LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Sec14, cytosolic factor

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sec14, cytosolic factor
Gene product:
sec14, cytosolic factor
Species:
Leishmania infantum
UniProt:
A4ICS6_LEIIN
TriTrypDb:
LINF_360011400
Length:
426

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, transport Sec14, cytosolic factor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 389

Expansion

Sequence features

A4ICS6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 53 57 PF00656 0.421
CLV_MEL_PAP_1 98 104 PF00089 0.449
CLV_NRD_NRD_1 190 192 PF00675 0.383
CLV_NRD_NRD_1 305 307 PF00675 0.449
CLV_NRD_NRD_1 419 421 PF00675 0.689
CLV_NRD_NRD_1 75 77 PF00675 0.330
CLV_PCSK_FUR_1 219 223 PF00082 0.407
CLV_PCSK_KEX2_1 221 223 PF00082 0.311
CLV_PCSK_KEX2_1 419 421 PF00082 0.689
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.311
CLV_PCSK_PC1ET2_1 419 421 PF00082 0.689
CLV_PCSK_SKI1_1 105 109 PF00082 0.468
CLV_PCSK_SKI1_1 275 279 PF00082 0.340
CLV_PCSK_SKI1_1 79 83 PF00082 0.365
DEG_MDM2_SWIB_1 270 277 PF02201 0.336
DEG_SCF_FBW7_1 388 395 PF00400 0.661
DEG_SPOP_SBC_1 374 378 PF00917 0.721
DEG_SPOP_SBC_1 392 396 PF00917 0.562
DEG_SPOP_SBC_1 408 412 PF00917 0.772
DOC_MAPK_gen_1 191 197 PF00069 0.407
DOC_MAPK_gen_1 219 229 PF00069 0.307
DOC_MAPK_gen_1 76 83 PF00069 0.423
DOC_PP1_RVXF_1 132 139 PF00149 0.421
DOC_PP1_RVXF_1 285 292 PF00149 0.312
DOC_PP4_FxxP_1 291 294 PF00568 0.366
DOC_PP4_FxxP_1 380 383 PF00568 0.611
DOC_USP7_MATH_1 365 369 PF00917 0.675
DOC_USP7_MATH_1 392 396 PF00917 0.766
DOC_USP7_MATH_1 408 412 PF00917 0.556
DOC_USP7_MATH_1 58 62 PF00917 0.372
DOC_USP7_UBL2_3 41 45 PF12436 0.432
DOC_WW_Pin1_4 341 346 PF00397 0.574
DOC_WW_Pin1_4 35 40 PF00397 0.455
DOC_WW_Pin1_4 361 366 PF00397 0.654
DOC_WW_Pin1_4 388 393 PF00397 0.766
DOC_WW_Pin1_4 395 400 PF00397 0.721
LIG_14-3-3_CanoR_1 105 110 PF00244 0.468
LIG_14-3-3_CanoR_1 191 196 PF00244 0.361
LIG_APCC_ABBA_1 277 282 PF00400 0.293
LIG_BIR_II_1 1 5 PF00653 0.501
LIG_BRCT_BRCA1_1 386 390 PF00533 0.643
LIG_CtBP_PxDLS_1 255 259 PF00389 0.407
LIG_CtBP_PxDLS_1 345 349 PF00389 0.354
LIG_FHA_1 192 198 PF00498 0.407
LIG_FHA_1 376 382 PF00498 0.660
LIG_FHA_1 90 96 PF00498 0.478
LIG_FHA_2 106 112 PF00498 0.479
LIG_FHA_2 151 157 PF00498 0.473
LIG_FHA_2 164 170 PF00498 0.399
LIG_FHA_2 347 353 PF00498 0.452
LIG_FHA_2 5 11 PF00498 0.510
LIG_LIR_Apic_2 341 346 PF02991 0.570
LIG_LIR_Apic_2 377 383 PF02991 0.595
LIG_LIR_Gen_1 108 117 PF02991 0.357
LIG_LIR_Gen_1 126 136 PF02991 0.322
LIG_LIR_Nem_3 108 112 PF02991 0.375
LIG_LIR_Nem_3 126 132 PF02991 0.343
LIG_LIR_Nem_3 43 49 PF02991 0.340
LIG_PCNA_yPIPBox_3 116 129 PF02747 0.436
LIG_PCNA_yPIPBox_3 288 302 PF02747 0.423
LIG_Pex14_1 138 142 PF04695 0.360
LIG_Pex14_2 270 274 PF04695 0.293
LIG_SH2_CRK 193 197 PF00017 0.345
LIG_SH2_CRK 343 347 PF00017 0.576
LIG_SH2_NCK_1 343 347 PF00017 0.561
LIG_SH2_NCK_1 87 91 PF00017 0.484
LIG_SH2_SRC 87 90 PF00017 0.489
LIG_SH2_STAP1 168 172 PF00017 0.312
LIG_SH2_STAT3 149 152 PF00017 0.468
LIG_SH2_STAT5 149 152 PF00017 0.397
LIG_SH2_STAT5 162 165 PF00017 0.293
LIG_SH2_STAT5 174 177 PF00017 0.247
LIG_SH2_STAT5 193 196 PF00017 0.345
LIG_SH2_STAT5 70 73 PF00017 0.293
LIG_SH3_3 261 267 PF00018 0.294
LIG_SH3_3 396 402 PF00018 0.750
LIG_TRAF2_1 349 352 PF00917 0.469
LIG_TRAF2_1 398 401 PF00917 0.684
LIG_UBA3_1 301 307 PF00899 0.437
MOD_CDC14_SPxK_1 364 367 PF00782 0.719
MOD_CDC14_SPxK_1 38 41 PF00782 0.455
MOD_CDK_SPxK_1 35 41 PF00069 0.423
MOD_CDK_SPxK_1 361 367 PF00069 0.689
MOD_CK1_1 344 350 PF00069 0.549
MOD_CK1_1 395 401 PF00069 0.695
MOD_CK1_1 411 417 PF00069 0.725
MOD_CK1_1 61 67 PF00069 0.407
MOD_CK2_1 150 156 PF00069 0.383
MOD_CK2_1 346 352 PF00069 0.485
MOD_CK2_1 365 371 PF00069 0.651
MOD_CK2_1 395 401 PF00069 0.766
MOD_Cter_Amidation 416 419 PF01082 0.734
MOD_GlcNHglycan 405 408 PF01048 0.690
MOD_GlcNHglycan 415 418 PF01048 0.738
MOD_GSK3_1 213 220 PF00069 0.398
MOD_GSK3_1 361 368 PF00069 0.591
MOD_GSK3_1 384 391 PF00069 0.636
MOD_GSK3_1 403 410 PF00069 0.661
MOD_N-GLC_1 35 40 PF02516 0.190
MOD_N-GLC_1 353 358 PF02516 0.587
MOD_N-GLC_1 61 66 PF02516 0.423
MOD_N-GLC_2 290 292 PF02516 0.407
MOD_N-GLC_2 312 314 PF02516 0.391
MOD_N-GLC_2 66 68 PF02516 0.190
MOD_NEK2_1 1 6 PF00069 0.546
MOD_NEK2_1 213 218 PF00069 0.312
MOD_NEK2_1 235 240 PF00069 0.297
MOD_NEK2_1 242 247 PF00069 0.286
MOD_NEK2_1 353 358 PF00069 0.519
MOD_NEK2_2 23 28 PF00069 0.423
MOD_NEK2_2 365 370 PF00069 0.696
MOD_PIKK_1 353 359 PF00454 0.590
MOD_PKA_1 191 197 PF00069 0.407
MOD_PKA_2 213 219 PF00069 0.381
MOD_Plk_1 353 359 PF00069 0.367
MOD_ProDKin_1 341 347 PF00069 0.577
MOD_ProDKin_1 35 41 PF00069 0.455
MOD_ProDKin_1 361 367 PF00069 0.658
MOD_ProDKin_1 388 394 PF00069 0.767
MOD_ProDKin_1 395 401 PF00069 0.722
MOD_SUMO_rev_2 395 405 PF00179 0.763
MOD_SUMO_rev_2 9 13 PF00179 0.520
TRG_ENDOCYTIC_2 129 132 PF00928 0.375
TRG_ENDOCYTIC_2 87 90 PF00928 0.433
TRG_ER_diArg_1 138 141 PF00400 0.526
TRG_NLS_MonoCore_2 417 422 PF00514 0.683
TRG_NLS_MonoExtN_4 418 423 PF00514 0.681
TRG_NLS_MonoExtN_4 75 80 PF00514 0.345
TRG_Pf-PMV_PEXEL_1 367 371 PF00026 0.714

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF64 Leptomonas seymouri 69% 99%
A0A0S4J1X8 Bodo saltans 46% 100%
A0A1X0P8J0 Trypanosomatidae 47% 100%
A0A3R7LCT9 Trypanosoma rangeli 48% 100%
A0A3S5H815 Leishmania donovani 99% 100%
E9ASH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
P24859 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 25% 100%
V5BZX6 Trypanosoma cruzi 50% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS