Eukaryotic translation initiation factor 6

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 6 (eIF-6) - putative

Species:

Leishmania infantum

UniProt:

A4ICP5_LEIIN

TriTrypDb:

LINF_360014600

Length:

249

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 6 EIF6

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005829	cytosol	2	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4ICP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042255	ribosome assembly	7	12
GO:0042256	cytosolic ribosome assembly	8	12
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0140694	non-membrane-bounded organelle assembly	6	12
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902626	assembly of large subunit precursor of preribosome	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0043023	ribosomal large subunit binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.492
CLV_C14_Caspase3-7	87	91	PF00656	0.438
CLV_NRD_NRD_1	225	227	PF00675	0.502
CLV_PCSK_KEX2_1	225	227	PF00082	0.502
DOC_CKS1_1	163	168	PF01111	0.438
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.438
DOC_PP2B_LxvP_1	177	180	PF13499	0.438
DOC_PP2B_LxvP_1	70	73	PF13499	0.438
DOC_USP7_MATH_1	192	196	PF00917	0.438
DOC_USP7_MATH_1	28	32	PF00917	0.449
DOC_WW_Pin1_4	162	167	PF00397	0.438
LIG_14-3-3_CanoR_1	100	108	PF00244	0.481
LIG_14-3-3_CanoR_1	61	65	PF00244	0.397
LIG_14-3-3_CanoR_1	85	89	PF00244	0.454
LIG_BRCT_BRCA1_1	30	34	PF00533	0.463
LIG_deltaCOP1_diTrp_1	201	205	PF00928	0.438
LIG_FHA_1	123	129	PF00498	0.442
LIG_FHA_1	130	136	PF00498	0.433
LIG_FHA_2	209	215	PF00498	0.338
LIG_FHA_2	241	247	PF00498	0.455
LIG_FHA_2	3	9	PF00498	0.275
LIG_FHA_2	75	81	PF00498	0.444
LIG_LIR_Gen_1	20	30	PF02991	0.438
LIG_LIR_Gen_1	201	208	PF02991	0.470
LIG_LIR_LC3C_4	195	199	PF02991	0.441
LIG_LIR_Nem_3	20	26	PF02991	0.438
LIG_LIR_Nem_3	201	205	PF02991	0.438
LIG_LIR_Nem_3	31	37	PF02991	0.465
LIG_PDZ_Class_3	244	249	PF00595	0.464
LIG_Pex14_2	34	38	PF04695	0.461
LIG_SH2_CRK	23	27	PF00017	0.438
LIG_SH2_CRK	50	54	PF00017	0.441
LIG_SH2_NCK_1	151	155	PF00017	0.449
LIG_SH2_NCK_1	50	54	PF00017	0.438
LIG_SH2_STAT5	23	26	PF00017	0.440
LIG_SH2_STAT5	50	53	PF00017	0.438
LIG_SH3_3	160	166	PF00018	0.438
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.456
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.345
LIG_TRAF2_1	77	80	PF00917	0.438
LIG_TRAF2_2	166	171	PF00917	0.438
LIG_TYR_ITIM	48	53	PF00017	0.438
LIG_WRC_WIRS_1	135	140	PF05994	0.466
MOD_CK1_1	122	128	PF00069	0.446
MOD_CK1_1	17	23	PF00069	0.505
MOD_CK1_1	74	80	PF00069	0.445
MOD_CK2_1	138	144	PF00069	0.438
MOD_CK2_1	2	8	PF00069	0.275
MOD_CK2_1	208	214	PF00069	0.346
MOD_CK2_1	33	39	PF00069	0.450
MOD_CK2_1	74	80	PF00069	0.444
MOD_GlcNHglycan	101	104	PF01048	0.249
MOD_GlcNHglycan	194	197	PF01048	0.241
MOD_GSK3_1	134	141	PF00069	0.438
MOD_GSK3_1	2	9	PF00069	0.275
MOD_GSK3_1	84	91	PF00069	0.478
MOD_N-GLC_1	208	213	PF02516	0.367
MOD_NEK2_1	138	143	PF00069	0.448
MOD_NEK2_1	147	152	PF00069	0.462
MOD_NEK2_1	208	213	PF00069	0.364
MOD_NEK2_1	84	89	PF00069	0.461
MOD_PIKK_1	28	34	PF00454	0.438
MOD_PKA_2	122	128	PF00069	0.447
MOD_PKA_2	129	135	PF00069	0.440
MOD_PKA_2	138	144	PF00069	0.411
MOD_PKA_2	17	23	PF00069	0.449
MOD_PKA_2	240	246	PF00069	0.443
MOD_PKA_2	60	66	PF00069	0.463
MOD_PKA_2	84	90	PF00069	0.454
MOD_PKA_2	99	105	PF00069	0.454
MOD_PKB_1	4	12	PF00069	0.438
MOD_Plk_1	171	177	PF00069	0.505
MOD_Plk_1	213	219	PF00069	0.346
MOD_Plk_4	172	178	PF00069	0.461
MOD_Plk_4	240	246	PF00069	0.461
MOD_Plk_4	33	39	PF00069	0.452
MOD_ProDKin_1	162	168	PF00069	0.438
TRG_DiLeu_BaEn_1	172	177	PF01217	0.438
TRG_ENDOCYTIC_2	23	26	PF00928	0.438
TRG_ENDOCYTIC_2	35	38	PF00928	0.439
TRG_ENDOCYTIC_2	50	53	PF00928	0.461
TRG_ER_diArg_1	224	226	PF00400	0.444
TRG_ER_diArg_1	3	6	PF00400	0.275
TRG_NES_CRM1_1	214	227	PF08389	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDV4	Leptomonas seymouri	96%	100%
A0A0S4IVB2	Bodo saltans	87%	100%
A0A1X0P9I9	Trypanosomatidae	91%	100%
A0A3Q8IVS9	Leishmania donovani	100%	100%
A0A422NK30	Trypanosoma rangeli	91%	100%
A0RYC3	Cenarchaeum symbiosum (strain A)	28%	100%
A1RXF3	Thermofilum pendens (strain DSM 2475 / Hrk 5)	30%	100%
A2BN57	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	30%	100%
A2STI7	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	27%	100%
A3CWZ4	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	30%	100%
A3DNH5	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	30%	100%
A4G0C9	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	32%	100%
A4HNU9	Leishmania braziliensis	98%	100%
A4RSQ6	Ostreococcus lucimarinus (strain CCE9901)	60%	100%
A4WL95	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	24%	100%
A5UL31	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	27%	100%
A6UR54	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	32%	100%
A6UT95	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	29%	100%
A6VI48	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	32%	100%
A7ANL7	Babesia bovis	55%	100%
A7I9I6	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	33%	100%
A9A305	Nitrosopumilus maritimus (strain SCM1)	31%	100%
A9A8N1	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	33%	100%
B0EMY3	Entamoeba dispar (strain ATCC PRA-260 / SAW760)	57%	100%
B0R7X7	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	34%	100%
B6YWY2	Thermococcus onnurineus (strain NA1)	30%	100%
B8GEU6	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	28%	100%
B8MDN4	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	61%	100%
B9LUU8	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	32%	100%
B9PVB9	Toxoplasma gondii (strain ATCC 50861 / VEG)	64%	94%
C3MR78	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	32%	100%
C3MXG7	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	32%	100%
C3MZB3	Sulfolobus islandicus (strain M.16.27)	32%	100%
C3N7D3	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	32%	100%
C3NGA1	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	32%	100%
C4KIJ1	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	32%	100%
C5A7H2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	32%	100%
C9SV08	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	57%	100%
D0A2R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	92%	100%
D1ZG64	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	60%	100%
E9ASK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O22290	Arabidopsis thaliana	54%	100%
O27648	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O28214	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	25%	100%
O55135	Mus musculus	59%	100%
O58264	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	32%	100%
O62106	Caenorhabditis elegans	57%	100%
O81920	Beta vulgaris	63%	100%
O94476	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	100%
P38619	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	30%	100%
P56537	Homo sapiens	58%	100%
P56538	Drosophila melanogaster	65%	100%
Q0W5H2	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	29%	100%
Q12522	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
Q12ZJ5	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	31%	100%
Q18EU8	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	35%	100%
Q245F2	Tetrahymena thermophila (strain SB210)	63%	100%
Q2FS97	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	30%	100%
Q2NGQ7	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	29%	100%
Q2UTN7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	63%	100%
Q3ITD5	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	35%	100%
Q3KRD8	Rattus norvegicus	58%	100%
Q46FA1	Methanosarcina barkeri (strain Fusaro / DSM 804)	36%	100%
Q4E097	Trypanosoma cruzi (strain CL Brener)	91%	100%
Q4Q1Y7	Leishmania major	99%	100%
Q551M2	Dictyostelium discoideum	56%	100%
Q59L13	Candida albicans (strain SC5314 / ATCC MYA-2876)	59%	100%
Q5ASA6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	63%	100%
Q5JGT4	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	100%
Q60357	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
Q6GR45	Xenopus laevis	58%	100%
Q6L2L0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	28%	100%
Q6M156	Methanococcus maripaludis (strain S2 / LL)	33%	100%
Q6ZM19	Danio rerio	58%	100%
Q7S2W6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	60%	100%
Q8PYQ3	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	35%	100%
Q8SS47	Encephalitozoon cuniculi (strain GB-M1)	47%	100%
Q8TIN4	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	34%	100%
Q8TUY5	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	30%	100%
Q8U3S8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	100%
Q8ZTU1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	25%	100%
Q971I4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	31%	100%
Q97CU0	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q980G0	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	32%	100%
Q98RM8	Guillardia theta	34%	100%
Q9HM16	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	29%	100%
Q9M060	Arabidopsis thaliana	59%	100%
Q9TU47	Bos taurus	59%	100%
Q9UYI6	Pyrococcus abyssi (strain GE5 / Orsay)	32%	100%
V5B9X2	Trypanosoma cruzi	91%	82%