LeishMANIAdb
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Protein phosphatase 2C-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase 2C-like protein
Gene product:
protein phosphatase 2C-like protein
Species:
Leishmania infantum
UniProt:
A4ICT4_LEIIN
TriTrypDb:
LINF_360010600
Length:
298

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Annotations by Jardim et al.

Phosphatase, phosphatase 2C-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICT4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICT4

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 22
GO:0006793 phosphorus metabolic process 3 22
GO:0006796 phosphate-containing compound metabolic process 4 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0016311 dephosphorylation 5 22
GO:0019538 protein metabolic process 3 22
GO:0036211 protein modification process 4 22
GO:0043170 macromolecule metabolic process 3 22
GO:0043412 macromolecule modification 4 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 22
GO:0004721 phosphoprotein phosphatase activity 3 22
GO:0004722 protein serine/threonine phosphatase activity 4 22
GO:0016787 hydrolase activity 2 22
GO:0016788 hydrolase activity, acting on ester bonds 3 22
GO:0016791 phosphatase activity 5 22
GO:0042578 phosphoric ester hydrolase activity 4 22
GO:0140096 catalytic activity, acting on a protein 2 22
GO:0017018 myosin phosphatase activity 5 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 32 34 PF00675 0.179
CLV_PCSK_SKI1_1 134 138 PF00082 0.250
DEG_SCF_FBW7_1 207 214 PF00400 0.345
DOC_MAPK_gen_1 139 148 PF00069 0.345
DOC_MAPK_HePTP_8 136 148 PF00069 0.345
DOC_MAPK_MEF2A_6 139 148 PF00069 0.345
DOC_MAPK_MEF2A_6 172 179 PF00069 0.345
DOC_MAPK_MEF2A_6 250 259 PF00069 0.315
DOC_MAPK_NFAT4_5 172 180 PF00069 0.345
DOC_PP2B_PxIxI_1 204 210 PF00149 0.345
DOC_PP4_FxxP_1 291 294 PF00568 0.397
DOC_USP7_MATH_1 130 134 PF00917 0.179
DOC_USP7_MATH_1 192 196 PF00917 0.316
DOC_USP7_MATH_1 211 215 PF00917 0.372
DOC_USP7_UBL2_3 102 106 PF12436 0.379
DOC_WW_Pin1_4 207 212 PF00397 0.315
LIG_14-3-3_CanoR_1 172 178 PF00244 0.169
LIG_14-3-3_CanoR_1 33 37 PF00244 0.213
LIG_Actin_WH2_2 9 25 PF00022 0.424
LIG_APCC_ABBA_1 82 87 PF00400 0.191
LIG_BRCT_BRCA1_1 13 17 PF00533 0.445
LIG_FHA_1 17 23 PF00498 0.273
LIG_FHA_1 174 180 PF00498 0.208
LIG_FHA_1 283 289 PF00498 0.290
LIG_FHA_2 13 19 PF00498 0.416
LIG_Integrin_isoDGR_2 170 172 PF01839 0.345
LIG_LIR_Apic_2 290 294 PF02991 0.394
LIG_LIR_Gen_1 10 17 PF02991 0.487
LIG_LIR_Gen_1 215 226 PF02991 0.252
LIG_LIR_Gen_1 94 104 PF02991 0.261
LIG_LIR_Nem_3 10 16 PF02991 0.466
LIG_LIR_Nem_3 215 221 PF02991 0.251
LIG_LIR_Nem_3 224 230 PF02991 0.261
LIG_LIR_Nem_3 51 57 PF02991 0.283
LIG_LIR_Nem_3 94 100 PF02991 0.274
LIG_NRBOX 74 80 PF00104 0.345
LIG_PDZ_Class_2 293 298 PF00595 0.341
LIG_Pex14_2 13 17 PF04695 0.437
LIG_Pex14_2 291 295 PF04695 0.297
LIG_Pex14_2 54 58 PF04695 0.187
LIG_Pex14_2 93 97 PF04695 0.245
LIG_REV1ctd_RIR_1 293 298 PF16727 0.277
LIG_SH2_STAT5 119 122 PF00017 0.350
LIG_SH2_STAT5 69 72 PF00017 0.222
LIG_SH3_3 149 155 PF00018 0.269
LIG_SH3_4 7 14 PF00018 0.443
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.345
LIG_SUMO_SIM_anti_2 285 290 PF11976 0.320
LIG_SUMO_SIM_par_1 144 149 PF11976 0.345
LIG_SUMO_SIM_par_1 175 180 PF11976 0.230
LIG_SUMO_SIM_par_1 253 258 PF11976 0.259
LIG_SUMO_SIM_par_1 284 290 PF11976 0.361
LIG_TRAF2_1 155 158 PF00917 0.345
LIG_TRAF2_1 231 234 PF00917 0.305
LIG_TRAF2_1 96 99 PF00917 0.373
LIG_UBA3_1 74 80 PF00899 0.345
MOD_CDK_SPxK_1 207 213 PF00069 0.191
MOD_CK1_1 110 116 PF00069 0.327
MOD_CK2_1 12 18 PF00069 0.274
MOD_CK2_1 211 217 PF00069 0.269
MOD_CK2_1 228 234 PF00069 0.332
MOD_CK2_1 93 99 PF00069 0.338
MOD_GlcNHglycan 110 113 PF01048 0.335
MOD_GSK3_1 107 114 PF00069 0.247
MOD_GSK3_1 173 180 PF00069 0.208
MOD_GSK3_1 205 212 PF00069 0.388
MOD_GSK3_1 278 285 PF00069 0.422
MOD_GSK3_1 60 67 PF00069 0.425
MOD_GSK3_1 7 14 PF00069 0.366
MOD_N-GLC_1 173 178 PF02516 0.208
MOD_N-GLC_1 282 287 PF02516 0.276
MOD_NEK2_1 108 113 PF00069 0.213
MOD_NEK2_1 17 22 PF00069 0.345
MOD_NEK2_1 177 182 PF00069 0.258
MOD_NEK2_1 238 243 PF00069 0.300
MOD_NEK2_1 271 276 PF00069 0.191
MOD_NEK2_1 93 98 PF00069 0.299
MOD_PIKK_1 7 13 PF00454 0.471
MOD_PKA_2 32 38 PF00069 0.233
MOD_Plk_1 17 23 PF00069 0.256
MOD_Plk_1 173 179 PF00069 0.414
MOD_Plk_1 205 211 PF00069 0.253
MOD_Plk_1 257 263 PF00069 0.345
MOD_Plk_1 282 288 PF00069 0.274
MOD_Plk_1 64 70 PF00069 0.191
MOD_Plk_1 93 99 PF00069 0.351
MOD_Plk_4 12 18 PF00069 0.484
MOD_Plk_4 192 198 PF00069 0.142
MOD_Plk_4 238 244 PF00069 0.345
MOD_Plk_4 282 288 PF00069 0.274
MOD_ProDKin_1 207 213 PF00069 0.315
MOD_SUMO_for_1 6 9 PF00179 0.438
MOD_SUMO_rev_2 147 153 PF00179 0.256
MOD_SUMO_rev_2 185 190 PF00179 0.340
TRG_DiLeu_BaEn_1 234 239 PF01217 0.258
TRG_Pf-PMV_PEXEL_1 181 185 PF00026 0.179
TRG_Pf-PMV_PEXEL_1 269 273 PF00026 0.289

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C7 Leptomonas seymouri 38% 75%
A0A0N0P8F8 Leptomonas seymouri 42% 100%
A0A0N1I0H9 Leptomonas seymouri 85% 100%
A0A0N1I8W9 Leptomonas seymouri 32% 68%
A0A0N1IHU6 Leptomonas seymouri 30% 73%
A0A0N1PAL8 Leptomonas seymouri 37% 78%
A0A0N1PEL9 Leptomonas seymouri 32% 80%
A0A0S4IY95 Bodo saltans 39% 83%
A0A0S4J0A6 Bodo saltans 34% 73%
A0A0S4JHB4 Bodo saltans 32% 78%
A0A0S4JPC3 Bodo saltans 52% 100%
A0A0S4JPM8 Bodo saltans 39% 79%
A0A0S4KJV9 Bodo saltans 41% 69%
A0A1X0NRG3 Trypanosomatidae 41% 94%
A0A1X0NVC4 Trypanosomatidae 38% 73%
A0A1X0P2A0 Trypanosomatidae 31% 78%
A0A1X0P568 Trypanosomatidae 32% 73%
A0A1X0P991 Trypanosomatidae 55% 100%
A0A1X0PAN4 Trypanosomatidae 27% 93%
A0A3Q8IEK6 Leishmania donovani 42% 95%
A0A3Q8IFG7 Leishmania donovani 37% 78%
A0A3Q8IK65 Leishmania donovani 100% 100%
A0A3Q8IL63 Leishmania donovani 31% 76%
A0A3S7WTA2 Leishmania donovani 41% 74%
A0A3S7WZ14 Leishmania donovani 31% 73%
A0A3S7X808 Leishmania donovani 31% 66%
A0A422N8D7 Trypanosoma rangeli 27% 94%
A0A422NAJ1 Trypanosoma rangeli 41% 94%
A0A422NBV9 Trypanosoma rangeli 32% 73%
A0A422NL94 Trypanosoma rangeli 40% 68%
A0A422NML6 Trypanosoma rangeli 34% 78%
A0A422NS77 Trypanosoma rangeli 38% 72%
A0A422P293 Trypanosoma rangeli 54% 100%
A0BLX0 Paramecium tetraurelia 33% 99%
A0BQL0 Paramecium tetraurelia 36% 99%
A0CUB5 Paramecium tetraurelia 32% 100%
A0DSB3 Paramecium tetraurelia 34% 100%
A0DTY1 Paramecium tetraurelia 33% 99%
A3A8W2 Oryza sativa subsp. japonica 31% 88%
A4H7Y6 Leishmania braziliensis 41% 100%
A4HAW5 Leishmania braziliensis 32% 100%
A4HAW6 Leishmania braziliensis 31% 66%
A4HE10 Leishmania braziliensis 30% 100%
A4HG10 Leishmania braziliensis 42% 100%
A4HHY5 Leishmania braziliensis 37% 100%
A4HNR1 Leishmania braziliensis 94% 100%
A4HWB4 Leishmania infantum 41% 100%
A4I1B7 Leishmania infantum 31% 100%
A4I329 Leishmania infantum 42% 100%
A4I565 Leishmania infantum 37% 100%
A4IA25 Leishmania infantum 31% 100%
A4IA26 Leishmania infantum 31% 66%
A5PJZ2 Bos taurus 31% 83%
C9ZJK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 93%
C9ZMJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 95%
C9ZNW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 70%
C9ZQJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 78%
D0A2L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A5L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 73%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 69%
E9ACV0 Leishmania major 42% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B541 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
O04719 Arabidopsis thaliana 31% 70%
O14189 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 67%
O62829 Bos taurus 39% 78%
O64583 Arabidopsis thaliana 29% 88%
O80492 Arabidopsis thaliana 30% 70%
O80871 Arabidopsis thaliana 29% 75%
O81716 Arabidopsis thaliana 34% 84%
O81760 Arabidopsis thaliana 27% 78%
O82637 Arabidopsis thaliana 34% 91%
P20650 Rattus norvegicus 39% 78%
P35182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P35813 Homo sapiens 39% 78%
