General transcription factor IIH subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor subunit - putative

Species:

Leishmania infantum

UniProt:

A4ICQ4_LEIIN

TriTrypDb:

LINF_360013700

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0000439	transcription factor TFIIH core complex	4	12
GO:0005654	nucleoplasm	2	1
GO:0005667	transcription regulator complex	2	12
GO:0005675	transcription factor TFIIH holo complex	4	1
GO:0032806	carboxy-terminal domain protein kinase complex	3	1
GO:0032991	protein-containing complex	1	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0090575	RNA polymerase II transcription regulator complex	3	12
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	12

Previous1 2Next

Expansion

Sequence features

A4ICQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICQ4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006289	nucleotide-excision repair	6	12
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006468	protein phosphorylation	5	1
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1

Previous1 2 3 4 5Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	12
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12
GO:1901363	heterocyclic compound binding	2	1

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.666
CLV_NRD_NRD_1	205	207	PF00675	0.359
CLV_NRD_NRD_1	309	311	PF00675	0.416
CLV_NRD_NRD_1	350	352	PF00675	0.344
CLV_NRD_NRD_1	406	408	PF00675	0.381
CLV_NRD_NRD_1	429	431	PF00675	0.657
CLV_NRD_NRD_1	461	463	PF00675	0.755
CLV_NRD_NRD_1	48	50	PF00675	0.461
CLV_NRD_NRD_1	498	500	PF00675	0.466
CLV_PCSK_KEX2_1	160	162	PF00082	0.540

Previous1 2 3 4 5…19Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V5	Leptomonas seymouri	64%	100%
A0A0S4JS94	Bodo saltans	29%	100%
A0A1X0P966	Trypanosomatidae	42%	100%
A0A3S5H816	Leishmania donovani	100%	100%
A0A422NK89	Trypanosoma rangeli	44%	100%
A4HNU0	Leishmania braziliensis	81%	100%
D0A2Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ASK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1Z6	Leishmania major	93%	100%
V5B9Y1	Trypanosoma cruzi	44%	100%

Previous1Next