EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UAA transporter family/EamA-like transporter family - putative

Species:

Leishmania infantum

UniProt:

A4ICR7_LEIIN

TriTrypDb:

LINF_360012300

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000139	Golgi membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A4ICR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICR7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0009987	cellular process	1	4
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	4
GO:0008643	carbohydrate transport	5	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	4
GO:0022857	transmembrane transporter activity	2	4
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.274
CLV_NRD_NRD_1	432	434	PF00675	0.354
CLV_NRD_NRD_1	99	101	PF00675	0.420
CLV_PCSK_SKI1_1	100	104	PF00082	0.413
CLV_PCSK_SKI1_1	368	372	PF00082	0.283
DOC_CDC14_PxL_1	243	251	PF14671	0.475
DOC_MAPK_DCC_7	242	251	PF00069	0.461
DOC_MAPK_gen_1	433	442	PF00069	0.552
DOC_MAPK_MEF2A_6	242	251	PF00069	0.461
DOC_MAPK_MEF2A_6	332	339	PF00069	0.384
DOC_PP1_RVXF_1	199	206	PF00149	0.346
DOC_PP2B_LxvP_1	311	314	PF13499	0.352
DOC_PP2B_LxvP_1	377	380	PF13499	0.326
DOC_PP4_FxxP_1	40	43	PF00568	0.410
DOC_PP4_FxxP_1	61	64	PF00568	0.243
DOC_USP7_MATH_1	105	109	PF00917	0.464
DOC_USP7_MATH_1	4	8	PF00917	0.431
DOC_USP7_MATH_1	74	78	PF00917	0.304
LIG_14-3-3_CanoR_1	100	107	PF00244	0.524
LIG_14-3-3_CanoR_1	368	373	PF00244	0.314
LIG_14-3-3_CanoR_1	56	62	PF00244	0.359
LIG_Actin_WH2_2	16	31	PF00022	0.363
LIG_BIR_III_2	423	427	PF00653	0.498
LIG_BRCT_BRCA1_1	340	344	PF00533	0.320
LIG_BRCT_BRCA1_1	36	40	PF00533	0.355
LIG_BRCT_BRCA1_1	6	10	PF00533	0.303
LIG_EH1_1	386	394	PF00400	0.165
LIG_FHA_1	23	29	PF00498	0.349
LIG_FHA_1	252	258	PF00498	0.469
LIG_FHA_1	357	363	PF00498	0.467
LIG_FHA_1	369	375	PF00498	0.236
LIG_FHA_1	74	80	PF00498	0.359
LIG_FHA_2	174	180	PF00498	0.521
LIG_FHA_2	409	415	PF00498	0.637
LIG_FHA_2	447	453	PF00498	0.613
LIG_LIR_Apic_2	115	120	PF02991	0.515
LIG_LIR_Apic_2	124	129	PF02991	0.270
LIG_LIR_Apic_2	37	43	PF02991	0.392
LIG_LIR_Apic_2	60	64	PF02991	0.262
LIG_LIR_Gen_1	145	155	PF02991	0.262
LIG_LIR_Gen_1	159	169	PF02991	0.238
LIG_LIR_Gen_1	384	395	PF02991	0.226
LIG_LIR_Gen_1	411	421	PF02991	0.540
LIG_LIR_Gen_1	7	18	PF02991	0.270
LIG_LIR_Nem_3	145	151	PF02991	0.272
LIG_LIR_Nem_3	159	165	PF02991	0.270
LIG_LIR_Nem_3	167	173	PF02991	0.292
LIG_LIR_Nem_3	384	390	PF02991	0.290
LIG_LIR_Nem_3	411	416	PF02991	0.615
LIG_LIR_Nem_3	66	72	PF02991	0.301
LIG_LIR_Nem_3	7	13	PF02991	0.359
LIG_LIR_Nem_3	85	91	PF02991	0.340
LIG_MLH1_MIPbox_1	340	344	PF16413	0.320
LIG_NRBOX	194	200	PF00104	0.303
LIG_NRBOX	217	223	PF00104	0.379
LIG_NRBOX	335	341	PF00104	0.245
LIG_NRBOX	373	379	PF00104	0.464
LIG_PCNA_yPIPBox_3	212	222	PF02747	0.251
LIG_Pex14_2	383	387	PF04695	0.283
LIG_Pex14_2	61	65	PF04695	0.256
LIG_PTB_Apo_2	399	406	PF02174	0.379
LIG_SH2_CRK	117	121	PF00017	0.549
LIG_SH2_CRK	148	152	PF00017	0.259
LIG_SH2_CRK	232	236	PF00017	0.257
LIG_SH2_CRK	244	248	PF00017	0.435
LIG_SH2_NCK_1	148	152	PF00017	0.271
LIG_SH2_PTP2	91	94	PF00017	0.477
LIG_SH2_SRC	315	318	PF00017	0.305
LIG_SH2_STAP1	148	152	PF00017	0.271
LIG_SH2_STAP1	315	319	PF00017	0.312
LIG_SH2_STAT5	338	341	PF00017	0.291
LIG_SH2_STAT5	355	358	PF00017	0.482
LIG_SH2_STAT5	91	94	PF00017	0.499
LIG_SH3_1	117	123	PF00018	0.527
LIG_SH3_3	117	123	PF00018	0.533
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.326
LIG_SUMO_SIM_par_1	359	366	PF11976	0.546
LIG_TRAF2_1	284	287	PF00917	0.303
LIG_TRAF2_2	418	423	PF00917	0.494
LIG_TYR_ITIM	146	151	PF00017	0.269
LIG_TYR_ITIM	313	318	PF00017	0.305
LIG_UBA3_1	240	245	PF00899	0.471
LIG_WRC_WIRS_1	58	63	PF05994	0.278
MOD_CK2_1	173	179	PF00069	0.494
MOD_CK2_1	378	384	PF00069	0.328
MOD_CK2_1	446	452	PF00069	0.721
MOD_GlcNHglycan	107	110	PF01048	0.364
MOD_GlcNHglycan	129	132	PF01048	0.387
MOD_GlcNHglycan	290	293	PF01048	0.607
MOD_GlcNHglycan	340	343	PF01048	0.372
MOD_GlcNHglycan	356	359	PF01048	0.191
MOD_GlcNHglycan	44	47	PF01048	0.704
MOD_GlcNHglycan	6	9	PF01048	0.379
MOD_GSK3_1	30	37	PF00069	0.335
MOD_GSK3_1	354	361	PF00069	0.486
MOD_GSK3_1	38	45	PF00069	0.395
MOD_GSK3_1	96	103	PF00069	0.617
MOD_N-GLC_1	299	304	PF02516	0.553
MOD_N-GLC_1	368	373	PF02516	0.338
MOD_N-GLC_2	346	348	PF02516	0.291
MOD_NEK2_1	134	139	PF00069	0.226
MOD_NEK2_1	144	149	PF00069	0.368
MOD_NEK2_1	155	160	PF00069	0.266
MOD_NEK2_1	19	24	PF00069	0.283
MOD_NEK2_1	205	210	PF00069	0.467
MOD_NEK2_1	262	267	PF00069	0.379
MOD_NEK2_1	288	293	PF00069	0.306
MOD_NEK2_1	363	368	PF00069	0.337
MOD_NEK2_1	57	62	PF00069	0.312
MOD_NEK2_1	82	87	PF00069	0.451
MOD_NEK2_1	96	101	PF00069	0.467
MOD_OFUCOSY	73	78	PF10250	0.245
MOD_PIKK_1	63	69	PF00454	0.335
MOD_PKA_1	100	106	PF00069	0.590
MOD_PKA_2	173	179	PF00069	0.479
MOD_PKA_2	325	331	PF00069	0.367
MOD_PKA_2	446	452	PF00069	0.680
MOD_PKB_1	445	453	PF00069	0.592
MOD_Plk_1	299	305	PF00069	0.358
MOD_Plk_1	368	374	PF00069	0.384
MOD_Plk_1	447	453	PF00069	0.624
MOD_Plk_1	74	80	PF00069	0.245
MOD_Plk_4	121	127	PF00069	0.458
MOD_Plk_4	134	140	PF00069	0.229
MOD_Plk_4	147	153	PF00069	0.270
MOD_Plk_4	156	162	PF00069	0.247
MOD_Plk_4	262	268	PF00069	0.330
MOD_Plk_4	299	305	PF00069	0.374
MOD_Plk_4	348	354	PF00069	0.378
MOD_Plk_4	358	364	PF00069	0.441
MOD_Plk_4	368	374	PF00069	0.285
MOD_Plk_4	378	384	PF00069	0.345
MOD_Plk_4	82	88	PF00069	0.321
MOD_SUMO_for_1	440	443	PF00179	0.578
MOD_SUMO_rev_2	327	334	PF00179	0.227
TRG_DiLeu_BaEn_1	75	80	PF01217	0.326
TRG_DiLeu_BaEn_2	329	335	PF01217	0.270
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.506
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.279
TRG_ENDOCYTIC_2	148	151	PF00928	0.268
TRG_ENDOCYTIC_2	152	155	PF00928	0.266
TRG_ENDOCYTIC_2	232	235	PF00928	0.285
TRG_ENDOCYTIC_2	315	318	PF00928	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC3	Leptomonas seymouri	59%	99%
A0A0S4JLV3	Bodo saltans	32%	100%
A0A0S4JVX5	Bodo saltans	32%	100%
A0A1X0P938	Trypanosomatidae	48%	100%
A0A3Q8INC1	Leishmania donovani	100%	100%
A0A3R7N2L5	Trypanosoma rangeli	48%	100%
A4HNS7	Leishmania braziliensis	74%	100%
E9ASI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q209	Leishmania major	93%	100%
Q5RFT1	Pongo abelii	30%	100%
Q5RKH7	Rattus norvegicus	30%	100%
Q8N357	Homo sapiens	30%	100%
Q8VE96	Mus musculus	29%	100%