P35814 Oryctolagus cuniculus 39% 78%
P35815 Rattus norvegicus 39% 76%
P36982 Leishmania chagasi 31% 73%
P36993 Mus musculus 38% 76%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 76%
P40371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 86%
P49443 Mus musculus 39% 78%
P49444 Paramecium tetraurelia 34% 99%
P49594 Caenorhabditis elegans 25% 66%
P49596 Caenorhabditis elegans 41% 84%
P49597 Arabidopsis thaliana 31% 69%
P49598 Arabidopsis thaliana 33% 75%
P49599 Arabidopsis thaliana 29% 77%
P93006 Arabidopsis thaliana 34% 78%
Q09172 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 81%
Q09173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 72%
Q0D673 Oryza sativa subsp. japonica 31% 100%
Q0DBU3 Oryza sativa subsp. japonica 33% 85%
Q0IIF0 Bos taurus 30% 81%
Q0J2L7 Oryza sativa subsp. japonica 32% 83%
Q0J2R1 Oryza sativa subsp. japonica 32% 81%
Q0JAA0 Oryza sativa subsp. japonica 32% 93%
Q0JL75 Oryza sativa subsp. japonica 31% 79%
Q0V7V2 Arabidopsis thaliana 25% 78%
Q0WRB2 Arabidopsis thaliana 30% 80%
Q10MN6 Oryza sativa subsp. japonica 27% 69%
Q10MX1 Oryza sativa subsp. japonica 32% 76%
Q10S32 Oryza sativa subsp. japonica 27% 75%
Q2PC20 Bos taurus 30% 80%
Q2QN36 Oryza sativa subsp. japonica 27% 76%
Q2QWE3 Oryza sativa subsp. japonica 30% 71%
Q2R637 Oryza sativa subsp. japonica 29% 69%
Q2RBJ6 Oryza sativa subsp. japonica 29% 71%
Q3EAF9 Arabidopsis thaliana 33% 78%
Q4PSE8 Arabidopsis thaliana 34% 67%
Q4Q225 Leishmania major 97% 100%
Q4Q2U5 Leishmania major 30% 66%
Q4Q2U6 Leishmania major 32% 100%
Q4Q7S1 Leishmania major 37% 100%
Q4QA19 Leishmania major 30% 100%
Q4QFG7 Leishmania major 39% 100%
Q501F9 Arabidopsis thaliana 29% 81%
Q53Q11 Oryza sativa subsp. japonica 28% 75%
Q5JKN1 Oryza sativa subsp. japonica 25% 77%
Q5MFV5 Oryza sativa subsp. indica 24% 78%
Q5N9N2 Oryza sativa subsp. japonica 35% 72%
Q5PNS9 Arabidopsis thaliana 27% 74%
Q5R522 Pongo abelii 31% 91%
Q5SGD2 Homo sapiens 31% 83%
Q5SMK6 Oryza sativa subsp. japonica 32% 83%
Q5SN75 Oryza sativa subsp. japonica 31% 74%
Q5Z6F5 Oryza sativa subsp. japonica 33% 91%
Q5Z8P0 Oryza sativa subsp. japonica 26% 76%
Q652Z7 Oryza sativa subsp. japonica 36% 79%
Q653S3 Oryza sativa subsp. japonica 36% 82%
Q65XG6 Oryza sativa subsp. japonica 35% 72%
Q65XK7 Oryza sativa subsp. japonica 32% 78%
Q67J17 Oryza sativa subsp. japonica 26% 71%
Q67UP9 Oryza sativa subsp. japonica 36% 81%
Q67UX7 Oryza sativa subsp. japonica 33% 86%
Q69QZ0 Oryza sativa subsp. japonica 31% 84%
Q69VD9 Oryza sativa subsp. japonica 30% 81%
Q6AUQ4 Oryza sativa subsp. japonica 32% 77%
Q6EN45 Oryza sativa subsp. japonica 32% 82%
Q6ETK3 Oryza sativa subsp. japonica 36% 82%
Q6ING9 Xenopus laevis 31% 80%
Q6L4R7 Oryza sativa subsp. japonica 30% 67%
Q6L5H6 Oryza sativa subsp. japonica 31% 77%
Q6NKS1 Arabidopsis thaliana 32% 78%
Q6YTI2 Oryza sativa subsp. japonica 28% 67%
Q7XCJ7 Oryza sativa subsp. japonica 26% 76%
Q7XHN8 Oryza sativa subsp. japonica 29% 79%
Q7XJ53 Arabidopsis thaliana 25% 86%
Q7XQU7 Oryza sativa subsp. japonica 31% 100%
Q7XR06 Oryza sativa subsp. japonica 30% 100%
Q7XU84 Oryza sativa subsp. japonica 33% 85%
Q7XUC5 Oryza sativa subsp. japonica 28% 77%
Q7Y138 Oryza sativa subsp. japonica 26% 77%
Q84JD5 Arabidopsis thaliana 25% 76%
Q84JI0 Oryza sativa subsp. japonica 34% 74%
Q8BGL1 Mus musculus 34% 74%
Q8BHN0 Mus musculus 31% 83%
Q8BXN7 Mus musculus 30% 80%
Q8H063 Oryza sativa subsp. japonica 25% 76%
Q8H4S6 Oryza sativa subsp. japonica 29% 70%
Q8L7I4 Arabidopsis thaliana 34% 100%
Q8LAY8 Arabidopsis thaliana 35% 84%
Q8N3J5 Homo sapiens 30% 80%
Q8N819 Homo sapiens 34% 69%
Q8R0F6 Mus musculus 30% 76%
Q8RX37 Arabidopsis thaliana 29% 78%
Q8RXV3 Arabidopsis thaliana 34% 96%
Q8VZN9 Arabidopsis thaliana 33% 80%
Q93YW5 Arabidopsis thaliana 33% 100%
Q94AT1 Arabidopsis thaliana 30% 71%
Q94CL8 Arabidopsis thaliana 28% 78%
Q94H98 Oryza sativa subsp. japonica 24% 78%
Q9FG61 Arabidopsis thaliana 28% 67%
Q9FIF5 Arabidopsis thaliana 32% 72%
Q9FKX4 Arabidopsis thaliana 27% 77%
Q9FLI3 Arabidopsis thaliana 31% 72%
Q9FX08 Arabidopsis thaliana 29% 70%
Q9FXE4 Arabidopsis thaliana 36% 67%
Q9FYN7 Oryza sativa subsp. japonica 33% 78%
Q9H0C8 Homo sapiens 29% 76%
Q9LDA7 Arabidopsis thaliana 30% 100%
Q9LHJ9 Arabidopsis thaliana 30% 77%
Q9LME4 Arabidopsis thaliana 31% 100%
Q9LMT1 Arabidopsis thaliana 31% 85%
Q9LNF4 Arabidopsis thaliana 31% 78%
Q9LNW3 Arabidopsis thaliana 36% 67%
Q9LRZ4 Arabidopsis thaliana 30% 85%
Q9LUU7 Arabidopsis thaliana 29% 71%
Q9M1V8 Arabidopsis thaliana 26% 70%
Q9M9C6 Arabidopsis thaliana 27% 68%
Q9M9W9 Arabidopsis thaliana 31% 83%
Q9S9Z7 Arabidopsis thaliana 29% 100%
Q9SD02 Arabidopsis thaliana 33% 83%
Q9SD12 Arabidopsis thaliana 25% 79%
Q9SIU8 Arabidopsis thaliana 32% 100%
Q9SLA1 Arabidopsis thaliana 34% 76%
Q9SUF4 Arabidopsis thaliana 29% 100%
Q9SZ53 Arabidopsis thaliana 35% 83%
Q9WVR7 Rattus norvegicus 29% 66%
Q9XEE8 Arabidopsis thaliana 31% 76%
Q9XGZ9 Arabidopsis thaliana 30% 90%
Q9Z1Z6 Rattus norvegicus 30% 76%
Q9ZW21 Arabidopsis thaliana 32% 82%
V5AZJ4 Trypanosoma cruzi 41% 75%
V5BA03 Trypanosoma cruzi 55% 100%
V5BCX6 Trypanosoma cruzi 41% 99%
V5BH00 Trypanosoma cruzi 34% 84%
V5BSS7 Trypanosoma cruzi 33% 73%
V5DCR6 Trypanosoma cruzi 36% 72%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS