LeishMANIAdb
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Putative GPI transamidase component Tta2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GPI transamidase component Tta2
Gene product:
GPI transamidase component Tta2 - putative
Species:
Leishmania infantum
UniProt:
A4ICR9_LEIIN
TriTrypDb:
LINF_360012100
Length:
494

Annotations

Annotations by Jardim et al.

GPI anchor biosynthesis, GPI transamidase component Tta2 TTA2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005635 nuclear envelope 4 1
GO:0005783 endoplasmic reticulum 5 1
GO:0008303 caspase complex 5 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0032991 protein-containing complex 1 1
GO:0042765 GPI-anchor transamidase complex 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 9
GO:0140534 endoplasmic reticulum protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1905368 peptidase complex 3 1
GO:1905369 endopeptidase complex 4 1
GO:0016020 membrane 2 8

Expansion

Sequence features

A4ICR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICR9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0003923 GPI-anchor transamidase activity 6 1
GO:0004175 endopeptidase activity 4 1
GO:0004197 cysteine-type endopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008234 cysteine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.585
CLV_NRD_NRD_1 214 216 PF00675 0.363
CLV_PCSK_KEX2_1 214 216 PF00082 0.361
CLV_PCSK_SKI1_1 21 25 PF00082 0.325
CLV_PCSK_SKI1_1 214 218 PF00082 0.454
CLV_PCSK_SKI1_1 253 257 PF00082 0.521
CLV_PCSK_SKI1_1 351 355 PF00082 0.308
CLV_PCSK_SKI1_1 37 41 PF00082 0.262
CLV_PCSK_SKI1_1 391 395 PF00082 0.442
CLV_PCSK_SKI1_1 399 403 PF00082 0.404
CLV_PCSK_SKI1_1 91 95 PF00082 0.708
DEG_APCC_DBOX_1 350 358 PF00400 0.536
DEG_APCC_DBOX_1 36 44 PF00400 0.266
DEG_MDM2_SWIB_1 457 465 PF02201 0.447
DEG_ODPH_VHL_1 244 256 PF01847 0.441
DEG_ODPH_VHL_1 317 329 PF01847 0.599
DEG_SPOP_SBC_1 337 341 PF00917 0.662
DOC_CDC14_PxL_1 315 323 PF14671 0.590
DOC_CKS1_1 92 97 PF01111 0.467
DOC_CYCLIN_RxL_1 296 305 PF00134 0.674
DOC_CYCLIN_yCln2_LP_2 23 29 PF00134 0.331
DOC_CYCLIN_yCln2_LP_2 321 327 PF00134 0.573
DOC_CYCLIN_yCln2_LP_2 369 375 PF00134 0.642
DOC_CYCLIN_yCln2_LP_2 411 417 PF00134 0.373
DOC_MAPK_DCC_7 408 417 PF00069 0.562
DOC_MAPK_DCC_7 91 100 PF00069 0.519
DOC_MAPK_gen_1 408 417 PF00069 0.538
DOC_MAPK_MEF2A_6 21 30 PF00069 0.501
DOC_MAPK_MEF2A_6 408 417 PF00069 0.517
DOC_MAPK_MEF2A_6 91 100 PF00069 0.519
DOC_MAPK_RevD_3 200 215 PF00069 0.442
DOC_PP1_RVXF_1 251 257 PF00149 0.330
DOC_PP2B_LxvP_1 243 246 PF13499 0.501
DOC_PP2B_LxvP_1 286 289 PF13499 0.660
DOC_PP2B_LxvP_1 301 304 PF13499 0.549
DOC_PP2B_LxvP_1 321 324 PF13499 0.400
DOC_PP2B_LxvP_1 369 372 PF13499 0.588
DOC_PP2B_LxvP_1 411 414 PF13499 0.373
DOC_USP7_MATH_1 165 169 PF00917 0.491
DOC_USP7_MATH_1 337 341 PF00917 0.646
DOC_USP7_MATH_1 387 391 PF00917 0.620
DOC_USP7_MATH_1 57 61 PF00917 0.465
DOC_USP7_MATH_1 80 84 PF00917 0.502
DOC_WW_Pin1_4 401 406 PF00397 0.664
DOC_WW_Pin1_4 50 55 PF00397 0.508
DOC_WW_Pin1_4 91 96 PF00397 0.464
LIG_14-3-3_CanoR_1 169 178 PF00244 0.562
LIG_14-3-3_CanoR_1 214 222 PF00244 0.600
LIG_14-3-3_CanoR_1 282 287 PF00244 0.617
LIG_14-3-3_CanoR_1 335 344 PF00244 0.677
LIG_14-3-3_CanoR_1 366 372 PF00244 0.616
LIG_14-3-3_CanoR_1 399 404 PF00244 0.625
LIG_14-3-3_CanoR_1 44 48 PF00244 0.442
LIG_AP_GAE_1 120 126 PF02883 0.429
LIG_BIR_II_1 1 5 PF00653 0.648
LIG_BIR_III_3 1 5 PF00653 0.648
LIG_BRCT_BRCA1_1 279 283 PF00533 0.674
LIG_BRCT_BRCA1_1 361 365 PF00533 0.568
LIG_EH_1 24 28 PF12763 0.305
LIG_EH1_1 255 263 PF00400 0.266
LIG_eIF4E_1 406 412 PF01652 0.562
LIG_EVH1_2 96 100 PF00568 0.482
LIG_FHA_1 150 156 PF00498 0.374
LIG_FHA_1 161 167 PF00498 0.473
LIG_FHA_1 204 210 PF00498 0.355
LIG_FHA_1 221 227 PF00498 0.496
LIG_FHA_1 390 396 PF00498 0.652
LIG_FHA_1 461 467 PF00498 0.436
LIG_FHA_2 109 115 PF00498 0.353
LIG_FHA_2 15 21 PF00498 0.695
LIG_FHA_2 190 196 PF00498 0.539
LIG_FHA_2 392 398 PF00498 0.669
LIG_HP1_1 240 244 PF01393 0.441
LIG_LIR_Apic_2 285 290 PF02991 0.622
LIG_LIR_Gen_1 120 131 PF02991 0.461
LIG_LIR_Gen_1 198 207 PF02991 0.463
LIG_LIR_Gen_1 234 244 PF02991 0.381
LIG_LIR_Gen_1 280 290 PF02991 0.699
LIG_LIR_Gen_1 370 381 PF02991 0.593
LIG_LIR_Gen_1 404 414 PF02991 0.490
LIG_LIR_Nem_3 110 115 PF02991 0.417
LIG_LIR_Nem_3 120 126 PF02991 0.428
LIG_LIR_Nem_3 198 203 PF02991 0.461
LIG_LIR_Nem_3 234 239 PF02991 0.377
LIG_LIR_Nem_3 280 286 PF02991 0.667
LIG_LIR_Nem_3 370 376 PF02991 0.581
LIG_LIR_Nem_3 402 406 PF02991 0.595
LIG_LIR_Nem_3 455 460 PF02991 0.363
LIG_Pex14_1 137 141 PF04695 0.440
LIG_Pex14_2 30 34 PF04695 0.447
LIG_Pex14_2 428 432 PF04695 0.512
LIG_Pex14_2 457 461 PF04695 0.335
LIG_RPA_C_Fungi 164 176 PF08784 0.457
LIG_SH2_CRK 269 273 PF00017 0.480
LIG_SH2_CRK 373 377 PF00017 0.486
LIG_SH2_CRK 382 386 PF00017 0.489
LIG_SH2_CRK 406 410 PF00017 0.547
LIG_SH2_NCK_1 287 291 PF00017 0.525
LIG_SH2_SRC 273 276 PF00017 0.532
LIG_SH2_SRC 287 290 PF00017 0.589
LIG_SH2_STAP1 179 183 PF00017 0.389
LIG_SH2_STAP1 269 273 PF00017 0.414
LIG_SH2_STAP1 275 279 PF00017 0.490
LIG_SH2_STAP1 462 466 PF00017 0.519
LIG_SH2_STAT3 129 132 PF00017 0.591
LIG_SH2_STAT3 297 300 PF00017 0.609
LIG_SH2_STAT3 333 336 PF00017 0.579
LIG_SH2_STAT5 130 133 PF00017 0.462
LIG_SH2_STAT5 138 141 PF00017 0.437
LIG_SH2_STAT5 222 225 PF00017 0.308
LIG_SH2_STAT5 273 276 PF00017 0.434
LIG_SH2_STAT5 297 300 PF00017 0.497
LIG_SH2_STAT5 333 336 PF00017 0.546
LIG_SH2_STAT5 373 376 PF00017 0.489
LIG_SH2_STAT5 462 465 PF00017 0.509
LIG_SH2_STAT5 50 53 PF00017 0.685
LIG_SH2_STAT5 81 84 PF00017 0.690
LIG_SH3_3 10 16 PF00018 0.581
LIG_SH3_3 180 186 PF00018 0.335
LIG_SH3_3 324 330 PF00018 0.475
LIG_SH3_3 51 57 PF00018 0.634
LIG_SH3_3 90 96 PF00018 0.625
LIG_SUMO_SIM_anti_2 201 206 PF11976 0.434
LIG_SUMO_SIM_anti_2 359 365 PF11976 0.483
LIG_SUMO_SIM_par_1 185 196 PF11976 0.487
LIG_SUMO_SIM_par_1 201 206 PF11976 0.237
LIG_SUMO_SIM_par_1 390 397 PF11976 0.545
LIG_TRFH_1 182 186 PF08558 0.355
LIG_TYR_ITIM 371 376 PF00017 0.496
LIG_TYR_ITIM 460 465 PF00017 0.473
LIG_WRC_WIRS_1 197 202 PF05994 0.480
LIG_WRC_WIRS_1 303 308 PF05994 0.573
LIG_WRC_WIRS_1 31 36 PF05994 0.408
MOD_CDK_SPxxK_3 401 408 PF00069 0.603
MOD_CK1_1 168 174 PF00069 0.511
MOD_CK1_1 196 202 PF00069 0.480
MOD_CK2_1 102 108 PF00069 0.397
MOD_CK2_1 14 20 PF00069 0.649
MOD_CK2_1 189 195 PF00069 0.544
MOD_CK2_1 84 90 PF00069 0.672
MOD_GlcNHglycan 120 123 PF01048 0.518
MOD_GlcNHglycan 156 159 PF01048 0.429
MOD_GlcNHglycan 17 20 PF01048 0.423
MOD_GlcNHglycan 171 174 PF01048 0.237
MOD_GlcNHglycan 217 220 PF01048 0.511
MOD_GlcNHglycan 483 486 PF01048 0.671
MOD_GlcNHglycan 78 81 PF01048 0.641
MOD_GlcNHglycan 82 85 PF01048 0.666
MOD_GSK3_1 165 172 PF00069 0.390
MOD_GSK3_1 189 196 PF00069 0.530
MOD_GSK3_1 273 280 PF00069 0.454
MOD_GSK3_1 387 394 PF00069 0.495
MOD_GSK3_1 39 46 PF00069 0.587
MOD_GSK3_1 76 83 PF00069 0.679
MOD_GSK3_1 98 105 PF00069 0.499
MOD_NEK2_1 100 105 PF00069 0.507
MOD_NEK2_1 107 112 PF00069 0.436
MOD_NEK2_1 154 159 PF00069 0.448
MOD_NEK2_1 188 193 PF00069 0.408
MOD_NEK2_1 203 208 PF00069 0.233
MOD_NEK2_1 220 225 PF00069 0.355
MOD_NEK2_1 30 35 PF00069 0.447
MOD_NEK2_1 338 343 PF00069 0.651
MOD_NEK2_1 381 386 PF00069 0.395
MOD_NEK2_1 424 429 PF00069 0.366
MOD_NEK2_1 434 439 PF00069 0.529
MOD_NEK2_1 488 493 PF00069 0.747
MOD_NEK2_2 39 44 PF00069 0.482
MOD_PIKK_1 246 252 PF00454 0.498
MOD_PIKK_1 84 90 PF00454 0.643
MOD_PKA_2 118 124 PF00069 0.518
MOD_PKA_2 168 174 PF00069 0.511
MOD_PKA_2 43 49 PF00069 0.580
MOD_PKA_2 434 440 PF00069 0.614
MOD_Plk_1 107 113 PF00069 0.562
MOD_Plk_1 424 430 PF00069 0.480
MOD_Plk_2-3 108 114 PF00069 0.533
MOD_Plk_4 282 288 PF00069 0.499
MOD_Plk_4 329 335 PF00069 0.453
MOD_Plk_4 359 365 PF00069 0.459
MOD_Plk_4 424 430 PF00069 0.408
MOD_ProDKin_1 401 407 PF00069 0.598
MOD_ProDKin_1 50 56 PF00069 0.651
MOD_ProDKin_1 91 97 PF00069 0.595
TRG_DiLeu_BaLyEn_6 18 23 PF01217 0.596
TRG_DiLeu_BaLyEn_6 407 412 PF01217 0.480
TRG_ENDOCYTIC_2 138 141 PF00928 0.479
TRG_ENDOCYTIC_2 179 182 PF00928 0.408
TRG_ENDOCYTIC_2 269 272 PF00928 0.456
TRG_ENDOCYTIC_2 373 376 PF00928 0.415
TRG_ENDOCYTIC_2 382 385 PF00928 0.328
TRG_ENDOCYTIC_2 406 409 PF00928 0.502
TRG_ENDOCYTIC_2 462 465 PF00928 0.486
TRG_ER_diArg_1 407 410 PF00400 0.593

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Y0 Leptomonas seymouri 63% 96%
A0A1X0P8I4 Trypanosomatidae 38% 100%
A0A3Q8IIQ8 Leishmania donovani 100% 100%
A0A422P255 Trypanosoma rangeli 37% 100%
A4HNS5 Leishmania braziliensis 80% 100%
D0A2N5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9ASI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q211 Leishmania major 93% 100%
V5BZX2 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS