Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4ICS7_LEIIN

TriTrypDb:

LINF_360011300

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15

Expansion

Sequence features

A4ICS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	2
GO:0009987	cellular process	1	4
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.345
CLV_NRD_NRD_1	137	139	PF00675	0.551
CLV_NRD_NRD_1	2	4	PF00675	0.657
CLV_NRD_NRD_1	230	232	PF00675	0.260
CLV_NRD_NRD_1	375	377	PF00675	0.600
CLV_NRD_NRD_1	432	434	PF00675	0.500
CLV_PCSK_KEX2_1	137	139	PF00082	0.449
CLV_PCSK_KEX2_1	2	4	PF00082	0.647
CLV_PCSK_KEX2_1	230	232	PF00082	0.501
CLV_PCSK_KEX2_1	375	377	PF00082	0.591
CLV_PCSK_KEX2_1	388	390	PF00082	0.535
CLV_PCSK_KEX2_1	419	421	PF00082	0.304
CLV_PCSK_KEX2_1	431	433	PF00082	0.461
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.741
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.295
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.436
CLV_PCSK_SKI1_1	156	160	PF00082	0.387
CLV_PCSK_SKI1_1	175	179	PF00082	0.258
CLV_PCSK_SKI1_1	231	235	PF00082	0.359
CLV_PCSK_SKI1_1	295	299	PF00082	0.435
CLV_PCSK_SKI1_1	476	480	PF00082	0.468
CLV_PCSK_SKI1_1	486	490	PF00082	0.403
DEG_APCC_DBOX_1	406	414	PF00400	0.317
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DEG_SCF_FBW7_1	67	74	PF00400	0.540
DEG_SPOP_SBC_1	210	214	PF00917	0.525
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.495
DOC_MAPK_gen_1	322	331	PF00069	0.363
DOC_PP1_RVXF_1	154	161	PF00149	0.534
DOC_PP1_RVXF_1	474	480	PF00149	0.482
DOC_PP2B_LxvP_1	93	96	PF13499	0.460
DOC_PP4_FxxP_1	314	317	PF00568	0.378
DOC_USP7_MATH_1	105	109	PF00917	0.603
DOC_USP7_MATH_1	129	133	PF00917	0.700
DOC_USP7_MATH_1	211	215	PF00917	0.486
DOC_USP7_MATH_1	284	288	PF00917	0.414
DOC_USP7_MATH_1	299	303	PF00917	0.447
DOC_USP7_MATH_1	414	418	PF00917	0.440
DOC_USP7_MATH_1	465	469	PF00917	0.366
DOC_USP7_MATH_1	71	75	PF00917	0.626
DOC_USP7_MATH_1	81	85	PF00917	0.565
DOC_WW_Pin1_4	201	206	PF00397	0.506
DOC_WW_Pin1_4	312	317	PF00397	0.402
DOC_WW_Pin1_4	369	374	PF00397	0.471
DOC_WW_Pin1_4	461	466	PF00397	0.361
DOC_WW_Pin1_4	67	72	PF00397	0.704
LIG_14-3-3_CanoR_1	106	110	PF00244	0.673
LIG_14-3-3_CanoR_1	115	121	PF00244	0.627
LIG_14-3-3_CanoR_1	137	143	PF00244	0.530
LIG_14-3-3_CanoR_1	175	184	PF00244	0.569
LIG_14-3-3_CanoR_1	230	236	PF00244	0.420
LIG_14-3-3_CanoR_1	243	251	PF00244	0.543
LIG_14-3-3_CanoR_1	261	266	PF00244	0.445
LIG_14-3-3_CanoR_1	322	331	PF00244	0.396
LIG_14-3-3_CanoR_1	389	393	PF00244	0.639
LIG_14-3-3_CanoR_1	432	438	PF00244	0.503
LIG_14-3-3_CanoR_1	463	473	PF00244	0.534
LIG_14-3-3_CanoR_1	49	59	PF00244	0.694
LIG_BRCT_BRCA1_1	116	120	PF00533	0.685
LIG_BRCT_BRCA1_1	87	91	PF00533	0.528
LIG_FHA_1	216	222	PF00498	0.476
LIG_FHA_1	346	352	PF00498	0.407
LIG_FHA_1	354	360	PF00498	0.361
LIG_FHA_1	36	42	PF00498	0.689
LIG_FHA_2	211	217	PF00498	0.434
LIG_FHA_2	341	347	PF00498	0.482
LIG_FHA_2	379	385	PF00498	0.534
LIG_FHA_2	87	93	PF00498	0.399
LIG_LIR_Apic_2	312	317	PF02991	0.378
LIG_LIR_Nem_3	405	411	PF02991	0.477
LIG_SH2_STAT5	307	310	PF00017	0.451
LIG_SH2_STAT5	32	35	PF00017	0.512
LIG_SH2_STAT5	422	425	PF00017	0.433
LIG_SH2_STAT5	487	490	PF00017	0.347
LIG_SH3_5	28	32	PF00018	0.541
LIG_Sin3_3	155	162	PF02671	0.270
LIG_Sin3_3	408	415	PF02671	0.306
LIG_SUMO_SIM_anti_2	356	361	PF11976	0.392
LIG_SUMO_SIM_par_1	326	332	PF11976	0.394
LIG_SUMO_SIM_par_1	455	461	PF11976	0.368
LIG_TRAF2_1	343	346	PF00917	0.316
LIG_TRFH_1	142	146	PF08558	0.317
LIG_UBA3_1	220	228	PF00899	0.515
MOD_CDC14_SPxK_1	372	375	PF00782	0.466
MOD_CDK_SPxK_1	369	375	PF00069	0.452
MOD_CDK_SPxxK_3	369	376	PF00069	0.485
MOD_CK1_1	100	106	PF00069	0.506
MOD_CK1_1	116	122	PF00069	0.648
MOD_CK1_1	125	131	PF00069	0.580
MOD_CK1_1	169	175	PF00069	0.359
MOD_CK1_1	246	252	PF00069	0.454
MOD_CK1_1	383	389	PF00069	0.534
MOD_CK1_1	452	458	PF00069	0.565
MOD_CK1_1	461	467	PF00069	0.442
MOD_CK1_1	468	474	PF00069	0.373
MOD_CK1_1	55	61	PF00069	0.659
MOD_CK1_1	73	79	PF00069	0.578
MOD_CK2_1	244	250	PF00069	0.525
MOD_CK2_1	340	346	PF00069	0.393
MOD_CK2_1	378	384	PF00069	0.531
MOD_CK2_1	55	61	PF00069	0.654
MOD_CK2_1	63	69	PF00069	0.629
MOD_GlcNHglycan	127	130	PF01048	0.681
MOD_GlcNHglycan	246	249	PF01048	0.301
MOD_GlcNHglycan	265	268	PF01048	0.446
MOD_GlcNHglycan	301	304	PF01048	0.423
MOD_GlcNHglycan	325	328	PF01048	0.457
MOD_GlcNHglycan	433	436	PF01048	0.657
MOD_GlcNHglycan	451	454	PF01048	0.593
MOD_GlcNHglycan	470	473	PF01048	0.411
MOD_GlcNHglycan	52	55	PF01048	0.619
MOD_GlcNHglycan	79	82	PF01048	0.617
MOD_GSK3_1	123	130	PF00069	0.720
MOD_GSK3_1	201	208	PF00069	0.504
MOD_GSK3_1	211	218	PF00069	0.429
MOD_GSK3_1	242	249	PF00069	0.594
MOD_GSK3_1	261	268	PF00069	0.420
MOD_GSK3_1	284	291	PF00069	0.329
MOD_GSK3_1	31	38	PF00069	0.513
MOD_GSK3_1	323	330	PF00069	0.421
MOD_GSK3_1	378	385	PF00069	0.737
MOD_GSK3_1	452	459	PF00069	0.487
MOD_GSK3_1	461	468	PF00069	0.393
MOD_GSK3_1	63	70	PF00069	0.642
MOD_GSK3_1	71	78	PF00069	0.605
MOD_GSK3_1	81	88	PF00069	0.582
MOD_NEK2_1	168	173	PF00069	0.442
MOD_NEK2_1	209	214	PF00069	0.428
MOD_NEK2_1	244	249	PF00069	0.493
MOD_NEK2_1	288	293	PF00069	0.382
MOD_NEK2_1	396	401	PF00069	0.412
MOD_NEK2_1	403	408	PF00069	0.390
MOD_NEK2_1	426	431	PF00069	0.437
MOD_NEK2_1	442	447	PF00069	0.457
MOD_NEK2_1	458	463	PF00069	0.445
MOD_NEK2_1	479	484	PF00069	0.452
MOD_NEK2_1	63	68	PF00069	0.620
MOD_NEK2_1	75	80	PF00069	0.517
MOD_OFUCOSY	127	133	PF10250	0.492
MOD_PIKK_1	437	443	PF00454	0.530
MOD_PKA_1	388	394	PF00069	0.507
MOD_PKA_1	431	437	PF00069	0.476
MOD_PKA_2	105	111	PF00069	0.676
MOD_PKA_2	114	120	PF00069	0.624
MOD_PKA_2	229	235	PF00069	0.393
MOD_PKA_2	242	248	PF00069	0.525
MOD_PKA_2	388	394	PF00069	0.507
MOD_PKA_2	431	437	PF00069	0.502
MOD_Plk_1	205	211	PF00069	0.493
MOD_Plk_1	215	221	PF00069	0.454
MOD_Plk_1	345	351	PF00069	0.442
MOD_Plk_1	363	369	PF00069	0.540
MOD_Plk_1	383	389	PF00069	0.534
MOD_Plk_1	55	61	PF00069	0.653
MOD_Plk_4	105	111	PF00069	0.508
MOD_Plk_4	205	211	PF00069	0.530
MOD_Plk_4	345	351	PF00069	0.423
MOD_Plk_4	55	61	PF00069	0.676
MOD_ProDKin_1	201	207	PF00069	0.506
MOD_ProDKin_1	312	318	PF00069	0.404
MOD_ProDKin_1	369	375	PF00069	0.478
MOD_ProDKin_1	461	467	PF00069	0.358
MOD_ProDKin_1	67	73	PF00069	0.703
TRG_DiLeu_BaEn_1	187	192	PF01217	0.393
TRG_DiLeu_BaEn_1	345	350	PF01217	0.315
TRG_ER_diArg_1	1	3	PF00400	0.660
TRG_ER_diArg_1	137	139	PF00400	0.542
TRG_ER_diArg_1	374	376	PF00400	0.640
TRG_NLS_Bipartite_1	419	435	PF00514	0.374
TRG_NLS_MonoExtC_3	430	436	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	26%	69%
A0A0N1ILR3	Leptomonas seymouri	51%	88%
A0A0S4J2H1	Bodo saltans	30%	100%
A0A1X0NT03	Trypanosomatidae	26%	88%
A0A3Q8IDW5	Leishmania donovani	27%	70%
A0A3Q8IGX5	Leishmania donovani	99%	100%
A0A3R7NBP1	Trypanosoma rangeli	26%	91%
A4H8W6	Leishmania braziliensis	25%	70%
A4HX90	Leishmania infantum	27%	80%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	70%
E9ASH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEH1	Leishmania major	27%	74%