Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial ATP synthase epsilon chain - putative

Species:

Leishmania infantum

UniProt:

A4ICS2_LEIIN

TriTrypDb:

LINF_360011800

Length:

265

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase subunit epsilon

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

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Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	3
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	3
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	3
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	3
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3
GO:0098800	inner mitochondrial membrane protein complex	3	3
GO:0110165	cellular anatomical entity	1	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005215	transporter activity	1	3
GO:0005216	monoatomic ion channel activity	4	3
GO:0005261	monoatomic cation channel activity	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015078	proton transmembrane transporter activity	5	3
GO:0015252	proton channel activity	6	3
GO:0015267	channel activity	4	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	114	120	PF00089	0.710
CLV_NRD_NRD_1	178	180	PF00675	0.658
CLV_NRD_NRD_1	195	197	PF00675	0.504
CLV_PCSK_FUR_1	145	149	PF00082	0.725
CLV_PCSK_KEX2_1	147	149	PF00082	0.726
CLV_PCSK_KEX2_1	178	180	PF00082	0.658
CLV_PCSK_KEX2_1	195	197	PF00082	0.519
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.726
CLV_PCSK_SKI1_1	165	169	PF00082	0.660
DEG_APCC_DBOX_1	185	193	PF00400	0.484

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAE3	Leishmania donovani	99%	100%

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