Eukaryotic initiation factor 4E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E type 5 - putative

Species:

Leishmania infantum

UniProt:

A4ICS5_LEIIN

TriTrypDb:

LINF_360011500

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

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Expansion

Sequence features

A4ICS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS5

PDB structure(s): 7kcj_A , 7kcj_B

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2
GO:0003676	nucleic acid binding	3	21
GO:0003723	RNA binding	4	21
GO:0003743	translation initiation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	195	199	PF00082	0.578
DEG_SPOP_SBC_1	199	203	PF00917	0.474
DOC_MAPK_gen_1	8	15	PF00069	0.440
DOC_PP1_RVXF_1	40	46	PF00149	0.488
DOC_PP2B_LxvP_1	97	100	PF13499	0.545
DOC_USP7_MATH_1	136	140	PF00917	0.537
DOC_USP7_MATH_1	175	179	PF00917	0.557
DOC_USP7_MATH_1	182	186	PF00917	0.461
DOC_USP7_MATH_1	189	193	PF00917	0.571
DOC_USP7_MATH_1	87	91	PF00917	0.547

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E4	Leptomonas seymouri	33%	100%
A0A0N1ILF7	Leptomonas seymouri	81%	100%
A0A0S4IN32	Bodo saltans	31%	100%
A0A0S4IZ31	Bodo saltans	41%	100%
A0A1X0NSI0	Trypanosomatidae	35%	100%
A0A1X0P9L6	Trypanosomatidae	51%	100%
A0A3S7WZL5	Leishmania donovani	33%	100%
A0A3S7XAF1	Leishmania donovani	100%	100%
A0A422P286	Trypanosoma rangeli	47%	100%
A4HEN3	Leishmania braziliensis	32%	100%

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