LeishMANIAdb
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Putative mitogen-activated protein kinase kinase 5

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitogen-activated protein kinase kinase 5
Gene product:
mitogen-activated protein kinase kinase - putative
Species:
Leishmania infantum
UniProt:
A4ICP8_LEIIN
TriTrypDb:
LINF_360014300
Length:
525

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 5
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4ICP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP8

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 28
GO:0006793 phosphorus metabolic process 3 28
GO:0006796 phosphate-containing compound metabolic process 4 28
GO:0006807 nitrogen compound metabolic process 2 28
GO:0008152 metabolic process 1 28
GO:0009987 cellular process 1 28
GO:0016310 phosphorylation 5 28
GO:0019538 protein metabolic process 3 28
GO:0036211 protein modification process 4 28
GO:0043170 macromolecule metabolic process 3 28
GO:0043412 macromolecule modification 4 28
GO:0044237 cellular metabolic process 2 28
GO:0044238 primary metabolic process 2 28
GO:0071704 organic substance metabolic process 2 28
GO:1901564 organonitrogen compound metabolic process 3 28
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0007165 signal transduction 2 2
GO:0022402 cell cycle process 2 1
GO:0035556 intracellular signal transduction 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0065007 biological regulation 1 2
GO:1903047 mitotic cell cycle process 3 1
GO:0000165 MAPK cascade 4 1
GO:0001932 regulation of protein phosphorylation 7 1
GO:0001934 positive regulation of protein phosphorylation 8 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009966 regulation of signal transduction 4 1
GO:0009967 positive regulation of signal transduction 5 1
GO:0010562 positive regulation of phosphorus metabolic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010647 positive regulation of cell communication 5 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0023051 regulation of signaling 3 1
GO:0023056 positive regulation of signaling 4 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0031401 positive regulation of protein modification process 7 1
GO:0033674 positive regulation of kinase activity 6 1
GO:0042325 regulation of phosphorylation 7 1
GO:0042327 positive regulation of phosphorylation 8 1
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043405 regulation of MAP kinase activity 8 1
GO:0043406 positive regulation of MAP kinase activity 8 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0043410 positive regulation of MAPK cascade 7 1
GO:0043549 regulation of kinase activity 5 1
GO:0044093 positive regulation of molecular function 3 1
GO:0045859 regulation of protein kinase activity 6 1
GO:0045860 positive regulation of protein kinase activity 7 1
GO:0045937 positive regulation of phosphate metabolic process 7 1
GO:0046777 protein autophosphorylation 6 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048584 positive regulation of response to stimulus 4 1
GO:0050790 regulation of catalytic activity 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0051338 regulation of transferase activity 4 1
GO:0051347 positive regulation of transferase activity 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065009 regulation of molecular function 2 1
GO:0071900 regulation of protein serine/threonine kinase activity 7 1
GO:0071902 positive regulation of protein serine/threonine kinase activity 8 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902533 positive regulation of intracellular signal transduction 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 28
GO:0003824 catalytic activity 1 28
GO:0004672 protein kinase activity 3 28
GO:0005488 binding 1 28
GO:0005524 ATP binding 5 28
GO:0016301 kinase activity 4 28
GO:0016740 transferase activity 2 28
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 28
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 28
GO:0017076 purine nucleotide binding 4 28
GO:0030554 adenyl nucleotide binding 5 28
GO:0032553 ribonucleotide binding 3 28
GO:0032555 purine ribonucleotide binding 4 28
GO:0032559 adenyl ribonucleotide binding 5 28
GO:0035639 purine ribonucleoside triphosphate binding 4 28
GO:0036094 small molecule binding 2 28
GO:0043167 ion binding 2 28
GO:0043168 anion binding 3 28
GO:0097159 organic cyclic compound binding 2 28
GO:0097367 carbohydrate derivative binding 2 28
GO:0140096 catalytic activity, acting on a protein 2 28
GO:1901265 nucleoside phosphate binding 3 28
GO:1901363 heterocyclic compound binding 2 28
GO:0004674 protein serine/threonine kinase activity 4 10
GO:0004707 MAP kinase activity 5 5
GO:0004140 dephospho-CoA kinase activity 5 1
GO:0004708 MAP kinase kinase activity 5 1
GO:0004712 protein serine/threonine/tyrosine kinase activity 4 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0051019 mitogen-activated protein kinase binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.211
CLV_C14_Caspase3-7 207 211 PF00656 0.211
CLV_NRD_NRD_1 102 104 PF00675 0.238
CLV_NRD_NRD_1 304 306 PF00675 0.406
CLV_NRD_NRD_1 414 416 PF00675 0.364
CLV_NRD_NRD_1 505 507 PF00675 0.526
CLV_NRD_NRD_1 74 76 PF00675 0.282
CLV_PCSK_KEX2_1 102 104 PF00082 0.243
CLV_PCSK_KEX2_1 304 306 PF00082 0.316
CLV_PCSK_KEX2_1 505 507 PF00082 0.516
CLV_PCSK_KEX2_1 74 76 PF00082 0.287
CLV_PCSK_SKI1_1 159 163 PF00082 0.281
CLV_PCSK_SKI1_1 177 181 PF00082 0.330
CLV_PCSK_SKI1_1 415 419 PF00082 0.409
CLV_PCSK_SKI1_1 497 501 PF00082 0.506
CLV_PCSK_SKI1_1 88 92 PF00082 0.295
CLV_Separin_Metazoa 310 314 PF03568 0.218
DEG_APCC_DBOX_1 101 109 PF00400 0.211
DEG_APCC_DBOX_1 158 166 PF00400 0.211
DEG_SPOP_SBC_1 331 335 PF00917 0.499
DOC_ANK_TNKS_1 477 484 PF00023 0.500
DOC_CKS1_1 113 118 PF01111 0.225
DOC_CYCLIN_yClb1_LxF_4 520 525 PF00134 0.432
DOC_CYCLIN_yCln2_LP_2 145 151 PF00134 0.218
DOC_CYCLIN_yCln2_LP_2 312 318 PF00134 0.256
DOC_PP1_SILK_1 366 371 PF00149 0.465
DOC_PP2B_LxvP_1 280 283 PF13499 0.246
DOC_PP2B_LxvP_1 382 385 PF13499 0.473
DOC_PP4_FxxP_1 113 116 PF00568 0.218
DOC_USP7_MATH_1 361 365 PF00917 0.462
DOC_USP7_MATH_1 435 439 PF00917 0.553
DOC_USP7_MATH_1 452 456 PF00917 0.605
DOC_USP7_MATH_2 283 289 PF00917 0.206
DOC_WW_Pin1_4 112 117 PF00397 0.250
DOC_WW_Pin1_4 219 224 PF00397 0.290
DOC_WW_Pin1_4 298 303 PF00397 0.236
DOC_WW_Pin1_4 344 349 PF00397 0.491
DOC_WW_Pin1_4 350 355 PF00397 0.471
DOC_WW_Pin1_4 370 375 PF00397 0.530
DOC_WW_Pin1_4 383 388 PF00397 0.600
LIG_14-3-3_CanoR_1 258 267 PF00244 0.323
LIG_14-3-3_CanoR_1 305 315 PF00244 0.269
LIG_14-3-3_CanoR_1 319 325 PF00244 0.447
LIG_14-3-3_CanoR_1 497 504 PF00244 0.639
LIG_14-3-3_CanoR_1 505 514 PF00244 0.516
LIG_Actin_WH2_2 244 260 PF00022 0.269
LIG_Actin_WH2_2 489 507 PF00022 0.484
LIG_APCC_ABBAyCdc20_2 172 178 PF00400 0.271
LIG_BIR_II_1 1 5 PF00653 0.482
LIG_FHA_1 113 119 PF00498 0.290
LIG_FHA_1 169 175 PF00498 0.221
LIG_FHA_1 188 194 PF00498 0.338
LIG_FHA_1 307 313 PF00498 0.292
LIG_FHA_2 205 211 PF00498 0.238
LIG_FHA_2 305 311 PF00498 0.300
LIG_FHA_2 393 399 PF00498 0.377
LIG_FHA_2 498 504 PF00498 0.488
LIG_GBD_Chelix_1 405 413 PF00786 0.303
LIG_LIR_Apic_2 112 116 PF02991 0.218
LIG_LIR_Apic_2 217 223 PF02991 0.325
LIG_LIR_Gen_1 130 138 PF02991 0.245
LIG_LIR_LC3C_4 239 244 PF02991 0.294
LIG_LIR_Nem_3 144 149 PF02991 0.273
LIG_LIR_Nem_3 229 233 PF02991 0.204
LIG_LIR_Nem_3 263 269 PF02991 0.246
LIG_MYND_1 429 433 PF01753 0.480
LIG_NRBOX 519 525 PF00104 0.461
LIG_PDZ_Class_2 520 525 PF00595 0.461
LIG_Pex14_2 121 125 PF04695 0.238
LIG_SH2_CRK 146 150 PF00017 0.223
LIG_SH2_CRK 254 258 PF00017 0.220
LIG_SH2_STAT5 117 120 PF00017 0.285
LIG_SH2_STAT5 167 170 PF00017 0.269
LIG_SH3_3 145 151 PF00018 0.255
LIG_SH3_3 296 302 PF00018 0.246
LIG_SUMO_SIM_anti_2 52 61 PF11976 0.334
LIG_SUMO_SIM_par_1 46 53 PF11976 0.339
LIG_SUMO_SIM_par_1 83 89 PF11976 0.220
MOD_CDC14_SPxK_1 222 225 PF00782 0.274
MOD_CDC14_SPxK_1 301 304 PF00782 0.218
MOD_CDC14_SPxK_1 373 376 PF00782 0.470
MOD_CDK_SPxK_1 219 225 PF00069 0.274
MOD_CDK_SPxK_1 298 304 PF00069 0.218
MOD_CDK_SPxK_1 370 376 PF00069 0.471
MOD_CDK_SPxxK_3 298 305 PF00069 0.236
MOD_CDK_SPxxK_3 344 351 PF00069 0.489
MOD_CDK_SPxxK_3 383 390 PF00069 0.481
MOD_CK1_1 333 339 PF00069 0.544
MOD_CK1_1 364 370 PF00069 0.510
MOD_CK1_1 438 444 PF00069 0.676
MOD_CK1_1 455 461 PF00069 0.531
MOD_CK1_1 69 75 PF00069 0.225
MOD_CK2_1 138 144 PF00069 0.257
MOD_CK2_1 14 20 PF00069 0.473
MOD_CK2_1 199 205 PF00069 0.246
MOD_CK2_1 304 310 PF00069 0.356
MOD_CK2_1 383 389 PF00069 0.534
MOD_CK2_1 49 55 PF00069 0.351
MOD_CK2_1 505 511 PF00069 0.570
MOD_GlcNHglycan 16 19 PF01048 0.482
MOD_GlcNHglycan 294 297 PF01048 0.339
MOD_GlcNHglycan 357 360 PF01048 0.477
MOD_GlcNHglycan 437 440 PF01048 0.760
MOD_GlcNHglycan 454 457 PF01048 0.583
MOD_GlcNHglycan 479 482 PF01048 0.617
MOD_GlcNHglycan 484 487 PF01048 0.601
MOD_GlcNHglycan 69 72 PF01048 0.275
MOD_GSK3_1 210 217 PF00069 0.326
MOD_GSK3_1 28 35 PF00069 0.332
MOD_GSK3_1 330 337 PF00069 0.551
MOD_GSK3_1 43 50 PF00069 0.346
MOD_GSK3_1 452 459 PF00069 0.580
MOD_GSK3_1 506 513 PF00069 0.541
MOD_N-GLC_2 45 47 PF02516 0.344
MOD_NEK2_1 138 143 PF00069 0.255
MOD_NEK2_1 168 173 PF00069 0.419
MOD_NEK2_1 185 190 PF00069 0.328
MOD_NEK2_1 198 203 PF00069 0.263
MOD_NEK2_1 204 209 PF00069 0.274
MOD_NEK2_1 214 219 PF00069 0.356
MOD_NEK2_1 318 323 PF00069 0.379
MOD_NEK2_1 332 337 PF00069 0.574
MOD_NEK2_1 369 374 PF00069 0.499
MOD_NEK2_1 504 509 PF00069 0.505
MOD_PKA_1 304 310 PF00069 0.269
MOD_PKA_1 505 511 PF00069 0.488
MOD_PKA_2 304 310 PF00069 0.316
MOD_PKA_2 318 324 PF00069 0.476
MOD_PKA_2 477 483 PF00069 0.562
MOD_PKA_2 504 510 PF00069 0.521
MOD_PKA_2 78 84 PF00069 0.235
MOD_Plk_1 400 406 PF00069 0.304
MOD_Plk_2-3 392 398 PF00069 0.399
MOD_Plk_4 127 133 PF00069 0.198
MOD_Plk_4 163 169 PF00069 0.255
MOD_Plk_4 210 216 PF00069 0.318
MOD_Plk_4 28 34 PF00069 0.336
MOD_Plk_4 364 370 PF00069 0.473
MOD_ProDKin_1 112 118 PF00069 0.250
MOD_ProDKin_1 219 225 PF00069 0.290
MOD_ProDKin_1 298 304 PF00069 0.236
MOD_ProDKin_1 344 350 PF00069 0.488
MOD_ProDKin_1 370 376 PF00069 0.533
MOD_ProDKin_1 383 389 PF00069 0.598
MOD_SUMO_rev_2 188 196 PF00179 0.263
TRG_DiLeu_BaEn_1 519 524 PF01217 0.456
TRG_DiLeu_BaEn_2 127 133 PF01217 0.211
TRG_DiLeu_LyEn_5 519 524 PF01217 0.415
TRG_ENDOCYTIC_2 122 125 PF00928 0.303
TRG_ENDOCYTIC_2 146 149 PF00928 0.223
TRG_ENDOCYTIC_2 254 257 PF00928 0.249
TRG_ER_diArg_1 101 103 PF00400 0.238
TRG_ER_diArg_1 304 306 PF00400 0.300
TRG_ER_diArg_1 504 506 PF00400 0.511
TRG_ER_diArg_1 73 75 PF00400 0.252
TRG_Pf-PMV_PEXEL_1 497 502 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0B6 Leptomonas seymouri 58% 98%
A0A1X0NKG4 Trypanosomatidae 27% 68%
A0A1X0P795 Trypanosomatidae 24% 77%
A0A1X0P919 Trypanosomatidae 56% 100%
A0A3Q8IE25 Leishmania donovani 26% 80%
A0A3Q8IIG1 Leishmania donovani 32% 100%
A0A3Q8IND3 Leishmania donovani 99% 100%
A0A3S7WYP4 Leishmania donovani 34% 100%
A0A3S7X2W3 Leishmania donovani 37% 100%
A0A3S7X7Y2 Leishmania donovani 35% 100%
A0A422NT49 Trypanosoma rangeli 27% 74%
A4H7V0 Leishmania braziliensis 26% 74%
A4HAS1 Leishmania braziliensis 34% 100%
A4HDU3 Leishmania braziliensis 34% 100%
A4HFC9 Leishmania braziliensis 27% 80%
A4HHN1 Leishmania braziliensis 37% 100%
A4HNU6 Leishmania braziliensis 77% 100%
A4I140 Leishmania infantum 34% 100%
A4I2K6 Leishmania infantum 26% 80%
A4I435 Leishmania infantum 32% 100%
A4I4U6 Leishmania infantum 37% 100%
A4I9Y5 Leishmania infantum 35% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9ASK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P53350 Homo sapiens 28% 87%
Q0PKV7 Leishmania mexicana 90% 100%
Q4Q1Z0 Leishmania major 90% 98%
Q4Q204 Leishmania major 29% 100%
Q4Q2Z2 Leishmania major 34% 100%
Q4Q7W2 Leishmania major 32% 100%
Q4QA98 Leishmania major 34% 100%
Q9Y077 Leishmania major 38% 100%
Q9Z1J2 Mus musculus 26% 66%
V5BDF5 Trypanosoma cruzi 27% 80%
V5BI43 Trypanosoma cruzi 25% 100%
V5C234 Trypanosoma cruzi 28% 97%
V5DCD4 Trypanosoma cruzi 25% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS