Guanylate cyclase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Guanylate cyclase

Gene product:

mitogen-activated protein kinase-like protein

Species:

Leishmania infantum

UniProt:

A4ICP3_LEIIN

TriTrypDb:

LINF_360014800

Length:

1563

Annotations

Annotations by Jardim et al.

Protein kinase, Mitogen-activated kinase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

A4ICP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP3

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006163	purine nucleotide metabolic process	5	7
GO:0006164	purine nucleotide biosynthetic process	6	7
GO:0006171	cAMP biosynthetic process	8	7
GO:0006182	cGMP biosynthetic process	8	7
GO:0006468	protein phosphorylation	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1143	1147	PF00656	0.744
CLV_C14_Caspase3-7	1448	1452	PF00656	0.524
CLV_C14_Caspase3-7	196	200	PF00656	0.605
CLV_C14_Caspase3-7	777	781	PF00656	0.610
CLV_MEL_PAP_1	545	551	PF00089	0.530
CLV_MEL_PAP_1	560	566	PF00089	0.527
CLV_NRD_NRD_1	102	104	PF00675	0.488
CLV_NRD_NRD_1	1089	1091	PF00675	0.479
CLV_NRD_NRD_1	1209	1211	PF00675	0.481
CLV_NRD_NRD_1	1398	1400	PF00675	0.279

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P883	Leptomonas seymouri	48%	100%
A0A3S7XAH3	Leishmania donovani	99%	100%
A4HNV1	Leishmania braziliensis	63%	99%
E9ASL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q1Y5	Leishmania major	88%	100%

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