Eukaryotic initiation factor 4E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E type 5 - putative

Species:

Leishmania infantum

UniProt:

A4ICS5_LEIIN

TriTrypDb:

LINF_360011500

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS5

PDB structure(s): 7kcj_A , 7kcj_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003723	RNA binding	4	21
GO:0003743	translation initiation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	195	199	PF00082	0.578
DEG_SPOP_SBC_1	199	203	PF00917	0.474
DOC_MAPK_gen_1	8	15	PF00069	0.440
DOC_PP1_RVXF_1	40	46	PF00149	0.488
DOC_PP2B_LxvP_1	97	100	PF13499	0.545
DOC_USP7_MATH_1	136	140	PF00917	0.537
DOC_USP7_MATH_1	175	179	PF00917	0.557
DOC_USP7_MATH_1	182	186	PF00917	0.461
DOC_USP7_MATH_1	189	193	PF00917	0.571
DOC_USP7_MATH_1	87	91	PF00917	0.547
DOC_WW_Pin1_4	202	207	PF00397	0.543
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_deltaCOP1_diTrp_1	9	15	PF00928	0.510
LIG_FHA_1	2	8	PF00498	0.472
LIG_FHA_1	38	44	PF00498	0.551
LIG_FHA_2	115	121	PF00498	0.443
LIG_FHA_2	45	51	PF00498	0.463
LIG_GBD_Chelix_1	161	169	PF00786	0.333
LIG_LIR_Gen_1	50	60	PF02991	0.478
LIG_LIR_Gen_1	9	19	PF02991	0.440
LIG_LIR_Nem_3	82	86	PF02991	0.458
LIG_LIR_Nem_3	9	15	PF02991	0.477
LIG_Pex14_1	11	15	PF04695	0.468
LIG_PTB_Apo_2	22	29	PF02174	0.440
LIG_PTB_Phospho_1	22	28	PF10480	0.440
LIG_SH2_NCK_1	179	183	PF00017	0.368
LIG_SH3_3	203	209	PF00018	0.699
LIG_TRAF2_1	35	38	PF00917	0.530
LIG_TRAF2_1	48	51	PF00917	0.423
LIG_UBA3_1	92	98	PF00899	0.512
LIG_WRC_WIRS_1	12	17	PF05994	0.440
LIG_WW_1	80	83	PF00397	0.546
MOD_CK1_1	153	159	PF00069	0.506
MOD_CK1_1	205	211	PF00069	0.570
MOD_CK2_1	114	120	PF00069	0.494
MOD_CK2_1	44	50	PF00069	0.455
MOD_GlcNHglycan	1	4	PF01048	0.597
MOD_GSK3_1	136	143	PF00069	0.546
MOD_GSK3_1	198	205	PF00069	0.718
MOD_GSK3_1	51	58	PF00069	0.493
MOD_N-GLC_1	87	92	PF02516	0.311
MOD_NEK2_1	1	6	PF00069	0.454
MOD_NEK2_1	114	119	PF00069	0.539
MOD_NEK2_1	152	157	PF00069	0.554
MOD_NEK2_1	198	203	PF00069	0.558
MOD_NEK2_1	52	57	PF00069	0.440
MOD_NEK2_1	67	72	PF00069	0.522
MOD_PIKK_1	37	43	PF00454	0.554
MOD_PKA_2	136	142	PF00069	0.475
MOD_Plk_1	182	188	PF00069	0.501
MOD_Plk_2-3	79	85	PF00069	0.545
MOD_Plk_4	11	17	PF00069	0.435
MOD_Plk_4	67	73	PF00069	0.442
MOD_ProDKin_1	202	208	PF00069	0.542
MOD_SUMO_rev_2	120	128	PF00179	0.547
MOD_SUMO_rev_2	192	198	PF00179	0.565
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E4	Leptomonas seymouri	33%	100%
A0A0N1ILF7	Leptomonas seymouri	81%	100%
A0A0S4IN32	Bodo saltans	31%	100%
A0A0S4IZ31	Bodo saltans	41%	100%
A0A1X0NSI0	Trypanosomatidae	35%	100%
A0A1X0P9L6	Trypanosomatidae	51%	100%
A0A3S7WZL5	Leishmania donovani	33%	100%
A0A3S7XAF1	Leishmania donovani	100%	100%
A0A422P286	Trypanosoma rangeli	47%	100%
A4HEN3	Leishmania braziliensis	32%	100%
A4HNR9	Leishmania braziliensis	95%	100%
A4I1W1	Leishmania infantum	33%	100%
C9ZS59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A2M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AY06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q217	Leishmania major	98%	100%
Q4Q9G7	Leishmania major	33%	100%
V5BZH5	Trypanosoma cruzi	34%	100%