LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Mitochondrial ATP synthase epsilon chain - putative
Species:
Leishmania infantum
UniProt:
A4ICS2_LEIIN
TriTrypDb:
LINF_360011800 *
Length:
265

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase subunit epsilon

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) 4 3
GO:0016020 membrane 2 2
GO:0032991 protein-containing complex 1 3
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain 3 3
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) 4 3
GO:0098796 membrane protein complex 2 3
GO:0098798 mitochondrial protein-containing complex 2 3
GO:0098800 inner mitochondrial membrane protein complex 3 3
GO:0110165 cellular anatomical entity 1 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICS2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0005215 transporter activity 1 3
GO:0005216 monoatomic ion channel activity 4 3
GO:0005261 monoatomic cation channel activity 5 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015078 proton transmembrane transporter activity 5 3
GO:0015252 proton channel activity 6 3
GO:0015267 channel activity 4 3
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 3
GO:0016874 ligase activity 2 3
GO:0022803 passive transmembrane transporter activity 3 3
GO:0022857 transmembrane transporter activity 2 3
GO:0022890 inorganic cation transmembrane transporter activity 4 3
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 114 120 PF00089 0.710
CLV_NRD_NRD_1 178 180 PF00675 0.658
CLV_NRD_NRD_1 195 197 PF00675 0.504
CLV_PCSK_FUR_1 145 149 PF00082 0.725
CLV_PCSK_KEX2_1 147 149 PF00082 0.726
CLV_PCSK_KEX2_1 178 180 PF00082 0.658
CLV_PCSK_KEX2_1 195 197 PF00082 0.519
CLV_PCSK_PC1ET2_1 147 149 PF00082 0.726
CLV_PCSK_SKI1_1 165 169 PF00082 0.660
DEG_APCC_DBOX_1 185 193 PF00400 0.484
DEG_APCC_DBOX_1 194 202 PF00400 0.373
DEG_Nend_UBRbox_4 1 3 PF02207 0.661
DEG_SPOP_SBC_1 80 84 PF00917 0.509
DOC_CKS1_1 140 145 PF01111 0.415
DOC_CYCLIN_yCln2_LP_2 122 128 PF00134 0.506
DOC_MAPK_DCC_7 43 52 PF00069 0.482
DOC_MAPK_gen_1 195 201 PF00069 0.469
DOC_MAPK_HePTP_8 118 130 PF00069 0.506
DOC_MAPK_HePTP_8 40 52 PF00069 0.484
DOC_MAPK_JIP1_4 5 11 PF00069 0.544
DOC_MAPK_MEF2A_6 121 130 PF00069 0.507
DOC_MAPK_MEF2A_6 43 52 PF00069 0.482
DOC_PP1_RVXF_1 169 176 PF00149 0.445
DOC_PP2B_LxvP_1 122 125 PF13499 0.501
DOC_PP2B_LxvP_1 138 141 PF13499 0.357
DOC_PP2B_LxvP_1 55 58 PF13499 0.499
DOC_PP4_FxxP_1 236 239 PF00568 0.421
DOC_PP4_FxxP_1 66 69 PF00568 0.495
DOC_USP7_MATH_1 116 120 PF00917 0.357
DOC_USP7_MATH_1 151 155 PF00917 0.517
DOC_USP7_MATH_1 157 161 PF00917 0.439
DOC_USP7_MATH_1 70 74 PF00917 0.509
DOC_USP7_UBL2_3 228 232 PF12436 0.439
DOC_WW_Pin1_4 112 117 PF00397 0.453
DOC_WW_Pin1_4 12 17 PF00397 0.424
DOC_WW_Pin1_4 120 125 PF00397 0.483
DOC_WW_Pin1_4 136 141 PF00397 0.360
DOC_WW_Pin1_4 187 192 PF00397 0.480
DOC_WW_Pin1_4 81 86 PF00397 0.510
LIG_14-3-3_CanoR_1 117 125 PF00244 0.422
LIG_14-3-3_CanoR_1 145 155 PF00244 0.522
LIG_14-3-3_CanoR_1 156 164 PF00244 0.381
LIG_14-3-3_CanoR_1 178 183 PF00244 0.466
LIG_14-3-3_CanoR_1 195 199 PF00244 0.322
LIG_14-3-3_CanoR_1 235 239 PF00244 0.425
LIG_BRCT_BRCA1_1 29 33 PF00533 0.485
LIG_FHA_1 147 153 PF00498 0.524
LIG_FHA_1 216 222 PF00498 0.404
LIG_FHA_2 130 136 PF00498 0.512
LIG_LIR_Apic_2 234 239 PF02991 0.426
LIG_LIR_Apic_2 65 69 PF02991 0.499
LIG_LIR_Nem_3 109 114 PF02991 0.476
LIG_LIR_Nem_3 161 167 PF02991 0.469
LIG_LIR_Nem_3 209 213 PF02991 0.320
LIG_Pex14_2 168 172 PF04695 0.454
LIG_Pex14_2 49 53 PF04695 0.485
LIG_SH2_CRK 164 168 PF00017 0.462
LIG_SH2_CRK 45 49 PF00017 0.480
LIG_SH2_GRB2like 213 216 PF00017 0.405
LIG_SH2_GRB2like 88 91 PF00017 0.523
LIG_SH2_SRC 213 216 PF00017 0.405
LIG_SH2_STAP1 88 92 PF00017 0.535
LIG_SH2_STAT3 107 110 PF00017 0.504
LIG_SH2_STAT5 127 130 PF00017 0.512
LIG_SH2_STAT5 210 213 PF00017 0.317
LIG_SH2_STAT5 241 244 PF00017 0.437
LIG_SH3_2 140 145 PF14604 0.415
LIG_SH3_3 10 16 PF00018 0.424
LIG_SH3_3 134 140 PF00018 0.519
LIG_SH3_3 74 80 PF00018 0.468
LIG_SH3_3 98 104 PF00018 0.517
LIG_SUMO_SIM_par_1 5 10 PF11976 0.544
LIG_TRAF2_1 106 109 PF00917 0.505
LIG_TRAF2_1 251 254 PF00917 0.448
LIG_TYR_ITIM 211 216 PF00017 0.405
LIG_UBA3_1 52 56 PF00899 0.498
LIG_WRC_WIRS_1 8 13 PF05994 0.424
LIG_WW_1 124 127 PF00397 0.508
LIG_WW_3 142 146 PF00397 0.418
MOD_CDK_SPK_2 112 117 PF00069 0.363
MOD_CDK_SPxK_1 139 145 PF00069 0.417
MOD_CK1_1 12 18 PF00069 0.424
MOD_CK1_1 120 126 PF00069 0.504
MOD_CK1_1 139 145 PF00069 0.327
MOD_CK1_1 160 166 PF00069 0.474
MOD_CK1_1 234 240 PF00069 0.430
MOD_CK1_1 84 90 PF00069 0.515
MOD_GlcNHglycan 236 239 PF01048 0.550
MOD_GSK3_1 112 119 PF00069 0.510
MOD_GSK3_1 129 136 PF00069 0.341
MOD_GSK3_1 7 14 PF00069 0.424
MOD_GSK3_1 80 87 PF00069 0.447
MOD_LATS_1 176 182 PF00433 0.456
MOD_N-GLC_1 214 219 PF02516 0.604
MOD_N-GLC_1 245 250 PF02516 0.588
MOD_NEK2_1 194 199 PF00069 0.473
MOD_NEK2_1 7 12 PF00069 0.424
MOD_NEK2_2 151 156 PF00069 0.483
MOD_PK_1 178 184 PF00069 0.469
MOD_PKA_1 178 184 PF00069 0.469
MOD_PKA_2 116 122 PF00069 0.432
MOD_PKA_2 158 164 PF00069 0.486
MOD_PKA_2 178 184 PF00069 0.269
MOD_PKA_2 185 191 PF00069 0.417
MOD_PKA_2 194 200 PF00069 0.311
MOD_PKA_2 234 240 PF00069 0.430
MOD_PKA_2 93 99 PF00069 0.442
MOD_Plk_4 133 139 PF00069 0.519
MOD_Plk_4 178 184 PF00069 0.459
MOD_ProDKin_1 112 118 PF00069 0.452
MOD_ProDKin_1 12 18 PF00069 0.424
MOD_ProDKin_1 120 126 PF00069 0.484
MOD_ProDKin_1 136 142 PF00069 0.360
MOD_ProDKin_1 187 193 PF00069 0.478
MOD_ProDKin_1 81 87 PF00069 0.509
MOD_SUMO_rev_2 248 258 PF00179 0.456
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.710
TRG_ENDOCYTIC_2 127 130 PF00928 0.512
TRG_ENDOCYTIC_2 164 167 PF00928 0.464
TRG_ENDOCYTIC_2 213 216 PF00928 0.405
TRG_ENDOCYTIC_2 233 236 PF00928 0.433
TRG_ENDOCYTIC_2 241 244 PF00928 0.357
TRG_ER_diArg_1 168 171 PF00400 0.459
TRG_ER_diArg_1 177 179 PF00400 0.364
TRG_ER_diArg_1 194 196 PF00400 0.307
TRG_NES_CRM1_1 206 219 PF08389 0.406

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7XAE3 Leishmania donovani 99% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS