LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICQ5_LEIIN
TriTrypDb:
LINF_360013600
Length:
561

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICQ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICQ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.524
CLV_C14_Caspase3-7 22 26 PF00656 0.576
CLV_NRD_NRD_1 134 136 PF00675 0.499
CLV_NRD_NRD_1 284 286 PF00675 0.775
CLV_NRD_NRD_1 348 350 PF00675 0.788
CLV_NRD_NRD_1 412 414 PF00675 0.782
CLV_NRD_NRD_1 426 428 PF00675 0.583
CLV_NRD_NRD_1 435 437 PF00675 0.603
CLV_NRD_NRD_1 60 62 PF00675 0.646
CLV_PCSK_KEX2_1 134 136 PF00082 0.499
CLV_PCSK_KEX2_1 243 245 PF00082 0.811
CLV_PCSK_KEX2_1 284 286 PF00082 0.635
CLV_PCSK_KEX2_1 305 307 PF00082 0.737
CLV_PCSK_KEX2_1 348 350 PF00082 0.785
CLV_PCSK_KEX2_1 426 428 PF00082 0.623
CLV_PCSK_KEX2_1 435 437 PF00082 0.603
CLV_PCSK_KEX2_1 60 62 PF00082 0.646
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.671
CLV_PCSK_PC1ET2_1 305 307 PF00082 0.643
CLV_PCSK_PC7_1 344 350 PF00082 0.667
CLV_PCSK_SKI1_1 207 211 PF00082 0.517
CLV_PCSK_SKI1_1 293 297 PF00082 0.661
CLV_PCSK_SKI1_1 377 381 PF00082 0.631
CLV_PCSK_SKI1_1 388 392 PF00082 0.505
CLV_PCSK_SKI1_1 526 530 PF00082 0.616
CLV_PCSK_SKI1_1 532 536 PF00082 0.545
CLV_Separin_Metazoa 423 427 PF03568 0.599
DEG_APCC_DBOX_1 211 219 PF00400 0.523
DEG_APCC_DBOX_1 387 395 PF00400 0.572
DEG_Nend_UBRbox_2 1 3 PF02207 0.642
DEG_SPOP_SBC_1 298 302 PF00917 0.649
DEG_SPOP_SBC_1 316 320 PF00917 0.547
DEG_SPOP_SBC_1 336 340 PF00917 0.564
DEG_SPOP_SBC_1 399 403 PF00917 0.600
DOC_CKS1_1 50 55 PF01111 0.706
DOC_CYCLIN_yCln2_LP_2 479 485 PF00134 0.625
DOC_MAPK_DCC_7 3 12 PF00069 0.616
DOC_MAPK_DCC_7 475 485 PF00069 0.555
DOC_MAPK_gen_1 3 12 PF00069 0.616
DOC_MAPK_gen_1 475 485 PF00069 0.555
DOC_MAPK_MEF2A_6 3 12 PF00069 0.661
DOC_MAPK_MEF2A_6 506 515 PF00069 0.591
DOC_PP4_FxxP_1 361 364 PF00568 0.699
DOC_USP7_MATH_1 106 110 PF00917 0.616
DOC_USP7_MATH_1 179 183 PF00917 0.580
DOC_USP7_MATH_1 19 23 PF00917 0.581
DOC_USP7_MATH_1 245 249 PF00917 0.642
DOC_USP7_MATH_1 298 302 PF00917 0.744
DOC_USP7_MATH_1 32 36 PF00917 0.499
DOC_USP7_MATH_1 336 340 PF00917 0.673
DOC_USP7_MATH_1 351 355 PF00917 0.535
DOC_USP7_MATH_1 397 401 PF00917 0.639
DOC_USP7_MATH_1 416 420 PF00917 0.516
DOC_USP7_MATH_1 504 508 PF00917 0.628
DOC_USP7_MATH_1 522 526 PF00917 0.554
DOC_USP7_MATH_1 83 87 PF00917 0.693
DOC_USP7_UBL2_3 250 254 PF12436 0.578
DOC_WW_Pin1_4 243 248 PF00397 0.556
DOC_WW_Pin1_4 283 288 PF00397 0.691
DOC_WW_Pin1_4 306 311 PF00397 0.792
DOC_WW_Pin1_4 368 373 PF00397 0.635
DOC_WW_Pin1_4 37 42 PF00397 0.652
DOC_WW_Pin1_4 400 405 PF00397 0.609
DOC_WW_Pin1_4 429 434 PF00397 0.650
DOC_WW_Pin1_4 478 483 PF00397 0.663
DOC_WW_Pin1_4 49 54 PF00397 0.607
DOC_WW_Pin1_4 69 74 PF00397 0.607
LIG_14-3-3_CanoR_1 14 19 PF00244 0.768
LIG_14-3-3_CanoR_1 349 358 PF00244 0.631
LIG_14-3-3_CanoR_1 365 375 PF00244 0.574
LIG_14-3-3_CanoR_1 377 382 PF00244 0.518
LIG_14-3-3_CanoR_1 398 404 PF00244 0.651
LIG_14-3-3_CanoR_1 516 524 PF00244 0.599
LIG_BIR_III_4 126 130 PF00653 0.520
LIG_deltaCOP1_diTrp_1 541 547 PF00928 0.542
LIG_FHA_1 278 284 PF00498 0.634
LIG_FHA_1 390 396 PF00498 0.575
LIG_FHA_1 444 450 PF00498 0.704
LIG_FHA_1 500 506 PF00498 0.635
LIG_FHA_2 340 346 PF00498 0.709
LIG_LIR_Gen_1 186 191 PF02991 0.556
LIG_LIR_Gen_1 25 34 PF02991 0.578
LIG_LIR_Nem_3 153 158 PF02991 0.511
LIG_LIR_Nem_3 186 190 PF02991 0.563
LIG_LIR_Nem_3 25 31 PF02991 0.600
LIG_NRBOX 390 396 PF00104 0.530
LIG_Pex14_2 12 16 PF04695 0.661
LIG_PTB_Apo_2 181 188 PF02174 0.523
LIG_PTB_Phospho_1 181 187 PF10480 0.528
LIG_RPA_C_Fungi 219 231 PF08784 0.484
LIG_SH2_CRK 155 159 PF00017 0.533
LIG_SH2_NCK_1 187 191 PF00017 0.482
LIG_SH2_STAP1 187 191 PF00017 0.549
LIG_SH2_STAP1 383 387 PF00017 0.549
LIG_SH2_STAT5 299 302 PF00017 0.699
LIG_SH3_1 102 108 PF00018 0.596
LIG_SH3_1 284 290 PF00018 0.618
LIG_SH3_2 372 377 PF14604 0.656
LIG_SH3_3 102 108 PF00018 0.743
LIG_SH3_3 284 290 PF00018 0.618
LIG_SH3_3 369 375 PF00018 0.626
LIG_SH3_3 47 53 PF00018 0.711
LIG_SH3_3 512 518 PF00018 0.499
LIG_SH3_3 548 554 PF00018 0.602
LIG_SH3_3 67 73 PF00018 0.623
LIG_SH3_4 374 381 PF00018 0.611
LIG_SUMO_SIM_par_1 119 126 PF11976 0.506
LIG_SUMO_SIM_par_1 444 451 PF11976 0.565
LIG_TRAF2_1 146 149 PF00917 0.526
LIG_WW_3 432 436 PF00397 0.665
MOD_CDC14_SPxK_1 371 374 PF00782 0.659
MOD_CDC14_SPxK_1 403 406 PF00782 0.619
MOD_CDC14_SPxK_1 432 435 PF00782 0.642
MOD_CDC14_SPxK_1 54 57 PF00782 0.706
MOD_CDK_SPK_2 306 311 PF00069 0.659
MOD_CDK_SPxK_1 368 374 PF00069 0.656
MOD_CDK_SPxK_1 400 406 PF00069 0.613
MOD_CDK_SPxK_1 429 435 PF00069 0.649
MOD_CDK_SPxK_1 51 57 PF00069 0.704
MOD_CDK_SPxxK_3 243 250 PF00069 0.558
MOD_CDK_SPxxK_3 39 46 PF00069 0.631
MOD_CDK_SPxxK_3 429 436 PF00069 0.648
MOD_CK1_1 172 178 PF00069 0.724
MOD_CK1_1 21 27 PF00069 0.570
MOD_CK1_1 246 252 PF00069 0.645
MOD_CK1_1 272 278 PF00069 0.705
MOD_CK1_1 318 324 PF00069 0.782
MOD_CK1_1 325 331 PF00069 0.674
MOD_CK1_1 334 340 PF00069 0.606
MOD_CK1_1 35 41 PF00069 0.566
MOD_CK1_1 368 374 PF00069 0.671
MOD_CK1_1 400 406 PF00069 0.651
MOD_CK1_1 79 85 PF00069 0.643
MOD_CK2_1 339 345 PF00069 0.644
MOD_CK2_1 425 431 PF00069 0.639
MOD_CK2_1 447 453 PF00069 0.678
MOD_CMANNOS 544 547 PF00535 0.583
MOD_Cter_Amidation 346 349 PF01082 0.667
MOD_Cter_Amidation 58 61 PF01082 0.646
MOD_GlcNHglycan 108 111 PF01048 0.626
MOD_GlcNHglycan 21 24 PF01048 0.602
MOD_GlcNHglycan 302 305 PF01048 0.749
MOD_GlcNHglycan 320 323 PF01048 0.578
MOD_GlcNHglycan 345 348 PF01048 0.742
MOD_GlcNHglycan 353 356 PF01048 0.597
MOD_GlcNHglycan 395 398 PF01048 0.608
MOD_GlcNHglycan 443 446 PF01048 0.683
MOD_GlcNHglycan 519 522 PF01048 0.618
MOD_GlcNHglycan 529 532 PF01048 0.559
MOD_GlcNHglycan 557 560 PF01048 0.683
MOD_GlcNHglycan 80 84 PF01048 0.652
MOD_GlcNHglycan 85 88 PF01048 0.619
MOD_GSK3_1 14 21 PF00069 0.663
MOD_GSK3_1 169 176 PF00069 0.707
MOD_GSK3_1 179 186 PF00069 0.545
MOD_GSK3_1 239 246 PF00069 0.602
MOD_GSK3_1 264 271 PF00069 0.669
MOD_GSK3_1 272 279 PF00069 0.603
MOD_GSK3_1 289 296 PF00069 0.610
MOD_GSK3_1 306 313 PF00069 0.697
MOD_GSK3_1 318 325 PF00069 0.623
MOD_GSK3_1 328 335 PF00069 0.660
MOD_GSK3_1 339 346 PF00069 0.700
MOD_GSK3_1 35 42 PF00069 0.610
MOD_GSK3_1 373 380 PF00069 0.635
MOD_GSK3_1 389 396 PF00069 0.485
MOD_GSK3_1 398 405 PF00069 0.570
MOD_GSK3_1 425 432 PF00069 0.672
MOD_GSK3_1 443 450 PF00069 0.581
MOD_GSK3_1 474 481 PF00069 0.619
MOD_GSK3_1 79 86 PF00069 0.695
MOD_LATS_1 262 268 PF00433 0.619
MOD_N-GLC_1 351 356 PF02516 0.630
MOD_N-GLC_1 44 49 PF02516 0.582
MOD_NEK2_1 169 174 PF00069 0.631
MOD_NEK2_1 425 430 PF00069 0.594
MOD_NEK2_1 44 49 PF00069 0.672
MOD_NEK2_1 443 448 PF00069 0.506
MOD_NEK2_1 64 69 PF00069 0.523
MOD_OFUCOSY 269 274 PF10250 0.566
MOD_PIKK_1 274 280 PF00454 0.574
MOD_PIKK_1 44 50 PF00454 0.660
MOD_PK_1 291 297 PF00069 0.594
MOD_PKA_2 263 269 PF00069 0.760
MOD_PKA_2 331 337 PF00069 0.686
MOD_PKA_2 343 349 PF00069 0.645
MOD_PKA_2 366 372 PF00069 0.613
MOD_PKA_2 397 403 PF00069 0.643
MOD_PKA_2 425 431 PF00069 0.639
MOD_PKA_2 474 480 PF00069 0.572
MOD_PKA_2 98 104 PF00069 0.625
MOD_PKB_1 291 299 PF00069 0.595
MOD_Plk_1 325 331 PF00069 0.635
MOD_Plk_1 44 50 PF00069 0.582
MOD_Plk_1 79 85 PF00069 0.650
MOD_Plk_1 93 99 PF00069 0.674
MOD_Plk_4 128 134 PF00069 0.546
MOD_Plk_4 150 156 PF00069 0.432
MOD_Plk_4 173 179 PF00069 0.764
MOD_Plk_4 325 331 PF00069 0.635
MOD_Plk_4 389 395 PF00069 0.573
MOD_ProDKin_1 243 249 PF00069 0.554
MOD_ProDKin_1 283 289 PF00069 0.689
MOD_ProDKin_1 306 312 PF00069 0.790
MOD_ProDKin_1 368 374 PF00069 0.636
MOD_ProDKin_1 37 43 PF00069 0.656
MOD_ProDKin_1 400 406 PF00069 0.613
MOD_ProDKin_1 429 435 PF00069 0.649
MOD_ProDKin_1 478 484 PF00069 0.664
MOD_ProDKin_1 49 55 PF00069 0.606
MOD_ProDKin_1 69 75 PF00069 0.606
MOD_SUMO_for_1 304 307 PF00179 0.640
MOD_SUMO_rev_2 125 132 PF00179 0.509
MOD_SUMO_rev_2 148 154 PF00179 0.419
MOD_SUMO_rev_2 488 497 PF00179 0.631
TRG_DiLeu_BaEn_1 206 211 PF01217 0.519
TRG_DiLeu_BaEn_1 386 391 PF01217 0.572
TRG_DiLeu_BaLyEn_6 475 480 PF01217 0.741
TRG_ENDOCYTIC_2 155 158 PF00928 0.566
TRG_ENDOCYTIC_2 187 190 PF00928 0.556
TRG_ER_diArg_1 133 135 PF00400 0.504
TRG_ER_diArg_1 211 214 PF00400 0.520
TRG_ER_diArg_1 283 285 PF00400 0.636
TRG_ER_diArg_1 290 293 PF00400 0.648
TRG_ER_diArg_1 364 367 PF00400 0.611
TRG_ER_diArg_1 425 427 PF00400 0.659
TRG_ER_diArg_1 434 436 PF00400 0.609
TRG_Pf-PMV_PEXEL_1 156 161 PF00026 0.519

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGY6 Leishmania donovani 99% 100%
A4HNT9 Leishmania braziliensis 54% 100%
E9ASJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q1Z7 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS