Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNF1-related protein kinases - putative

Species:

Leishmania infantum

UniProt:

A4ICP4_LEIIN

TriTrypDb:

LINF_360014700

Length:

790

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 179

Expansion

Sequence features

A4ICP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.692
CLV_MEL_PAP_1	14	20	PF00089	0.617
CLV_NRD_NRD_1	356	358	PF00675	0.646
CLV_NRD_NRD_1	53	55	PF00675	0.338
CLV_NRD_NRD_1	553	555	PF00675	0.717
CLV_PCSK_KEX2_1	356	358	PF00082	0.643
CLV_PCSK_KEX2_1	553	555	PF00082	0.717
CLV_PCSK_KEX2_1	68	70	PF00082	0.472
CLV_PCSK_KEX2_1	772	774	PF00082	0.499
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.472
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.518
CLV_PCSK_PC7_1	768	774	PF00082	0.544
CLV_PCSK_SKI1_1	123	127	PF00082	0.318
CLV_PCSK_SKI1_1	144	148	PF00082	0.329
CLV_PCSK_SKI1_1	249	253	PF00082	0.252
CLV_PCSK_SKI1_1	281	285	PF00082	0.509
CLV_PCSK_SKI1_1	46	50	PF00082	0.348
CLV_PCSK_SKI1_1	529	533	PF00082	0.636
CLV_PCSK_SKI1_1	553	557	PF00082	0.696
CLV_PCSK_SKI1_1	558	562	PF00082	0.720
CLV_PCSK_SKI1_1	62	66	PF00082	0.297
CLV_PCSK_SKI1_1	69	73	PF00082	0.314
CLV_Separin_Metazoa	311	315	PF03568	0.531
DEG_APCC_DBOX_1	248	256	PF00400	0.386
DEG_APCC_DBOX_1	45	53	PF00400	0.441
DEG_SCF_FBW7_1	785	790	PF00400	0.632
DEG_SPOP_SBC_1	688	692	PF00917	0.585
DOC_CKS1_1	376	381	PF01111	0.685
DOC_CYCLIN_RxL_1	120	130	PF00134	0.388
DOC_CYCLIN_RxL_1	276	285	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.713
DOC_MAPK_DCC_7	374	382	PF00069	0.553
DOC_MAPK_gen_1	44	51	PF00069	0.372
DOC_MAPK_gen_1	66	76	PF00069	0.348
DOC_MAPK_gen_1	90	97	PF00069	0.441
DOC_MAPK_MEF2A_6	281	288	PF00069	0.382
DOC_MAPK_MEF2A_6	44	51	PF00069	0.372
DOC_MAPK_MEF2A_6	541	549	PF00069	0.558
DOC_MAPK_MEF2A_6	722	730	PF00069	0.563
DOC_MAPK_MEF2A_6	90	99	PF00069	0.377
DOC_MAPK_NFAT4_5	281	289	PF00069	0.383
DOC_MAPK_NFAT4_5	92	100	PF00069	0.402
DOC_MAPK_RevD_3	540	554	PF00069	0.669
DOC_PP4_FxxP_1	569	572	PF00568	0.689
DOC_SPAK_OSR1_1	319	323	PF12202	0.524
DOC_USP7_MATH_1	239	243	PF00917	0.384
DOC_USP7_MATH_1	418	422	PF00917	0.655
DOC_USP7_MATH_1	511	515	PF00917	0.705
DOC_USP7_MATH_1	643	647	PF00917	0.743
DOC_USP7_MATH_2	324	330	PF00917	0.516
DOC_USP7_UBL2_3	406	410	PF12436	0.672
DOC_USP7_UBL2_3	558	562	PF12436	0.685
DOC_USP7_UBL2_3	68	72	PF12436	0.455
DOC_USP7_UBL2_3	727	731	PF12436	0.465
DOC_WW_Pin1_4	180	185	PF00397	0.329
DOC_WW_Pin1_4	320	325	PF00397	0.559
DOC_WW_Pin1_4	375	380	PF00397	0.631
DOC_WW_Pin1_4	471	476	PF00397	0.745
DOC_WW_Pin1_4	490	495	PF00397	0.472
DOC_WW_Pin1_4	568	573	PF00397	0.693
DOC_WW_Pin1_4	575	580	PF00397	0.676
DOC_WW_Pin1_4	605	610	PF00397	0.742
DOC_WW_Pin1_4	633	638	PF00397	0.764
DOC_WW_Pin1_4	783	788	PF00397	0.704
LIG_14-3-3_CanoR_1	138	148	PF00244	0.441
LIG_14-3-3_CanoR_1	263	267	PF00244	0.346
LIG_14-3-3_CanoR_1	281	287	PF00244	0.350
LIG_14-3-3_CanoR_1	296	302	PF00244	0.526
LIG_14-3-3_CanoR_1	342	351	PF00244	0.747
LIG_14-3-3_CanoR_1	466	475	PF00244	0.541
LIG_14-3-3_CanoR_1	553	558	PF00244	0.630
LIG_14-3-3_CanoR_1	612	621	PF00244	0.802
LIG_AP2alpha_2	510	512	PF02296	0.697
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_BRCT_BRCA1_1	284	288	PF00533	0.512
LIG_BRCT_BRCA1_1	565	569	PF00533	0.722
LIG_FHA_1	128	134	PF00498	0.388
LIG_FHA_1	298	304	PF00498	0.610
LIG_FHA_1	40	46	PF00498	0.491
LIG_FHA_1	530	536	PF00498	0.612
LIG_FHA_1	565	571	PF00498	0.689
LIG_FHA_1	765	771	PF00498	0.540
LIG_FHA_2	140	146	PF00498	0.441
LIG_FHA_2	376	382	PF00498	0.679
LIG_FHA_2	660	666	PF00498	0.710
LIG_FHA_2	689	695	PF00498	0.557
LIG_FHA_2	733	739	PF00498	0.584
LIG_FHA_2	89	95	PF00498	0.329
LIG_GBD_Chelix_1	757	765	PF00786	0.477
LIG_LIR_Apic_2	183	189	PF02991	0.329
LIG_LIR_Apic_2	235	241	PF02991	0.331
LIG_LIR_Apic_2	373	379	PF02991	0.683
LIG_LIR_Apic_2	566	572	PF02991	0.690
LIG_LIR_Gen_1	285	292	PF02991	0.484
LIG_LIR_Gen_1	31	39	PF02991	0.402
LIG_LIR_Gen_1	365	375	PF02991	0.621
LIG_LIR_Gen_1	514	524	PF02991	0.565
LIG_LIR_Gen_1	578	589	PF02991	0.760
LIG_LIR_Gen_1	698	708	PF02991	0.568
LIG_LIR_Gen_1	715	726	PF02991	0.354
LIG_LIR_Nem_3	106	111	PF02991	0.323
LIG_LIR_Nem_3	278	282	PF02991	0.498
LIG_LIR_Nem_3	285	291	PF02991	0.459
LIG_LIR_Nem_3	31	35	PF02991	0.383
LIG_LIR_Nem_3	365	370	PF02991	0.567
LIG_LIR_Nem_3	395	400	PF02991	0.525
LIG_LIR_Nem_3	453	458	PF02991	0.750
LIG_LIR_Nem_3	514	519	PF02991	0.555
LIG_LIR_Nem_3	578	584	PF02991	0.754
LIG_LIR_Nem_3	715	721	PF02991	0.477
LIG_LIR_Nem_3	83	89	PF02991	0.428
LIG_LYPXL_SIV_4	754	762	PF13949	0.558
LIG_LYPXL_yS_3	723	726	PF13949	0.557
LIG_MYND_1	273	277	PF01753	0.402
LIG_NRBOX	535	541	PF00104	0.527
LIG_Pex14_1	512	516	PF04695	0.652
LIG_Pex14_1	710	714	PF04695	0.567
LIG_Pex14_2	676	680	PF04695	0.593
LIG_PTAP_UEV_1	594	599	PF05743	0.589
LIG_PTB_Apo_2	416	423	PF02174	0.686
LIG_Rb_pABgroove_1	80	88	PF01858	0.348
LIG_SH2_CRK	212	216	PF00017	0.329
LIG_SH2_CRK	238	242	PF00017	0.346
LIG_SH2_CRK	367	371	PF00017	0.606
LIG_SH2_CRK	438	442	PF00017	0.607
LIG_SH2_CRK	516	520	PF00017	0.551
LIG_SH2_CRK	86	90	PF00017	0.329
LIG_SH2_GRB2like	367	370	PF00017	0.568
LIG_SH2_GRB2like	5	8	PF00017	0.663
LIG_SH2_NCK_1	186	190	PF00017	0.329
LIG_SH2_NCK_1	238	242	PF00017	0.379
LIG_SH2_NCK_1	516	520	PF00017	0.620
LIG_SH2_PTP2	400	403	PF00017	0.656
LIG_SH2_SRC	238	241	PF00017	0.441
LIG_SH2_STAP1	367	371	PF00017	0.580
LIG_SH2_STAP1	714	718	PF00017	0.523
LIG_SH2_STAP1	755	759	PF00017	0.572
LIG_SH2_STAT5	101	104	PF00017	0.329
LIG_SH2_STAT5	110	113	PF00017	0.329
LIG_SH2_STAT5	135	138	PF00017	0.316
LIG_SH2_STAT5	282	285	PF00017	0.469
LIG_SH2_STAT5	302	305	PF00017	0.307
LIG_SH2_STAT5	363	366	PF00017	0.696
LIG_SH2_STAT5	397	400	PF00017	0.530
LIG_SH2_STAT5	717	720	PF00017	0.457
LIG_SH3_3	254	260	PF00018	0.329
LIG_SH3_3	274	280	PF00018	0.214
LIG_SH3_3	501	507	PF00018	0.732
LIG_SH3_3	516	522	PF00018	0.565
LIG_SH3_3	569	575	PF00018	0.737
LIG_SH3_3	592	598	PF00018	0.697
LIG_SH3_3	6	12	PF00018	0.649
LIG_SH3_3	631	637	PF00018	0.732
LIG_SH3_3	718	724	PF00018	0.434
LIG_SH3_4	558	565	PF00018	0.572
LIG_SUMO_SIM_anti_2	222	230	PF11976	0.472
LIG_TRAF2_1	323	326	PF00917	0.517
LIG_TRAF2_1	333	336	PF00917	0.506
LIG_TRAF2_1	412	415	PF00917	0.741
LIG_TRAF2_1	695	698	PF00917	0.483
LIG_TRAF2_2	20	25	PF00917	0.425
LIG_TYR_ITIM	210	215	PF00017	0.329
LIG_TYR_ITIM	398	403	PF00017	0.511
LIG_TYR_ITIM	721	726	PF00017	0.539
MOD_CDK_SPxxK_3	471	478	PF00069	0.704
MOD_CDK_SPxxK_3	605	612	PF00069	0.755
MOD_CK1_1	168	174	PF00069	0.375
MOD_CK1_1	180	186	PF00069	0.256
MOD_CK1_1	242	248	PF00069	0.427
MOD_CK1_1	425	431	PF00069	0.668
MOD_CK1_1	453	459	PF00069	0.599
MOD_CK1_1	464	470	PF00069	0.559
MOD_CK1_1	474	480	PF00069	0.583
MOD_CK1_1	593	599	PF00069	0.734
MOD_CK1_1	608	614	PF00069	0.586
MOD_CK1_1	692	698	PF00069	0.562
MOD_CK1_1	747	753	PF00069	0.497
MOD_CK1_1	780	786	PF00069	0.615
MOD_CK2_1	100	106	PF00069	0.329
MOD_CK2_1	320	326	PF00069	0.481
MOD_CK2_1	330	336	PF00069	0.470
MOD_CK2_1	375	381	PF00069	0.676
MOD_CK2_1	418	424	PF00069	0.741
MOD_CK2_1	456	462	PF00069	0.756
MOD_CK2_1	622	628	PF00069	0.714
MOD_CK2_1	688	694	PF00069	0.564
MOD_CK2_1	757	763	PF00069	0.550
MOD_GlcNHglycan	102	105	PF01048	0.325
MOD_GlcNHglycan	192	195	PF01048	0.348
MOD_GlcNHglycan	244	247	PF01048	0.385
MOD_GlcNHglycan	424	427	PF01048	0.752
MOD_GlcNHglycan	513	516	PF01048	0.671
MOD_GlcNHglycan	614	617	PF01048	0.716
MOD_GlcNHglycan	62	65	PF01048	0.441
MOD_GlcNHglycan	746	749	PF01048	0.503
MOD_GlcNHglycan	782	785	PF01048	0.601
MOD_GSK3_1	156	163	PF00069	0.441
MOD_GSK3_1	176	183	PF00069	0.144
MOD_GSK3_1	292	299	PF00069	0.556
MOD_GSK3_1	326	333	PF00069	0.496
MOD_GSK3_1	418	425	PF00069	0.648
MOD_GSK3_1	447	454	PF00069	0.596
MOD_GSK3_1	456	463	PF00069	0.586
MOD_GSK3_1	466	473	PF00069	0.604
MOD_GSK3_1	549	556	PF00069	0.588
MOD_GSK3_1	56	63	PF00069	0.327
MOD_GSK3_1	564	571	PF00069	0.636
MOD_GSK3_1	589	596	PF00069	0.662
MOD_GSK3_1	608	615	PF00069	0.622
MOD_GSK3_1	629	636	PF00069	0.673
MOD_GSK3_1	659	666	PF00069	0.647
MOD_GSK3_1	688	695	PF00069	0.471
MOD_GSK3_1	783	790	PF00069	0.690
MOD_LATS_1	527	533	PF00433	0.633
MOD_N-GLC_1	451	456	PF02516	0.687
MOD_N-GLC_1	489	494	PF02516	0.627
MOD_N-GLC_1	499	504	PF02516	0.703
MOD_N-GLC_1	688	693	PF02516	0.593
MOD_NEK2_1	165	170	PF00069	0.339
MOD_NEK2_1	176	181	PF00069	0.310
MOD_NEK2_1	215	220	PF00069	0.377
MOD_NEK2_1	221	226	PF00069	0.318
MOD_NEK2_1	297	302	PF00069	0.607
MOD_NEK2_1	422	427	PF00069	0.656
MOD_NEK2_1	429	434	PF00069	0.552
MOD_NEK2_1	460	465	PF00069	0.711
MOD_NEK2_1	499	504	PF00069	0.677
MOD_NEK2_1	549	554	PF00069	0.624
MOD_NEK2_1	687	692	PF00069	0.548
MOD_NEK2_2	156	161	PF00069	0.372
MOD_NEK2_2	282	287	PF00069	0.473
MOD_NEK2_2	564	569	PF00069	0.687
MOD_NEK2_2	663	668	PF00069	0.703
MOD_PIKK_1	401	407	PF00454	0.634
MOD_PIKK_1	429	435	PF00454	0.648
MOD_PIKK_1	772	778	PF00454	0.580
MOD_PKA_1	553	559	PF00069	0.757
MOD_PKA_1	772	778	PF00069	0.594
MOD_PKA_2	139	145	PF00069	0.439
MOD_PKA_2	262	268	PF00069	0.329
MOD_PKA_2	28	34	PF00069	0.329
MOD_PKA_2	553	559	PF00069	0.717
MOD_PKA_2	772	778	PF00069	0.532
MOD_Plk_1	292	298	PF00069	0.569
MOD_Plk_1	451	457	PF00069	0.686
MOD_Plk_1	499	505	PF00069	0.688
MOD_Plk_2-3	262	268	PF00069	0.329
MOD_Plk_4	297	303	PF00069	0.614
MOD_Plk_4	326	332	PF00069	0.571
MOD_Plk_4	396	402	PF00069	0.533
MOD_Plk_4	425	431	PF00069	0.624
MOD_Plk_4	531	537	PF00069	0.515
MOD_Plk_4	564	570	PF00069	0.689
MOD_Plk_4	616	622	PF00069	0.739
MOD_Plk_4	663	669	PF00069	0.707
MOD_Plk_4	757	763	PF00069	0.519
MOD_ProDKin_1	180	186	PF00069	0.329
MOD_ProDKin_1	320	326	PF00069	0.559
MOD_ProDKin_1	375	381	PF00069	0.634
MOD_ProDKin_1	471	477	PF00069	0.744
MOD_ProDKin_1	490	496	PF00069	0.472
MOD_ProDKin_1	568	574	PF00069	0.691
MOD_ProDKin_1	575	581	PF00069	0.679
MOD_ProDKin_1	605	611	PF00069	0.741
MOD_ProDKin_1	633	639	PF00069	0.764
MOD_ProDKin_1	783	789	PF00069	0.708
MOD_SUMO_for_1	146	149	PF00179	0.329
MOD_SUMO_for_1	560	563	PF00179	0.770
MOD_SUMO_for_1	67	70	PF00179	0.472
MOD_SUMO_for_1	703	706	PF00179	0.454
MOD_SUMO_rev_2	368	375	PF00179	0.662
MOD_SUMO_rev_2	737	747	PF00179	0.466
TRG_ENDOCYTIC_2	212	215	PF00928	0.313
TRG_ENDOCYTIC_2	363	366	PF00928	0.614
TRG_ENDOCYTIC_2	367	370	PF00928	0.563
TRG_ENDOCYTIC_2	400	403	PF00928	0.514
TRG_ENDOCYTIC_2	438	441	PF00928	0.612
TRG_ENDOCYTIC_2	516	519	PF00928	0.517
TRG_ENDOCYTIC_2	700	703	PF00928	0.411
TRG_ENDOCYTIC_2	717	720	PF00928	0.387
TRG_ENDOCYTIC_2	723	726	PF00928	0.531
TRG_ENDOCYTIC_2	86	89	PF00928	0.329
TRG_ER_diArg_1	356	358	PF00400	0.675
TRG_ER_diArg_1	553	555	PF00400	0.715
TRG_ER_diArg_1	765	768	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V2	Leptomonas seymouri	71%	97%
A0A1X0P956	Trypanosomatidae	50%	100%
A0A3R7KDE9	Trypanosoma rangeli	47%	100%
A0A3S7XAF4	Leishmania donovani	100%	100%
A4HNV0	Leishmania braziliensis	81%	100%
D0A2R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q1Y6	Leishmania major	95%	100%
V5BQE9	Trypanosoma cruzi	48%	100%