EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UAA transporter family/EamA-like transporter family - putative

Species:

Leishmania infantum

UniProt:

A4ICR7_LEIIN

TriTrypDb:

LINF_360012300

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4ICR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICR7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0008643	carbohydrate transport	5	1
GO:0009987	cellular process	1	4
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	4
GO:0071702	organic substance transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	4
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	4
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.274
CLV_NRD_NRD_1	432	434	PF00675	0.354
CLV_NRD_NRD_1	99	101	PF00675	0.420
CLV_PCSK_SKI1_1	100	104	PF00082	0.413
CLV_PCSK_SKI1_1	368	372	PF00082	0.283
DOC_CDC14_PxL_1	243	251	PF14671	0.475
DOC_MAPK_DCC_7	242	251	PF00069	0.461
DOC_MAPK_gen_1	433	442	PF00069	0.552
DOC_MAPK_MEF2A_6	242	251	PF00069	0.461
DOC_MAPK_MEF2A_6	332	339	PF00069	0.384

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC3	Leptomonas seymouri	59%	99%
A0A0S4JLV3	Bodo saltans	32%	100%
A0A0S4JVX5	Bodo saltans	32%	100%
A0A1X0P938	Trypanosomatidae	48%	100%
A0A3Q8INC1	Leishmania donovani	100%	100%
A0A3R7N2L5	Trypanosoma rangeli	48%	100%
A4HNS7	Leishmania braziliensis	74%	100%
E9ASI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q209	Leishmania major	93%	100%
Q5RFT1	Pongo abelii	30%	100%

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