00899 0.471
LIG_WRC_WIRS_1 265 270 PF05994 0.532
MOD_CDK_SPxxK_3 55 62 PF00069 0.555
MOD_CK1_1 119 125 PF00069 0.419
MOD_CK1_1 318 324 PF00069 0.490
MOD_CK1_1 337 343 PF00069 0.465
MOD_CK1_1 58 64 PF00069 0.750
MOD_CK2_1 352 358 PF00069 0.462
MOD_CK2_1 398 404 PF00069 0.426
MOD_Cter_Amidation 198 201 PF01082 0.497
MOD_Cter_Amidation 73 76 PF01082 0.512
MOD_GlcNHglycan 103 106 PF01048 0.652
MOD_GlcNHglycan 178 181 PF01048 0.421
MOD_GlcNHglycan 201 204 PF01048 0.445
MOD_GlcNHglycan 324 327 PF01048 0.649
MOD_GlcNHglycan 52 55 PF01048 0.626
MOD_GSK3_1 115 122 PF00069 0.378
MOD_GSK3_1 237 244 PF00069 0.471
MOD_GSK3_1 318 325 PF00069 0.588
MOD_GSK3_1 348 355 PF00069 0.506
MOD_GSK3_1 99 106 PF00069 0.723
MOD_N-GLC_1 159 164 PF02516 0.497
MOD_N-GLC_1 21 26 PF02516 0.516
MOD_NEK2_1 103 108 PF00069 0.509
MOD_NEK2_1 133 138 PF00069 0.477
MOD_NEK2_1 140 145 PF00069 0.519
MOD_NEK2_1 185 190 PF00069 0.534
MOD_NEK2_1 264 269 PF00069 0.601
MOD_NEK2_1 398 403 PF00069 0.459
MOD_NEK2_1 90 95 PF00069 0.742
MOD_NEK2_2 21 26 PF00069 0.516
MOD_NEK2_2 221 226 PF00069 0.380
MOD_NEK2_2 246 251 PF00069 0.469
MOD_OFUCOSY 100 107 PF10250 0.549
MOD_PIKK_1 119 125 PF00454 0.460
MOD_PIKK_1 270 276 PF00454 0.442
MOD_PIKK_1 315 321 PF00454 0.526
MOD_PIKK_1 384 390 PF00454 0.528
MOD_PIKK_1 48 54 PF00454 0.508
MOD_PKA_1 322 328 PF00069 0.599
MOD_PKA_2 140 146 PF00069 0.464
MOD_PKA_2 199 205 PF00069 0.408
MOD_PKA_2 334 340 PF00069 0.555
MOD_PKA_2 384 390 PF00069 0.583
MOD_Plk_1 241 247 PF00069 0.381
MOD_Plk_1 42 48 PF00069 0.558
MOD_Plk_4 125 131 PF00069 0.408
MOD_Plk_4 241 247 PF00069 0.430
MOD_Plk_4 264 270 PF00069 0.576
MOD_Plk_4 352 358 PF00069 0.546
MOD_ProDKin_1 55 61 PF00069 0.671
MOD_ProDKin_1 85 91 PF00069 0.595
MOD_SUMO_for_1 4 7 PF00179 0.426
MOD_SUMO_for_1 429 432 PF00179 0.415
MOD_SUMO_rev_2 355 361 PF00179 0.463
MOD_SUMO_rev_2 384 394 PF00179 0.399
TRG_DiLeu_BaEn_1 6 11 PF01217 0.483
TRG_DiLeu_BaLyEn_6 135 140 PF01217 0.404
TRG_DiLeu_BaLyEn_6 14 19 PF01217 0.436
TRG_ENDOCYTIC_2 130 133 PF00928 0.345
TRG_ENDOCYTIC_2 283 286 PF00928 0.577
TRG_ENDOCYTIC_2 426 429 PF00928 0.495
TRG_ER_diArg_1 36 39 PF00400 0.415
TRG_ER_diArg_1 411 414 PF00400 0.492
TRG_NES_CRM1_1 28 43 PF08389 0.435
TRG_NLS_MonoExtN_4 32 39 PF00514 0.385
TRG_Pf-PMV_PEXEL_1 211 215 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JPJ4 Bodo saltans 35% 86%
A0A1X0P9M8 Trypanosomatidae 37% 100%
A0A3Q8IFS3 Leishmania donovani 99% 100%
A0A422P297 Trypanosoma rangeli 36% 99%
A4HNR0 Leishmania braziliensis 74% 100%
D0A2L8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9ASG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q226 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS