Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICP9_LEIIN

TriTrypDb:

LINF_360014200

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.596
CLV_C14_Caspase3-7	524	528	PF00656	0.588
CLV_C14_Caspase3-7	561	565	PF00656	0.685
CLV_NRD_NRD_1	206	208	PF00675	0.573
CLV_NRD_NRD_1	402	404	PF00675	0.697
CLV_NRD_NRD_1	515	517	PF00675	0.606
CLV_NRD_NRD_1	533	535	PF00675	0.509
CLV_NRD_NRD_1	68	70	PF00675	0.549
CLV_NRD_NRD_1	811	813	PF00675	0.575
CLV_PCSK_KEX2_1	159	161	PF00082	0.569
CLV_PCSK_KEX2_1	206	208	PF00082	0.573
CLV_PCSK_KEX2_1	279	281	PF00082	0.643
CLV_PCSK_KEX2_1	402	404	PF00082	0.697
CLV_PCSK_KEX2_1	515	517	PF00082	0.606
CLV_PCSK_KEX2_1	533	535	PF00082	0.509
CLV_PCSK_KEX2_1	68	70	PF00082	0.546
CLV_PCSK_KEX2_1	811	813	PF00082	0.575
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.569
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.643
CLV_PCSK_PC7_1	275	281	PF00082	0.547
CLV_PCSK_SKI1_1	136	140	PF00082	0.569
CLV_PCSK_SKI1_1	384	388	PF00082	0.467
CLV_PCSK_SKI1_1	417	421	PF00082	0.629
CLV_PCSK_SKI1_1	555	559	PF00082	0.649
CLV_PCSK_SKI1_1	632	636	PF00082	0.642
CLV_PCSK_SKI1_1	657	661	PF00082	0.573
CLV_PCSK_SKI1_1	828	832	PF00082	0.440
CLV_PCSK_SKI1_1	864	868	PF00082	0.432
DEG_APCC_DBOX_1	309	317	PF00400	0.562
DEG_APCC_DBOX_1	383	391	PF00400	0.471
DEG_APCC_DBOX_1	416	424	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DEG_SCF_FBW7_1	750	757	PF00400	0.622
DEG_SCF_SKP2-CKS1_1	592	599	PF00560	0.584
DEG_SPOP_SBC_1	694	698	PF00917	0.548
DEG_SPOP_SBC_1	749	753	PF00917	0.615
DOC_CKS1_1	281	286	PF01111	0.608
DOC_CKS1_1	648	653	PF01111	0.614
DOC_CKS1_1	703	708	PF01111	0.561
DOC_CYCLIN_RxL_1	140	154	PF00134	0.551
DOC_MAPK_gen_1	767	775	PF00069	0.390
DOC_MAPK_MEF2A_6	279	288	PF00069	0.575
DOC_MAPK_MEF2A_6	384	392	PF00069	0.470
DOC_PP1_RVXF_1	769	776	PF00149	0.359
DOC_PP2B_PxIxI_1	283	289	PF00149	0.568
DOC_PP4_FxxP_1	121	124	PF00568	0.601
DOC_PP4_FxxP_1	539	542	PF00568	0.638
DOC_PP4_FxxP_1	806	809	PF00568	0.503
DOC_SPAK_OSR1_1	837	841	PF12202	0.454
DOC_USP7_MATH_1	106	110	PF00917	0.544
DOC_USP7_MATH_1	221	225	PF00917	0.588
DOC_USP7_MATH_1	302	306	PF00917	0.554
DOC_USP7_MATH_1	471	475	PF00917	0.520
DOC_USP7_MATH_1	559	563	PF00917	0.661
DOC_USP7_MATH_1	605	609	PF00917	0.668
DOC_USP7_MATH_1	714	718	PF00917	0.676
DOC_USP7_MATH_1	727	731	PF00917	0.544
DOC_USP7_MATH_1	749	753	PF00917	0.580
DOC_USP7_MATH_1	95	99	PF00917	0.659
DOC_USP7_UBL2_3	48	52	PF12436	0.573
DOC_WW_Pin1_4	112	117	PF00397	0.586
DOC_WW_Pin1_4	15	20	PF00397	0.540
DOC_WW_Pin1_4	229	234	PF00397	0.539
DOC_WW_Pin1_4	280	285	PF00397	0.653
DOC_WW_Pin1_4	326	331	PF00397	0.714
DOC_WW_Pin1_4	411	416	PF00397	0.629
DOC_WW_Pin1_4	450	455	PF00397	0.639
DOC_WW_Pin1_4	534	539	PF00397	0.682
DOC_WW_Pin1_4	555	560	PF00397	0.652
DOC_WW_Pin1_4	585	590	PF00397	0.685
DOC_WW_Pin1_4	593	598	PF00397	0.588
DOC_WW_Pin1_4	647	652	PF00397	0.615
DOC_WW_Pin1_4	670	675	PF00397	0.555
DOC_WW_Pin1_4	702	707	PF00397	0.614
DOC_WW_Pin1_4	725	730	PF00397	0.688
DOC_WW_Pin1_4	750	755	PF00397	0.723
DOC_WW_Pin1_4	872	877	PF00397	0.394
LIG_14-3-3_CanoR_1	127	134	PF00244	0.553
LIG_14-3-3_CanoR_1	178	186	PF00244	0.582
LIG_14-3-3_CanoR_1	187	191	PF00244	0.518
LIG_14-3-3_CanoR_1	192	198	PF00244	0.454
LIG_14-3-3_CanoR_1	23	29	PF00244	0.636
LIG_14-3-3_CanoR_1	280	284	PF00244	0.561
LIG_14-3-3_CanoR_1	521	530	PF00244	0.503
LIG_14-3-3_CanoR_1	695	700	PF00244	0.592
LIG_14-3-3_CanoR_1	811	819	PF00244	0.476
LIG_14-3-3_CanoR_1	828	836	PF00244	0.373
LIG_Actin_WH2_2	176	194	PF00022	0.526
LIG_Actin_WH2_2	486	502	PF00022	0.390
LIG_BIR_III_2	34	38	PF00653	0.527
LIG_BIR_III_2	594	598	PF00653	0.602
LIG_BRCT_BRCA1_1	92	96	PF00533	0.622
LIG_EVH1_1	736	740	PF00568	0.656
LIG_FHA_1	100	106	PF00498	0.607
LIG_FHA_1	133	139	PF00498	0.588
LIG_FHA_1	281	287	PF00498	0.674
LIG_FHA_1	457	463	PF00498	0.502
LIG_FHA_1	487	493	PF00498	0.496
LIG_FHA_1	502	508	PF00498	0.331
LIG_FHA_1	572	578	PF00498	0.640
LIG_FHA_1	640	646	PF00498	0.655
LIG_FHA_1	694	700	PF00498	0.658
LIG_FHA_1	720	726	PF00498	0.697
LIG_FHA_1	825	831	PF00498	0.503
LIG_FHA_2	2	8	PF00498	0.537
LIG_FHA_2	355	361	PF00498	0.556
LIG_FHA_2	439	445	PF00498	0.474
LIG_FHA_2	648	654	PF00498	0.664
LIG_FHA_2	830	836	PF00498	0.377
LIG_GBD_Chelix_1	316	324	PF00786	0.555
LIG_LIR_Apic_2	120	124	PF02991	0.601
LIG_LIR_Apic_2	537	542	PF02991	0.632
LIG_LIR_Apic_2	735	739	PF02991	0.650
LIG_LIR_Apic_2	803	809	PF02991	0.512
LIG_LIR_Gen_1	208	215	PF02991	0.559
LIG_LIR_Gen_1	504	512	PF02991	0.364
LIG_LIR_Gen_1	59	67	PF02991	0.509
LIG_LIR_Gen_1	835	846	PF02991	0.460
LIG_LIR_Nem_3	208	213	PF02991	0.564
LIG_LIR_Nem_3	504	509	PF02991	0.366
LIG_LIR_Nem_3	518	523	PF02991	0.494
LIG_LIR_Nem_3	59	64	PF02991	0.509
LIG_LIR_Nem_3	835	841	PF02991	0.489
LIG_MYND_1	585	589	PF01753	0.701
LIG_PTAP_UEV_1	728	733	PF05743	0.594
LIG_SH2_CRK	210	214	PF00017	0.558
LIG_SH2_CRK	26	30	PF00017	0.636
LIG_SH2_CRK	435	439	PF00017	0.392
LIG_SH2_CRK	520	524	PF00017	0.593
LIG_SH2_CRK	703	707	PF00017	0.562
LIG_SH2_NCK_1	703	707	PF00017	0.540
LIG_SH2_STAP1	342	346	PF00017	0.457
LIG_SH2_STAP1	764	768	PF00017	0.374
LIG_SH3_1	726	732	PF00018	0.571
LIG_SH3_3	40	46	PF00018	0.485
LIG_SH3_3	612	618	PF00018	0.620
LIG_SH3_3	705	711	PF00018	0.604
LIG_SH3_3	726	732	PF00018	0.671
LIG_SH3_3	734	740	PF00018	0.680
LIG_SH3_3	742	748	PF00018	0.600
LIG_SUMO_SIM_anti_2	865	870	PF11976	0.463
LIG_SUMO_SIM_par_1	459	466	PF11976	0.454
LIG_SUMO_SIM_par_1	867	872	PF11976	0.385
LIG_TRAF2_1	832	835	PF00917	0.507
LIG_WW_3	709	713	PF00397	0.571
MOD_CDC14_SPxK_1	414	417	PF00782	0.627
MOD_CDC14_SPxK_1	588	591	PF00782	0.707
MOD_CDK_SPK_2	538	543	PF00069	0.570
MOD_CDK_SPxK_1	411	417	PF00069	0.602
MOD_CDK_SPxK_1	585	591	PF00069	0.702
MOD_CDK_SPxK_1	593	599	PF00069	0.606
MOD_CDK_SPxxK_3	326	333	PF00069	0.563
MOD_CK1_1	117	123	PF00069	0.632
MOD_CK1_1	232	238	PF00069	0.673
MOD_CK1_1	240	246	PF00069	0.527
MOD_CK1_1	270	276	PF00069	0.602
MOD_CK1_1	305	311	PF00069	0.526
MOD_CK1_1	347	353	PF00069	0.548
MOD_CK1_1	450	456	PF00069	0.620
MOD_CK1_1	486	492	PF00069	0.436
MOD_CK1_1	541	547	PF00069	0.624
MOD_CK1_1	607	613	PF00069	0.652
MOD_CK1_1	624	630	PF00069	0.550
MOD_CK1_1	652	658	PF00069	0.675
MOD_CK1_1	683	689	PF00069	0.689
MOD_CK1_1	717	723	PF00069	0.624
MOD_CK1_1	752	758	PF00069	0.632
MOD_CK1_1	872	878	PF00069	0.426
MOD_CK2_1	438	444	PF00069	0.434
MOD_CK2_1	471	477	PF00069	0.521
MOD_CK2_1	647	653	PF00069	0.669
MOD_CK2_1	829	835	PF00069	0.441
MOD_Cter_Amidation	277	280	PF01082	0.551
MOD_Cter_Amidation	531	534	PF01082	0.621
MOD_DYRK1A_RPxSP_1	555	559	PF00069	0.649
MOD_GlcNHglycan	116	119	PF01048	0.644
MOD_GlcNHglycan	128	131	PF01048	0.483
MOD_GlcNHglycan	179	182	PF01048	0.437
MOD_GlcNHglycan	223	226	PF01048	0.602
MOD_GlcNHglycan	26	29	PF01048	0.615
MOD_GlcNHglycan	298	302	PF01048	0.725
MOD_GlcNHglycan	307	310	PF01048	0.584
MOD_GlcNHglycan	427	430	PF01048	0.383
MOD_GlcNHglycan	473	476	PF01048	0.494
MOD_GlcNHglycan	517	520	PF01048	0.567
MOD_GlcNHglycan	554	558	PF01048	0.678
MOD_GlcNHglycan	561	564	PF01048	0.613
MOD_GlcNHglycan	566	569	PF01048	0.560
MOD_GlcNHglycan	626	629	PF01048	0.591
MOD_GlcNHglycan	668	671	PF01048	0.716
MOD_GlcNHglycan	687	691	PF01048	0.578
MOD_GlcNHglycan	70	74	PF01048	0.587
MOD_GlcNHglycan	729	732	PF01048	0.634
MOD_GlcNHglycan	82	85	PF01048	0.569
MOD_GlcNHglycan	860	863	PF01048	0.511
MOD_GlcNHglycan	871	874	PF01048	0.447
MOD_GlcNHglycan	93	96	PF01048	0.565
MOD_GSK3_1	106	113	PF00069	0.534
MOD_GSK3_1	134	141	PF00069	0.566
MOD_GSK3_1	177	184	PF00069	0.516
MOD_GSK3_1	221	228	PF00069	0.593
MOD_GSK3_1	234	241	PF00069	0.524
MOD_GSK3_1	267	274	PF00069	0.549
MOD_GSK3_1	438	445	PF00069	0.553
MOD_GSK3_1	450	457	PF00069	0.491
MOD_GSK3_1	463	470	PF00069	0.444
MOD_GSK3_1	52	59	PF00069	0.521
MOD_GSK3_1	521	528	PF00069	0.595
MOD_GSK3_1	534	541	PF00069	0.565
MOD_GSK3_1	555	562	PF00069	0.651
MOD_GSK3_1	605	612	PF00069	0.637
MOD_GSK3_1	666	673	PF00069	0.619
MOD_GSK3_1	713	720	PF00069	0.693
MOD_GSK3_1	748	755	PF00069	0.665
MOD_GSK3_1	76	83	PF00069	0.643
MOD_GSK3_1	807	814	PF00069	0.488
MOD_GSK3_1	822	829	PF00069	0.428
MOD_GSK3_1	91	98	PF00069	0.525
MOD_N-GLC_1	229	234	PF02516	0.659
MOD_N-GLC_1	732	737	PF02516	0.613
MOD_N-GLC_1	812	817	PF02516	0.484
MOD_N-GLC_1	858	863	PF02516	0.500
MOD_NEK2_1	1	6	PF00069	0.543
MOD_NEK2_1	110	115	PF00069	0.587
MOD_NEK2_1	186	191	PF00069	0.533
MOD_NEK2_1	344	349	PF00069	0.479
MOD_NEK2_1	401	406	PF00069	0.735
MOD_NEK2_1	423	428	PF00069	0.526
MOD_NEK2_1	467	472	PF00069	0.482
MOD_NEK2_1	499	504	PF00069	0.393
MOD_NEK2_1	604	609	PF00069	0.629
MOD_NEK2_1	826	831	PF00069	0.535
MOD_NEK2_1	869	874	PF00069	0.491
MOD_NEK2_2	483	488	PF00069	0.447
MOD_PIKK_1	161	167	PF00454	0.486
MOD_PIKK_1	216	222	PF00454	0.563
MOD_PIKK_1	235	241	PF00454	0.473
MOD_PIKK_1	354	360	PF00454	0.589
MOD_PIKK_1	680	686	PF00454	0.630
MOD_PIKK_1	845	851	PF00454	0.432
MOD_PK_1	370	376	PF00069	0.496
MOD_PKA_1	279	285	PF00069	0.555
MOD_PKA_1	515	521	PF00069	0.575
MOD_PKA_1	811	817	PF00069	0.481
MOD_PKA_2	126	132	PF00069	0.558
MOD_PKA_2	177	183	PF00069	0.515
MOD_PKA_2	186	192	PF00069	0.452
MOD_PKA_2	279	285	PF00069	0.555
MOD_PKA_2	347	353	PF00069	0.456
MOD_PKA_2	401	407	PF00069	0.770
MOD_PKA_2	423	429	PF00069	0.477
MOD_PKA_2	499	505	PF00069	0.487
MOD_PKA_2	507	513	PF00069	0.420
MOD_PKA_2	515	521	PF00069	0.470
MOD_PKA_2	624	630	PF00069	0.633
MOD_PKA_2	694	700	PF00069	0.551
MOD_PKA_2	811	817	PF00069	0.486
MOD_PKB_1	551	559	PF00069	0.601
MOD_Plk_1	344	350	PF00069	0.451
MOD_Plk_1	686	692	PF00069	0.578
MOD_Plk_1	732	738	PF00069	0.614
MOD_Plk_1	864	870	PF00069	0.441
MOD_Plk_4	186	192	PF00069	0.552
MOD_Plk_4	302	308	PF00069	0.523
MOD_Plk_4	370	376	PF00069	0.518
MOD_Plk_4	396	402	PF00069	0.622
MOD_Plk_4	463	469	PF00069	0.484
MOD_Plk_4	501	507	PF00069	0.358
MOD_Plk_4	695	701	PF00069	0.553
MOD_Plk_4	864	870	PF00069	0.441
MOD_Plk_4	878	884	PF00069	0.295
MOD_ProDKin_1	112	118	PF00069	0.587
MOD_ProDKin_1	15	21	PF00069	0.539
MOD_ProDKin_1	229	235	PF00069	0.543
MOD_ProDKin_1	280	286	PF00069	0.653
MOD_ProDKin_1	326	332	PF00069	0.716
MOD_ProDKin_1	411	417	PF00069	0.620
MOD_ProDKin_1	450	456	PF00069	0.622
MOD_ProDKin_1	534	540	PF00069	0.684
MOD_ProDKin_1	555	561	PF00069	0.652
MOD_ProDKin_1	585	591	PF00069	0.684
MOD_ProDKin_1	593	599	PF00069	0.588
MOD_ProDKin_1	647	653	PF00069	0.614
MOD_ProDKin_1	670	676	PF00069	0.556
MOD_ProDKin_1	702	708	PF00069	0.613
MOD_ProDKin_1	725	731	PF00069	0.687
MOD_ProDKin_1	750	756	PF00069	0.721
MOD_ProDKin_1	872	878	PF00069	0.384
MOD_SUMO_rev_2	154	161	PF00179	0.557
MOD_SUMO_rev_2	652	658	PF00179	0.584
TRG_DiLeu_BaEn_1	312	317	PF01217	0.548
TRG_ENDOCYTIC_2	210	213	PF00928	0.573
TRG_ENDOCYTIC_2	435	438	PF00928	0.461
TRG_ENDOCYTIC_2	520	523	PF00928	0.590
TRG_ER_diArg_1	401	403	PF00400	0.695
TRG_ER_diArg_1	515	517	PF00400	0.545
TRG_ER_diArg_1	550	553	PF00400	0.605
TRG_ER_diArg_1	58	61	PF00400	0.558
TRG_ER_diArg_1	67	69	PF00400	0.481
TRG_ER_diArg_1	766	769	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIS1	Leishmania donovani	99%	100%
A4HNU5	Leishmania braziliensis	62%	100%
E9ASK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q1Z1	Leishmania major	86%	100%