DUF383 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICQ3_LEIIN

TriTrypDb:

LINF_360013800

Length:

399

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.502
CLV_C14_Caspase3-7	216	220	PF00656	0.428
CLV_C14_Caspase3-7	45	49	PF00656	0.419
CLV_NRD_NRD_1	170	172	PF00675	0.438
CLV_NRD_NRD_1	97	99	PF00675	0.456
CLV_PCSK_FUR_1	380	384	PF00082	0.494
CLV_PCSK_KEX2_1	170	172	PF00082	0.438
CLV_PCSK_KEX2_1	382	384	PF00082	0.606
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.606
CLV_PCSK_SKI1_1	153	157	PF00082	0.451
CLV_PCSK_SKI1_1	170	174	PF00082	0.293
CLV_PCSK_SKI1_1	293	297	PF00082	0.509
CLV_PCSK_SKI1_1	34	38	PF00082	0.409
CLV_PCSK_SKI1_1	370	374	PF00082	0.435
CLV_PCSK_SKI1_1	382	386	PF00082	0.537
CLV_PCSK_SKI1_1	79	83	PF00082	0.385
CLV_PCSK_SKI1_1	99	103	PF00082	0.412
DEG_APCC_DBOX_1	33	41	PF00400	0.419
DEG_Nend_UBRbox_2	1	3	PF02207	0.440
DOC_CDC14_PxL_1	115	123	PF14671	0.393
DOC_CYCLIN_RxL_1	148	161	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.518
DOC_MAPK_gen_1	95	103	PF00069	0.452
DOC_MAPK_MEF2A_6	129	136	PF00069	0.384
DOC_PP1_RVXF_1	97	104	PF00149	0.420
DOC_PP2B_LxvP_1	16	19	PF13499	0.560
DOC_PP2B_LxvP_1	63	66	PF13499	0.491
DOC_PP4_FxxP_1	102	105	PF00568	0.350
DOC_PP4_FxxP_1	387	390	PF00568	0.655
DOC_USP7_MATH_1	117	121	PF00917	0.437
DOC_USP7_MATH_1	151	155	PF00917	0.352
DOC_USP7_MATH_1	252	256	PF00917	0.549
DOC_USP7_UBL2_3	211	215	PF12436	0.440
LIG_14-3-3_CanoR_1	153	158	PF00244	0.455
LIG_BIR_III_4	219	223	PF00653	0.408
LIG_FHA_1	11	17	PF00498	0.563
LIG_FHA_1	159	165	PF00498	0.549
LIG_FHA_1	197	203	PF00498	0.399
LIG_FHA_1	286	292	PF00498	0.500
LIG_FHA_1	294	300	PF00498	0.419
LIG_FHA_1	333	339	PF00498	0.417
LIG_FHA_1	369	375	PF00498	0.517
LIG_FHA_2	178	184	PF00498	0.512
LIG_GBD_Chelix_1	338	346	PF00786	0.494
LIG_GBD_Chelix_1	51	59	PF00786	0.434
LIG_IBAR_NPY_1	144	146	PF08397	0.593
LIG_LIR_Apic_2	385	390	PF02991	0.535
LIG_LIR_Gen_1	106	116	PF02991	0.353
LIG_LIR_Gen_1	2	11	PF02991	0.581
LIG_LIR_Gen_1	362	369	PF02991	0.516
LIG_LIR_Nem_3	106	111	PF02991	0.358
LIG_LIR_Nem_3	133	139	PF02991	0.402
LIG_LIR_Nem_3	194	200	PF02991	0.415
LIG_LIR_Nem_3	2	6	PF02991	0.582
LIG_LIR_Nem_3	21	27	PF02991	0.470
LIG_LIR_Nem_3	267	273	PF02991	0.382
LIG_LIR_Nem_3	279	284	PF02991	0.406
LIG_LIR_Nem_3	362	366	PF02991	0.531
LIG_LYPXL_yS_3	118	121	PF13949	0.397
LIG_PCNA_PIPBox_1	314	323	PF02747	0.391
LIG_SH2_CRK	146	150	PF00017	0.414
LIG_SH2_CRK	235	239	PF00017	0.419
LIG_SH2_SRC	356	359	PF00017	0.486
LIG_SH2_STAP1	146	150	PF00017	0.433
LIG_SH2_STAT5	124	127	PF00017	0.383
LIG_SH2_STAT5	321	324	PF00017	0.435
LIG_SH2_STAT5	50	53	PF00017	0.405
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.511
LIG_SUMO_SIM_anti_2	304	310	PF11976	0.538
LIG_SUMO_SIM_par_1	198	204	PF11976	0.381
LIG_SUMO_SIM_par_1	304	310	PF11976	0.501
LIG_UBA3_1	23	31	PF00899	0.490
LIG_UBA3_1	342	350	PF00899	0.402
LIG_UBA3_1	365	373	PF00899	0.508
LIG_WRC_WIRS_1	157	162	PF05994	0.476
MOD_CK1_1	329	335	PF00069	0.535
MOD_CK1_1	359	365	PF00069	0.422
MOD_CK2_1	117	123	PF00069	0.471
MOD_CK2_1	277	283	PF00069	0.522
MOD_Cter_Amidation	256	259	PF01082	0.594
MOD_GlcNHglycan	395	398	PF01048	0.767
MOD_GSK3_1	186	193	PF00069	0.446
MOD_GSK3_1	196	203	PF00069	0.380
MOD_GSK3_1	87	94	PF00069	0.512
MOD_N-GLC_2	231	233	PF02516	0.344
MOD_NEK2_1	158	163	PF00069	0.407
MOD_NEK2_1	200	205	PF00069	0.379
MOD_NEK2_1	277	282	PF00069	0.464
MOD_NEK2_1	294	299	PF00069	0.222
MOD_NEK2_1	89	94	PF00069	0.478
MOD_PIKK_1	158	164	PF00454	0.413
MOD_PKA_1	382	388	PF00069	0.630
MOD_PKA_2	139	145	PF00069	0.482
MOD_PKA_2	382	388	PF00069	0.587
MOD_Plk_1	326	332	PF00069	0.502
MOD_Plk_1	59	65	PF00069	0.461
MOD_Plk_1	82	88	PF00069	0.492
MOD_Plk_2-3	12	18	PF00069	0.687
MOD_Plk_4	153	159	PF00069	0.479
MOD_Plk_4	177	183	PF00069	0.511
MOD_Plk_4	196	202	PF00069	0.236
MOD_Plk_4	294	300	PF00069	0.397
TRG_DiLeu_BaEn_2	265	271	PF01217	0.396
TRG_DiLeu_BaEn_4	266	272	PF01217	0.453
TRG_ENDOCYTIC_2	118	121	PF00928	0.397
TRG_ENDOCYTIC_2	146	149	PF00928	0.419
TRG_ENDOCYTIC_2	235	238	PF00928	0.402
TRG_ENDOCYTIC_2	311	314	PF00928	0.378
TRG_ENDOCYTIC_2	363	366	PF00928	0.528
TRG_ER_diArg_1	170	172	PF00400	0.438
TRG_ER_FFAT_1	279	290	PF00635	0.486
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM88	Leptomonas seymouri	86%	88%
A0A0S4JVF0	Bodo saltans	59%	87%
A0A1X0P8C7	Trypanosomatidae	71%	89%
A0A3Q8IQJ6	Leishmania donovani	100%	87%
A0A3R7MNS3	Trypanosoma rangeli	71%	88%
A4HNU1	Leishmania braziliensis	91%	100%
D0A2Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	89%
E9ASK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q1Z5	Leishmania major	97%	100%
V5BQF8	Trypanosoma cruzi	70%	100%