LeishMANIAdb
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LRRcap domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LRRcap domain-containing protein
Gene product:
Protein C21orf2 homolog - putative
Species:
Leishmania infantum
UniProt:
A4ICR3_LEIIN
TriTrypDb:
LINF_360012700
Length:
259

Annotations

Annotations by Jardim et al.

Membrane associated proteins, C21orf2 homolog Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005929 cilium 4 10
GO:0042995 cell projection 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0110165 cellular anatomical entity 1 10
GO:0120025 plasma membrane bounded cell projection 3 10

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICR3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICR3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 132 134 PF00675 0.265
CLV_NRD_NRD_1 73 75 PF00675 0.195
CLV_PCSK_KEX2_1 138 140 PF00082 0.269
CLV_PCSK_PC1ET2_1 138 140 PF00082 0.269
CLV_PCSK_SKI1_1 10 14 PF00082 0.519
CLV_PCSK_SKI1_1 138 142 PF00082 0.241
CLV_PCSK_SKI1_1 203 207 PF00082 0.554
CLV_PCSK_SKI1_1 214 218 PF00082 0.335
CLV_PCSK_SKI1_1 82 86 PF00082 0.216
DEG_APCC_DBOX_1 213 221 PF00400 0.471
DEG_SCF_FBW7_1 179 184 PF00400 0.536
DOC_CDC14_PxL_1 87 95 PF14671 0.402
DOC_MAPK_gen_1 42 51 PF00069 0.469
DOC_MAPK_MEF2A_6 88 95 PF00069 0.432
DOC_PP1_RVXF_1 201 208 PF00149 0.550
DOC_USP7_MATH_1 163 167 PF00917 0.668
DOC_USP7_UBL2_3 134 138 PF12436 0.469
DOC_USP7_UBL2_3 15 19 PF12436 0.400
DOC_USP7_UBL2_3 245 249 PF12436 0.512
DOC_WW_Pin1_4 157 162 PF00397 0.623
DOC_WW_Pin1_4 169 174 PF00397 0.532
DOC_WW_Pin1_4 177 182 PF00397 0.725
LIG_14-3-3_CanoR_1 139 145 PF00244 0.505
LIG_BRCT_BRCA1_1 203 207 PF00533 0.439
LIG_FHA_1 140 146 PF00498 0.457
LIG_FHA_1 190 196 PF00498 0.702
LIG_FHA_1 249 255 PF00498 0.396
LIG_FHA_1 90 96 PF00498 0.412
LIG_FHA_2 127 133 PF00498 0.428
LIG_FHA_2 192 198 PF00498 0.532
LIG_LIR_Gen_1 204 215 PF02991 0.409
LIG_LIR_Nem_3 204 210 PF02991 0.428
LIG_MYND_3 43 47 PF01753 0.454
LIG_SH2_STAT5 253 256 PF00017 0.420
LIG_SH2_STAT5 72 75 PF00017 0.398
LIG_SUMO_SIM_anti_2 219 226 PF11976 0.428
LIG_SUMO_SIM_anti_2 230 236 PF11976 0.372
LIG_SUMO_SIM_anti_2 35 41 PF11976 0.402
LIG_SUMO_SIM_anti_2 92 97 PF11976 0.432
LIG_SUMO_SIM_par_1 216 222 PF11976 0.414
LIG_TRAF2_1 194 197 PF00917 0.530
LIG_UBA3_1 67 75 PF00899 0.513
MOD_CDC14_SPxK_1 172 175 PF00782 0.564
MOD_CDK_SPK_2 157 162 PF00069 0.575
MOD_CDK_SPxK_1 169 175 PF00069 0.565
MOD_CDK_SPxxK_3 157 164 PF00069 0.579
MOD_CK1_1 189 195 PF00069 0.586
MOD_CK1_1 201 207 PF00069 0.465
MOD_CK1_1 219 225 PF00069 0.428
MOD_CK2_1 126 132 PF00069 0.385
MOD_CK2_1 191 197 PF00069 0.666
MOD_GlcNHglycan 153 156 PF01048 0.565
MOD_GlcNHglycan 166 169 PF01048 0.562
MOD_GlcNHglycan 200 203 PF01048 0.535
MOD_GSK3_1 13 20 PF00069 0.409
MOD_GSK3_1 164 171 PF00069 0.634
MOD_GSK3_1 177 184 PF00069 0.641
MOD_GSK3_1 201 208 PF00069 0.504
MOD_N-GLC_1 198 203 PF02516 0.474
MOD_N-GLC_1 54 59 PF02516 0.269
MOD_NEK2_1 13 18 PF00069 0.326
MOD_NEK2_1 149 154 PF00069 0.454
MOD_NEK2_1 206 211 PF00069 0.478
MOD_NEK2_1 216 221 PF00069 0.435
MOD_NMyristoyl 1 7 PF02799 0.323
MOD_PKA_1 138 144 PF00069 0.445
MOD_PKA_1 164 170 PF00069 0.663
MOD_PKA_2 138 144 PF00069 0.484
MOD_Plk_1 225 231 PF00069 0.371
MOD_Plk_1 35 41 PF00069 0.385
MOD_Plk_1 54 60 PF00069 0.385
MOD_Plk_1 82 88 PF00069 0.469
MOD_Plk_4 216 222 PF00069 0.358
MOD_Plk_4 91 97 PF00069 0.447
MOD_ProDKin_1 157 163 PF00069 0.624
MOD_ProDKin_1 169 175 PF00069 0.515
MOD_ProDKin_1 177 183 PF00069 0.725
MOD_SUMO_rev_2 127 136 PF00179 0.469
TRG_DiLeu_BaEn_1 230 235 PF01217 0.467
TRG_ENDOCYTIC_2 109 112 PF00928 0.420
TRG_Pf-PMV_PEXEL_1 143 147 PF00026 0.197
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.350

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7V8 Leptomonas seymouri 65% 100%
A0A0S4JS78 Bodo saltans 45% 100%
A0A3S7XAD6 Leishmania donovani 100% 100%
A4HNT1 Leishmania braziliensis 83% 100%
D0A2P1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 94%
E9ASJ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O43822 Homo sapiens 31% 100%
Q4Q205 Leishmania major 97% 100%
Q8C6G1 Mus musculus 36% 100%
Q9BV99 Homo sapiens 31% 100%
V5DRP5 Trypanosoma cruzi 40% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS