Ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease

Gene product:

ribonuclease H - putative

Species:

Leishmania infantum

UniProt:

A4ICS0_LEIIN

TriTrypDb:

LINF_360012000

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032299	ribonuclease H2 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4ICS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICS0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043137	DNA replication, removal of RNA primer	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0004521	RNA endonuclease activity	5	11
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	11
GO:0004540	RNA nuclease activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	295	297	PF00675	0.499
CLV_NRD_NRD_1	92	94	PF00675	0.249
CLV_PCSK_KEX2_1	20	22	PF00082	0.640
CLV_PCSK_KEX2_1	297	299	PF00082	0.544
CLV_PCSK_KEX2_1	91	93	PF00082	0.276
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.629
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.656
CLV_PCSK_SKI1_1	101	105	PF00082	0.267
CLV_PCSK_SKI1_1	107	111	PF00082	0.266
CLV_PCSK_SKI1_1	120	124	PF00082	0.238
DEG_APCC_DBOX_1	90	98	PF00400	0.559
DOC_ANK_TNKS_1	53	60	PF00023	0.508
DOC_MAPK_FxFP_2	237	240	PF00069	0.408
DOC_MAPK_gen_1	104	113	PF00069	0.486
DOC_MAPK_gen_1	20	29	PF00069	0.537
DOC_MAPK_gen_1	247	256	PF00069	0.329
DOC_MAPK_MEF2A_6	174	182	PF00069	0.456
DOC_MAPK_MEF2A_6	247	256	PF00069	0.434
DOC_MAPK_RevD_3	77	92	PF00069	0.476
DOC_PP1_RVXF_1	286	292	PF00149	0.602
DOC_PP4_FxxP_1	237	240	PF00568	0.361
DOC_PP4_FxxP_1	291	294	PF00568	0.581
DOC_SPAK_OSR1_1	235	239	PF12202	0.369
DOC_USP7_MATH_1	10	14	PF00917	0.681
DOC_USP7_MATH_1	191	195	PF00917	0.464
DOC_USP7_MATH_1	22	26	PF00917	0.627
DOC_USP7_UBL2_3	293	297	PF12436	0.681
DOC_WW_Pin1_4	1	6	PF00397	0.728
DOC_WW_Pin1_4	111	116	PF00397	0.437
LIG_14-3-3_CanoR_1	101	107	PF00244	0.461
LIG_14-3-3_CanoR_1	128	134	PF00244	0.503
LIG_14-3-3_CanoR_1	179	183	PF00244	0.444
LIG_14-3-3_CanoR_1	228	237	PF00244	0.524
LIG_14-3-3_CanoR_1	309	315	PF00244	0.485
LIG_14-3-3_CanoR_1	92	98	PF00244	0.498
LIG_DLG_GKlike_1	93	100	PF00625	0.536
LIG_EH1_1	28	36	PF00400	0.558
LIG_FHA_1	108	114	PF00498	0.460
LIG_FHA_1	301	307	PF00498	0.475
LIG_FHA_1	310	316	PF00498	0.443
LIG_FHA_1	62	68	PF00498	0.519
LIG_FHA_2	164	170	PF00498	0.406
LIG_FHA_2	200	206	PF00498	0.536
LIG_FHA_2	85	91	PF00498	0.406
LIG_LIR_Apic_2	290	294	PF02991	0.581
LIG_LIR_Gen_1	41	52	PF02991	0.437
LIG_LIR_Nem_3	105	109	PF02991	0.456
LIG_LIR_Nem_3	187	193	PF02991	0.528
LIG_LIR_Nem_3	41	47	PF02991	0.449
LIG_SH2_CRK	243	247	PF00017	0.462
LIG_SH2_STAP1	302	306	PF00017	0.507
LIG_SH2_STAT5	157	160	PF00017	0.456
LIG_SH2_STAT5	302	305	PF00017	0.513
LIG_SH2_STAT5	44	47	PF00017	0.428
LIG_SH2_STAT5	63	66	PF00017	0.448
LIG_SH3_3	217	223	PF00018	0.446
LIG_SH3_3	259	265	PF00018	0.437
LIG_SH3_3	54	60	PF00018	0.470
LIG_SH3_4	293	300	PF00018	0.667
LIG_SUMO_SIM_par_1	66	72	PF11976	0.456
LIG_TRAF2_1	114	117	PF00917	0.536
LIG_TRAF2_1	166	169	PF00917	0.406
LIG_Vh1_VBS_1	192	210	PF01044	0.337
LIG_WRC_WIRS_1	103	108	PF05994	0.309
LIG_WW_3	293	297	PF00397	0.528
MOD_CK1_1	134	140	PF00069	0.309
MOD_CK1_1	143	149	PF00069	0.309
MOD_CK1_1	194	200	PF00069	0.421
MOD_CK1_1	6	12	PF00069	0.620
MOD_CK2_1	111	117	PF00069	0.309
MOD_CK2_1	163	169	PF00069	0.240
MOD_CK2_1	203	209	PF00069	0.290
MOD_CK2_1	22	28	PF00069	0.546
MOD_CK2_1	310	316	PF00069	0.490
MOD_CK2_1	66	72	PF00069	0.421
MOD_CK2_1	84	90	PF00069	0.240
MOD_GlcNHglycan	125	128	PF01048	0.415
MOD_GlcNHglycan	148	151	PF01048	0.382
MOD_GlcNHglycan	16	19	PF01048	0.589
MOD_GlcNHglycan	193	196	PF01048	0.396
MOD_GlcNHglycan	8	11	PF01048	0.649
MOD_GSK3_1	107	114	PF00069	0.309
MOD_GSK3_1	116	123	PF00069	0.306
MOD_GSK3_1	199	206	PF00069	0.373
MOD_GSK3_1	214	221	PF00069	0.203
MOD_GSK3_1	34	41	PF00069	0.388
MOD_GSK3_1	6	13	PF00069	0.618
MOD_NEK2_1	102	107	PF00069	0.240
MOD_NEK2_1	178	183	PF00069	0.309
MOD_PIKK_1	185	191	PF00454	0.240
MOD_PKA_2	10	16	PF00069	0.668
MOD_PKA_2	178	184	PF00069	0.315
MOD_PKA_2	203	209	PF00069	0.317
MOD_PKA_2	22	28	PF00069	0.560
MOD_PKA_2	246	252	PF00069	0.388
MOD_PKA_2	53	59	PF00069	0.460
MOD_PKB_1	91	99	PF00069	0.421
MOD_Plk_2-3	222	228	PF00069	0.337
MOD_Plk_2-3	84	90	PF00069	0.240
MOD_Plk_4	194	200	PF00069	0.296
MOD_Plk_4	22	28	PF00069	0.685
MOD_Plk_4	310	316	PF00069	0.547
MOD_Plk_4	53	59	PF00069	0.422
MOD_ProDKin_1	1	7	PF00069	0.730
MOD_ProDKin_1	111	117	PF00069	0.282
TRG_DiLeu_BaEn_1	72	77	PF01217	0.309
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.162
TRG_ENDOCYTIC_2	243	246	PF00928	0.435
TRG_ENDOCYTIC_2	302	305	PF00928	0.513
TRG_ENDOCYTIC_2	44	47	PF00928	0.428
TRG_ER_diArg_1	295	298	PF00400	0.486
TRG_ER_diArg_1	91	93	PF00400	0.420
TRG_NLS_MonoExtC_3	295	300	PF00514	0.476
TRG_NLS_MonoExtN_4	293	300	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W5	Leptomonas seymouri	76%	99%
A0A1X0P866	Trypanosomatidae	56%	96%
A0A3R7RS79	Trypanosoma rangeli	59%	98%
A0A3S7XAC0	Leishmania donovani	98%	100%
A0B796	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	33%	100%
A2BL34	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	36%	100%
A4FWE5	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	29%	100%
A4HNS4	Leishmania braziliensis	82%	100%
A6VGW0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	28%	100%
A9A9T9	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	28%	100%
D0A2N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	97%
E9ASI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
O75792	Homo sapiens	41%	100%
P53942	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q10236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	97%
Q2TBT5	Bos taurus	43%	100%
Q468N6	Methanosarcina barkeri (strain Fusaro / DSM 804)	29%	100%
Q54D13	Dictyostelium discoideum	31%	100%
Q5U209	Rattus norvegicus	43%	100%
Q6LXH7	Methanococcus maripaludis (strain S2 / LL)	26%	100%
Q8ISS8	Leishmania major	88%	100%
Q8U036	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	100%
Q9CWY8	Mus musculus	43%	100%
Q9SEZ6	Arabidopsis thaliana	39%	100%
Q9U6P6	Caenorhabditis elegans	37%	100%
Q9VPP5	Drosophila melanogaster	38%	91%
Q9YET5	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	31%	100%
V5BQG7	Trypanosoma cruzi	58%	98%