Enriched in surface-labeled proteome protein 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 18

Species:

Leishmania infantum

UniProt:

A4ICR8_LEIIN

TriTrypDb:

LINF_360012200

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 3
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0009986	cell surface	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.387
CLV_NRD_NRD_1	104	106	PF00675	0.606
CLV_PCSK_KEX2_1	104	106	PF00082	0.599
CLV_PCSK_SKI1_1	104	108	PF00082	0.621
CLV_PCSK_SKI1_1	94	98	PF00082	0.529
DEG_APCC_DBOX_1	144	152	PF00400	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.506
DEG_SPOP_SBC_1	50	54	PF00917	0.516
DOC_CDC14_PxL_1	148	156	PF14671	0.397
DOC_MAPK_MEF2A_6	149	156	PF00069	0.401
DOC_PP2B_LxvP_1	154	157	PF13499	0.400
DOC_WW_Pin1_4	34	39	PF00397	0.515
DOC_WW_Pin1_4	53	58	PF00397	0.502
DOC_WW_Pin1_4	80	85	PF00397	0.412
LIG_14-3-3_CanoR_1	104	114	PF00244	0.433
LIG_14-3-3_CanoR_1	3	7	PF00244	0.501
LIG_eIF4E_1	166	172	PF01652	0.349
LIG_FHA_1	105	111	PF00498	0.437
LIG_FHA_1	45	51	PF00498	0.583
LIG_GBD_Chelix_1	15	23	PF00786	0.418
LIG_LIR_Gen_1	108	119	PF02991	0.395
LIG_LIR_Gen_1	163	172	PF02991	0.387
LIG_LIR_Nem_3	108	114	PF02991	0.413
LIG_LIR_Nem_3	163	169	PF02991	0.314
LIG_LIR_Nem_3	5	9	PF02991	0.347
LIG_NBox_RRM_1	10	20	PF00076	0.365
LIG_Pex14_2	6	10	PF04695	0.351
LIG_SH2_STAT5	76	79	PF00017	0.392
LIG_SH3_2	81	86	PF14604	0.415
LIG_SH3_3	56	62	PF00018	0.436
LIG_SH3_3	78	84	PF00018	0.420
LIG_SUMO_SIM_par_1	61	67	PF11976	0.402
LIG_TRAF2_1	64	67	PF00917	0.459
MOD_CDC14_SPxK_1	83	86	PF00782	0.400
MOD_CDK_SPxK_1	80	86	PF00069	0.413
MOD_CK1_1	24	30	PF00069	0.666
MOD_CK2_1	61	67	PF00069	0.424
MOD_CK2_1	95	101	PF00069	0.430
MOD_GlcNHglycan	107	110	PF01048	0.629
MOD_GlcNHglycan	162	165	PF01048	0.579
MOD_GlcNHglycan	23	26	PF01048	0.421
MOD_GlcNHglycan	38	41	PF01048	0.591
MOD_GSK3_1	105	112	PF00069	0.392
MOD_GSK3_1	24	31	PF00069	0.631
MOD_GSK3_1	44	51	PF00069	0.370
MOD_N-GLC_1	43	48	PF02516	0.754
MOD_NEK2_1	21	26	PF00069	0.367
MOD_NEK2_1	28	33	PF00069	0.435
MOD_NEK2_2	165	170	PF00069	0.375
MOD_PIKK_1	44	50	PF00454	0.436
MOD_PKA_1	104	110	PF00069	0.437
MOD_PKA_2	104	110	PF00069	0.449
MOD_PKA_2	2	8	PF00069	0.414
MOD_Plk_4	114	120	PF00069	0.328
MOD_ProDKin_1	34	40	PF00069	0.515
MOD_ProDKin_1	53	59	PF00069	0.496
MOD_ProDKin_1	80	86	PF00069	0.413
MOD_SUMO_rev_2	67	75	PF00179	0.366
TRG_DiLeu_BaEn_1	167	172	PF01217	0.394
TRG_DiLeu_BaEn_4	101	107	PF01217	0.328
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.433
TRG_ENDOCYTIC_2	111	114	PF00928	0.433
TRG_ENDOCYTIC_2	166	169	PF00928	0.309
TRG_ER_diArg_1	103	105	PF00400	0.419
TRG_ER_diArg_1	184	187	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L4	Leptomonas seymouri	49%	92%
A0A1X0P888	Trypanosomatidae	28%	99%
A0A3R7NU99	Trypanosoma rangeli	30%	100%
A0A3S7XAF9	Leishmania donovani	96%	96%
A4HNS6	Leishmania braziliensis	74%	100%
D0A2N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q210	Leishmania major	87%	100%