LeishMANIAdb
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Guanylate cyclase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanylate cyclase
Gene product:
mitogen-activated protein kinase-like protein
Species:
Leishmania infantum
UniProt:
A4ICP3_LEIIN
TriTrypDb:
LINF_360014800
Length:
1563

Annotations

Annotations by Jardim et al.

Protein kinase, Mitogen-activated kinase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5
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Expansion

Sequence features

A4ICP3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICP3

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006163 purine nucleotide metabolic process 5 7
GO:0006164 purine nucleotide biosynthetic process 6 7
GO:0006171 cAMP biosynthetic process 8 7
GO:0006182 cGMP biosynthetic process 8 7
GO:0006468 protein phosphorylation 5 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006753 nucleoside phosphate metabolic process 4 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1143 1147 PF00656 0.744
CLV_C14_Caspase3-7 1448 1452 PF00656 0.524
CLV_C14_Caspase3-7 196 200 PF00656 0.605
CLV_C14_Caspase3-7 777 781 PF00656 0.610
CLV_MEL_PAP_1 545 551 PF00089 0.530
CLV_MEL_PAP_1 560 566 PF00089 0.527
CLV_NRD_NRD_1 102 104 PF00675 0.488
CLV_NRD_NRD_1 1089 1091 PF00675 0.479
CLV_NRD_NRD_1 1209 1211 PF00675 0.481
CLV_NRD_NRD_1 1398 1400 PF00675 0.279
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P883 Leptomonas seymouri 48% 100%
A0A3S7XAH3 Leishmania donovani 99% 100%
A4HNV1 Leishmania braziliensis 63% 99%
E9ASL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q1Y5 Leishmania major 88% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS