Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICQ7_LEIIN

TriTrypDb:

LINF_360013300

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.422
CLV_NRD_NRD_1	102	104	PF00675	0.564
CLV_NRD_NRD_1	331	333	PF00675	0.595
CLV_NRD_NRD_1	411	413	PF00675	0.777
CLV_NRD_NRD_1	421	423	PF00675	0.581
CLV_PCSK_FUR_1	100	104	PF00082	0.505
CLV_PCSK_KEX2_1	100	102	PF00082	0.577
CLV_PCSK_KEX2_1	331	333	PF00082	0.567
CLV_PCSK_KEX2_1	421	423	PF00082	0.632
CLV_PCSK_SKI1_1	282	286	PF00082	0.479
DEG_SPOP_SBC_1	373	377	PF00917	0.655
DEG_SPOP_SBC_1	397	401	PF00917	0.600
DOC_CKS1_1	204	209	PF01111	0.556
DOC_CKS1_1	60	65	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.671
DOC_MAPK_HePTP_8	19	31	PF00069	0.418
DOC_MAPK_MEF2A_6	22	31	PF00069	0.431
DOC_PP1_RVXF_1	183	190	PF00149	0.516
DOC_PP2B_LxvP_1	249	252	PF13499	0.664
DOC_PP4_FxxP_1	23	26	PF00568	0.340
DOC_USP7_MATH_1	114	118	PF00917	0.681
DOC_USP7_MATH_1	180	184	PF00917	0.705
DOC_USP7_MATH_1	188	192	PF00917	0.758
DOC_USP7_MATH_1	229	233	PF00917	0.481
DOC_USP7_MATH_1	253	257	PF00917	0.734
DOC_USP7_MATH_1	268	272	PF00917	0.796
DOC_USP7_MATH_1	372	376	PF00917	0.688
DOC_USP7_MATH_1	378	382	PF00917	0.637
DOC_USP7_MATH_1	383	387	PF00917	0.547
DOC_USP7_MATH_1	396	400	PF00917	0.739
DOC_USP7_MATH_1	404	408	PF00917	0.689
DOC_WW_Pin1_4	203	208	PF00397	0.672
DOC_WW_Pin1_4	367	372	PF00397	0.783
DOC_WW_Pin1_4	376	381	PF00397	0.751
DOC_WW_Pin1_4	59	64	PF00397	0.523
LIG_14-3-3_CanoR_1	157	161	PF00244	0.429
LIG_14-3-3_CanoR_1	298	305	PF00244	0.565
LIG_14-3-3_CanoR_1	61	71	PF00244	0.452
LIG_Actin_WH2_2	321	337	PF00022	0.660
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	185	189	PF00533	0.515
LIG_FHA_1	179	185	PF00498	0.635
LIG_FHA_2	1	7	PF00498	0.464
LIG_FHA_2	165	171	PF00498	0.711
LIG_FHA_2	204	210	PF00498	0.490
LIG_FHA_2	63	69	PF00498	0.398
LIG_FHA_2	8	14	PF00498	0.386
LIG_LIR_Gen_1	194	204	PF02991	0.581
LIG_LIR_Nem_3	151	156	PF02991	0.454
LIG_LIR_Nem_3	194	199	PF02991	0.582
LIG_LIR_Nem_3	232	238	PF02991	0.531
LIG_LIR_Nem_3	6	11	PF02991	0.409
LIG_NRBOX	14	20	PF00104	0.449
LIG_SH2_CRK	153	157	PF00017	0.428
LIG_SH2_GRB2like	305	308	PF00017	0.593
LIG_SH2_SRC	11	14	PF00017	0.457
LIG_SH2_STAT5	11	14	PF00017	0.335
LIG_SH2_STAT5	305	308	PF00017	0.593
LIG_SH3_3	245	251	PF00018	0.537
LIG_SH3_3	291	297	PF00018	0.694
LIG_SH3_3	330	336	PF00018	0.576
LIG_SH3_CIN85_PxpxPR_1	295	300	PF14604	0.574
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.450
LIG_SUMO_SIM_par_1	25	30	PF11976	0.565
LIG_TRAF2_1	208	211	PF00917	0.481
LIG_TRAF2_1	30	33	PF00917	0.482
LIG_TRAF2_1	65	68	PF00917	0.471
LIG_ULM_U2AF65_1	421	426	PF00076	0.660
LIG_WRC_WIRS_1	5	10	PF05994	0.393
LIG_WW_3	295	299	PF00397	0.611
MOD_CK1_1	183	189	PF00069	0.711
MOD_CK1_1	191	197	PF00069	0.502
MOD_CK1_1	386	392	PF00069	0.637
MOD_CK1_1	399	405	PF00069	0.698
MOD_CK1_1	7	13	PF00069	0.431
MOD_CK2_1	191	197	PF00069	0.580
MOD_CK2_1	203	209	PF00069	0.397
MOD_CK2_1	27	33	PF00069	0.430
MOD_CK2_1	275	281	PF00069	0.632
MOD_CK2_1	62	68	PF00069	0.397
MOD_GlcNHglycan	111	114	PF01048	0.584
MOD_GlcNHglycan	116	119	PF01048	0.638
MOD_GlcNHglycan	192	196	PF01048	0.566
MOD_GlcNHglycan	231	234	PF01048	0.440
MOD_GlcNHglycan	270	273	PF01048	0.652
MOD_GlcNHglycan	308	311	PF01048	0.781
MOD_GlcNHglycan	336	339	PF01048	0.617
MOD_GlcNHglycan	364	367	PF01048	0.741
MOD_GlcNHglycan	376	379	PF01048	0.648
MOD_GlcNHglycan	385	388	PF01048	0.710
MOD_GlcNHglycan	41	44	PF01048	0.573
MOD_GlcNHglycan	80	83	PF01048	0.397
MOD_GSK3_1	114	121	PF00069	0.626
MOD_GSK3_1	156	163	PF00069	0.538
MOD_GSK3_1	35	42	PF00069	0.611
MOD_GSK3_1	362	369	PF00069	0.724
MOD_GSK3_1	372	379	PF00069	0.555
MOD_GSK3_1	398	405	PF00069	0.739
MOD_N-GLC_1	121	126	PF02516	0.717
MOD_N-GLC_1	303	308	PF02516	0.773
MOD_N-GLC_1	39	44	PF02516	0.704
MOD_N-GLC_2	360	362	PF02516	0.626
MOD_NEK2_1	109	114	PF00069	0.628
MOD_NEK2_1	361	366	PF00069	0.774
MOD_NEK2_1	80	85	PF00069	0.418
MOD_NEK2_2	180	185	PF00069	0.530
MOD_PIKK_1	222	228	PF00454	0.616
MOD_PIKK_1	298	304	PF00454	0.703
MOD_PIKK_1	399	405	PF00454	0.661
MOD_PKA_1	412	418	PF00069	0.647
MOD_PKA_2	156	162	PF00069	0.541
MOD_PKA_2	334	340	PF00069	0.536
MOD_PKB_1	349	357	PF00069	0.540
MOD_Plk_1	27	33	PF00069	0.522
MOD_Plk_4	148	154	PF00069	0.537
MOD_Plk_4	244	250	PF00069	0.442
MOD_Plk_4	320	326	PF00069	0.616
MOD_Plk_4	343	349	PF00069	0.623
MOD_Plk_4	7	13	PF00069	0.406
MOD_ProDKin_1	203	209	PF00069	0.665
MOD_ProDKin_1	367	373	PF00069	0.784
MOD_ProDKin_1	376	382	PF00069	0.751
MOD_ProDKin_1	59	65	PF00069	0.525
TRG_DiLeu_BaEn_1	105	110	PF01217	0.421
TRG_DiLeu_BaEn_1	211	216	PF01217	0.592
TRG_DiLeu_BaEn_1	281	286	PF01217	0.617
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.449
TRG_ENDOCYTIC_2	153	156	PF00928	0.432
TRG_ER_diArg_1	100	103	PF00400	0.478
TRG_ER_diArg_1	297	300	PF00400	0.624
TRG_ER_diArg_1	330	332	PF00400	0.599
TRG_ER_diArg_1	348	351	PF00400	0.394
TRG_ER_diArg_1	421	424	PF00400	0.665
TRG_ER_diArg_1	88	91	PF00400	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFS7	Leptomonas seymouri	44%	99%
A0A1X0P881	Trypanosomatidae	28%	94%
A0A3Q8IFT7	Leishmania donovani	99%	100%
A0A422NK60	Trypanosoma rangeli	29%	100%
A4HNT7	Leishmania braziliensis	68%	100%
D0A2Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ASJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1Z9	Leishmania major	90%	100%
V5BZW6	Trypanosoma cruzi	28%	100%