LeishMANIAdb
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General transcription factor IIH subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
General transcription factor IIH subunit 4
Gene product:
TFIIH basal transcription factor subunit - putative
Species:
Leishmania infantum
UniProt:
A4ICQ4_LEIIN
TriTrypDb:
LINF_360013700
Length:
557

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000439 transcription factor TFIIH core complex 4 12
GO:0005667 transcription regulator complex 2 12
GO:0032991 protein-containing complex 1 12
GO:0090575 RNA polymerase II transcription regulator complex 3 12
GO:0140513 nuclear protein-containing complex 2 12
GO:0005654 nucleoplasm 2 1
GO:0005675 transcription factor TFIIH holo complex 4 1
GO:0032806 carboxy-terminal domain protein kinase complex 3 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
GO:1902554 serine/threonine protein kinase complex 6 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4ICQ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICQ4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006281 DNA repair 5 12
GO:0006289 nucleotide-excision repair 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0033554 cellular response to stress 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0006468 protein phosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0016310 phosphorylation 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0019538 protein metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0036211 protein modification process 4 1
GO:0043412 macromolecule modification 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0070816 obsolete phosphorylation of RNA polymerase II C-terminal domain 6 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0001671 ATPase activator activity 3 12
GO:0098772 molecular function regulator activity 1 12
GO:0140677 molecular function activator activity 2 12
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1
GO:0003690 double-stranded DNA binding 5 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 472 476 PF00656 0.666
CLV_NRD_NRD_1 205 207 PF00675 0.359
CLV_NRD_NRD_1 309 311 PF00675 0.416
CLV_NRD_NRD_1 350 352 PF00675 0.344
CLV_NRD_NRD_1 406 408 PF00675 0.381
CLV_NRD_NRD_1 429 431 PF00675 0.657
CLV_NRD_NRD_1 461 463 PF00675 0.755
CLV_NRD_NRD_1 48 50 PF00675 0.461
CLV_NRD_NRD_1 498 500 PF00675 0.466
CLV_PCSK_KEX2_1 160 162 PF00082 0.540
CLV_PCSK_KEX2_1 350 352 PF00082 0.344
CLV_PCSK_KEX2_1 429 431 PF00082 0.624
CLV_PCSK_KEX2_1 460 462 PF00082 0.769
CLV_PCSK_KEX2_1 48 50 PF00082 0.458
CLV_PCSK_KEX2_1 498 500 PF00082 0.451
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.540
CLV_PCSK_SKI1_1 118 122 PF00082 0.557
CLV_PCSK_SKI1_1 160 164 PF00082 0.428
CLV_PCSK_SKI1_1 186 190 PF00082 0.401
CLV_PCSK_SKI1_1 207 211 PF00082 0.384
CLV_PCSK_SKI1_1 235 239 PF00082 0.492
CLV_PCSK_SKI1_1 258 262 PF00082 0.371
CLV_PCSK_SKI1_1 408 412 PF00082 0.428
CLV_PCSK_SKI1_1 499 503 PF00082 0.489
CLV_PCSK_SKI1_1 518 522 PF00082 0.269
DEG_APCC_DBOX_1 117 125 PF00400 0.545
DEG_SPOP_SBC_1 2 6 PF00917 0.497
DOC_CKS1_1 196 201 PF01111 0.398
DOC_CYCLIN_RxL_1 113 122 PF00134 0.587
DOC_CYCLIN_RxL_1 232 240 PF00134 0.413
DOC_MAPK_FxFP_2 278 281 PF00069 0.417
DOC_PP1_RVXF_1 256 263 PF00149 0.413
DOC_PP1_RVXF_1 496 503 PF00149 0.475
DOC_PP2B_LxvP_1 480 483 PF13499 0.522
DOC_PP2B_LxvP_1 551 554 PF13499 0.483
DOC_PP2B_LxvP_1 8 11 PF13499 0.597
DOC_PP4_FxxP_1 132 135 PF00568 0.663
DOC_PP4_FxxP_1 278 281 PF00568 0.417
DOC_USP7_MATH_1 2 6 PF00917 0.629
DOC_USP7_MATH_1 423 427 PF00917 0.344
DOC_USP7_MATH_1 449 453 PF00917 0.683
DOC_WW_Pin1_4 137 142 PF00397 0.616
DOC_WW_Pin1_4 195 200 PF00397 0.375
DOC_WW_Pin1_4 207 212 PF00397 0.417
DOC_WW_Pin1_4 313 318 PF00397 0.342
DOC_WW_Pin1_4 326 331 PF00397 0.220
DOC_WW_Pin1_4 439 444 PF00397 0.760
DOC_WW_Pin1_4 455 460 PF00397 0.488
LIG_14-3-3_CanoR_1 102 106 PF00244 0.534
LIG_14-3-3_CanoR_1 118 128 PF00244 0.554
LIG_14-3-3_CanoR_1 154 163 PF00244 0.493
LIG_14-3-3_CanoR_1 295 303 PF00244 0.325
LIG_14-3-3_CanoR_1 407 416 PF00244 0.353
LIG_14-3-3_CanoR_1 417 422 PF00244 0.433
LIG_14-3-3_CanoR_1 510 520 PF00244 0.533
LIG_14-3-3_CanoR_1 70 79 PF00244 0.487
LIG_Actin_WH2_2 149 166 PF00022 0.477
LIG_BRCT_BRCA1_1 158 162 PF00533 0.530
LIG_BRCT_BRCA1_1 315 319 PF00533 0.352
LIG_BRCT_BRCA1_1 331 335 PF00533 0.449
LIG_BRCT_BRCA1_1 449 453 PF00533 0.747
LIG_BRCT_BRCA1_1 72 76 PF00533 0.530
LIG_CaM_IQ_9 41 57 PF13499 0.589
LIG_CtBP_PxDLS_1 330 334 PF00389 0.437
LIG_FHA_1 166 172 PF00498 0.481
LIG_FHA_1 173 179 PF00498 0.489
LIG_FHA_1 255 261 PF00498 0.427
LIG_FHA_1 352 358 PF00498 0.423
LIG_FHA_1 469 475 PF00498 0.667
LIG_FHA_1 477 483 PF00498 0.509
LIG_FHA_1 519 525 PF00498 0.556
LIG_FHA_2 138 144 PF00498 0.688
LIG_FHA_2 470 476 PF00498 0.717
LIG_FHA_2 85 91 PF00498 0.649
LIG_HCF-1_HBM_1 77 80 PF13415 0.349
LIG_LIR_Apic_2 106 112 PF02991 0.577
LIG_LIR_Gen_1 215 221 PF02991 0.463
LIG_LIR_Gen_1 259 270 PF02991 0.251
LIG_LIR_Gen_1 537 548 PF02991 0.441
LIG_LIR_Gen_1 73 82 PF02991 0.513
LIG_LIR_LC3C_4 478 482 PF02991 0.559
LIG_LIR_Nem_3 215 219 PF02991 0.428
LIG_LIR_Nem_3 259 265 PF02991 0.234
LIG_LIR_Nem_3 360 366 PF02991 0.315
LIG_LIR_Nem_3 537 543 PF02991 0.441
LIG_LIR_Nem_3 545 551 PF02991 0.413
LIG_LIR_Nem_3 73 79 PF02991 0.469
LIG_LYPXL_S_1 302 306 PF13949 0.344
LIG_LYPXL_yS_3 303 306 PF13949 0.344
LIG_NRBOX 260 266 PF00104 0.344
LIG_NRBOX 62 68 PF00104 0.525
LIG_PCNA_PIPBox_1 517 526 PF02747 0.567
LIG_PCNA_yPIPBox_3 181 189 PF02747 0.415
LIG_PCNA_yPIPBox_3 224 237 PF02747 0.475
LIG_PCNA_yPIPBox_3 510 524 PF02747 0.566
LIG_SH2_CRK 540 544 PF00017 0.466
LIG_SH2_SRC 37 40 PF00017 0.498
LIG_SH2_STAP1 368 372 PF00017 0.437
LIG_SH2_STAT5 276 279 PF00017 0.417
LIG_SH2_STAT5 368 371 PF00017 0.328
LIG_SH2_STAT5 523 526 PF00017 0.570
LIG_SH3_3 143 149 PF00018 0.552
LIG_SH3_3 193 199 PF00018 0.406
LIG_SH3_3 311 317 PF00018 0.377
LIG_SUMO_SIM_anti_2 234 240 PF11976 0.409
LIG_SUMO_SIM_par_1 148 153 PF11976 0.573
LIG_SUMO_SIM_par_1 234 240 PF11976 0.385
LIG_SUMO_SIM_par_1 263 269 PF11976 0.475
LIG_SUMO_SIM_par_1 328 334 PF11976 0.437
LIG_TRFH_1 145 149 PF08558 0.601
LIG_TRFH_1 313 317 PF08558 0.340
LIG_TYR_ITIM 301 306 PF00017 0.385
LIG_TYR_ITIM 35 40 PF00017 0.455
LIG_UBA3_1 374 383 PF00899 0.262
LIG_WW_3 203 207 PF00397 0.359
MOD_CDC14_SPxK_1 458 461 PF00782 0.642
MOD_CDK_SPK_2 455 460 PF00069 0.643
MOD_CDK_SPxK_1 455 461 PF00069 0.644
MOD_CDK_SPxxK_3 455 462 PF00069 0.548
MOD_CK1_1 18 24 PF00069 0.426
MOD_CK1_1 251 257 PF00069 0.423
MOD_CK1_1 3 9 PF00069 0.659
MOD_CK1_1 344 350 PF00069 0.443
MOD_CK1_1 401 407 PF00069 0.364
MOD_CK1_1 442 448 PF00069 0.720
MOD_CK1_1 451 457 PF00069 0.717
MOD_CK1_1 470 476 PF00069 0.399
MOD_CK2_1 137 143 PF00069 0.612
MOD_CK2_1 68 74 PF00069 0.428
MOD_CK2_1 84 90 PF00069 0.559
MOD_Cter_Amidation 46 49 PF01082 0.494
MOD_GlcNHglycan 250 253 PF01048 0.420
MOD_GlcNHglycan 343 346 PF01048 0.423
MOD_GlcNHglycan 403 406 PF01048 0.350
MOD_GlcNHglycan 444 447 PF01048 0.691
MOD_GlcNHglycan 455 458 PF01048 0.674
MOD_GlcNHglycan 5 8 PF01048 0.595
MOD_GSK3_1 247 254 PF00069 0.462
MOD_GSK3_1 266 273 PF00069 0.449
MOD_GSK3_1 325 332 PF00069 0.369
MOD_GSK3_1 437 444 PF00069 0.689
MOD_GSK3_1 447 454 PF00069 0.700
MOD_GSK3_1 464 471 PF00069 0.475
MOD_GSK3_1 80 87 PF00069 0.553
MOD_GSK3_1 88 95 PF00069 0.668
MOD_N-GLC_1 248 253 PF02516 0.456
MOD_N-GLC_1 510 515 PF02516 0.477
MOD_NEK2_1 156 161 PF00069 0.435
MOD_NEK2_1 162 167 PF00069 0.406
MOD_NEK2_1 237 242 PF00069 0.384
MOD_NEK2_1 331 336 PF00069 0.381
MOD_NEK2_1 339 344 PF00069 0.356
MOD_NEK2_1 453 458 PF00069 0.771
MOD_NEK2_1 54 59 PF00069 0.561
MOD_NEK2_1 82 87 PF00069 0.663
MOD_NEK2_1 88 93 PF00069 0.671
MOD_PIKK_1 119 125 PF00454 0.523
MOD_PIKK_1 80 86 PF00454 0.662
MOD_PIKK_1 92 98 PF00454 0.533
MOD_PKA_2 101 107 PF00069 0.529
MOD_PKA_2 294 300 PF00069 0.340
MOD_PKA_2 395 401 PF00069 0.337
MOD_PKA_2 54 60 PF00069 0.621
MOD_Plk_4 256 262 PF00069 0.400
MOD_Plk_4 266 272 PF00069 0.479
MOD_Plk_4 353 359 PF00069 0.328
MOD_Plk_4 423 429 PF00069 0.480
MOD_Plk_4 476 482 PF00069 0.549
MOD_ProDKin_1 137 143 PF00069 0.612
MOD_ProDKin_1 195 201 PF00069 0.375
MOD_ProDKin_1 207 213 PF00069 0.417
MOD_ProDKin_1 313 319 PF00069 0.342
MOD_ProDKin_1 326 332 PF00069 0.220
MOD_ProDKin_1 439 445 PF00069 0.759
MOD_ProDKin_1 455 461 PF00069 0.488
MOD_SUMO_for_1 382 385 PF00179 0.262
MOD_SUMO_rev_2 307 313 PF00179 0.398
TRG_DiLeu_BaEn_1 234 239 PF01217 0.475
TRG_DiLeu_BaEn_1 28 33 PF01217 0.416
TRG_DiLeu_BaLyEn_6 301 306 PF01217 0.364
TRG_DiLeu_BaLyEn_6 551 556 PF01217 0.438
TRG_ENDOCYTIC_2 303 306 PF00928 0.329
TRG_ENDOCYTIC_2 37 40 PF00928 0.413
TRG_ENDOCYTIC_2 540 543 PF00928 0.411
TRG_ER_diArg_1 349 351 PF00400 0.348
TRG_ER_diArg_1 428 430 PF00400 0.658
TRG_ER_diArg_1 459 462 PF00400 0.725
TRG_ER_diArg_1 498 500 PF00400 0.467
TRG_Pf-PMV_PEXEL_1 118 123 PF00026 0.548
TRG_Pf-PMV_PEXEL_1 70 74 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7V5 Leptomonas seymouri 64% 100%
A0A0S4JS94 Bodo saltans 29% 100%
A0A1X0P966 Trypanosomatidae 42% 100%
A0A3S5H816 Leishmania donovani 100% 100%
A0A422NK89 Trypanosoma rangeli 44% 100%
A4HNU0 Leishmania braziliensis 81% 100%
D0A2Q5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ASK0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q1Z6 Leishmania major 93% 100%
V5B9Y1 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS