Nfu_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICP6_LEIIN

TriTrypDb:

LINF_360014500

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4ICP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP6

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016043	cellular component organization	3	16
GO:0016226	iron-sulfur cluster assembly	4	16
GO:0022607	cellular component assembly	4	16
GO:0031163	metallo-sulfur cluster assembly	5	16
GO:0044237	cellular metabolic process	2	16
GO:0071840	cellular component organization or biogenesis	2	16
GO:0006807	nitrogen compound metabolic process	2	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	16
GO:0005506	iron ion binding	6	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0046914	transition metal ion binding	5	16
GO:0051536	iron-sulfur cluster binding	3	16
GO:0051540	metal cluster binding	2	16
GO:0051539	4 iron, 4 sulfur cluster binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.339
CLV_C14_Caspase3-7	223	227	PF00656	0.465
CLV_NRD_NRD_1	21	23	PF00675	0.653
CLV_NRD_NRD_1	24	26	PF00675	0.389
CLV_NRD_NRD_1	42	44	PF00675	0.506
CLV_NRD_NRD_1	47	49	PF00675	0.502
CLV_PCSK_KEX2_1	21	23	PF00082	0.653
CLV_PCSK_KEX2_1	42	44	PF00082	0.526
CLV_PCSK_KEX2_1	47	49	PF00082	0.519
CLV_PCSK_PC7_1	43	49	PF00082	0.610
CLV_PCSK_SKI1_1	176	180	PF00082	0.288
CLV_PCSK_SKI1_1	230	234	PF00082	0.247
CLV_PCSK_SKI1_1	262	266	PF00082	0.436
CLV_Separin_Metazoa	177	181	PF03568	0.447
DEG_APCC_DBOX_1	279	287	PF00400	0.607
DOC_CKS1_1	55	60	PF01111	0.318
DOC_CYCLIN_RxL_1	173	181	PF00134	0.350
DOC_MAPK_gen_1	25	35	PF00069	0.416
DOC_MAPK_gen_1	280	288	PF00069	0.499
DOC_MAPK_MEF2A_6	202	210	PF00069	0.465
DOC_MAPK_MEF2A_6	29	37	PF00069	0.572
DOC_PP1_RVXF_1	127	133	PF00149	0.352
DOC_PP1_RVXF_1	193	200	PF00149	0.433
DOC_PP1_RVXF_1	85	92	PF00149	0.318
DOC_PP4_FxxP_1	111	114	PF00568	0.293
DOC_PP4_FxxP_1	65	68	PF00568	0.299
DOC_USP7_MATH_1	10	14	PF00917	0.477
DOC_USP7_MATH_1	68	72	PF00917	0.356
DOC_USP7_MATH_2	104	110	PF00917	0.315
DOC_USP7_UBL2_3	262	266	PF12436	0.486
DOC_WW_Pin1_4	147	152	PF00397	0.384
DOC_WW_Pin1_4	281	286	PF00397	0.586
DOC_WW_Pin1_4	54	59	PF00397	0.315
LIG_14-3-3_CanoR_1	42	46	PF00244	0.499
LIG_Actin_WH2_2	11	27	PF00022	0.411
LIG_deltaCOP1_diTrp_1	126	132	PF00928	0.278
LIG_eIF4E_1	251	257	PF01652	0.420
LIG_FHA_1	201	207	PF00498	0.463
LIG_FHA_1	238	244	PF00498	0.465
LIG_FHA_1	282	288	PF00498	0.515
LIG_FHA_2	121	127	PF00498	0.437
LIG_FHA_2	154	160	PF00498	0.478
LIG_FHA_2	221	227	PF00498	0.438
LIG_LIR_Apic_2	109	114	PF02991	0.270
LIG_LIR_Apic_2	13	19	PF02991	0.412
LIG_LIR_Apic_2	64	68	PF02991	0.368
LIG_LIR_Gen_1	120	130	PF02991	0.319
LIG_LIR_Gen_1	154	162	PF02991	0.419
LIG_LIR_Gen_1	289	296	PF02991	0.515
LIG_LIR_Gen_1	70	77	PF02991	0.313
LIG_LIR_Nem_3	120	125	PF02991	0.314
LIG_LIR_Nem_3	126	130	PF02991	0.293
LIG_LIR_Nem_3	154	158	PF02991	0.371
LIG_LIR_Nem_3	252	257	PF02991	0.412
LIG_LIR_Nem_3	289	293	PF02991	0.514
LIG_LIR_Nem_3	70	75	PF02991	0.294
LIG_SH2_CRK	254	258	PF00017	0.441
LIG_SH2_CRK	290	294	PF00017	0.572
LIG_SH2_GRB2like	122	125	PF00017	0.302
LIG_SH2_NCK_1	122	126	PF00017	0.302
LIG_SH2_NCK_1	155	159	PF00017	0.359
LIG_SH2_STAT5	122	125	PF00017	0.392
LIG_SH2_STAT5	141	144	PF00017	0.198
LIG_SH2_STAT5	155	158	PF00017	0.313
LIG_SH3_3	2	8	PF00018	0.546
LIG_TYR_ITIM	288	293	PF00017	0.601
LIG_WRC_WIRS_1	134	139	PF05994	0.273
LIG_WRC_WIRS_1	72	77	PF05994	0.402
MOD_CDC14_SPxK_1	150	153	PF00782	0.399
MOD_CDK_SPxK_1	147	153	PF00069	0.394
MOD_CK1_1	120	126	PF00069	0.363
MOD_CK1_1	133	139	PF00069	0.199
MOD_CK1_1	220	226	PF00069	0.457
MOD_CK1_1	71	77	PF00069	0.441
MOD_CK2_1	125	131	PF00069	0.361
MOD_CK2_1	153	159	PF00069	0.451
MOD_CK2_1	164	170	PF00069	0.399
MOD_GSK3_1	200	207	PF00069	0.446
MOD_GSK3_1	213	220	PF00069	0.486
MOD_N-GLC_2	146	148	PF02516	0.384
MOD_NEK2_1	142	147	PF00069	0.399
MOD_NEK2_1	36	41	PF00069	0.492
MOD_NEK2_1	61	66	PF00069	0.399
MOD_PIKK_1	217	223	PF00454	0.447
MOD_PIKK_1	93	99	PF00454	0.346
MOD_PK_1	115	121	PF00069	0.293
MOD_PKA_2	41	47	PF00069	0.471
MOD_Plk_1	130	136	PF00069	0.273
MOD_Plk_1	153	159	PF00069	0.462
MOD_Plk_4	10	16	PF00069	0.670
MOD_Plk_4	106	112	PF00069	0.270
MOD_Plk_4	133	139	PF00069	0.263
MOD_Plk_4	153	159	PF00069	0.253
MOD_Plk_4	36	42	PF00069	0.587
MOD_Plk_4	71	77	PF00069	0.391
MOD_ProDKin_1	147	153	PF00069	0.394
MOD_ProDKin_1	281	287	PF00069	0.585
MOD_ProDKin_1	54	60	PF00069	0.315
MOD_SUMO_rev_2	159	167	PF00179	0.412
MOD_SUMO_rev_2	190	197	PF00179	0.430
TRG_DiLeu_BaEn_1	252	257	PF01217	0.428
TRG_ENDOCYTIC_2	122	125	PF00928	0.347
TRG_ENDOCYTIC_2	141	144	PF00928	0.205
TRG_ENDOCYTIC_2	155	158	PF00928	0.311
TRG_ENDOCYTIC_2	254	257	PF00928	0.396
TRG_ENDOCYTIC_2	290	293	PF00928	0.549
TRG_ER_diArg_1	20	22	PF00400	0.655
TRG_ER_diArg_1	41	43	PF00400	0.534
TRG_ER_diArg_1	47	49	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Q0	Leptomonas seymouri	35%	100%
A0A0N1I735	Leptomonas seymouri	82%	100%
A0A0S4IJH0	Bodo saltans	33%	100%
A0A0S4IVB5	Bodo saltans	58%	100%
A0A1X0NST9	Trypanosomatidae	33%	100%
A0A1X0P8F8	Trypanosomatidae	67%	100%
A0A3S5H7F5	Leishmania donovani	34%	100%
A0A3S7XAI2	Leishmania donovani	99%	100%
A4HEM5	Leishmania braziliensis	34%	100%
A4HNU8	Leishmania braziliensis	92%	100%
A4I1V6	Leishmania infantum	34%	100%
B3MRT7	Drosophila ananassae	29%	100%
B3NYF7	Drosophila erecta	29%	100%
B4H303	Drosophila persimilis	29%	100%
B4IMF6	Drosophila sechellia	28%	100%
B4JWR9	Drosophila grimshawi	27%	100%
B4M375	Drosophila virilis	29%	100%
B4NE93	Drosophila willistoni	29%	100%
B4PZ52	Drosophila yakuba	30%	100%
B4R3T1	Drosophila simulans	30%	100%
B5DKJ8	Drosophila pseudoobscura pseudoobscura	29%	100%
C9ZS65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A2R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ASK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AY01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P32860	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4Q1Y8	Leishmania major	95%	100%
Q4Q9H2	Leishmania major	34%	100%
Q8SY96	Drosophila melanogaster	28%	100%
Q9C8J2	Arabidopsis thaliana	33%	100%
Q9LIG6	Arabidopsis thaliana	32%	100%
Q9QZ23	Mus musculus	33%	100%
V5DRN0	Trypanosoma cruzi	73%	100%