LeishMANIAdb
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Zinc finger protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Zinc finger protein
Gene product:
zinc finger protein family member - putative
Species:
Leishmania infantum
UniProt:
A4ICR1_LEIIN
TriTrypDb:
LINF_360012900
Length:
505

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICR1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICR1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 158 162 PF00656 0.431
CLV_C14_Caspase3-7 378 382 PF00656 0.642
CLV_MEL_PAP_1 429 435 PF00089 0.618
CLV_NRD_NRD_1 32 34 PF00675 0.574
CLV_NRD_NRD_1 38 40 PF00675 0.510
CLV_NRD_NRD_1 490 492 PF00675 0.623
CLV_PCSK_KEX2_1 32 34 PF00082 0.574
CLV_PCSK_KEX2_1 38 40 PF00082 0.510
CLV_PCSK_KEX2_1 490 492 PF00082 0.623
CLV_PCSK_SKI1_1 115 119 PF00082 0.511
DEG_SPOP_SBC_1 25 29 PF00917 0.581
DEG_SPOP_SBC_1 311 315 PF00917 0.588
DEG_SPOP_SBC_1 499 503 PF00917 0.673
DOC_CKS1_1 228 233 PF01111 0.467
DOC_CKS1_1 450 455 PF01111 0.649
DOC_MAPK_DCC_7 213 223 PF00069 0.416
DOC_MAPK_DCC_7 256 266 PF00069 0.408
DOC_MAPK_DCC_7 439 449 PF00069 0.643
DOC_MAPK_FxFP_2 118 121 PF00069 0.372
DOC_MAPK_MEF2A_6 285 294 PF00069 0.370
DOC_MAPK_MEF2A_6 443 451 PF00069 0.642
DOC_PP4_FxxP_1 118 121 PF00568 0.372
DOC_PP4_FxxP_1 50 53 PF00568 0.377
DOC_USP7_MATH_1 385 389 PF00917 0.622
DOC_USP7_MATH_2 299 305 PF00917 0.602
DOC_WW_Pin1_4 106 111 PF00397 0.449
DOC_WW_Pin1_4 126 131 PF00397 0.346
DOC_WW_Pin1_4 21 26 PF00397 0.574
DOC_WW_Pin1_4 227 232 PF00397 0.458
DOC_WW_Pin1_4 293 298 PF00397 0.425
DOC_WW_Pin1_4 305 310 PF00397 0.589
DOC_WW_Pin1_4 31 36 PF00397 0.569
DOC_WW_Pin1_4 323 328 PF00397 0.553
DOC_WW_Pin1_4 331 336 PF00397 0.585
DOC_WW_Pin1_4 431 436 PF00397 0.698
DOC_WW_Pin1_4 442 447 PF00397 0.576
DOC_WW_Pin1_4 449 454 PF00397 0.579
DOC_WW_Pin1_4 462 467 PF00397 0.489
DOC_WW_Pin1_4 474 479 PF00397 0.609
DOC_WW_Pin1_4 484 489 PF00397 0.600
DOC_WW_Pin1_4 495 500 PF00397 0.598
LIG_14-3-3_CanoR_1 38 42 PF00244 0.493
LIG_14-3-3_CanoR_1 44 49 PF00244 0.408
LIG_14-3-3_CanoR_1 9 19 PF00244 0.632
LIG_APCC_ABBA_1 108 113 PF00400 0.397
LIG_APCC_ABBA_1 132 137 PF00400 0.340
LIG_APCC_ABBA_1 153 158 PF00400 0.432
LIG_CtBP_PxDLS_1 423 427 PF00389 0.583
LIG_FHA_1 256 262 PF00498 0.591
LIG_FHA_1 272 278 PF00498 0.264
LIG_FHA_1 339 345 PF00498 0.630
LIG_FHA_1 396 402 PF00498 0.605
LIG_FHA_1 484 490 PF00498 0.696
LIG_FHA_2 228 234 PF00498 0.500
LIG_FHA_2 247 253 PF00498 0.507
LIG_FHA_2 69 75 PF00498 0.620
LIG_IBAR_NPY_1 493 495 PF08397 0.592
LIG_Integrin_isoDGR_2 36 38 PF01839 0.551
LIG_Integrin_isoDGR_2 390 392 PF01839 0.653
LIG_LIR_Apic_2 116 121 PF02991 0.387
LIG_LIR_Apic_2 47 53 PF02991 0.379
LIG_LIR_Gen_1 149 156 PF02991 0.424
LIG_LIR_Nem_3 149 155 PF02991 0.520
LIG_LIR_Nem_3 196 201 PF02991 0.387
LIG_MYND_2 218 222 PF01753 0.423
LIG_NRBOX 103 109 PF00104 0.439
LIG_SH2_CRK 136 140 PF00017 0.390
LIG_SH2_CRK 409 413 PF00017 0.629
LIG_SH2_CRK 421 425 PF00017 0.547
LIG_SH2_NCK_1 136 140 PF00017 0.342
LIG_SH2_NCK_1 251 255 PF00017 0.389
LIG_SH2_PTP2 152 155 PF00017 0.378
LIG_SH2_PTP2 96 99 PF00017 0.406
LIG_SH2_SRC 136 139 PF00017 0.343
LIG_SH2_SRC 251 254 PF00017 0.389
LIG_SH2_SRC 409 412 PF00017 0.514
LIG_SH2_SRC 96 99 PF00017 0.406
LIG_SH2_STAP1 251 255 PF00017 0.429
LIG_SH2_STAT3 396 399 PF00017 0.669
LIG_SH2_STAT5 103 106 PF00017 0.401
LIG_SH2_STAT5 128 131 PF00017 0.436
LIG_SH2_STAT5 152 155 PF00017 0.469
LIG_SH2_STAT5 375 378 PF00017 0.767
LIG_SH2_STAT5 96 99 PF00017 0.418
LIG_SH3_1 409 415 PF00018 0.545
LIG_SH3_3 222 228 PF00018 0.436
LIG_SH3_3 400 406 PF00018 0.553
LIG_SH3_3 409 415 PF00018 0.565
LIG_SH3_3 417 423 PF00018 0.554
LIG_SH3_3 447 453 PF00018 0.713
LIG_SH3_3 94 100 PF00018 0.351
LIG_TRAF2_1 299 302 PF00917 0.677
LIG_TRAF2_1 369 372 PF00917 0.542
LIG_TRAF2_1 40 43 PF00917 0.454
LIG_TRFH_1 495 499 PF08558 0.597
MOD_CDC14_SPxK_1 445 448 PF00782 0.579
MOD_CDC14_SPxK_1 487 490 PF00782 0.629
MOD_CDK_SPxK_1 442 448 PF00069 0.579
MOD_CDK_SPxK_1 484 490 PF00069 0.632
MOD_CDK_SPxxK_3 31 38 PF00069 0.564
MOD_CDK_SPxxK_3 484 491 PF00069 0.632
MOD_CK1_1 13 19 PF00069 0.604
MOD_CK1_1 21 27 PF00069 0.610
MOD_CK1_1 304 310 PF00069 0.650
MOD_CK1_1 317 323 PF00069 0.521
MOD_CK1_1 465 471 PF00069 0.609
MOD_CK1_1 474 480 PF00069 0.612
MOD_CK1_1 484 490 PF00069 0.632
MOD_CK1_1 498 504 PF00069 0.533
MOD_CK2_1 24 30 PF00069 0.578
MOD_CK2_1 246 252 PF00069 0.451
MOD_CK2_1 37 43 PF00069 0.490
MOD_CK2_1 51 57 PF00069 0.403
MOD_CK2_1 68 74 PF00069 0.476
MOD_Cter_Amidation 30 33 PF01082 0.578
MOD_Cter_Amidation 36 39 PF01082 0.543
MOD_GlcNHglycan 15 18 PF01048 0.489
MOD_GlcNHglycan 2 5 PF01048 0.726
MOD_GlcNHglycan 316 319 PF01048 0.635
MOD_GlcNHglycan 322 325 PF01048 0.598
MOD_GlcNHglycan 440 443 PF01048 0.681
MOD_GlcNHglycan 470 473 PF01048 0.612
MOD_GlcNHglycan 474 477 PF01048 0.606
MOD_GlcNHglycan 89 92 PF01048 0.597
MOD_GSK3_1 200 207 PF00069 0.424
MOD_GSK3_1 21 28 PF00069 0.573
MOD_GSK3_1 242 249 PF00069 0.442
MOD_GSK3_1 301 308 PF00069 0.632
MOD_GSK3_1 310 317 PF00069 0.562
MOD_GSK3_1 323 330 PF00069 0.535
MOD_GSK3_1 331 338 PF00069 0.532
MOD_GSK3_1 438 445 PF00069 0.699
MOD_GSK3_1 468 475 PF00069 0.676
MOD_GSK3_1 493 500 PF00069 0.659
MOD_GSK3_1 51 58 PF00069 0.448
MOD_GSK3_1 9 16 PF00069 0.582
MOD_N-GLC_1 9 14 PF02516 0.630
MOD_N-GLC_2 92 94 PF02516 0.382
MOD_NEK2_1 79 84 PF00069 0.418
MOD_PIKK_1 246 252 PF00454 0.451
MOD_PIKK_1 395 401 PF00454 0.645
MOD_PIKK_1 476 482 PF00454 0.680
MOD_PKA_2 204 210 PF00069 0.393
MOD_PKA_2 37 43 PF00069 0.490
MOD_PKA_2 438 444 PF00069 0.584
MOD_Plk_1 301 307 PF00069 0.585
MOD_Plk_1 380 386 PF00069 0.586
MOD_Plk_4 113 119 PF00069 0.374
MOD_Plk_4 414 420 PF00069 0.604
MOD_Plk_4 79 85 PF00069 0.424
MOD_ProDKin_1 106 112 PF00069 0.445
MOD_ProDKin_1 126 132 PF00069 0.345
MOD_ProDKin_1 21 27 PF00069 0.574
MOD_ProDKin_1 227 233 PF00069 0.463
MOD_ProDKin_1 293 299 PF00069 0.431
MOD_ProDKin_1 305 311 PF00069 0.587
MOD_ProDKin_1 31 37 PF00069 0.565
MOD_ProDKin_1 323 329 PF00069 0.553
MOD_ProDKin_1 331 337 PF00069 0.586
MOD_ProDKin_1 431 437 PF00069 0.700
MOD_ProDKin_1 442 448 PF00069 0.579
MOD_ProDKin_1 449 455 PF00069 0.581
MOD_ProDKin_1 462 468 PF00069 0.489
MOD_ProDKin_1 474 480 PF00069 0.612
MOD_ProDKin_1 484 490 PF00069 0.597
MOD_ProDKin_1 495 501 PF00069 0.600
MOD_SUMO_rev_2 109 117 PF00179 0.573
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.432
TRG_ENDOCYTIC_2 120 123 PF00928 0.416
TRG_ENDOCYTIC_2 135 138 PF00928 0.509
TRG_ENDOCYTIC_2 152 155 PF00928 0.426
TRG_ENDOCYTIC_2 214 217 PF00928 0.449
TRG_ENDOCYTIC_2 421 424 PF00928 0.637
TRG_ENDOCYTIC_2 96 99 PF00928 0.406
TRG_ER_diArg_1 489 491 PF00400 0.631
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.569

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P889 Leptomonas seymouri 62% 100%
A0A3S7XAD0 Leishmania donovani 100% 100%
A4HNT3 Leishmania braziliensis 86% 98%
E9ASJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q203 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS