Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ - putative

Species:

Leishmania infantum

UniProt:

A4ICQ8_LEIIN

TriTrypDb:

LINF_360013200

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.621
CLV_C14_Caspase3-7	360	364	PF00656	0.714
CLV_C14_Caspase3-7	628	632	PF00656	0.446
CLV_NRD_NRD_1	190	192	PF00675	0.719
CLV_NRD_NRD_1	344	346	PF00675	0.675
CLV_NRD_NRD_1	646	648	PF00675	0.370
CLV_NRD_NRD_1	716	718	PF00675	0.570
CLV_NRD_NRD_1	762	764	PF00675	0.671
CLV_NRD_NRD_1	96	98	PF00675	0.777
CLV_NRD_NRD_1	99	101	PF00675	0.738
CLV_PCSK_FUR_1	97	101	PF00082	0.763
CLV_PCSK_KEX2_1	344	346	PF00082	0.675
CLV_PCSK_KEX2_1	497	499	PF00082	0.515
CLV_PCSK_KEX2_1	509	511	PF00082	0.530
CLV_PCSK_KEX2_1	646	648	PF00082	0.370
CLV_PCSK_KEX2_1	716	718	PF00082	0.570
CLV_PCSK_KEX2_1	762	764	PF00082	0.671
CLV_PCSK_KEX2_1	96	98	PF00082	0.777
CLV_PCSK_KEX2_1	99	101	PF00082	0.751
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.515
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.530
CLV_PCSK_SKI1_1	305	309	PF00082	0.374
CLV_PCSK_SKI1_1	388	392	PF00082	0.534
CLV_PCSK_SKI1_1	396	400	PF00082	0.490
CLV_PCSK_SKI1_1	430	434	PF00082	0.490
CLV_PCSK_SKI1_1	459	463	PF00082	0.541
CLV_PCSK_SKI1_1	484	488	PF00082	0.377
CLV_PCSK_SKI1_1	624	628	PF00082	0.446
CLV_PCSK_SKI1_1	663	667	PF00082	0.597
CLV_PCSK_SKI1_1	717	721	PF00082	0.603
CLV_PCSK_SKI1_1	816	820	PF00082	0.396
CLV_PCSK_SKI1_1	9	13	PF00082	0.712
DEG_APCC_DBOX_1	648	656	PF00400	0.512
DEG_APCC_DBOX_1	99	107	PF00400	0.744
DEG_SPOP_SBC_1	371	375	PF00917	0.683
DEG_SPOP_SBC_1	735	739	PF00917	0.699
DOC_CDC14_PxL_1	476	484	PF14671	0.503
DOC_CKS1_1	85	90	PF01111	0.662
DOC_CYCLIN_RxL_1	495	505	PF00134	0.531
DOC_CYCLIN_RxL_1	774	782	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.709
DOC_MAPK_gen_1	646	654	PF00069	0.430
DOC_MAPK_gen_1	843	850	PF00069	0.567
DOC_MAPK_gen_1	96	106	PF00069	0.735
DOC_PP4_FxxP_1	210	213	PF00568	0.736
DOC_USP7_MATH_1	147	151	PF00917	0.725
DOC_USP7_MATH_1	174	178	PF00917	0.739
DOC_USP7_MATH_1	340	344	PF00917	0.652
DOC_USP7_MATH_1	370	374	PF00917	0.722
DOC_USP7_MATH_1	46	50	PF00917	0.706
DOC_USP7_MATH_1	587	591	PF00917	0.512
DOC_USP7_MATH_1	667	671	PF00917	0.552
DOC_USP7_MATH_1	730	734	PF00917	0.707
DOC_USP7_MATH_1	735	739	PF00917	0.694
DOC_USP7_UBL2_3	720	724	PF12436	0.611
DOC_USP7_UBL2_3	799	803	PF12436	0.407
DOC_WW_Pin1_4	119	124	PF00397	0.644
DOC_WW_Pin1_4	148	153	PF00397	0.702
DOC_WW_Pin1_4	182	187	PF00397	0.715
DOC_WW_Pin1_4	213	218	PF00397	0.725
DOC_WW_Pin1_4	358	363	PF00397	0.785
DOC_WW_Pin1_4	40	45	PF00397	0.764
DOC_WW_Pin1_4	634	639	PF00397	0.526
DOC_WW_Pin1_4	697	702	PF00397	0.559
DOC_WW_Pin1_4	726	731	PF00397	0.756
DOC_WW_Pin1_4	751	756	PF00397	0.752
DOC_WW_Pin1_4	81	86	PF00397	0.790
DOC_WW_Pin1_4	818	823	PF00397	0.442
LIG_14-3-3_CanoR_1	3	8	PF00244	0.713
LIG_14-3-3_CanoR_1	344	350	PF00244	0.739
LIG_14-3-3_CanoR_1	388	398	PF00244	0.557
LIG_14-3-3_CanoR_1	522	532	PF00244	0.501
LIG_14-3-3_CanoR_1	748	757	PF00244	0.803
LIG_14-3-3_CanoR_1	99	104	PF00244	0.763
LIG_BIR_III_4	199	203	PF00653	0.627
LIG_BIR_III_4	369	373	PF00653	0.595
LIG_BRCT_BRCA1_1	110	114	PF00533	0.723
LIG_BRCT_BRCA1_1	732	736	PF00533	0.749
LIG_deltaCOP1_diTrp_1	266	276	PF00928	0.459
LIG_FHA_1	126	132	PF00498	0.679
LIG_FHA_1	166	172	PF00498	0.708
LIG_FHA_1	226	232	PF00498	0.571
LIG_FHA_1	254	260	PF00498	0.495
LIG_FHA_1	26	32	PF00498	0.601
LIG_FHA_1	344	350	PF00498	0.688
LIG_FHA_1	537	543	PF00498	0.523
LIG_FHA_1	557	563	PF00498	0.298
LIG_FHA_1	56	62	PF00498	0.733
LIG_FHA_1	591	597	PF00498	0.400
LIG_FHA_1	692	698	PF00498	0.504
LIG_FHA_1	771	777	PF00498	0.488
LIG_FHA_2	252	258	PF00498	0.532
LIG_FHA_2	819	825	PF00498	0.442
LIG_GSK3_LRP6_1	213	219	PF00069	0.711
LIG_LIR_Apic_2	208	213	PF02991	0.736
LIG_LIR_Apic_2	436	440	PF02991	0.527
LIG_LIR_Gen_1	410	419	PF02991	0.484
LIG_LIR_Gen_1	444	453	PF02991	0.407
LIG_LIR_Nem_3	130	136	PF02991	0.561
LIG_LIR_Nem_3	279	283	PF02991	0.454
LIG_LIR_Nem_3	410	416	PF02991	0.471
LIG_LIR_Nem_3	444	448	PF02991	0.406
LIG_LIR_Nem_3	466	472	PF02991	0.506
LIG_LIR_Nem_3	477	482	PF02991	0.414
LIG_LIR_Nem_3	485	490	PF02991	0.259
LIG_LIR_Nem_3	545	550	PF02991	0.537
LIG_LIR_Nem_3	791	795	PF02991	0.600
LIG_LIR_Nem_3	829	835	PF02991	0.342
LIG_LYPXL_S_1	478	482	PF13949	0.498
LIG_LYPXL_yS_3	479	482	PF13949	0.498
LIG_NRBOX	449	455	PF00104	0.465
LIG_PDZ_Class_2	845	850	PF00595	0.572
LIG_Pex14_2	276	280	PF04695	0.457
LIG_PTAP_UEV_1	785	790	PF05743	0.608
LIG_SH2_CRK	437	441	PF00017	0.523
LIG_SH2_CRK	839	843	PF00017	0.327
LIG_SH2_NCK_1	310	314	PF00017	0.453
LIG_SH2_NCK_1	640	644	PF00017	0.490
LIG_SH2_NCK_1	685	689	PF00017	0.528
LIG_SH2_SRC	282	285	PF00017	0.417
LIG_SH2_SRC	685	688	PF00017	0.537
LIG_SH2_STAP1	255	259	PF00017	0.403
LIG_SH2_STAP1	310	314	PF00017	0.434
LIG_SH2_STAP1	592	596	PF00017	0.398
LIG_SH2_STAP1	640	644	PF00017	0.436
LIG_SH2_STAP1	685	689	PF00017	0.528
LIG_SH2_STAT3	116	119	PF00017	0.614
LIG_SH2_STAT3	659	662	PF00017	0.575
LIG_SH2_STAT5	255	258	PF00017	0.484
LIG_SH2_STAT5	282	285	PF00017	0.392
LIG_SH2_STAT5	291	294	PF00017	0.401
LIG_SH2_STAT5	437	440	PF00017	0.560
LIG_SH2_STAT5	523	526	PF00017	0.477
LIG_SH2_STAT5	552	555	PF00017	0.564
LIG_SH2_STAT5	592	595	PF00017	0.401
LIG_SH2_STAT5	610	613	PF00017	0.381
LIG_SH2_STAT5	653	656	PF00017	0.455
LIG_SH2_STAT5	79	82	PF00017	0.805
LIG_SH3_1	82	88	PF00018	0.779
LIG_SH3_2	86	91	PF14604	0.723
LIG_SH3_3	211	217	PF00018	0.690
LIG_SH3_3	359	365	PF00018	0.607
LIG_SH3_3	783	789	PF00018	0.643
LIG_SH3_3	80	86	PF00018	0.748
LIG_SH3_CIN85_PxpxPR_1	86	91	PF14604	0.723
LIG_SUMO_SIM_par_1	102	108	PF11976	0.714
LIG_SUMO_SIM_par_1	429	436	PF11976	0.565
LIG_SUMO_SIM_par_1	9	14	PF11976	0.719
LIG_TRAF2_1	123	126	PF00917	0.625
LIG_TRAF2_1	143	146	PF00917	0.501
LIG_TRAF2_1	400	403	PF00917	0.554
LIG_TYR_ITIM	837	842	PF00017	0.351
LIG_UBA3_1	136	144	PF00899	0.572
LIG_UBA3_1	453	460	PF00899	0.481
LIG_WRC_WIRS_1	277	282	PF05994	0.470
LIG_WW_3	88	92	PF00397	0.741
MOD_CDK_SPK_2	726	731	PF00069	0.713
MOD_CDK_SPxxK_3	213	220	PF00069	0.606
MOD_CDK_SPxxK_3	818	825	PF00069	0.424
MOD_CDK_SPxxK_3	84	91	PF00069	0.669
MOD_CK1_1	102	108	PF00069	0.725
MOD_CK1_1	110	116	PF00069	0.631
MOD_CK1_1	177	183	PF00069	0.701
MOD_CK1_1	216	222	PF00069	0.718
MOD_CK1_1	30	36	PF00069	0.660
MOD_CK1_1	339	345	PF00069	0.652
MOD_CK1_1	348	354	PF00069	0.721
MOD_CK1_1	49	55	PF00069	0.622
MOD_CK1_1	590	596	PF00069	0.441
MOD_CK1_1	63	69	PF00069	0.665
MOD_CK1_1	632	638	PF00069	0.504
MOD_CK1_1	737	743	PF00069	0.724
MOD_CK1_1	751	757	PF00069	0.599
MOD_CK1_1	81	87	PF00069	0.790
MOD_CK2_1	119	125	PF00069	0.746
MOD_CK2_1	148	154	PF00069	0.782
MOD_CK2_1	251	257	PF00069	0.530
MOD_CK2_1	371	377	PF00069	0.702
MOD_CK2_1	389	395	PF00069	0.553
MOD_CK2_1	460	466	PF00069	0.490
MOD_CK2_1	59	65	PF00069	0.771
MOD_CK2_1	737	743	PF00069	0.745
MOD_CK2_1	818	824	PF00069	0.442
MOD_GlcNHglycan	110	113	PF01048	0.707
MOD_GlcNHglycan	139	143	PF01048	0.667
MOD_GlcNHglycan	176	179	PF01048	0.633
MOD_GlcNHglycan	32	35	PF01048	0.637
MOD_GlcNHglycan	338	341	PF01048	0.716
MOD_GlcNHglycan	374	377	PF01048	0.611
MOD_GlcNHglycan	51	54	PF01048	0.650
MOD_GlcNHglycan	589	592	PF01048	0.437
MOD_GlcNHglycan	631	634	PF01048	0.492
MOD_GlcNHglycan	669	672	PF01048	0.621
MOD_GlcNHglycan	739	742	PF01048	0.672
MOD_GlcNHglycan	750	753	PF01048	0.632
MOD_GlcNHglycan	765	768	PF01048	0.613
MOD_GlcNHglycan	786	789	PF01048	0.626
MOD_GlcNHglycan	844	848	PF01048	0.561
MOD_GSK3_1	11	18	PF00069	0.700
MOD_GSK3_1	154	161	PF00069	0.741
MOD_GSK3_1	201	208	PF00069	0.736
MOD_GSK3_1	26	33	PF00069	0.578
MOD_GSK3_1	336	343	PF00069	0.706
MOD_GSK3_1	347	354	PF00069	0.721
MOD_GSK3_1	40	47	PF00069	0.753
MOD_GSK3_1	55	62	PF00069	0.566
MOD_GSK3_1	625	632	PF00069	0.390
MOD_GSK3_1	719	726	PF00069	0.623
MOD_GSK3_1	730	737	PF00069	0.688
MOD_GSK3_1	74	81	PF00069	0.727
MOD_GSK3_1	95	102	PF00069	0.790
MOD_N-GLC_1	108	113	PF02516	0.757
MOD_N-GLC_1	119	124	PF02516	0.474
MOD_N-GLC_1	611	616	PF02516	0.409
MOD_NEK2_1	1	6	PF00069	0.755
MOD_NEK2_1	158	163	PF00069	0.782
MOD_NEK2_1	165	170	PF00069	0.655
MOD_NEK2_1	276	281	PF00069	0.445
MOD_NEK2_1	389	394	PF00069	0.504
MOD_NEK2_1	408	413	PF00069	0.508
MOD_NEK2_1	482	487	PF00069	0.397
MOD_NEK2_1	55	60	PF00069	0.691
MOD_NEK2_1	736	741	PF00069	0.616
MOD_NEK2_1	779	784	PF00069	0.517
MOD_NEK2_2	127	132	PF00069	0.738
MOD_PIKK_1	389	395	PF00454	0.550
MOD_PIKK_1	523	529	PF00454	0.482
MOD_PIKK_1	704	710	PF00454	0.507
MOD_PK_1	132	138	PF00069	0.561
MOD_PKA_1	99	105	PF00069	0.748
MOD_PKA_2	2	8	PF00069	0.720
MOD_PKA_2	336	342	PF00069	0.725
MOD_PKA_2	343	349	PF00069	0.584
MOD_PKA_2	562	568	PF00069	0.508
MOD_PKA_2	95	101	PF00069	0.763
MOD_PKB_1	746	754	PF00069	0.797
MOD_PKB_1	97	105	PF00069	0.753
MOD_Plk_1	154	160	PF00069	0.777
MOD_Plk_1	26	32	PF00069	0.601
MOD_Plk_1	611	617	PF00069	0.410
MOD_Plk_2-3	625	631	PF00069	0.443
MOD_Plk_4	110	116	PF00069	0.581
MOD_Plk_4	160	166	PF00069	0.728
MOD_Plk_4	219	225	PF00069	0.767
MOD_Plk_4	408	414	PF00069	0.551
MOD_Plk_4	482	488	PF00069	0.444
MOD_Plk_4	74	80	PF00069	0.725
MOD_Plk_4	779	785	PF00069	0.584
MOD_Plk_4	99	105	PF00069	0.786
MOD_ProDKin_1	119	125	PF00069	0.641
MOD_ProDKin_1	148	154	PF00069	0.702
MOD_ProDKin_1	182	188	PF00069	0.718
MOD_ProDKin_1	213	219	PF00069	0.725
MOD_ProDKin_1	358	364	PF00069	0.786
MOD_ProDKin_1	40	46	PF00069	0.764
MOD_ProDKin_1	634	640	PF00069	0.525
MOD_ProDKin_1	697	703	PF00069	0.564
MOD_ProDKin_1	726	732	PF00069	0.755
MOD_ProDKin_1	751	757	PF00069	0.749
MOD_ProDKin_1	81	87	PF00069	0.790
MOD_ProDKin_1	818	824	PF00069	0.442
MOD_SUMO_for_1	143	146	PF00179	0.663
MOD_SUMO_rev_2	51	61	PF00179	0.715
MOD_SUMO_rev_2	698	707	PF00179	0.603
MOD_SUMO_rev_2	791	801	PF00179	0.614
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.628
TRG_ENDOCYTIC_2	314	317	PF00928	0.455
TRG_ENDOCYTIC_2	322	325	PF00928	0.471
TRG_ENDOCYTIC_2	479	482	PF00928	0.427
TRG_ENDOCYTIC_2	839	842	PF00928	0.327
TRG_ER_diArg_1	646	649	PF00400	0.399
TRG_ER_diArg_1	762	764	PF00400	0.639
TRG_ER_diArg_1	96	99	PF00400	0.773
TRG_Pf-PMV_PEXEL_1	388	393	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	594	599	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I741	Leptomonas seymouri	48%	71%
A0A0S4JSA3	Bodo saltans	26%	88%
A0A3R7RK92	Trypanosoma rangeli	29%	88%
A0A3S7XAG9	Leishmania donovani	100%	100%
A4HNT6	Leishmania braziliensis	74%	100%
D0A2Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
E9ASJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q200	Leishmania major	93%	100%